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[Christopher1]

How will the castor oil improve my damaged skin? I seem to have lost a lot of natural turgor since the DMSO, sadly - a sign of aging.

I am curious why castor oil in particular.

[melting]

I burned my skin with DMSO once and it then pealed off for some days until new skin appeared. Castor oil helped me.
I can imagine it taking some time to heal. I cant imagine turgor totally gone forever.
How long ago was it christopher? Is it just getting worse or is there any improvement? If there is an infection to the skin apply some cortisone lotion/cream.

Castor oil stays rather sticky to the skin and coats the skin nicely moisturizing it. Its like a second skin so to say.
It softens the skin nicely if applied overnight or long duration. Take care with clothes as it stains them.
The parts in it can replenish the skin it seems.

[If you ever do dmso again use it mixed in at least a 70/30 ratio. It truly has great properties but will burn skin if applied in undiluted strength.
If you take the dmso and mix it with some water it will have a heat reaction(which happened unfortunately in your skin now). Applying it after diluting wont create the reaction on the skin then.
Actually mixing it in a concentration like 10% with castor oil might improve your condition driving the ingredients of the castor oil deeper.]

[Christopher1]

I will give it another try.

Thank you!

[melting]

DMSO needs to be premixed with water or another aqueous solution before applying to skin.
DMSO + water creates a heat reaction. If undiluted DMSO solution is put on skin the DMSO will react with water in the skin=burn.

When DMSO is advised people often say its 99% which means the quality of it.
Use 99%-Quality DMSO and mix it with water 50/50 up to 90/10.

Also dont mix with chemcials on skin or any other harmful substance as it will carry into skin.

[Christopher1]

I did not know it was an exothermic reaction.

Interesting stuff.

[melting]

DMSO is quiet an interesting substance.
It "freezes" above 0°C.
It plays with the lipid layers of the skin which are normaly not penetrable for most substances.

There is a lot of mumbo jumbo talk about it on the web but also a huge amount of detailed science.

http://www.sciencedirect.com/science/article/pii/S0006349507714601
"The simulations also reveal that at high concentrations DMSO can induce water pores into the bilayer, which may be an important mechanism for permeability enhancement of solutes."
Couple this with the exothermic reaction and you have a good "burn". As it goes so deep the "burn" is also deep and not just the upper layer. Not in a fire type burn but in this weird way of displacing.
Half of my skin was peeling off for days like a snake skin and looking old and wrinkled.
I can see how it would scare you off from using it ever again.

But yeah in concentrations below 90% coupled with some afterwards skin moisturizing nothing bad happens at all.
Daily applications(which I think are needed when targeting the scar tissue) necessitate some skin care. Aloe vera and Castor oil are my favourites.

The only solution that was even at lower DMSO% a bit stingy was when I mixed it with Iodine.

[Christopher1]

Interesting.

[kuaka]

I'm about to try something.  I have ordered some liquid bromaline.  My plan is to mix it with DMSO as a carrier.  Wrap up for 15-20 minutes...cotton wrap should be ok, no latex or other exotic materials which the DMSO will suck into me.  Follow that with a VED session.  I plan on doing this once a day for a while.  If it appears too help and not hurt, I may up it to twice.

[Christopher1]

Bromelain - a pineapple protease - will digest all peptides.

I would not do it. Sounds like a disaster waiting to happen.

[skunkworks]

Didn't notice this post earlier, I hope Kuaka has not tried this yet. This does not sound like a good idea at all.

You'd be using DMSO to allow an enzyme that digests protein to penetrate into your penis. Best case it does absolutely nothing as it's a pretty big molecule. Worst case it could cause you serious harm. Natural does not mean safe.

[melting]

Bromelain is too big of a molecule.
Other then that your idea is good. Combine with some other stuff like vitaminC,vitE or magnesium.(lots of info in this thread)

Make sure to warm up the VED with a heating pad(for example). Heat gives more expansion.
Also make sure that if you have DMSO on your skin that it doesnt come in contact with plastic from the VED or similar.

[kuaka]

I've been researching injectable Bromaline for Dupreyne's...I'll do a lot more research before trying anything.  Right now I have ZERO time to devote to ANYTHING, so NOTHING is happening on this front.

[peyter]

Dear all,

Did a lot a of efforts to try dmso and combined components applied to my penis skin in last times.
I ve been trying since january.
Dmso + evit + iodine
Dmso 70, 80, 90 % by itself
Dmso + castor oil
Dmso + contractubex
Dmso + all mixed together...

No improvements for the time being. My curvature has been progressing till an stable state.

Thats my personal feedback. I hope it has worth for anyone.

Im going to have a xiaflex cycle to stop or improve my condition.

Best for all

[james1947]

Thank you for the report peyter
I am not trying to convince no one that DMSO is not working.
Hope some people can learn from your experience

James

[pey ron]

Dmso + evit + iodine

@Peyter: what is evit???

I seem to be having good success with DMSO + iosol + PABA and ALCAR both to saturation and magnesium chloride flakes, followed by the Thacker's Formula to rinse out the red stain from the iodine. I don't remember the exact proportions, but I tried to maximize PABA and ALCAR and only later add the magnesium chloride and the iosol.

[Christopher1]

Probably vitamin E.

[Spika]

We might be having news  soon -from a reputable source-that will lead us to the right path...

I have contacted and spoke with, the Chief Science Officer of a Canadian Bio Medical Company.

They have a product (applied on the plaque) that they have finished Phase 1 clinical trials, and they are ready to start Phase 2.
The results so far are good.. The name of this product is known to this forum.

He is  open to the idea of contacting a separate and parallel Phase 2 clinical trial from this forum's members.

He will discuss it with the board this week and he will let me know.

Please stay tune...

Just in case that I get many PM and my box gets full, my email is: [email protected]

[pey ron]

@spika: how is their product related to DMSO?

other than that, i'm definitely interested in being part of a trial

[Spika]

@ Pey ron

Please either PM me, or email me : [email protected]

[peyter]

Probably vitamin E.

E vitamin oil...its nice.

[peyter]

Thanks to all.

On my personal case today i have no improvements by applying DMSO. I hope otther can have success.
I have to say i have no damage on my pennis and all products are ok...to do trials and never give up is on my way to face this condition...nex step for me will be xiaflex. I will report about it in the main thread on this forum.

Best of lucks

[JayGould]

Anyone tried hydrocortisone cream? Any possible negative side effects?

[PTalk]

Hi all,

I've had peyronies for about 3 years now and still have constant pain especially after anything sexual which can leave me with burning pain for days.  At 28 it's kind of destroyed my sex life.

I'm on Pentox & Ubiquinol, but a user informed me that he had the following DMSO based ointment made up by a compounding pharmacy - I am hoping you guys can help me fill in the blanks here so I can take the exact %'s / amounts required to my doc, and he will write the prescription for it.

"The active ingredients in the ointment I used include Verapamil 10%, Pentoxifyline 0.5% DMSO (don't know the percent) and the inactive ingredients lipoderm, vitamin E, and iodine.  The ointment is topically applied to the affected area twice a day."


As you can see I have the %'s for Verapamil & Pentox, however the DMSO and inactive ingredient %'s he did not know.  Anyone here have any suggestions on what would be a suitable % for the DMSO & other ingredients?

Basically just want the exact compound written down so I can get it made up - taking the list as-is to my doc would mean he would be doing "guesswork" for the DMSO and inactive ingredients - I figured you guys here may be able to help determine a proper % for all of these since you all know a lot more than most general doctors.

Also, what do you think of that compound mix?  The guy who provided me with it said a local naturopath had it made for him and it greatly reduced his plaque & bend by 90%.  My condition is different in that most of the left side shaft is affected and I have some cord-like structures as well, plus the constant pain which he did not have - nevertheless I think this could be a really good option since applying castor oil by itself doesn't really help me that much.

[Paolo]

Hi Ptalk, You should be taking ALC, it will/should help with pain 

There was talk some time ago about a mix called H-100, it consisted of a composition of combinations of calcium channel blockers (for efficacy)  nicardipine, verapamil, nifedipine, diltiazem, amalodipine, felodipine, isradipine, nimodipine, nisoldipine, bepridil, or a combination thereof along with superoxide dismutase (SOD), and emu oil plus suitable co-enhancers.

Patent EP2804606A1 - Topical therapeutic formulations - Google Patents

Hybrid Medical | Treatment for Peyronie's Disease

It unfortunately hasn't been trialed yet, but you could see what your Doctor thinks of it and he may help.

The variety of treatment options for Peyronie's disease is testament to the serious need that remains for an effective treatment

Peyronie's disease may develop following trauma to the penis that causes localized internal bleeding, and can result in painful erections and penile disfigurement. The physical structure of the penis includes the corpora cavernosa - two erectile rods, the urethra - a conduit through which urine flows from the bladder, and the tunica, which separates the cavernosa from the outer layers of skin of the penis. Peyronie's disease can involve the formation of a plaque or scar tissue between the tunica and the outer layers of the skin (e.g., subdermal scar tissue).

Erectile dysfunction due to fibrosis is common after 40 years of age, while the capacity for erection often is not changed. Because fibrosis underlies certain forms of erectile dysfunction, an effective topically applied antioxidant and/or calcium channel blocker formulation can be useful in treating forms of erectile dysfunction that arise from fibrosis

[PTalk]

Hi Paolo,

Thanks for the reply.  I have ALC plus all the rest of the supplements under the sun for Peyronies (haha!) although I've been experiencing a lot of hair loss lately (150-200 hairs a day) and knowing that some of those supplements increase testosterone in the body I'm worried that a few years of taking things like ALC or Acetyl-L-Carnitine etc. have brought it on or accelerated things.  That's why I'm stopping.  I also relied heavily on Celebrex which is a powerful NSAID which was very helpful for the pain - I would take it a few times a week but I now know an uncommon side-effect is hair loss, so I've stopped taking that despite the increased pain levels.  I digress.

Those are interesting articles, thanks for those.  I will look into these further.

In relation to the compound I listed above, could anyone or yourself offer some advice on what would be a good % mix for the missing % ingredients?  Furthermore, if you think it would be effective?  I feel like the Pentox and Verapamil (plus the others) in DMSO form could be really great.  Especially when combined with oral Pentox etc.  The guy said he had great results with it hence why I'm looking for some comments / advice on correct %'s.

[kuaka]

I got zero relief from celebrex for my joint pains.  Have you ever tried Diclofenac?

[JayGould]

In relation to the compound I listed above, could anyone or yourself offer some advice on what would be a good % mix for the missing % ingredients?  Furthermore, if you think it would be effective?  I feel like the Pentox and Verapamil (plus the others) in DMSO form could be really great.  Especially when combined with oral Pentox etc.  The guy said he had great results with it hence why I'm looking for some comments / advice on correct %'s.

Ask him who the Doctor/naturopath was who prescribed it to him. If you find out the Doctor's name I will try to find the formula for you.

[Paolo]

Meanwhile I have e-mailed Hybridmedical asking on how H-100 specifically for Peyronie's use is progressing, I will share any replies if received, whether positive or negative

[JayGould]

Wondering how to get Magnesium and Vitamin C into the DMSO solution. Do you just crush a pill and mix it with the DMSO, or do you purchase topical Vit C/Magnesium?

I think I may try Verapamil mixed with DMSO too, and why not Pentox and Cialis too.

[pey ron]

Where do we find pentox and verapamil in powder form? crashing pills and dissolving them in DMSO will get a lot of the caking agents in solution as well... Unless we find a good and very specific solvent first to get the active component out of the pills and then add the DMSO later after having taken out all of the precipitate...

[kuaka]

Something to consider when working with vitamins.  Commercially produced Vitamin C is ascorbic acid.  Vitamin C is much more than ascorbic acid, which is only a small part of the actual vitamin.  This is also true of D.  The commonly available D3 is actually a hormone, and not a vitamin at all.  For ANY vitamin supplementation, source a natural, whole vitamin.

Most of us are magnesium deficient, which contributes to all fibrosis conditions among many other modern health conditions. 

Magnesium supplements to avoid are:
citrate
ascorbate
carbonate with citric acid
aspartate
glutamate

Magnesium supplements to use are:
Chloride
Glycinate
Malate
Oxide - small amounts are ok, but still not great
Sulfate - epsom salts...soak in a bath
Taurate & orotate
Threonate

[TonySa]

Hello, can you provide any instructions on how you prepare and apply these ingredients?  Thanks!

[goodluck]

Kuaka, Can you provide any insight in to why those forms listed as bad are bad and why those listed as acceptable are good?

[kuaka]

There is a chemical dance involving Iron/Copper/Magnesium which is way out of kilter in people who eat a Western diet.  There is more to a mineral supplement than simple bioavailability.  There are cofactors involved and an overall process of using Magnesium in the body which works better under certain circumstances.  Some forms of Magnesium are not very available, like Oxide.  Other forms include compounds which are themselves undesirable, such as citrates, aspartates and glutamates.  Most of "our" (those who eat a Western diet) Magnesium is "burned" to bind up excess Iron as well.

There is much more to how the minerals, vitamins and cofactors (other compounds used to process) than is taught or "generally accepted" in the west. 

As an example of how off we are, Ascorbic Acid is legally defined as Vitamin C, but that is only one very small part of the actual Vitamin C molecule.  It is easy to detect, and easy to synthesize, so we do...but it is like taking the box of food and eating the box without the food.

If you want some heavy reading, pay a visit to gotmag.org. 

[TonySa]

What about all topical: DMSO +  diclofenac + verapramil + xiaflex?

[Dorian Gray]

Burning pain after intercourse may mean compression of the dorsal nerve of the penis by the plaque. Worrying condition.

[Steveo]

I'm not sure why these voodoo topicals are popular when people could be spending time and money on VEDs and Traction, which are proven to work (and which I have seen work on my own dong).

I've done the DMSO, the SSKI, the Castor oil, all that meaningless crap.  All it did was waste my time and money when I could have been doing meaningful therapy like stretching, heating, massage and pumping.

Don't waste your time with this stuff.  Applying DMSO and hoping that it causes some other substance to penetrate the outer layers of your penis and then magically heal your internal scars is nonsense. These witch doctor scams aren't going to do anything to remodel the scar tissue in the penis.  Sorry, they just aren't.  Only mechanical means will help. 

Even Xiaflex, which does dissolve certain parts of certain scars (if injected perfectly) requires the patient to mechanically bend the penis in the opposite direction while it's working.

[QuackAttack]

Stevo,

I am going to back you 100% on this. I tried all the stupid rubs and they are worthless. Xiaflex and traction is the way to go in combination.

[kovasis]

Well, stretching, heating, massage and pumping also sometimes reported to be the reason of making the condition worse...

So even that should not be stated as the "better" solution , besides DMSO is no crap , but this condition is crap.

I've already postet it in another answer of another thread.

As soon as someone reports a possible solution , this solution will be destroyed , or at least the pro's and con's turns it out be with no Effect in the majority of the cases, they were used...

The Reason why we all are here is that currently literally NOTHING REALLY helps.

I dont really see a light in any direction , so i wouldnt say this is better or that is not.

Simply face the fact that this disease will stay a miracle as soon as someone (in 50 or 100 Years) maybe really understand it and thus may have a cure for it...

[dplookin]

Kovasis............I tend to agree with you.  I've done all the topical stuff, and I have done Traction for 7 or 8 months, and I've used a VED for 7 months, and I still have only 3 inches with a 90 degree bend to the right.  No, I did not start with just 3 inches.  Originally it was only 6 inches.  I saw one Urologist, and he didn't know what to tell me.  He couldn't find any plaque.  So what is the Real Answer ?  I hate to think of how many years it has been since I had a sex life.  Good Luck to You.  dplookin

[TonySa]

Dp,  r u considering xiaflex?

[TonySa]

Oh, and pentox?

[dplookin]

Tsanchez12369.........Thanks for your response and suggestions.  I tried Pentox...........Not Good, Bad Side Effects.  And about the other stuff, I am having a problem getting enough attention from an Urologist.  I am using the Veterans Hospital for my medical needs and they are constantly changing the Urologists.  This makes it difficult to keep one Doctor's attention to my problem.  Some of them don't care.  Not sure what I'm going to do.  The Problem is Depressing (as everyone knows it is).  dplookin

[TonySa]

Dp, since xiaflex sounds like not much of an option...although I would insist...u might give pentox another consideration.  Most side effects can be addressed and possibly eliminated w another med like anti-nausea or anti-diahrreal, of course depending on what side effect your having.  Also, consider starting out slow like 1 tab a day and when side effects diminish-which they often will-add another pill and repeat till side effects remain then back off to what you can tolerate.  A low dose may  he better than nothing.  Hope I'm not being pushy...just some thoughts.  Tony

[QuackAttack]

DP,

If you are in the DC Metro and have military benefits and can go to Walter Reed in Bethesda, go see Dr. Robert Dean. Dr. Dan is the Chief of Urology and I have found him to be outstanding.

[dplookin]

QuackAttack..........Thanks, but I'm on the West Coast.  It seems like every time I go to the VA to see an Urologist, there's a different one there, and the last time I was there (recently) there was some young female urologist and I couldn't really discuss this problem with her.  It would be too uncomfortable.  Even though my problem is in the the computer there, she didn't bring it up.  I was initially there due to some past cancer issues.  I did drop some hints about the Peyronies, but she just ignored it.  I attempted to get some Cialis, but that was a No No.  She gave me a prescription for Levitra.  The prescription consisted of 2 pills only.  What a Joke.  Thank you, dplookin


TSanchez............About the Pentox, I really can't take that stuff.  It was OK until the 4th week, and it caused Severe Constipation, which happens to 71 % of the people in my age group.  I did some research on Pentox back when I was taking it.  It's not for me for sure.  Thanks, dplookin

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