New evidence: PDE-4 may target peyronie’s at its root mechanism

[ClarkKent79]

Hi everyone,

I wanted to ask whether anyone here has looked into this study below showing that PDE-4 inhibitors appear significantly more potent than PDE-5 inhibitors (such as Tadalafil/Cialis) when it comes to blocking the myofibroblast transformation that drives Peyronie's-related fibrosis.

Specifically, the study highlights Roflumilast (brand name Daxas) and its active metabolite as very strong PDE-4 inhibitors with a much stronger anti-fibrotic profile compared to PDE-5 inhibitors.

I'm curious:

Has anyone here ever used Roflumilast/Daxas, maybe for COPD, and noticed any changes related to their Peyronie's condition?

Has anyone actively experimented with PDE-4 inhibition or looked deeper into this mechanism?

Are there any positive or negative experiences regarding inflammation, plaque hardness, curvature progression, or overall tissue response while on Daxas yet?

I find the data in this study quite thought-provoking, and it seems like PDE-4 inhibition might deserve more serious attention in the context of Peyronie's, especially given how strongly it suppressed fibrosis pathways in the experiments.

Here is the link to the study for anyone interested:
https://bjui-journals.onlinelibrary.wiley.com/doi/10.1111/bju.16631

Looking forward to hearing your thoughts or experiences.