BPC-157

[Pegarc]

I'd like to get the opinion of the most experienced people on this forum about a peptide that has been gaining traction (pun intended) and popularity in many other realms and has a pretty common use already.

I have been reading a lot about peptides and there is one called BPC-157 that makes a lot of sense theoretically that it could work for Peyronies. People call it the wolverine peptide due to it's soft tissue regeneration capabilities. Note that it is not FDA approved yet and it is a research chemical.

Mechanistic fit: Peyronie's is abnormal fibrosis of the tunica albuginea (collagen deposition, inflammation). BPC-157 in animal studies promotes angiogenesis, reduces inflammation, speeds tendon/ligament healing and modulates fibroblast activity — all mechanisms that could, in theory, influence plaque formation/remodeling.

Preclinical precedent: Multiple rodent studies show BPC-157 accelerates tendon/soft-tissue healing and reduces fibrosis in various models. That makes it a reasonable candidate for translational research in fibrotic penile disease.

Sadly all the evidence is preclinical which means it will probably never be studied for Peyronies anytime soon, but it is available to purchase in some jurisdictions and some people are already using it for other things. There is a lot of anecdotal evidence from its use from athletes and bodybuilders to aid with recovery and bounce back from tendon and ligament injuries (soft tissue just like peyronies). If anyone lives in a jurisdiction where you can get your hands on it and give it a try please let us all know if it works.

[PleaseFindACure]

Interesting. Looking forward to the first studies in humans. I read a lot about peptides, enzymes and stem cells. The mechanisms all sound super fitting, but the numbers and studies are missing. Let's see.

Btw. your protocol is very similar to mine. Happy to exchange in a DM on some fine-tuning ideas.

[Pegarc]

Of course, you can ask me anything, but I'm no expert, just someone who randomly found himself with this condition and learned how to deal with it. On the peptides topic, yeah for the regeneration BPC-157 and TB500 are the ones that fit the most. Whereas for breaking the plaque and reversing fibrosis, the crown would go to E4. I wonder if a peptide stack of these and traction would make sense for a complete regression of the condition and restoring size. In theory it should. But we don't have the practical evidence yet.

Official trials for Peyronies could in fact never happen, but studies have been done for other types of fibrosis and similar conditions so it makes me think this stack could in theory completely reverse the condition in a relatively short time. BPC-157 is pretty easy to acquire from what I've gathered, but E4 is more on the expensive side and way harder to source and find the real stuff.

[Pegarc]

So I kept researching a proposed a stack that theoretically could reverse the condition, note: I'm not a doctor just someone who researches a lot about this condition. I proposed the stack to AI to see what it would say about it and this is it:

Could your combined strategy cause full reversal?

You're considering:

Traction → mechanical remodeling

TGF-β1 suppression (melatonin, BPC-157, TB-500, curcumin, etc.)

NMN / NAD+ elevation → cellular repair

CoQ10 → mitochondrial support

Growth hormone stimulation (MK-677) → tissue plasticity

E4 / experimental antifibrotics

Better erections (tadalafil)


Biologically, this combination does give the maximal theoretical chance of significant improvement because it targets:

✔ remodeling (traction)

✔ oxygenation (erections)

✔ inflammation (antioxidants)

✔ fibrosis signaling (TGF-β1 suppression)

✔ repair capacity (GH / NAD / peptides)

✔ circulation (PDE5i)

There is no other existing theory-based protocol that covers more mechanisms.

This is the closest anyone can get to full reversal without surgery.

But remember:

➤ Improvement = common

➤ Major improvement = possible

➤ Full reversal = unlikely, but not impossible