New member.

[yellow fever]

I'm 25 years old. I've had Peyronie's for over 5 years. I'll run through some of the key features of my condition.  

1. Mine was a gradual onset. No trauma, no illness. I'm convinced that the damage occurred (and continues to occur) when I sleep. Particularly when I'm in the fetal position...the legs cut off circulation, blood pressure spikes, and then you 'clench' - similar to ejaculation. If you're predisposed, this leads to progressive damage and fibrosis. Ideas for preventing nighttime erections will be appreciated.

2. I have one major plaque near the glans. This makes sense...you would expect the blood pressure to be greatest at the end of the chamber. I also have diffuse scarring throughout the left chamber...it almost feels like I have 'cords' running the length of the shaft. Very little damage on the right side, which is odd. Curvature is modest. The problem is I have virtually no flexibility trying to bend downwards or to the right. Plus discomfort. And, things continue to progress.

3. Given the early onset (~19yo), the lack of an acute injury, and the diffuse nature of the scarring, I'm quite sure there's a genetic component. My urologist seems to agree, claiming that diffuse scarring is indicative of a defect.

4. Although it hasn't been adequately addressed by my MD or uro, I'm convinced, for a number of reasons, that the endocrine (androgen) system might be a source of the problem. I've had T levels tested, no issue there. However, nothing tested with respect to other variants, free v total, etc. or utilization (T concentration only tells you so much). If anyone can recommend tests, it would be appreciated. DHT is my suspicion, but it's like pulling teeth to get the test done. Further, even if something is identified I'm unsure of treatment options, risk.

5. Prescriptions: verapamil (stopped using) and pentox. I haven't taken any supplements, but would be interested in hearing about alternative methods, inflammation management, and so on.

6. Psychological side-effects, yes.

Any feedback on these points will be appreciated.

I'm also interested in hearing more about the state of Peyronie's R&D. I work in the field, and I haven't encountered any patient-driven research programs or datasets yet. It would be good to open up some data for gene/target discovery and so forth.

I look forward to your feedback. Should have done this 5 years ago.

And kudos to the founders and administrators. Great resource.

[james1947]

yellow fever

Proposing you to read on the forum as much as you can to better understand this disease.
Pentox is fine, but I am proposing you to add other components to the treatment.
Regarding:

...alternative methods, inflammation management, and so on.

You may find information on the specific boards

James