Neprinol, Ubiquinol- Worth it?

[Sargonnas]

Right now the pain its intense.

Do anyone know or have any experience with NEPRINOL for Peyrone, this is, does it help with pain (im positive it does since it has systemic enzymes), does it help with erections and most important its true that eventually it can remove scar tissue or prevent fibrin build up (it seems im in the development stage of Peyrone´s and my scars are not plaques yet, since my morning woods are almost straight although uncomfortable).

Ubiquinol, a form of coenzyme q10 does that help and why? I will research it but would appreciate your input.

What about stacking Neprinol with Pentox and Ubiquinol, can neprinol have a conflict with pentox? I think they have opposite effects on blood viscosity. Or I should simply get Pentox from online or in the pharmacy without prescription better than neprinol. They are both expensive. But will be impossible to convince my parents to get Pentox without a Peyrone´s diagnosis (im 21 unemployed and virgin because of increasing impotence now with pain... wow when you write that of yourself its like there are some seconds in which reality gets a weird consistency, its really me who its writting that)

I know getting to a good uro to get tested, diagnosed and treated with Pentox and with a VED (this can be beneficial for me since I cannot get real erections during the day or when standing up) etc its best but I cant do that for now. I will need to pay a private doc since the appointment for the specialist that the uro sent me to its in 2 months and nope im not waiting 2 months with pain and something nasty developing down there. No wayyyyy.

[George999]

Neprinol did nothing for me despite spending a ton of money on it.  ALC helped some.  Pentoxifylline and Ubiquinol helped a lot.  Both Pentoxifylline and CoQ10 were clinically tested for Peyronie's by an Iranian research team and found to be effective.  My own experience was that they are extremely effective when used together.

Pentoxifylline is effective mainly because it blocks TGF-beta1, an immune system cytokine, and secondly because it makes red blood cell flexible which allows them to flow through damaged capillaries that they would otherwise not be able to pass allowing oxygen to reach oxygen starved areas.  CoQ10 is effective because it protects and enhances cellular mitochondria which provide life energy to the tissues.

Pentox Evidence:

https://www.peyroniesforum.net/index.php/topic,2083.0.html
https://www.peyroniesforum.net/index.php/topic,2070.0.html
https://www.peyroniesforum.net/index.php/topic,1004.0.html
https://www.peyroniesforum.net/index.php/topic,772.0.html
https://www.peyroniesforum.net/index.php/topic,723.0.html

CoQ10 (Ubiquinol) Evidence:

http://www.nature.com/ijir/journal/v22/n5/full/ijir201020a.html

It is VERY important to stick with those few treatments with scientific evidence supporting their effectiveness.  There is absolutely zero research evidence showing any degree of effectiveness with Neprinol, but there is a lot of marketing money behind trying to sell this very profitable product to Peyronie's patients.  Pentoxifylline and CoQ10 have both been shown effective AND both are generic products, meaning that no one company can profit from their sales.  Thus their is no incentive for any company to try to market them to Peyronie's patients.

EVEN if you don't have Peyronie's, you OBVIOUSLY DO HAVE inflammation in your penis because of all the discomfort you are experiencing.  This alone should be reason enough to start on a combination of Pentoxifylline and CoQ10.  And neither of these should be nearly as expensive as Neprinol.

I suggest you print out the documentation I referenced above and share it with your dad and see if you might be able to convince him to help you with this.  I wish you all the best.  - George

[Sargonnas]

That was SO helpful George. Thanks a bunch. My dad its lately really starting to support me. He is seeing my life wasting away and everyone its starting to realise my problems are real and I am suffering. I hope we can get to someone here in Spain that recipes Pentox. I wonder if you can buy that without prescription. Yeah I see, you are the most experienced supplement-guy around here (hehe) and your point about Neprinol was very convincing. But what dosage did you try of it? Its just because this supplement seems to be involved with two success stories in the forum. And this guy SET 4 CPPS says its good for reducing pain/inflammation. He even has a photo of himself and says he goes to church etc lol so looks like a real person.

Normal Coq10 will do? I have a botlle of that in my house. I have at least 20 bottles of supplements in my house, most of them half emptied. Right now using half of them with some success in mental and body feelings except in the penis area which seems a lot worse. This is because I have much more problems that my penis problems alone and indeed for me the penis disorder its a result of the other inflammatory/autoimmune problems combined with the injury that triggered everything in that area.

Or that last exploration of the urologist caused further damage. It really hurted me... But I dont think so. This pain isnt worse than the one I got in July. I screamed several times.

[George999]

You might also want to give LDN a try.

http://www.lowdosenaltrexone.org/

- George

[pizzaman]

I'm not sure what's in neprinol, but I've gotten significant relief form the combination of curcumin and serrapeptase 3x per day. They don't do much on their own, but they seem to have a nice synergy together. Since I began taking that combination, I've seen the combo being marketed as a pain medication, so someone else noticed too.

I read a bit in another thread about some guys experimenting with LDN for Peyronie's, but it sounded like it didn't really go anywhere. Have you heard any success stories with it?

[George999]

I'm NOT recommending LDN for Peyronie's.  I am recommending it specifically to Sargonnas for other issues he is experiencing.  And for Peyronie's I ONLY recommend those treatments that have solid independent research supporting their effectiveness.  And when it comes to oral treatments, that means Pentox, CoQ10, and ALC.  A lot of us have gotten some degree of benefit from other things.  But the starting point should ALWAYS be with evidence based treatments, not with anecdotal recommendations.  - George

[skunkworks]

Yeah for low dose naltrexone I'd only really be recommending that if the person was experiencing other auto-immune conditions at the same time.

ie/ I also have psoriasis and eczema break outs sometimes.

[Sargonnas]

Yes the LDN thing seems to be popular in CFS and Autistic boards. I guess its because it works.

[goodluck]

I have asked my PC and an rhumatologist about LDN and neither has heard of it.

There is a Yahoo group that is devoted to it.  Lots of info there.  I have read that it is not a slam dunk for Autoimmune conditions as it does not work for everyone.


I did try Neprinol a few years ago when I first came down with this.  I fell for their marketing which is not backed by any serious studies.  It is one of those supplements that may help in theory.  I took it for three months and noticed nothing wrt Peyronies.  It did slightly lower BP and my CRP.  If your BP and CRP is high is may be worth taking. It may improve Sed rate but I honestly don't recall.  Mine was already acceptable so no practicle benefit.  
If I took it for three years whould it help?  Who knows ....perhaps.  As you know it is very expensive.   So if you have the money, and your BP or CRP is a bit high, give it a try.

I would think the parent company would be running a  serious study because it would be a gold mine if it truely helps.  Even over a 2-3 yr period. They are a small company and i am sure very much a slave to short term profits.  

[Sargonnas]

Oh yeah its practically a scam, peyronies wise... especially at that damn price.

[Moosio]

Hi,my husband has recently been diagnosed with peyronies , I read in your page on these miracle enzymes which may be helpfull but the problem is my husband already suffernig from a heart condition (cardiomaiapathy) and he is taking aspirin and blood pressure meds as I understood one of the things these enzymes do,they act as a blood thinner and they lower the blood pressure,I just wanted to know if its safe for him to take those and if it is what is the daily dosage?
Thanx

[dplookin]

To Moosio........Just my input about your questions.  I really don't believe that the Enzymes will help with the Peyronies.  I have been taking enzymes for years, and still got Peyronies.  Neprinol would probably be a waste of money.  Ubiquinol would be good to take and safe, but it causes insomnia in some people so it might be best to not take late in the day.  Nattokinase is a good enzyme to take because it helps to break up blood clots.  It should be taken 3 times a day On A Empty Stomach.  I fight with high blood pressure and I take the Nattokinase and Ubiquinol.  A lot of people take Nattokinase instead of aspirin because aspirin can cause stomach problems for some.  Nattokinase started with the Japanese many years ago.  This is about all the info I can give you about your questions.  I'm sure someone else will also respond to your question.  dplookin

[George999]

Ubiquinol works for Peyronie's.  Its not a cure, but it does work.  It worked in a very obvious way for me and there is a very well done Iranian study demonstrating its effectiveness.  Ubiquinol is also effective in treating heart failure.  So it would be a slam dunk for your husband.  Enzymes like Neprinol are useless for either heart failure or Peyronie's, so definitely not worth the money.

[bromania]

Ubiquinol and L-Argenine are worth taking for a variety of health reasons. I've been taking both for years and yet, I developed Peyronnie's a year and a half ago.  It isn't nearly as severe a case as many I'm sure.  I'll be doing the Xiaflex treatment with one of the leading Peyronnie specialists in the US.  Some have had treatments of 5-8 injections and I am receiving just two.  I gather that reflects the severity.  Still he maintains that L-Arg and Ubiquinol are well worth doing.  Who knows if they limited my severity.  It is not a pure science yet.

[hnoor0033]

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