ORAL TREATMENTS - GENERAL - Vitamins, Prescriptions , Herbs, Supplements

[newguy]

It's great that you'll be able to give LDN a try George. The ball is finally rolling. Do you currently have any peyronie's symptoms to gage its effectiveness against?

[George999]

Well guys, I just got a tentative diagnoses of multiple sclerosis today which puts me in an interesting position.  That 1) makes it more likely that I will be able to get an above board prescription for Low Dose Naltrexone and 2) will enable me to observe its long term effects on Peyronie's AND to have Dr Lue following me during that time (hopefully!).  I am really hopeful that Low Dose Naltrexone will prove effective for Peyronie's.  - George

You might find this interesting George:

http://darwinstable.wordpress.com/2008/11/21/the-paleo-diet-and-multiple-sclerosis/

All the best with putting together a good treatment plan for the MS, there are some effective treatments available these days.

WOW!  Thanks you so much for that link!  This has to be applicable on at least some levels for Peyronie's sufferers as well.  There are certainly a number of people with MS who have employed this approach with great success.  This series really outlines that process that triggers autoimmunity in the first place and does it very well and so it is indeed a must see.  The real fly in the ointment in trying to apply these dietary restrictions is in the difficulty of maintaining them over a long term.  Another factor is that some people can't really apply them at all because they already have medical restrictions on many of the allowed foods which leaves them at a loss for choices.  But I would certainly advocate following these guidelines as much as individually possible.  I, personally, am probably following them with 80% or more of my diet and in places where I am in violation, grains for example, I try to get the most whole grain products that I can.  I can also tell you that I avoid cheese because it exacerbates my problems in a very obvious way as does milk itself which I avoid completely.  But certainly the link you provide has greatly enhanced my understanding of the underlying process (I watch the whole presentation).  I recommend that everyone here take a look see.  - George

[George999]

Gosh, George, I'm very sorry to hear that.  I certainly know you will attack it with everything at your disposal, and we'll all be pulling for you.

Nemo

Thanks Nemo for those kind words of support!  - George

[George999]

It's great that you'll be able to give Low Dose Naltrexone a try George. The ball is finally rolling. Do you currently have any peyronie's symptoms to gage its effectiveness against?

At this point the Pentox has shut down the Peyronie's 100%.  It is just locked in place.  No inflammation or progression, but no significant return toward normalcy either.  My hope is that the Low Dose Naltrexone will be able to accomplish something that the Pentox has not been able to accomplish by suppressing the chronic silent inflammation in addition to the painful acute inflammation that is handily suppressed by Pentox.  But we will see how that works out.  My plan is to try stopping the Penox once I am established on the Low Dose Naltrexone and see what happens.  I know that s&s and some others here are already well along with the Low Dose Naltrexone (so the ball has really already been rolling around here for a while now) and I will be hoping for good news from them as well.  I am thinking that perhaps someone here who is already on Low Dose Naltrexone ought to start an Low Dose Naltrexone thread now that we have that option.  - George

[George999]

Often the topic of prescription drugs has come up concerning Peyronie's disease and guess what, is no different with MS.  For a long time now I have been taking Cozaar (losartan) as a BP med because it has a great reputation for being antifibrotic and in fact has been shown in research to protect people from kidney disease.  Well, NOW they are finding out that lisinopril seems to shut down MS.  The reason it does that is that it blocks Angiotensin Converting Enzyme (it is known as an ACE inhibitor).  Angiotensin Converting Enzyme, they have discovered, is a potent inflammatory factor in the brain.  Cozaar is an ARB or Angiotensin Receptor Blocker.  It blocks the BP raising process at its end point and thus actual causes levels of Angiotensin Converting Enzyme to RISE as the body tries to overcome the Cozaar blockade.  Thus Cozaar, which I was taking with the expectation that it would be helpful with the Peyronies, in all likelihood contributed to ending up with MS and is now likely aggravating and fueling the MS.  So now I am in the process of switching back to Lisinopril and hoping that I can tolerate it since I was having other problems with it, as well, when I switched to Cozaar.  What tangled webs we weave!  EVERYTHING in life interacts.  You change your drug regimen, supplements, or diet in order to try to fix one thing and that, in turn, screws up something else.    Thats one reason doctors are so cautious about everything and so minimalistic in their treatment approaches.  - George

Inexpensive hypertension drug could be multiple sclerosis treatment, study shows

[slowandsteady]

I know that s&s and some others here are already well along with the Low Dose Naltrexone (so the ball has really already been rolling around here for a while now) and I will be hoping for good news from them as well.

Sorry to hear about the diagnosis George; I hope it works out for you.

I found a different source for naltrexone here that is much more cost effective than anti-aging systems, though you'd have to mix it in water and put it in a bottle with a dropper.

I'm still going through the early phase with LDN. At 2.25 mg, I can sleep through the night much better than when I started. I had been getting tired, and took a couple of days off. LDN at my current dose doesn't handle all of the inflammation, so I still use some curcumin. I also take 600mg NAC, 4000 FU nattokinase, 100mg pycnogenol, and 2g l-arginine in the morning on an empty stomach.

s&s

[Hawk]

Geoge,

been busy with admin work on the forum and am sorry to just read about your tentative diagnosis.  Hopefully is will turn out to be corrected to a more benign condition, but in any event it has a strong adversary .

I wish you the best.

[Hawk]

On the subject of Whole wheat:  The FDA allows the uses of the term whole wheat or whole grain on products that include a mix of whole wheat or whole grain ALONG WITH REFINED FLOUR.  It simply means there is SOME whole wheat in the product.

A product must say 100% Whole Wheat in order to indicate the absence of refined flower.

[newguy]

s&s - That really is good value. The alldaychemist site one or two frequently mentioned on the LDN yahoo group. The other being riverpharmacy, which is more expensive: https://www.riverpharmacy.com/drugInformation.php?ActiveIngredient=638 . I ordered LDN from riverpaharamcy about 3 days ago, so we will probably have a few viable options. There is talk that sometimes people require a prescription with alldaychemist and sometimes they don't, but I assume they state the situation before you confirm your order.

George - My point was more that since pain may be low level, and beyond your ability to feel it, how will you know if LDN is working or not? I am interested to know.

[cowboyfood]

All,

Anyone have a trusted and reliable source for Sans Vasoflow?  I noticed that bodybuilding.com stopped selling it.

I've been using L-Arginine from puritan.com, but the company does not carry the Sans Vasoflow product.

Thanks.

CF

[Hawk]

Anyone have a trusted and reliable source for Sans Vasoflow?  I noticed that bodybuilding.com stopped selling it.

Bodybuilding.com is on our supplier list primarily BECAUSE they sell San Vasoflow.  If they no longer sell it they will be removed and replaced by some existing source.

[George999]

George - My point was more that since pain may be low level, and beyond your ability to feel it, how will you know if Low Dose Naltrexone is working or not? I am interested to know.

For low level inflammation, the way you would know is if the deformity began to gradually correct itself in a way that was obvious.  In other words, straightening itself doesn't necessarily indicate a good thing because the opposite side may be shortening BUT if there is measurable lengthening, THEN you would know that something good is happening.  Another way would be a positive ultrasound comparison v a previous ultrasound.  You are right, it is a bit difficult, but progress on this front would be unreal.  - George

[Fred22]

Well guys, I just got a tentative diagnoses of multiple sclerosis today George

George,

I'm sorry to hear about the diagnosis and as Nemo said, we'll all be pulling for you .  You're a real souce of inspiration and encouragement here on this forum and I've greatly benefited from your contributions and advice both here and in our private conversations.  Hopefully, the initial "tentative" diagnosis will turn out to be something less serious.  

Fred  

[newguy]

George - I think it could be argued that a sudden cessation of low dose inflammation could make the deformity better or worse. Better due to the body having the best opportunity to be able to heal itself, or worse since on occasion if somebody has active peyronie's the healing probably only begins once the inflammatory processes has died down totally. I suppose the occurence of changes, good or bad, coinciding with LDN intake could be taken to mean that it is reducing inflammation. I'm intrigued by LDN and hope that it does something for me. I'm quietly confident that it can help with the ms, especially since you're getting on it so soon after the diagnosis.

[George999]

All,

Anyone have a trusted and reliable source for Sans Vasoflow?  I noticed that bodybuilding.com stopped selling it.

I've been using L-Arginine from puritan.com, but the company does not carry the Sans Vasoflow product.

Thanks.

CF

I hate to recommend VitaCost as I am not a great fan of their major line of supplements, but I've never had a problem with them fulfilling their orders and they DO carry SAN VasoFlow.  Too bad bodybuilding.com seems to have dropped it as of a couple of days ago.  - George

http://www.vitacost.com/San-VasFlow?csrc=GPF-672898618003

UPDATE:  The reason that bodybuilding.com has discontinued it is because for some reason SAN is no longer making it.  There currently seems to be no reason given for why they are no longer producing it.  There seems to be quite a bit of it out there at them moment, but it won't last now that bodybuilding.com the major retailer has stopped carrying it.  Too bad, a lot of people found it very useful.  - George

[George999]

George - I think it could be argued that a sudden cessation of low dose inflammation could make the deformity better or worse. Better due to the body having the best opportunity to be able to heal itself, or worse since on occasion if somebody has active peyronie's the healing probably only begins once the inflammatory processes has died down totally. I suppose the occurence of changes, good or bad, coinciding with Low Dose Naltrexone intake could be taken to mean that it is reducing inflammation. I'm intrigued by Low Dose Naltrexone and hope that it does something for me. I'm quietly confident that it can help with the ms, especially since you're getting on it so soon after the diagnosis.

I agree, ALL the inflammation has to be gone for any real healing to take place.  - George

[nemo]

George, I'm sorry to hear about SAN VasoFlow being taken off the market, though I won't miss that nasty smell and taste of the oil those caps soak in in the jar.  Do you have a second choice as far as L-Arginine?  

Nemo

[slowandsteady]

I came across this study, "Pyridoxal 5'-phosphate as a novel weapon against
autoimmunity and transplant rejection" ([[http://pubmed.gov/14656979|PMID 14656979]]). It's from Iran in 2003. From the abstract:

Activation of CD4 T cells by antigenpresenting
cells is required for the full expression of
most autoimmune diseases and allogeneic transplant
rejection.

From the conclusion:

Considering that the D1 domain of CD4 plays a pivotal
role in the CD4–MHC II interaction and that PLP
binds tightly to this domain, and could therefore
prevent D1–beta2 interaction, it could be deducted that
PLP may be a useful addition to anti-autoimmunity and
anti-transplant rejection armamentarium. PLP is very
economical and could be administered to humans
intravenously in relatively high doses.

The full text of the article is available for download.

In another article:

Abnormalities of tryptophan metabolism have been reported in patients with rheumatoid arthritis (RA) and it has been suggested that these abnormalities are the result of disordered vitamin B6 metabolism. Fasting serum pyridoxal, assayed by an automated microbiological system, was found to be below normal in 35 out of 42 patients with RA while a similar abnormality was found in 8 out of 35 patients with osteoarthrosis (OA).

Another source: Abnormal vitamin B6 status is associated with severity of symptoms in patients with rheumatoid arthritis
The American Journal of Medicine, Volume 114, Issue 4, Pages 283-287

P5P is one of three forms of B6. Pyridoxine has been linked to peripheral neuropathy (noticeable by tingling extremities) in doses of 200 mg and above. P5P is supposedly far less likely to lead to this.

It would be interesting to see if a few hundred milligrams of P5P helps with Peyronies Disease symptoms. Stop if you get tingling in fingers or toes, but I don't think that would happen with the P5P form.

s&s

Edit: I see this topic has come up before.

[slowandsteady]

Thinking about what I wrote about P5P yesterday, I decided to try some. The only thing stopping me was that I had none on hand.

I did have some pyridoxamine (PM) though, another form of B6 that is well know for glycation reduction. After taking 300 mg last night, I had a very easy morning with only some inflammation in the afternoon. I took another 300 mg dose before supper and again am feeling quite good. I haven't taken pyridoxamine at this dose before. It has a half life of about 1.5 hours^R, so I might benefit from splitting it up a bit more across the day.

There are some qualities of PM that might be interesting in Peyronies Disease. In a rat model fo chronic allograft nephropathy (which causes kidney failure in transplants):

PM significantly decreased proteinuria (76 ± 18 vs 29 ± 3 mg/day), serum creatinine (130 ± 12 vs 98 ± 5 µmol/l), focal glomerulosclerosis (116 ± 27 vs 16 ± 5 AU), glomerular macrophage influx (5.6 ± 0.6 vs 3.3 ± 1.0), interstitial fibrosis (132 ± 24 vs 76 ± 2 AU) and interstitial macrophage influx (47.0 ± 8.7 vs 15.4 ± 5.0.

Decreased fibrosis, macrophage infiltration, and AGE formation -- sounds good to me.

I'll keep on with this and see how it works out.

s&s

[Iceman]

slow and steady - so couldnt this supp be the answer - has any one else heard of it and if so have they tried it and with what results -  

[newguy]

s&s - I take 10mg a day of pyiodoxaime as it is present in my multi-b Benfotiamine pill. I wonder if the higher doseage will work for you. One of the most tricky components of taking several supplements is getting the dosage right. Maybe there is a case for megadosing certain supplements, bu it's always hard to know because we're flying blind to a certain extent.

[Iceman]

CAN SOMEONE HELP - all the supp ive been taking has led to me getting burning mouth syndrome - can these supps do this ? - has this happened to anyone - bit panicky here!!!

[slowandsteady]

Lots of info on pyridoxamine on this site. In rats it's very non-toxic (it took 5000-7500 mg/kg oral to kill half of them, very roughly 58g for a 150 pound person, about 190 times less than I'm taking).

Iceman, I've just taken it for a couple of days. You might want to wait a bit.

What are you taking that causes your mouth to burn? That doesn't sound good.

[slowandsteady]

Pyridoxal 5'-phosphate (PLP) is potentially better than pyridoxamine (PM) according to this study in a rat model of diabletes (PMID 17449494):

PLP significantly inhibited expression of TGF-beta1, type 1 collagen, fibronectin and RAGE in the kidneys. PLP was superior to PM in inhibiting accumulation of AGEs, expression of TGF-beta1, type 1 collagen, and fibronectin, and the development of diabetic nephropathy.

This study has been brought up before (Hitman and George999), but I don't know how much follow-up it has received. George999, do you remember how much P5P were you taking?

s&s

[Iceman]

im taking - pentox, Larginine, ALC plus tribulus - i tried cucurum for about a week and that might be the cause - im not sure..

[George999]

Pyridoxal 5'-phosphate (PLP) is potentially better than pyridoxamine (PM) according to this study in a rat model of diabletes (PMID 17449494):

PLP significantly inhibited expression of TGF-beta1, type 1 collagen, fibronectin and RAGE in the kidneys. PLP was superior to PM in inhibiting accumulation of AGEs, expression of TGF-beta1, type 1 collagen, and fibronectin, and the development of diabetic nephropathy.

This study has been brought up before (Hitman and George999), but I don't know how much follow-up it has received. George999, do you remember how much P5P were you taking?

s&s

As I remember, I was taking 5mg per day for some time.  This was the product -> http://www.jarrow.com/product.php?prodid=255  I didn't notice any profound effect.  I see that NOW Foods has a product with significantly more P5P in it -> http://www.iherb.com/Now-Foods-P-5-P-Coenzyme-B6-50-mg-60-Tablets/740?at=0  - George

[newguy]

George , do you have many thoughts on the use of ACE Inhibitors as part of a wider oral treatment regime aimed at combating peyronie's? I've seen them come up in a few peyronie's studies where potential treatments are stated, and as being useful to combat fibrosis. Is the potential downside of such medications generally seen to be too great to encourage use in this condition? I know you yourself had a negative experience, but I'm still interested in hearing your view on this subject.

[George999]

George , do you have many thoughts on the use of ACE Inhibitors as part of a wider oral treatment regime aimed at combating peyronie's?

At this point I really don't have a clue on this one.  I left ACE Inhibitors for an ARB due to low level chest pain and chronic congestion.  Now that you bring it up, I don't know whether that was before I contracted Peyronie's or after??  That is actually a very good question, the answer may lie in the paper trail somewhere, I'll look into it further when I have the time.  Now I have to deal with MS and late breaking research is showing ACE Inhibitors to be potentially powerful tools for combating MS.  It turns out that while some ARBs have anti-fibrotic qualities, they do nothing to reduce ACE and in fact may even raise it.  Now ACE is implicated in fueling MS fairly powerfully.  So I am already on a path toward moving back to Lisinopril as quickly as possible since I will gladly trade my MS for a little old chest pain and congestion, although hopefully that won't reoccur.  And how might that relate to Peyronie's?  I really don't know at this point.  We have all of these hormones and drugs circulating in our bodies.  So many variations, in fact, that it would not be possible to study all of the combinations.  All or any of these have the potential to affect our immune systems and/or epigenetics in any number of unexpected ways.  Both are delicately balanced and unique to us as individuals.   I think there is probably at least one guy here now, and probably more, that is/are taking Lisinopril.  I don't know whether their Peyronie's is aggressive or easily controlled.  That is how little we know about these things.  But after what has been discovered with Lisinopril and MS, Lisinopril would probably be interesting to me even if I were not facing the MS issue.  I would have to wonder whether ACE might not also be making my Peyronie's more virulent.  I guess perhaps now I am about to find out.  In life you either never stop exploring or you end up trying to hide in a hole.  - George

[slowandsteady]

As I remember, I was taking 5mg per day for some time.  This was the product -> http://www.jarrow.com/product.php?prodid=255

Yeah, that product has 5mg of P5P as an afterthought. It's the 50 mg of pyridoxamine that's the main ingredient.

I'm going to trial P5P at higher doses (400 mg/day).

[slowandsteady]

After reading about the success of the ALK5 inhibitor IN-1130 which antagonizes TGF-beta signaling in the study PMID 19473283, I did some searching on ALK-5 inhibitors. I saw this patent, "Pyrimidine derivatives as alk-5 inhibitors".

Looking up pyrimidines, I found that orotic acid is a member of that family of compounds. Orotic acid can be taken as a supplement as magnesium or calcium orotate (and others).

Magnesium orotate has been shown to be beneficial in heart disease (PMID 19367681). I'm wondering if it might also benefit Peyronies Disease. Still digging.

s&s

[George999]

After reading about the success of the ALK5 inhibitor IN-1130 which antagonizes TGF-beta signaling in the study PMID 19473283, I did some searching on ALK-5 inhibitors. I saw this patent, "Pyrimidine derivatives as alk-5 inhibitors".

I think it should be helpful.  In the past I have used both magnesium orotate and potassium orotate.  I did not notice any significant benefit in terms of Peyornie's, but probably was not getting nearly enough of it to make much difference.  So the problem is how to get enough of it without potassium or magnesium overload.  Calcium orotate might be a solution.  But then the next issue is that in large amounts it becomes pretty pricey.  - George

[joecancer]

I've been on pentox for 6 months now - still no improvement.  I've also been taking cialis every other day, and using the VED 4-5 days a week for about 2 months. I'm scheduled to undergo a penile vascular study soon - a color doppler and possibly a DICC test.  Has anyone undergone one of these tests, and if so, is there anything I should know or be aware of?  And when do most improvements from pentox/VED start to take place?  I'm starting to get a little discouraged at this point.

[jackp]

Joe

Two months of VED therapy are not enough to start getting results.  In my case it took 3-4 months and the best was at about 1 year.

I would recommend a Color Doppler. What does DICC stand for?

Do not get discouraged just remember never - ever / never - ever ever give up.  If you are going to a general practice urologist I would suggest you find a Male Sexual Function Doctor, they are much better at treating our condition but extremely hard to find.

Jackp

[George999]

Pentox takes years to work, not months.  I have been on it close to two years and am just now really beginning to see some benefit.  But no other oral treatment comes close at this point.  There simply is no silver bullet, but if one does nothing, it will likely continue to get worse.  The ONLY instant fix is surgery and that carries its own downsides.  There is no easy solution.  - George

[Iceman]

George - you say you are starting to see some benefit from pentox after 2 yrs - what benefits are you seeing exactly as Ive been on pentox for 18 months now and would like to compare my observations with yours.

cheers

iceman

[skunkworks]

On the topic of cialis, levitra and viagra, these could all be taken on a daily basis?

And the purpose is to give us more nocturnal erections, which enhance bloodflow and healing? A secondary gain is the raised nitric oxide levels?

Is anyone taking any of these on a daily basis?

[LWillisjr]

On the topic of cialis, levitra and viagra, these could all be taken on a daily basis?

And the purpose is to give us more nocturnal erections, which enhance bloodflow and healing? A secondary gain is the raised nitric oxide levels?

Is anyone taking any of these on a daily basis?

It is often given on a daily basis post surgery. Also..... since it is typicaly to take something like Viagra twice per week, then each tablet could be cut into 3-4 pieces so a smaller dose taken on a daily basis. I personally cut my Cialis tablets in half and take one every other day.

[Tim468]

I almost always take Cialis daily at about 4-5 mg a day. Minimal side effects, good erectile function with sex whenever it happens, and good morning erections.

Tim

[Exile999]

Ive tried some Vitamin E tablets for the past few months, and they haven't been very successful. Almost no change at all. Do you guys think that masturbation and sexual activity could contribute to peyronies (after you found out you already have it)?

[slowandsteady]

Ive tried some Vitamin E tablets for the past few months, and they haven't been very successful. Almost no change at all. Do you guys think that masturbation and sexual activity could contribute to peyronies (after you found out you already have it)?

Tablets or gelcaps? Vitamin E is an oil soluble vitamin, so it's best taken in oil. I like NOW gamma E.

For sexual activity, I personally think it's not good if you have inflammation.

[newguy]

Exile999 - After reading your history I'm unsure of the nature of your condition and those you've seen about do not appeare to have helped lessen your concerns. Let's see if we can make some progress here.

Do you or have you ever experienced penis pain?
You mention curvature. Has it always been there, or is it recent? How curved is it?
Do you know what caused the 'squishy feeling' that you mention?
Has your condition changed much since you first noticed it?

Vitamin E in my opinion isn't really something that you should rely solely on for improvements, but it probably won't hurt wither.  The PAV cocktail is a good start for an oral treatment regime:  Pentoxifylline, L-Arginine and Viagra.

If sex and/or masturbation makes pain worse, then you might want to go easy on it for a while.

[Exile999]

Exile999 - After reading your history I'm unsure of the nature of your condition and those you've seen about do not appeare to have helped lessen your concerns. Let's see if we can make some progress here.

Do you or have you ever experienced penis pain?
You mention curvature. Has it always been there, or is it recent? How curved is it?
Do you know what caused the 'squishy feeling' that you mention?
Has your condition changed much since you first noticed it?

Vitamin E in my opinion isn't really something that you should rely solely on for improvements, but it probably won't hurt wither.  The PAV cocktail is a good start for an oral treatment regime:  Pentoxifylline, L-Arginine and Viagra.

If sex and/or masturbation makes pain worse, then you might want to go easy on it for a while.

The situation definitely has changed, I did indeed take vitamin E gelcaps, however I realized this, that the squishy feeling from before was simply a vein and even a doctor has confirmed that. I told him about the curve of my penis, and he said that I should give it some time and take some vitamin E tablets, which are indeed the gels. I already told him I simply waited for a few months already, but he told me to wait longer -_-. He also said these cases dont often occur to people my age.

I have also learned this, the curve is not caused by the vein, but in fact a hardened area on the base of my penis, and I have learned how to feel it (its definitely much tighter). There is no pain whatsoever in any way shape or from. From erections to masturbation there is no pain.

[newguy]

If there is no pain, then I wouldn't worry so much about cutting down on sexual activity. If the curve appeared recently and has not always been there, then maybe you would benefit from the PAV cocktail I mentioned previously. How pronounced is the curve?  

[Exile999]

truthfully i would say the curve is more psychologically damaging than anything else. When fully erect my guess is that the curve is slightly less than 45 degrees. Its similar to a curve like this " \ ".

[newguy]

In that case, I think you should try to find a doctor who will prescribe Pentoxifylline and Viagra (since you mentioned some erectile dysfunction issues). You should also buy l-arginine. That combo may help to improve matters, or hopefully top the situation getting worse. You might also want to think about starting on VED therapy: https://www.peyroniesforum.net/index.php/board,38.0.html

[Jackieo]

Hi, Exile999.  Welcome... I hope you will quickly see that you will find a lot of very helpful people on this site.
I saw your posts and I have a question for you:
Have you noticed any loss in penis length or girth?  In my case, I noticed a curvature first but almost immediately (within weeks/ maybe a month) I began to notice loss in both length and girth.  This is what really got my attention and got me to schedule my first Uro appointment.  I was diagnosed w/ Peyronies in April, 09 (my first symptoms appeared in Nov, 08).  I am on the PAV cocktail mentioned by Newguy (although I am on Potaba...not Pentox).  And, I am faithfully using a VED.  I am now seeing a reversal in the curvature and a re-gain in both length and girth (I have charted and measured monthly).  It took determination and a complete self-evaluation of diet, medicine, supplements, and exercise.  I don't think any one item is a cure-all.
Good luck.  The psychological issues are terrible at the onset....stay strong.
JackieO

[Exile999]

Sadly its been like this for about 9 months now so I have known about the curve relatively for a long time. I cant say that its gotten worse but it definitely hasn't gotten better in these past 9 months. Thanks for the idea of the PEV PAV, I'll definitely see what I can get from it. I do have a question however, are there any side effects?  

[Jackieo]

Exile999:  Did you mean to say PAV:  Pentoxifylline, L-Arginine and Viagra?
The "P" (Pentox) is generally tolerated.  I am on Potaba (Uro's choice) and it is regarded as having more side-effects (upset stomach, vomiting, diarrhea).  I have no side-effects on a low dosage.  However, on what is considered a preferred dosage (24 tablets daily) I had bleeding.  L-Arginine is generally accepted and w/o side-effects (to my knowledge) and Viagra.....you know the side-effect.  Actually, I take Cialis.
If you do a search on the website you will find a lot of data on these drugs/ supplements.
JackieO

[newguy]

and Viagra.....you know the side-effect.  Actually, I take Cialis.

For what it's worth I take Cialis too. My thinking , aside from the bovious benefits, is that it's best to have a PDE5 inhibitor in your system 24/7. As part of a comprehensive approach I am thinking/hoping that it's better able to combat some of the peyronies disease processes.

[newguy]

For those interested and unable to get Pentoxifylline through a urologist, you might want to try river pharmacy. I bought LDN from them as they are recommended on the LDN forums as being reliable. Previously I had managed to get inhousepharmacy to stock it, but it is so much cheaper on this site, that I feel like I was totally ripped off previously:


https://www.riverpharmacy.com/drugInformation.php?ActiveIngredient=332

It's listed as Pentoxiphylline, another name for Trental.