Does Xiaflex work in the stabilized phase?

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Jimmothy

The topic asks my question. Does Xiaflex still work after stabilization?

What other methods/ treatmenrs work after stabilization?
35 y, diagnosed 6-7 years ago
Had congenital downward curve, now have a ~ 30° bent to the right no longer bending downwards. Twisted while flaccid.
Recently engaged.

tsp

Practically all treatments, including Xiaflex, are targeted for use after stabilization. Research on acute phase treatments are relatively sparse, but increasing.
53 years old
Peyronie's onset in 2009, diagnosed in 2021.
Indentation in the left CC near the base.
Lost 5.5 cm, regained 4 with RestoreX
Cause: injury due to wife's vaginismus.

Lostand Looking24

Quote from: tsp on March 22, 2024, 10:23:24 AMPractically all treatments, including Xiaflex, are targeted for use after stabilization.

Yeah.

Would you have got better results in the acute phase with treatment? Most likely. Does that mean treatments don't work in the stable phase? Nope.

If your plaque has calcified however, it may be a different story. Though this only happens to a fraction of men with peyronies, even after stabilisation.
23
Symptoms at 22
Diagnosed
Curve to the right that fluctuates between 20-30 degrees and indentation. Indent is exactly where the curve is.

randyzon

I don't think the acute phase is a great time for treatment.  The first year for me was very fluid with changes until a plaque area and measurable physical damage finally formed. I second the suggestion to use COQ10 though.  I have taken it for a few years 300mg daily. I don't know if that is what helped but I did not form any calcification.
73 yr old, sex injury in May 2023, acute phase was very fluid for about a year then resulted in 70-90 degree curvature upward. Began Xiaflex treatments December 15, 2024 with Restorex treatments twice daily. Phoenix area U.S.

BentKnob

35 years old
Married & open relationship
In 2023 injury caused by repeated micro trauma, first noticed in early 2024
20°-30° curvature to left
Finasteride 10 years
ESWT
SOMAcorrect, RestoreX
Tadalafil, Acetyl-L-Carnitine, CoQ10, Vitamin D3 & K2