Any concerns with taking Vitamin C / Collagen in large doses?

[lonely_anon]

Hey all, newbie here. You can read my introduction here (https://www.peyroniesforum.net/index.php/topic,17218.msg149150.html#msg149150).

I have a question for you all who have been battling with Peyronie's for a while now. The onset/rapid progression of what I believe to be Peyronies Disease started happening about two weeks ago for me. During this time frame I'd been taking 3000mg of Vitamin C (1000mg 3x daily) and Collagen Protein (1x scoop a day) along with non-stop exercising through strenuous biking (potentially irritating my pudenal nerve), ab/core workouts (including hanging ab-lifts, mountain climbers, etc) and a bit of rough masturbation (which I believe to be the "trigger" for my onset).

Does anyone know if these two supplements can worsen Peyronie's plaques and other symptoms? I currently cut them out of my regime after noticing my issues and now my supplement routine looks like this:

- Active Hexose Correlated Compound 1x a day (1500 mg)
- Elderberry Immune Support 1x a day(400mg Elderberry, 6mg zinc)
- Vitamin E Pure dl-Alpha 1x a day (180mg)
- Qunol Ultra CoQ10 1x a day (68mg of Vitamin E, 100mg of Coenzyme Q10)
- L-Arginine 1-2x a day (1000mg each dose - can be inconsistent with this as I notice breathing becomes slightly more difficult for me, may be due to other vascular issues I'm unaware of)
- Men's Multivitamin x1 a day (Vit A, C, D3, Vitamin E, Thiamin, Riboflavin, Niacin, B6, Folate, B12, Biotin, Pantothenic Acid, Iodine, Zinc, Selenium, Sodium)
- Tumeric/Cucumin 1x a day (500mg Tumeric Blend)
- Hims Biotin Builder 1x a day (Vit A, C, D, E, Niacin, B6, Folate, B12, Biotin, Pantothenic Acid)


Thanks for any insight.

[MikecarrNY]

I don't know about for Peyronies but folks with Dupuytrens Contracture (related hand condition) are warned to stay away from all collagen supplements and vitamin C high dosing, which promotes collagen. Glucosamine and chondroitin are also to be avoided for similar reasons. I believe High dose vitamin C helped trigger my Dupuytrens although I am genetically predisposed (family history) and believe I likely would have gotten it at some point.

[nemo]

Yeah, I'm not a big believer in vitamins/supps in the first place, but I have always stayed away from stuff that claims to promote collagen ... I'd steer clear just to rule that possibility out.

nemo

[projectpd]

 I would steer clear of the dl-alpha tocopherol, and, i googled the qunol, and hims, which also look to be using that, if not the multivitamin too.  It's arguably the worst choice for vit E , although the cheapest, as it includes the non biologic l isomer, none of the non alpha forms, and no tocotrienols.
Vit C is typically reported with benefits for healing and scarring. Is there some evidence for the idea about a negative effect ?

[FlatteningTheCurve]

I have a question for you all who have been battling with Peyronie's for a while now. The onset/rapid progression of what I believe to be Peyronies Disease started happening about two weeks ago for me. During this time frame I'd been taking 3000mg of Vitamin C (1000mg 3x daily) and Collagen Protein (1x scoop a day) along with non-stop exercising through strenuous biking (potentially irritating my pudenal nerve), ab/core workouts (including hanging ab-lifts, mountain climbers, etc) and a bit of rough masturbation (which I believe to be the "trigger" for my onset).

I would not be too worried about these supplements triggering Peyronies Disease. Vitamin C should be harmless as its water-soluble and the collagen you get from protein supplements is not necessarily the same 'bad' collagen as the one that builds up during Peyronies Disease. There are many different types. I.e. taking collagen orally does not mean that you run the risk of developing a plaque or getting a larger plaque in your penis just because the plaque contains collagen.

I am more inclined to think that the non-stop biking or the 'rough' masturbation could have triggered it, especially if this is something that you did shortly before onset and more intensively than before. But that is just me.

[Christian]

Hi, I still have to fill in my signature, that will follow, I just saw your post and wanted to reply asap (even though it is a couple of years old). From personal experience with large doses of Vit C I am absolutely convinced that it aggravates Peyronies. I am a case for penile implant now and I directly attribute this to Vit C. Of course, this is not scientific but only anecdotal...

[JoeJoe]

I was taking collagen powder & mega-dosing Vitamin C daily before I got Peyronies Disease.  Now I wish that I hadn't, because I wouldn't be surprised if that helped trigger it.  

But I did immediately stop all that, and the Peyronies Disease still progressed to new plaques and indentations over the 2.5 years since my Peyronies Disease began -- so who knows.  That's a very frustrating part of this whole experience: not knowing exactly what I did wrong in terms of supplements or diet, if it was simply genetic, or some combination of the two.  

I'm also suspicious about copper -- very shortly before my first Peyronies Disease symptoms, I took a small copper supplement on top of the collagen and Vitamin C, and copper is involved in collagen production.  I also wonder if times I've indulged in stupidly large amounts of peanut butter has made my Peyronies Disease worse, since I've read that peanuts contain a lot of copper.

[onemillion]

Origin of Peyronie is unclear
I blamed certain behavior of mine too (like taking finsteride) then I found out my brother had it too (despite very different lifestyle and no finasteride..)
My opinion is that genetics is the main reason. Try to investigate.. even though not everyone will be open about it.