Peyronie's best treatment?

[DaveP]

Hi, First posting.
I read in this site that treatment should start in the acute stage , what treatment? My doctor at the hospital said I had to wait 18 months before then having surgery. Now I have a 60 degree bend and am not happy if something could have been done sooner. Any advice gratefully accepted.
Thanks

[LWillisjr]

Search this site for the PAV cocktail. This includes three drugs (Pentox, L'Arginine, and Viagra). This is used in combination with either traction or a VED. There are threads here on each and you will see where some prefer traction and others the VED. The VED is not used traditionally for creating an erection, but used as physical therapy for "exercising" your penis.

These are certainly procedures that allow us to try something and not sit back and "wait and see". But a 60 degree bend is considered close to severe and I don't know of many cases where a 60 degree bend was completely straightened due to these therapies.

Surgery is a last resort, as there are considerable risks with any surgery. So many here try other means mentioned above first. Several of us on this forum including myself have had successful surgeries, but again only after all other options have been exhausted.

Feel free to send a private message. Click on the link in my signature block to read my story or click on the globe symbol to the left for the full story.

I ended up with a 70 degree bend so can certainly related to your situation.

Les

[Luciano]

Well yes you should wait until things stabilize before having surgery.
Up to then there are non invasive treatments most here use.

Oral treatment, basic of which are:
3x400mg of Pentox (also known as Trental) -> needs prescription by doctor
3x100mg of Ubiquinol (Q10)

To this you can add Acetyl-L-Carnintine and L-Arginine or whatever you estimate your body needs (surf around the forums and you will find why people are taking what)

If you have ED, consider taking 5mg cialis/per day. (or 25mg viagra - as part of the PAV cocktail) it helps getting erections while you sleep.

What you should also do, is use

A Medical VED (vaccum device - there is a section for those in the forums - and a 26 week protocol to follow) or a Traction device.

Thats my 2 cents

Luc

[Edit]didn't see someone else posted while i was typing[/edit]

[waitingforxiaflex]

Hi Dave,

If you can, find a uro that know's Peyronies well ASAP. There is quite a few things that can be done at this stage to give you the best fighting chance. The earlier something is done, the better, before bad collagen is deposited in the wounded area.

These guys below are probably considered the best in the world, who are very up to date on current research

http://peyroniesassoc.org/x.php?p=Home,Medical_Advisory_Board

I can recommend Prof Levine who I have had a consultation with when he visited the UK and is excellent.

If you live near London then David Ralph or his accociates at UCHL or Harley Street is the sensible choice.

Otherwise, look at the link below:

http://clinicaltrials.gov/ct2/show/study/NCT01243411?term=peyronies&rank=1&show_locs=Y#locn

These are a list of all the investigators who are running the Xiaflex trials in the world at the moment and will be considered the best and most progressive clinics for Peyronies Disease.

There are a lot of Uros out there who do not specialise in Peyronies Disease and repeat what they learnt 15-30 years ago like "wait and see", "take vit e or potaba" and all that rubbish.


If that fails then I would do some research yourself on PubMed.

At this stage you want to:
1. promote blood flow to the penis
2. make sure your testosterone levels are normal
3. surpress TGF-Beta1 to encourage good collagen (elastic) being laid down in the damaged part of the tunica albuginea.

This is all to promote healthy healing whilst you can.

Blood flow can be promoted by: PDE5 inhibitors (ie viagra, cialis etc), arginine and pentoxifylline.
Testosterone levels can be promoted by exercise, testosterone replacement therapies or herbal supplements like Bulgarian Tribulis.
TGF-Beta1 can be surpressed by pentoxifylline and/or Co-enzyme Q

PDE5 inhibitors, testosterone replacement therapy and pentoxifylline are prescription only and so need a doc / uro
Arginine, co-enzyme Q and Tribulis are over the counter.

Here is some recent research to back this up:

Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study
http://www.nature.com/ijir/journal/v22/n5/full/ijir201020a.html

A double-blind placebo-controlled study of the efficacy and safety of pentoxifylline in early chronic Peyronie's disease.
http://www.ncbi.nlm.nih.gov/pubmed/19863517

L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures.
http://www.ncbi.nlm.nih.gov/pubmed/14996430

Testosterone deficiency and Peyronie's disease: pilot data suggesting a significant relationship.
http://www.ncbi.nlm.nih.gov/pubmed/19473459

The relationship between androgens, regulators of collagen metabolism, and Peyronie's disease: a case control study.
http://www.ncbi.nlm.nih.gov/pubmed/20584122


I hope this helps,

wfx

[quickguide90012]

I am pretty sure i have it and i have all the symptoms of it such as hourglass effect, not full erection.  I read that many people lose length.  


If i start treating it right now, does that mean i won't lose length and get more of those really bad side effects?  


I really want to start as soon as possible.  I see people mention pentox, dmso, L-Carnitine, L-Arginine.  I heard vitamin E doesn't work so don't waste your time.


Is there a chance that i start now, that i won't lose length and those other problems or is it too late?  I know there is no cure but i'm very worried right now because my penis erect normal size before this is 3.75-4 inches only and already have a small penis.


Can someone tell me what is the best treatment right now?  I hear some people say l-carnitine takes years to work but pentox works but some people have side effects?

[LWillisjr]

Search and read up on the PAV cocktail....

Check the forum threads here on traction and VED's and start using one or the other.

[bowillie]

I'm new as well. I share some of the symptoms you have. curvature upward, hourglass at the location of the plaque. Which is just behind the head. Had it for about 6 years now. Tried some of these things. Nothing helped. The curve has not increased, but my ED has gotten worse. My penis is shorter in length, and girth. I've searched for years in hopes of finding a cure, but to no avail.  I must tell you that I am 65 years old, and I'm sure my age plays into my ED to some degree. I have visited this site before but did not register. I feel everyone here is like me. Wishing, and hoping. But who knows.                                                                                                                               What brought me here this time was a website I came across about  Transdermal Verapamil 15% Gel. But after reading some of the post here, I don't think I'm going to bother with that either. I know I sound somewhat jaded regarding my quest for a cure. but I'm being honest. I feel if something comes along that is truly a cure for this disease it will be shouted from the roof tops. Meanwhile I think we remain wishing, and hoping.  

[BSSS]

I'm new as well. I share some of the symptoms you have. curvature upward, hourglass at the location of the plaque. Which is just behind the head. Had it for about 6 years now. Tried some of these things. Nothing helped. The curve has not increased, but my ED has gotten worse. My penis is shorter in length, and girth. I've searched for years in hopes of finding a cure, but to no avail.  I must tell you that I am 65 years old, and I'm sure my age plays into my ED to some degree. I have visited this site before but did not register. I feel everyone here is like me. Wishing, and hoping. But who knows.                                                                                                                               What brought me here this time was a website I came across about  Transdermal Verapamil 15% Gel. But after reading some of the post here, I don't think I'm going to bother with that either. I know I sound somewhat jaded regarding my quest for a cure. but I'm being honest. I feel if something comes along that is truly a cure for this disease it will be shouted from the roof tops. Meanwhile I think we remain wishing, and hoping.  

You gave the VED a good try?