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[camtheman]

hello everyone. I am still in the acute phase and am trying to do everything in my power to stop the progression of the disease. per NeoV I've been trying to do the keto diet but i have found it difficult to get calories in and as im trying to gain weight i feel this diet is not ideal. Should I just be trying harder to eat/up my calorie intake while doing keto? I want to know what others think of this diet in relation to peyronies.

Thanks,

Cam

[jan.schaller1958]

Diet has ZERO to do with Peyroines, so I’d forget all that nutrition, vitamins and minerals palaver. It’s nonsensical pseudoscience.

[NeoV]

Both Peyronie's and Dupuytren's are related to diabetes and metabolic dysfunction at the mitochondrial level.
There is even a study showing that men with undiagnosed diabetes had their Peyronie's improve once they lowered their blood sugar.
Fibrosis in all organs is strongly related to blood sugar and metabolism through the wnt pathway and tgf-beta. Even non-diabetics who have higher insulin levels have higher tgf-beta levels, this is because insulin directly increases tgf-beta receptors on cell surfaces. This increases fibrosis.

Jan, you said in your life you ate and drank whatever you wanted, and now you have coronary heart disease and Peyronie's, is that correct?

Keep in mind that the research also shows that those who are thin with blood sugar issues, actually have WORSE heart disease, cancer, and other issues.

[TonySa]

Keto and other anti-inflammatory diets or supplements can help w Peyronie’s ESPECIALLY in combination w other treatments.

[Paolo]

D-Limonene for diabetes and metabolic syndrome https://www.sciencedirect.com/science/article/abs/pii/S0278691517305392

Methylene Blue for improving Mitochondrial dysfunction (particularly Brain)
Methylene blue supports mitochondrial respiration by functioning as an additional electron carrier[5]. MB receives electrons from NADH through mitochondrial complex I, itself being reduced to leuco-MB (MBH 2 ). Leuco-MB then donates the electrons to cytochrome C, upon which it is recycled back to MB.

Methylene Blue also stimulates glucose metabolism.

I use 1-2mg MB and it appears to lift metabolism significantly, always use USP grade.

[AlterEgo]

Both Peyronie's and Dupuytren's are related to diabetes and metabolic dysfunction at the mitochondrial level.
There is even a study showing that men with undiagnosed diabetes had their Peyronie's improve once they lowered their blood sugar.
Fibrosis in all organs is strongly related to blood sugar and metabolism through the wnt pathway and tgf-beta. Even non-diabetics who have higher insulin levels have higher tgf-beta levels, this is because insulin directly increases tgf-beta receptors on cell surfaces. This increases fibrosis.

Jan, you said in your life you ate and drank whatever you wanted, and now you have coronary heart disease and Peyronie's, is that correct?

Keep in mind that the research also shows that those who are thin with blood sugar issues, actually have WORSE heart disease, cancer, and other issues.

NeoV it would be a common courtesy to reply to direct messages thank you

[jan.schaller1958]

NeoV
I don’t have and never have had diabetes or pre-diabetes.  My random non-fasting blood sugar was 103, (normal range 60-159), well within the normal range, taken just 2 weeks ago. You haven’t the slightest clue what you are even talking about. I’ve never heard more BS in my entire life. I don’t believe a word of your pseudoscientific mumbo jumbo.

[Godisreal]

Sounds like you haven’t accomplished sh*t in your 62 year old life, Jan.
If you don’t believe that diet has any impact on chronic diseases, you’re probably suffering from dementia, you old hag. Lol.

[McChicken94]

No need for namecalling, but obviously a healthy diet is important for your overall health so it can only help whatever disease you are dealing with. That said, Jan probably means that we are not gonna cure peyronie's trough fasting and he is right. I have seen this topic here foe a while now and I think fasting can be great, but it is highly overrated here. The reason this bothers me is because I feel it can be dangerous to start thinking that fasting can heal peyronies as there may be people here desperate enough to start prolonged fasting. Not that it will kill you, but I have done 3 day fasts in the past and it is tough, makes you temporarily a lot weaker (20lbs or more less weight on all my lifts and barely energy to workout at all on day three). It might have some benefits, but you will not notice anything shen it comes to peyronies. I also did intermittent fasting for about half a year and now that I am back to eating small.meals troughout the day I actually feel better and stronger. On my peyronies it simply did not have any effect wether I was fasting or not. For the rest of my body is was okay. Little uncomfortable and takes a lot of discipline to stick with, but it can work and you can evwn get stronger if you take in more calories than you burn. The problem for me is that I am very tall, lift weights, play basketball and deal with depression. I need to BINGE if I wanna take in enough calories in an eating window of 4 to 6 hours. This simply isn't comfortable for me. I eventually started to lose more and more weight especially on the days I couldn't eat cause I was depressed. Now I just eat the same products whenever I am truly hungry and I feel and look just as good, maybe better. I think taking care of your diet is always a good thing and keto/intermittent fasting are both popular diets or food timing plans that work and have been proven to have certain benefits from ketosis. But to think being in ketosis is gonna heal your penis is a little bit far fetched imo. So if any of y'all is thinking about going a week with no food in hopes of healing their dicks, don't bother.. you might even get worse from not getting the nutrition you need and the increased stress hormones.

[jan.schaller1958]

Godisreal,

You don’t have the slightest clue what I’ve accomplished in my life and no clue what I ate when I was younger or eat now. I never ate  a bad diet when I was younger anyway. I just ate like everyone else, and my diet now is very healthy. I never said bad eating habits have no impact of health. Of course they do. All I said is I don’t buy NeoV’s pseudoscience about the evils of sugar. That’s just blatant nonsense. Sounds like a sales pitch to buy vitamins or mineral supplements, which should not be necessary if you eat well,  or some book some retarded nobody wrote who just made up a load of mumbo jumbo to sell to gullible people who know nothing about science, or biology.

And you may call me an old man, but that’s exactly where you’re headed pal. Last time I check the world is still spinning and I’ve never seen a single person yet who ever got any younger with the passage of time. So lol to you too.

[Godisreal]

The fact that you’re 62 & on a forum disrespecting people who only have good intentions proves my point.
Calling NeoV’s arguments regarding sugar and metabolism pseudoscience is bullcrap.
They’re facts.
Also, he doesn’t sell anything, but he has been suffering from Peyronie’s since a young man.
Sugar is evil. It is, along with porn, one of the most underrated and atrocious drugs in the world.
But I wouldn’t expect you to understand. Old people VERY often have a more difficult time accepting new science and chooses to call it bullsh*t instead of reading into it.
You probably still think cigarettes is good for your health hahahahahah
Lastly, if you’re really such a fan of biology and science, then you should try DMSO.
It’s the cure for mild to moderate Peyronie’s, imo.

[jan.schaller1958]

Godisreal,

Ive never read such craziness in all my life. I’m only 62, not 102, and you keep calling me an „old man.“ Well. How old are you? 19? There are men in this forum older than I am you know. And you say I’m disrespecting people here? Wow. Unbelievable.

You describe yourself as „Youngster with Peyronie’s caused by repetitive micro trauma“. Okay, I’ll assume you got a proper diagnosis of Peyroines, but how do you know was it caused by repetitive micro trauma? That’s just a theory of a trigger for Peyroines along with a genetic predisposition. When I was a „youngster“ I can guarantee you my penis sure got a pretty good work out and I never got Peyroines from it (whatever age that is). I didn’t get Peyroines until 56, when the median age at onset is 55-60.

I don’t know a thing about NeoV, so I won’t say anything about whether he has or doesn‘t have Peyroines. I simply don’t know. I’m not disrespecting him or you, only what you say. You said, „Sugar is evil.“ Evil? What are you even talking about?
And, porn? What’s porn got to do with anything? You’re the one sounding like an old man now. Even back in the 70s most people didn’t pay any attention to whether someone liked porn or not. Who cares? And you call it a „drug“? What are you even talking about?

And, no I never smoked and everyone knew cigarettes were dangerous back in the 1970s, and even earlier. And you said DMSO was a „cure for mild to moderate Peyroine‘s“. Well, first off, what is „mild to moderate“ Peyroines?how do you define that? And the reality is, there is no cure for Peyroines. Simple as that. There are just treatment options. A small minority of Peyroines sufferers spontaneously resolve without treatment,  as I recall maybe 10-15% of cases, but for the rest there is no cure, certainly not DMSO or Keto diets or vitamins and minerals. If that were true, you or whoever started this mythology would have won the Nobel Prize in Medicine by now.

„Risk factors include diabetes mellitus, Dupuytren's contracture, plantar fibromatosis, penile trauma, smoking, excessive alcohol consumption, genetic predisposition, and European heritage.[9][10][11]“

These things above are just risk factors for Peyroines, they don’t mean any one of them causes it. Funny, I don’t see sugar on the list, or bad diet, or lack of vitamins and minerals or lack of a keto diet. Wonder why? (This is off the English version of Wikipedia). So, for me:

Diabetes mellitus: No
Dupuytren’s contracture: No
plantar fibromatosis: No
Penile trauma: I don’t think so, but I don’t recall any.
Smoking: No
Excessive alcohol consumption: No, but I’m not a teetotaler.
Genetic predisposition: Yes. My dad had it later in life.
European Heritage: Yes

You’re trying to make this out to be some simple thing you’ve all got figured out, like diet or something. Life’s just not that simple. Sorry.

[jan.schaller1958]

From English Wikipedia:

“There is no good evidence that low-carbohydrate dieting confers any particular health benefits apart from weight loss, where low-carbohydrate diets achieve outcomes similar to other diets, as weight loss is mainly determined by calorie restriction and adherence.[3]
An extreme form of low-carbohydrate diet – the ketogenic diet – was first established as a medical diet for treating epilepsy.[4] Through celebrity endorsement it has become a popular weight-loss fad diet, but there is no evidence of any distinctive benefit for this purpose, and it carries a risk of adverse effects.[4][5] The British Dietetic Association named it one of the "top 5 worst celeb diets to avoid in 2018".[4]”

[Tortão Pra Direita]

Diet has ZERO to do with Peyroines, so I’d forget all that nutrition, vitamins and minerals palaver. It’s nonsensical pseudoscience.

Food impacts EVERY process in your body.
FYI, the prevalence of Peyronie's disease is higher among men with diabetes.

It's funny when a guy calls himself scientific but have no clue what's saying.

From English Wikipedia:

You should read more scientific studies and go beyond WikiPedia.

[jan.schaller1958]

Food impacts EVERY process in your body“

Are you now a nutrition expert? No. You don‘t know a thing about food or diet. Yeah diet affects you body, of course, but people who just eat normally aren’t vitamins and mineral  deficient and don’t need diet supplements. That‘s bull++t. So unscientific.

Diabetes is a risk factor for diabetes only. I’ve never read anywhere that Peyroines is higher in men with Peyroines. Citation please?

And Wikipedia is filled with hundreds of citations. I just didn’t link them. Go look it up yourself in any language and you’ll get all the scientific citations you want. It’s more legit than the pseudoscience peddled by neoV.

[Tortão Pra Direita]

Are you now a nutrition expert? No. You don‘t know a thing about food or diet.

How do you know what I know or not? What's my profession? What college degrees do I have? You're a joke.

Yeah diet affects you body, of course, but people who just eat normally aren’t vitamins and mineral  deficient and don’t need diet supplements. That‘s bull++t. So unscientific.

First of all, you're wrong in your statement about deficiencies. A lot of people have some vitamin or mineral deficiency. More common are magnesium, vitamin D, K...
I'm not even talking about vegans. Among them, B12 and iron deficiencies are common too.
Just to get an idea, read this simple page. There are references there: https://www.healthline.com/nutrition/7-common-nutrient-deficiencies

Second of all, but not less important: nutrition is not just about vitamins. Inflammation and oxidation are greatly impacted by diet. Gut microbiota, gut lining, immunity, insulin levels, etc are also tied to diet. If you don't have any deficiencies but eat a ton of sugar, do you think your body is gonna respond well?
Dude, you're dismissing a whole universe of nutrition subjects. It's much better to admit ignorance instead of attacking others and claiming yourself scientific, something you're clearly not.

Diabetes is a risk factor for diabetes only.

WTF are you talking about?
If you have diabetes, your chances to have a heart attack or some cardiovascular illness are increased by a lot. And not just these diseases.

From: https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444#

Long-term complications of diabetes develop gradually. The longer you have diabetes — and the less controlled your blood sugar — the higher the risk of complications. Eventually, diabetes complications may be disabling or even life-threatening. Possible complications include:

Cardiovascular disease. Diabetes dramatically increases the risk of various cardiovascular problems, including coronary artery disease with chest pain (angina), heart attack, stroke and narrowing of arteries (atherosclerosis). If you have diabetes, you're more likely to have heart disease or stroke.

Nerve damage (neuropathy). Excess sugar can injure the walls of the tiny blood vessels (capillaries) that nourish your nerves, especially in your legs. This can cause tingling, numbness, burning or pain that usually begins at the tips of the toes or fingers and gradually spreads upward.
Left untreated, you could lose all sense of feeling in the affected limbs. Damage to the nerves related to digestion can cause problems with nausea, vomiting, diarrhea or constipation. For men, it may lead to erectile dysfunction.

Kidney damage (nephropathy). The kidneys contain millions of tiny blood vessel clusters (glomeruli) that filter waste from your blood. Diabetes can damage this delicate filtering system. Severe damage can lead to kidney failure or irreversible end-stage kidney disease, which may require dialysis or a kidney transplant.

Eye damage (retinopathy). Diabetes can damage the blood vessels of the retina (diabetic retinopathy), potentially leading to blindness. Diabetes also increases the risk of other serious vision conditions, such as cataracts and glaucoma.

Foot damage. Nerve damage in the feet or poor blood flow to the feet increases the risk of various foot complications. Left untreated, cuts and blisters can develop serious infections, which often heal poorly. These infections may ultimately require toe, foot or leg amputation.

Skin conditions. Diabetes may leave you more susceptible to skin problems, including bacterial and fungal infections.

Hearing impairment. Hearing problems are more common in people with diabetes.

Alzheimer's disease. Type 2 diabetes may increase the risk of dementia, such as Alzheimer's disease. The poorer your blood sugar control, the greater the risk appears to be. Although there are theories as to how these disorders might be connected, none has yet been proved.

Depression. Depression symptoms are common in people with type 1 and type 2 diabetes. Depression can affect diabetes management.

And diabetes is heavily impacted by what? DIET! FOOD!

I’ve never read anywhere that Peyroines is higher in men with Peyroines. Citation please?

It's cause you don't read at all. Simple that. You prefer to attack others and claim yourself as a science man. You're not.

The prevalence of Peyronie's disease in diabetic patients -2018- Yazd
https://pubmed.ncbi.nlm.nih.gov/30641773/
There was no difference in the prevalence of Peyronies Disease in our study with the global studies. But there is a higher prevalence of Peyronies Disease in diabetic patients than the general population.

Peyronie's disease: a silent consequence of diabetes mellitus.
https://pubmed.ncbi.nlm.nih.gov/16372122/
"DM probably exaggerates the fibrotic process in Peyronies Disease. Diabetic patients with Peyronies Disease have a higher risk of severe deformity and erectile dysfunction (Erectile Dysfunction). Peyronies Disease seems to be a silent consequence of DM and should be actively sought in diabetic men."

Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676820/
The presence of diabetes was significantly correlated with Peyronies Disease (P = 0.005). Patients with diabetes had a 7% higher incidence of Peyronies Disease.

Diabetes mellitus is associated with severe Peyronie's disease
https://pubmed.ncbi.nlm.nih.gov/17313425/


Your way of thinking is like: "If I have no clue about the subject, I'm not gonna even do research. It's pseudoscientific, endpoint."
Humble yourself. You're getting this from a guy that has not even half of your age (if you really have 62 yo). Shame on you.

[jan.schaller1958]

Tortao Pra Direita

Shame on me? You and another lunatic on this board who calls himself „god“ , sugar „evil“ and porn an „addiction“ managed to get the most intelligent and informed person on the board, Peter123, muted, all the while the two of you viciously and personally attacked me and him for just criticizing your ridiculous Vitamin and mineral hair- brained Ideas.You two guys violated the forum rules. I didn’t and Peter123 didn’t.  And I won’t even get into NeoV and his website. Bet he never even had Peyroines. You’re the one who should be apologizing to ME and to PETER after backing up what that other wacko said, who sounds like he just walked out of Psychiatry treatment. My God, unbelievable. You can believe all this craziness if you want but it’s not going to help you one bit.

And you keep yakking on about diabetes correlating with higher rates of Peyroines. What’s that got to do with me?  I don’t have and have never had diabetes, yet I wound up with Peyroines. Plenty of men are diabetic and have no Peyroines. Explain that mr know-it-all.

All you care about is getting good intelligent science-minded people black-listed and kicked off the board or muted, like Peter123, so you can harp on with your diabetes correlations (like who cares?) and your nutrition nonsense, which has ZERO correlation to Peyroines, with no opposition. It’s so obvious.

[NeoV]

I don’t have a website. I’ve been diagnosed twice. My dad has been diagnosed as well and he has Dupuytren’s. It’s not “diabetes,” it’s insulin resistance and mitochondria level glucose toxicity. Diabetes is end stage and is not required to suffer severe damage from metabolic dysfunction, which peyronie’s is clearly related to.

Alzheimer’s and heart disease are also metabolic consequences of insulin resistance. Which organ it affects depends on your genes. Some people get cancer, others get Peyronie’s.

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