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Author Topic: Why not use anti fibrotic drugs used for PF?  (Read 1011 times)

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Michiganguy19

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Why not use anti fibrotic drugs used for PF?
« on: August 29, 2020, 10:35:27 PM »

Lot of success treating pulmonary fibrosis with nintedanib and pirfenidone. Also ACE drug Lofarin been shown to stop and reverse fibrosis. Why no one trying it for Peyronie’s?
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Bent Ding Dong

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #1 on: September 07, 2020, 04:48:34 AM »

@Michiganguy19, are you taking any of these meds yet? Am interested to know if it does anything. What are the side effects?
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projectpd

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #2 on: September 07, 2020, 05:16:31 AM »

@Michiganguy19, i think you mean losartan. interesting. Used to lower blood pressure but has some antifibrotic research results.  Low cost @ 6 x 28 100mg tablet(s) - £29.95. Needs monitoring for low blood pressure, potassium and kidney function, but mostly low side effects. Not an ACE inhibitor. Molecular weight 423.
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hope794

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #3 on: September 07, 2020, 07:23:51 PM »

Makes a lot of sense. Honestly, this is unexplainable to me.
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drew67

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #4 on: September 09, 2020, 09:11:32 PM »

losartan lowers dht so it can potentially make Peyronies Disease worse
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projectpd

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #5 on: September 14, 2020, 04:24:35 PM »

@drew67 do you have a ref for the DHT effect?
I don't necessarily mind if it lowers DHT anyway, but I think if I tried this it would only be transdermal anyway.
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drew67

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #6 on: September 14, 2020, 04:58:05 PM »

you can find articles on pubmed

lowering DHT will also lower DHT in the penis where there are lots of DHT receptors
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peter123

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #7 on: September 19, 2020, 10:40:00 AM »

losartan lowers dht so it can potentially make Peyronies Disease worse

No data to support this, in theory l Arginin and increased NO should thelp peyronies which is doesn't therefore the assumption thag lowering NO by lowering dht cannot be supported
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THIS USER HAS BEEN BANNED FROM FORUM FOR REPEATED RULE VIOLATIONS He never had Peyronies Disease but has body dysmorphia and his pastime was to attack all treatments, medical resources, and opinions.

projectpd

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #8 on: September 20, 2020, 12:32:59 PM »

There are no references i could find on pubmed that find or suggest losartan lowers dht. There are a number of studies on losartan and valsartan in rats and humans looking for effects on male hormones & sexual function that found no adverse effects on them, but did improve sexual function & related parameters, at least in diabetic or hypertensive subjects.
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drew67

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projectpd

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #10 on: September 24, 2020, 01:49:35 PM »

What was the relevance of this link?
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Asphyxia

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #11 on: April 11, 2021, 01:46:31 PM »

Has anyone tried this?
Would it make sense to?
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mikel7

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #12 on: April 11, 2021, 02:14:25 PM »

I have been on losartan for BP for the past 7 years and it did nothing for my peyronies/fibrosis.  100mg QD.
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Dipstick

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #13 on: April 29, 2021, 10:07:11 AM »

I have perfenidone the raw powder from....

I am considering it a long with dmso!!!

It seems to be a preventive drug rather than restoring. None the less maybe worth while!
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Hawk

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Re: Why not use anti fibrotic drugs used for PF?
« Reply #14 on: April 29, 2021, 10:28:58 AM »

What is the molecular weight?

How certain are you it is pure?

Do you have any clinical studies that show it is effective for Peyronies Disease?
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