I've started noticing
***palpable*** improvements in my
plaque since adding
40mg of melatonin just before bed, at the same time as my last dose of
pentox for the day. In all fairness, I've also started taking Singulair (Montelukast) every late afternoon for the past two months. So this could be the combination of 6 months of
pentox, 2 months of Singulair and 2-3 weeks of high doses of melatonin.
Yes, I'm taking 40mg of melatonin. No, it's not a typo. I know it's huge. I know you must be thinking it's dangerous and I must be waking up hangover like a zombie. But I wake up just fine, probably thanks to the counteracting effect of
pentox and caffeine blocking my adenosine receptors.
I've seen some studies on rats where doses of 10mg per kilo per day can prevent or revert
fibrosis. The human equivalent dose is 1/6.2 times that. Since I weight 70 kilograms, that would be
113mg... So, I will keep on slowly increasing the dose.
As far as I know, melatonin triggers the production of adenosine in the brain, which puts us to sleep. Mind you, fair warning: I believe that adenosine is the enemy, since it is pro-fibrotic, and caffeine and pentoxifylline help because they block the adenosine receptor.
My hope is that the melatonin-induced adenosine will only be made in the brain and won't escape through the brain blood barrier.
I've seen a bunch of promising studies from many different angles on melatonin. It seems to be a powerful antioxidant. It seems to boost the production of NO. It seems to be anti-fibrotic.
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Topic: high-dose melatonin? (Read 3437 times)