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QuoteTransforming growth factor β-1 (TGFβ-1) is related to fibrosis by upregulating extracellular matrix (ECM) synthesis in many tissues and it causes epithelial inhibition in hair follicle, so it seems to play a fundamental role in AGA pathogenesis. Moreover, TGFβ-1 overexpression is induced by androgens in balding dermal papilla due to enhanced androgen sensitivity. Inui et al. have shown that this androgen sensitivity of dermal papilla cells is regulated by androgen receptor (AR) co-activator Hic-5/ARA55, a focal adhesion associated protein belonging to the family of paxillin. Although Hic-5 is located predominantly in the focal adhesion, it can also be found in the nucleus where it could directly affect TGFβ-1 gene expression in association with AR and dihydrotestosterone. Interestingly, a triggering stimulus that can alter the inactive standby status of Hic-5 is the deformation of the cytoskeleton by physical forces;[15,16] therefore, mechanical stimulation can promote overexpression of molecular signals implicated in AGA pathogenesis.
Quote from: QuackAttack on March 19, 2016, 10:36:24 PManewbie,The rod type traction devices like the SG are totally pull in their function. If you are having trouble needing to go to the bathroom, wear it at night. If you can pee at 10 or so and last throughout the night you will get 6 hours of stretch in. I have no problem wearing it throughout the night, plus another 4-6 hours a day so I can get 12-15 hours in per day.