Interesting. Looking forward to the first studies in humans. I read a lot about peptides, enzymes and stem cells. The mechanisms all sound super fitting, but the numbers and studies are missing. Let's see.

Btw. your protocol is very similar to mine. Happy to exchange in a DM on some fine-tuning ideas.

In a podcast I heard a out Nattokinase. It is a anti inflammatory and anti Fibrotic enzyme in Natto paste.

Apparently it might help with diabetes plaque a bit. So I wonder if it would help with fibromatose plaque like Peyronie's.

Does anyone here use it regularly and hat seen some benefits?

I haven't seen any comments regarding the Mayo Clinic for implants, unless I've missed them.  Has anyone gone there or know of anyone that has?  If so, how was the experience?

I'd like to get the opinion of the most experienced people on this forum about a peptide that has been gaining traction (pun intended) and popularity in many other realms and has a pretty common use already.

I have been reading a lot about peptides and there is one called BPC-157 that makes a lot of sense theoretically that it could work for Peyronies. People call it the wolverine peptide due to it's soft tissue regeneration capabilities. Note that it is not FDA approved yet and it is a research chemical.

Mechanistic fit: Peyronie's is abnormal fibrosis of the tunica albuginea (collagen deposition, inflammation). BPC-157 in animal studies promotes angiogenesis, reduces inflammation, speeds tendon/ligament healing and modulates fibroblast activity — all mechanisms that could, in theory, influence plaque formation/remodeling.

Preclinical precedent: Multiple rodent studies show BPC-157 accelerates tendon/soft-tissue healing and reduces fibrosis in various models. That makes it a reasonable candidate for translational research in fibrotic penile disease.

Sadly all the evidence is preclinical which means it will probably never be studied for Peyronies anytime soon, but it is available to purchase in some jurisdictions and some people are already using it for other things. There is a lot of anecdotal evidence from its use from athletes and bodybuilders to aid with recovery and bounce back from tendon and ligament injuries (soft tissue just like peyronies). If anyone lives in a jurisdiction where you can get your hands on it and give it a try please let us all know if it works.

I see it's been a while since you've posted, but I just want to ask if anyone who's tried RestoreX over the longer term noticed any changes in hourglass shape specifically, not just curvature. I've read mixed things and would love to hear more recent experiences. Did it help with girth or stability during erections for anyone here after consistent use?

I was 67 when diagnosed with Peyronies. My insurance (Medicare & TriCare) would not pay for Xiaflex injections. I have VA care, & they do pay for injections as well as for a traction device. I got a single injection at the VA and experienced an apparent allergic reaction. Very swollen scrotum and my penis literally disappeared into the swollen tissues. It was difficult to pull out the head to urinate. Swelling lasted a week to 10 days, with my swollen sack turning black & blue before the swelling eventually subsided. My female PA at the VA contacted the manufacturer and they confirmed that it's rare for a patient to have such an allergic reaction, but that I was apparently in that category. So, my civilian urologist suggested surgery as an option, and I said "absolutely not." My wife and I have only had intercourse about 5 times in the last 10 years, and none in the last 4 years. Yep, woe is me. She is uninterested in sex, and I have no clue how my new disease would affect her pleasure (or lack thereof), since we haven't had relations since this condition occurred. I have about an 80-85 degree upward curve, and have lost 1-2 inches (length). I can still get rock hard, without pain, only very slight discomfort. However, I can only achieve sexual release via masturbation. I sometimes wonder if the curve would provide pleasure to a woman's g-spot, and the female VA PA said that it's quite possible. But, unless my wife submits to my advances, I'll never know. There are many more pleasures in life than sex, and I refuse to get angry or depressed about it. It's just where I'm at in this stage of life. This is my story.

It is just shockwave technology with a new face and design. The original shockwave therapy was very costly and did not prove to correct or heal peyronies disease at all. Although Dr's made a lot of $$$$ off of it.

Peyronie IS a niche where most urologist lack training.
But anyway, this was not the goal of the post
Hope to hear any stories from other members using AI.

How could you be sure that this wasn't related? I mean, clamping a penis, stretching it and bending it.........isn't it logical that there is the potential for harm and that urethral stricture or any urethra injury is plausible? I'll see how things are without the restorex and might be able to form some conclusion in a week or so.

You wouldn't get issues with your urethra because of this device. Not to say that there isn't a possibility of an injury, but never heard anything about this nor read on the device manual or even Dr. Trost's/pathright medical youtube channel.

Lot's of things can cause ejaculation issues... self-diagnosing is not a good thing, more often than not.