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Peyronies Disease TREATMENT Discussion Boards => Alternative Treatments of Peyronie's Disease => Topic started by: pey ron on September 22, 2017, 11:25:18 PM

Title: high-dose melatonin?
Post by: pey ron on September 22, 2017, 11:25:18 PM
I've started noticing ***palpable*** improvements in my plaque since adding 40mg of melatonin just before bed, at the same time as my last dose of pentox for the day. In all fairness, I've also started taking Singulair (Montelukast) every late afternoon for the past two months. So this could be the combination of 6 months of pentox, 2 months of Singulair and 2-3 weeks of high doses of melatonin.

Yes, I'm taking 40mg of melatonin. No, it's not a typo. I know it's huge. I know you must be thinking it's dangerous and I must be waking up hangover like a zombie. But I wake up just fine, probably thanks to the counteracting effect of pentox and caffeine blocking my adenosine receptors.

I've seen some studies on rats where doses of 10mg per kilo per day can prevent or revert fibrosis. The human equivalent dose is 1/6.2 times that. Since I weight 70 kilograms, that would be 113mg... So, I will keep on slowly increasing the dose.

As far as I know, melatonin triggers the production of adenosine in the brain, which puts us to sleep. Mind you, fair warning: I believe that adenosine is the enemy, since it is pro-fibrotic, and caffeine and pentoxifylline help because they block the adenosine receptor.

My hope is that the melatonin-induced adenosine will only be made in the brain and won't escape through the brain blood barrier.

I've seen a bunch of promising studies from many different angles on melatonin. It seems to be a powerful antioxidant. It seems to boost the production of NO. It seems to be anti-fibrotic.
Title: Re: high-dose melatonin?
Post by: Christopher1 on September 23, 2017, 12:05:07 PM
How long have you been on this dose of melatonin?
Title: Re: high-dose melatonin?
Post by: Christopher1 on September 23, 2017, 12:05:52 PM
2-3 weeks?
Title: Re: high-dose melatonin?
Post by: pey ron on September 23, 2017, 10:14:00 PM
@Christopher1:

6 months of pentox, 2 months of Singulair and 2-3 weeks of high doses of melatonin.
Title: Re: high-dose melatonin?
Post by: Christopher1 on September 30, 2017, 11:57:00 AM
Keep us up-to-date. I hope all is well with your melatonin experiment.
Title: Re: high-dose melatonin?
Post by: pey ron on October 03, 2017, 09:50:14 PM
I gave up a few days later. It started making me wake up in the middle of the night, and it's still happening after having quit cold turkey. Too bad that I need to be alert during the day...
Title: Re: high-dose melatonin?
Post by: Christopher1 on October 09, 2017, 06:51:26 PM
Some people get hyperactive from an overdose of melatonin - the opposite effect.
Title: Re: high-dose melatonin?
Post by: drew67 on October 28, 2020, 08:55:36 PM
what about a transdermal application?
Title: Re: high-dose melatonin?
Post by: pey ron on December 08, 2020, 09:48:55 PM
has anyone else given this a try?
Title: Re: high-dose melatonin?
Post by: GianB1 on April 02, 2022, 08:50:15 PM
I've started noticing ***palpable*** improvements in my plaque since adding 40mg of melatonin just before bed, at the same time as my last dose of pentox for the day. In all fairness, I've also started taking Singulair (Montelukast) every late afternoon for the past two months. So this could be the combination of 6 months of pentox, 2 months of Singulair and 2-3 weeks of high doses of melatonin.

Yes, I'm taking 40mg of melatonin. No, it's not a typo. I know it's huge. I know you must be thinking it's dangerous and I must be waking up hangover like a zombie. But I wake up just fine, probably thanks to the counteracting effect of pentox and caffeine blocking my adenosine receptors.

I've seen some studies on rats where doses of 10mg per kilo per day can prevent or revert fibrosis. The human equivalent dose is 1/6.2 times that. Since I weight 70 kilograms, that would be 113mg... So, I will keep on slowly increasing the dose.

As far as I know, melatonin triggers the production of adenosine in the brain, which puts us to sleep. Mind you, fair warning: I believe that adenosine is the enemy, since it is pro-fibrotic, and caffeine and pentoxifylline help because they block the adenosine receptor.

My hope is that the melatonin-induced adenosine will only be made in the brain and won't escape through the brain blood barrier.

I've seen a bunch of promising studies from many different angles on melatonin. It seems to be a powerful antioxidant. It seems to boost the production of NO. It seems to be anti-fibrotic.



very interesting. I have been researching Melatonin for the past two weeks, and after seen some medical studies, I realized this could help with Peyronies. How is it going with that?
Title: Re: high-dose melatonin?
Post by: BrettC on April 04, 2022, 03:19:48 PM
I would be careful taking Melatonin regularly.  There have been recent studies that show a link to an increased chance of developing dementia in subjects that take it regularly.  Most doctors advise it should be used like any sleep aid - only occasionally when you need it to fight jet lag, some weird shift work, or just an off night here and there. 


https://www.wftv.com/news/local/doctors-warn-that-melatonin-can-be-linked-dementia/H3MEINV4R5BTRL5A7MYVHT5R6I/