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Peyronies Disease TREATMENT Discussion Boards => Alternative Treatments of Peyronie's Disease => Topic started by: Godisreal on April 07, 2021, 11:55:59 AM

Title: Study with Diclofenac.
Post by: Godisreal on April 07, 2021, 11:55:59 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706125/#!po=0.769231

This study showed good results and it says patients used Diclofenac, twice daily. Among other things (blueberry, PTX-oral, propolis, PTX-shot & Vitamin E.
Interesting since many on here has been asking if Diclofenac perhaps could do something.
Well, in this study, they use it officially.

I do, however, want to put the question out there - what actually made the difference?
If you bother to read the study, you'll see that they administered a Pentoxfylline-shot (100mg) every other week, directly into the penis. Has anyone else here had this done?
Perhaps this was the reason for the success of the patients on the study, but who knows.
I feel like antioxidants are important but we all know the mega-dosage of Vitamin E is Stone Age treatment. Is anyone on blueberry and Propolis combined with Pentox?

I will personally start using Diclofenac more, excluding the glans this time.
Actually, I might put on Hirudoid-cream when I wake up and Diclofenac when I go to sleep.
I can barley afford the supplements I get on which leads to me not taking them for an extended period of time, which is awful. Physical & psychological pain combined is devastating.
- GIR
Title: Re: Study with Diclofenac.
Post by: Winter on April 08, 2021, 12:16:17 AM
In my case I wouldn't mix Diclofenac and Hirudoid. I would use on or another, isolated, for a week. See each one improves the best and then make a choice. But that is just me. I am usually all in for combining treatments, but I am quite cautious about skin's allergic reactions.
Title: Re: Study with Diclofenac.
Post by: Godisreal on April 08, 2021, 12:21:57 PM
Yeah I hear you, man. My skin'a reaction to DMSO wasn't too bad until I washed it off with warm water... God what a mistake.
Nasty skin rash on my balls after that and still occasional discomfort and pain in scrotum area, 2 months later!!!
Watch out for that.
Hirudoid is nicer to the skin in my case, but Diclofenac is definitely more powerful.

I'm applying Hirudoid two times a day right now.
It's working, but I still feel a dull pain in my glans almost every day. Comes like a small wave.
Any suggestions to treat pain in the glans? I'm trying to avoid getting Hirudoid on there but it's difficult.
Title: Re: Study with Diclofenac.
Post by: Winter on April 08, 2021, 04:11:54 PM
If you have any reaction on your glans, do avoid it carefuly. On the Hirudoid's leaflet, it says to avoid using it on mucous membranes or sensitive areas. Same with diclofenac.

But obviously you may try both. The problem with trying them at same time is that, if you have an allergic reaction, you wouldn't know which one caused it.
Having said that, perhaps I will try Diclofenac as well after finishing my Hirudoid.

The study your posted is quite interesting. Specially because says that by doing nothing, you are very likely to experience noticeable worsening. What the heck people are teaching on the urology classes lately?

The main protagonist of this study is the perilesional injections of pentoxifiline. In my country I am 100% sure no urologist will agree on this!! I've visited 4 of them and 3 dismissed even oral pentox, with no room for arguments. The last one prescribed me, but only to get rid of me. Pentox injections? No chance at all. I also don't recall reading about any member here talking having taken pentox shots.
But the results on the B group are quite promising also. I see myself, more or less, followin the same protocol as they were.
Title: Re: Study with Diclofenac.
Post by: BillyJynx on April 09, 2021, 02:51:28 PM
Quote from: Godisreal on April 08, 2021, 12:21:57 PM
Hirudoid is nicer to the skin in my case, but Diclofenac is definitely more powerful.

How do? Which strength hirudoid are you using? I've just run out of hirudoid forte (mucopolysulphate saccharide) which worked very well for me. I can buy Diclofenac at the shops would love to know if it could work better.
Title: Re: Study with Diclofenac.
Post by: Godisreal on April 12, 2021, 02:06:50 PM
Thanks, lads. I just read a study where it was found that Diclofenac has a negative impact on sperm-quality and testosterone. Of course, lol. It's always something.
The study also concluded that Melantonin-supplementation eases the negative impacts on testicular health, caused by Diclofenac.

Just a heads up for people trying Diclofenac. I'm not gonna stop using it, since it's working.
I might ease up a little and I will also start Melatonin-supplementation soon, since it's also a powerful antioxidant.
But I guess try Hirudoid, first hand. Might be a little more easy on the body & especially testicles.
Title: Re: Study with Diclofenac.
Post by: bentoboy on October 09, 2022, 04:28:45 AM
Any update on using Diclofenac?
Title: Re: Study with Diclofenac.
Post by: hope4thebest on December 03, 2022, 05:48:28 PM
I'm also planning to use topical diclofenac. I bought the same formulation that they used in the study. 4% gel spray. It has a lot of different names in different countries. It's supposed to be the most powerful of all topical diclofenac preparations and have superior penetration due to lecithin, I believe. They say they used two pumps twice a day.

Also, I wouldn't be concerend about testosterone as we won't be applying it to testicles and the amount absorbed into general circulation will be very low. There really doesn't seem to be any downsides to trying, since it's cheap and maybe will have at least some effect.

I'm hoping to convince mu urologist to do PTX injections, since I can't take tablets due to terrible digestive issues I have and very poor general health. Urologist, of course, redommended wait and see... as seems to be the usual.
Title: Re: Study with Diclofenac.
Post by: YoungPrince on December 03, 2022, 06:37:33 PM
Quote from: Godisreal on April 12, 2021, 02:06:50 PM
Thanks, lads. I just read a study where it was found that Diclofenac has a negative impact on sperm-quality and testosterone. Of course, lol. It's always something.
The study also concluded that Melantonin-supplementation eases the negative impacts on testicular health, caused by Diclofenac.

Just a heads up for people trying Diclofenac. I'm not gonna stop using it, since it's working.
I might ease up a little and I will also start Melatonin-supplementation soon, since it's also a powerful antioxidant.
But I guess try Hirudoid, first hand. Might be a little more easy on the body & especially testicles.

Be care with melatonin, it does no good for dopamin and dopamin regulation affects testosteron.
Title: Re: Study with Diclofenac.
Post by: Sonic on December 04, 2022, 08:10:27 AM
I used it almost every day for a month or more. Be very careful with applying this on your penis since it is proven to penetrate skin. It definitely helped with some soreness/minor pain flare ups but it also quite drastically lowered my erectile quality for months.

Use at your own risk.
Title: Re: Study with Diclofenac.
Post by: hope4thebest on December 04, 2022, 10:19:27 AM
@sonic, interesting. I actually wondered yesterday if it could be a potential problem with it. I've just did a quick google search and it seems that NSAIDs are mildly associated with erectile dysfunction after prolonged use. Makes me wonder if it's really such a good idea. Interestingly, no such effects were observed in study subjects.

These same researchers also used propolis cream in another study. Maybe that's a good alternative option. I'm just not sure if it can penetrate deep enough to affect the plaque.
Title: Re: Study with Diclofenac.
Post by: hope4thebest on December 04, 2022, 01:20:44 PM
Actually it wasn't a study, just a three case report. Interestingly, one guy had complete regression even without pentoxi injections.

It's probably already been posted here, but here's the link:

Full Regression of Peyronie's Disease Plaque Following Combined Antioxidant Treatment: A Three-Case Report
https://pubmed.ncbi.nlm.nih.gov/36139736/
Title: Re: Study with Diclofenac.
Post by: Cehaleddin on December 06, 2022, 05:10:28 PM
I am not a very educated reader but my understanding is that propolis creme and antioxidants were the thing in common that these patients used, no?

If so what were the antioxidants? I could not see a list of them perhaps its in the longer version of the report.

Either way do you think this is valid? Total remission, sounds very promising.
Title: Re: Study with Diclofenac.
Post by: hope4thebest on December 07, 2022, 10:01:27 AM
I think the report shows that is indeed possible. Whether it's possible in every case, that's a different question. The one thing authors enmphasize in every paper is that it takes a long time and commitment to the multimodal therapy to achieve that. Just open the full paper, it's free. You'll find all the supplements listed.

Going back to.diclofenac and possibility of ED, I dug a little deeper and there seems to be a possible mechanism that would explain it. It has been proven in animal models.

Functional inhibition of erectile process in rats by indomethacin

Abstract
Objectives
Despite the important role played by prostaglandins in the control of erection, the potential contribution of non-steroidal anti-inflammatory drugs in erectile dysfunction in experimental animals has not been investigated. We examined the effect of the selective COX-2 inhibitor, celexocib, and the non-selective COX-inhibitors, indomethacin and diclofenac on erectile process in vivo.

Methods
Erectile responses to electrical stimulation of the cavernous nerve in anesthetized male rats were recorded after single and repeated administration and intracavernosal pressure/mean arterial pressure (ICP/MAP) was calculated. The effect on blood pressure during erection and total plasma nitrite/nitrate level was also investigated.

Results
Single-dose administration of indomethacin significantly reduced erectile responses to electrical stimulation at all frequencies tested; 15 mg/kg further reduced ICP/MAP to 0.016 ± 0.005 compared to 0.064 ± 0.012 and 0.104 ± 0.035 for indomethacin (5 mg/kg) and control, respectively at 0.5 Hz. Longer-term treatment with indomethacin completely abolished erectile responses at low frequencies and significantly reduced ICP/MAP at higher frequencies, accompanied by significant reduction in total plasma nitrite/nitrate level. Diclofenac reduced erectile responses only at low frequencies in contrast to celexocib that failed to negatively affect erectile responses.

Conclusion
Indomethacin, and to a lower extent diclofenac, may adversely affect erectile responses in rats.



Here's the link to a full article foe those interested:
https://sci-hub.se/10.1007/s00345-010-0600-0

But then again, no such problems were reported in the study so this problem may not be very significant.