alpha-Melanocyte-stimulating hormone (a-MSH) is a hormone that controls inflammation in the body, among other things. The peptide called Melanotan (used by people who want a tan) can be bought online. It has a pretty good safety profile as it has been used by hundreds of thousands of people for over a decade, with very little side effects reported.
Why could it work for Peyronie's disease?
1. a-MSH is often very low in people with autoimmune illnesses. These people often have high tgf-beta (which you probably have if you have Peyronie's). These two go together. If you increase a-MSH, you will automatically lower tgf-beta 1.
2. a-MSH increases nitric oxide. Therefore, more blood flow to your penis.
3. a-MSH raises libido and also helps with erections (so I am guessing this also helps with nocturnal erections).
4. a-MSH is anti-inflammatory and lowers systemic inflammation in the body.
My bet is that a lot of people with Peyronie's disease will have abnormally low levels of a-MSH. You can test this with a blood test to confirm it (I have done so myself, and I had barely detectable levels).
How to increase a-MSH? Quickest and most effective way is to supplement it (i.e. take Melanotan).
Do you know of any ongoing studies using Melanotan 2 for Peyronies disease?
I doubt any studies of that kind would ever be made. It's a peptide and not patentable so there is no money for big pharma doing that.
By the way, for Peyronie's I would think Melanotan 1 would be better than Melanotan 2. It has weaker tanning effects but is more closely resembling pure a-MSH. Melanotan 2 is not entirely a-MSH and may have additional side effects.
Quote from: JayGould on August 28, 2017, 11:42:53 AM1. a-MSH is often very low in people with autoimmune illnesses. These people often have high tgf-beta (which you probably have if you have Peyronie's). These two go together. If you increase a-MSH, you will automatically lower tgf-beta 1.
Very interesting info Jay, I did not know a-MSH was low in autoimmune sufferers. Much appreciated.
can you please provide some trustworthy sources that supply a high-purity one?
See below study reference melanotan 2 and ED
https://www.ncbi.nlm.nih.gov/pubmed/9679884
However what would be the long term health implications of using it???????
That's the thing, long term no-one knows I guess. But it has been sold on the grey/black market for a long time now with no big issues reported.
pey ron - Unfortunately I do not have any sources that I can say for sure carries good Melanotan (I am not sure it would be allowed either). I will say that Melanotan is quite a short and easy amino acid sequence to make so fakes should probably be less prevalent compared to more advanced peptides.
Paolo/skunkworks - I would say that if you have less than normal a-MSH already and you bring it up to normal or high normal levels, and just stay there, then there shouldn't be any side effects at all. It's a natural substance after all (like testosterone). So perhaps start with a loading phase for 3-4 weeks with daily injections, and then move to weekly injections and do those indefinitely. I am going to try this myself and report back with any possible improvements.
although I could use the side effect of spontaneous erections, lol, it sounds like M-1 is the way to go w lower side effects. Can anyone pm me if they've found a good distributor for peptides?