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Peyronies Disease TREATMENT Discussion Boards => Alternative Treatments of Peyronie's Disease => Topic started by: pey ron on July 30, 2020, 03:26:49 AM

Title: Relaxin-2
Post by: pey ron on July 30, 2020, 03:26:49 AM
Relaxin-2 is a peptide that seems to hold a lot of promise.

https://www.pnas.org/content/116/25/12183
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406285/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697124/

I found a cheap and reliable source for it, but I have never injected anything in my entire life and I am already very nervous when nurses inject me in an arm. I don't think I'd be ever capable of injecting myself, and let alone in my penis...
Title: Re: Relaxin-2
Post by: P1992 on July 30, 2020, 09:40:59 AM
It seems that her action is similar to xiaflex. It would be good for them to test her for peyronie's disease to see if the results are promising.
Title: Re: Relaxin-2
Post by: projectpd on July 30, 2020, 01:04:03 PM
interesting.. but only multiple intra artery injections had a benefit in the 1st study? ouch!.

this study used a subcutaneous infusion, but wasn't positive: https://pubmed.ncbi.nlm.nih.gov/19333948/

how cheap was your source ? i thought this kind of thing was super expensive.
Title: Re: Relaxin-2
Post by: hope794 on August 01, 2020, 03:29:59 PM
what about relaxin-2 + DMSO?
Title: Re: Relaxin-2
Post by: pey ron on August 01, 2020, 03:59:09 PM
My source is 22.36 dollars for 10 milligrams. It's a website I trust, I have used their letrozole and enclomiphene before and they were very effective, bloodwork at hand. I also bought the relaxin-2 but I am keeping it in my freezer until one day I will learn how to self-inject.
Title: Re: Relaxin-2
Post by: projectpd on August 01, 2020, 04:08:25 PM
Molecular weight about 6000 Da is far above usual supposed limit for DMSO of around 400. According to this, ML290 is also a relaxin agonist at 500 Da- and supposed to be low price?: (have no info on that) any thoughts?

https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.13656
Title: Re: Relaxin-2
Post by: pey ron on August 01, 2020, 09:59:45 PM
Peptides are extremely delicate. I am afraid DMSO is going to damage them.
Title: Re: Relaxin-2
Post by: projectpd on August 01, 2020, 10:39:26 PM
This ML290 isn't a peptide. but are you planning multiple injections per day?
Title: Re: Relaxin-2
Post by: pey ron on August 02, 2020, 04:35:06 PM
sorry, didn't notice you were talking about that. Very interesting!
Title: Re: Relaxin-2
Post by: hope794 on August 03, 2020, 04:50:11 PM
Wow, nice find!!!!!!!
Title: Re: Relaxin-2
Post by: Hontas on August 13, 2020, 09:22:57 AM
Quote from: pey ron on August 01, 2020, 03:59:09 PM
My source is 22.36 dollars for 10 milligrams. It's a website I trust, I have used their letrozole and enclomiphene before and they were very effective, bloodwork at hand. I also bought the relaxin-2 but I am keeping it in my freezer until one day I will learn how to self-inject.

How did letrozole affect your penis?
Title: Re: Relaxin-2
Post by: Gregd on February 09, 2021, 03:32:41 PM
Quote from: pey ron on August 01, 2020, 03:59:09 PM
My source is 22.36 dollars for 10 milligrams. It's a website I trust, I have used their letrozole and enclomiphene before and they were very effective, bloodwork at hand. I also bought the relaxin-2 but I am keeping it in my freezer until one day I will learn how to self-inject.

Have you tried this out yet? I'm willing to try this out. Can you message me your source. Thanks for the info
Title: Re: Relaxin-2
Post by: LuisFernandez on February 10, 2021, 08:55:38 PM
Relaxin is also cited i the Penis Enlargement patent: https://patents.google.com/patent/US20050065159A1/en

It sounds very interesting but sounds hard to get and correctly inject.
Title: Re: Relaxin-2
Post by: pey ron on February 14, 2021, 01:47:53 AM
it's easy to get
Title: Re: Relaxin-2
Post by: LuisFernandez on February 14, 2021, 08:37:09 PM
So,

According to the patent there's 3 different ways to apply relaxin to your penis:

"Relaxin can be administered at a dosage of 0.02 to 10 micrograms/kg body weight/day by intracavernosal injection.
Relaxin might be for topical administration at a dosage of 25 to 400 micrograms/kg body weight/day.
The relaxin might be for administration at a dosage of 0.02 to 1 micrograms/kg body weight/day by injection into the dense connective tissue surrounding the erectile tissue of the penis."

I'm not sure that topical administration would be much help. I'm also not sure if you could mix it with DMSO, I'm not sure what relaxin's molecular weight is.

I'm not brave enough to inject relaxin to my penis. I'm not sure if one should avoid the Neuro Vascular Bundle or something. Even though i regularly inject PGE-1 and apply DMSO to my penis.

Would be interested to see how this works, just won't do it on myself.
Title: Re: Relaxin-2
Post by: pey ron on February 16, 2021, 04:16:45 AM
how about injecting the pube, close to the penis? the stuff is powerful.
Title: Re: Relaxin-2
Post by: LuisFernandez on February 16, 2021, 05:06:08 AM
Not for me. I'd need to see other people try it and at least not have issues before i try it myself.
Title: Re: Relaxin-2
Post by: Gregd on February 26, 2021, 09:13:13 PM
Quote from: LuisFernandez on February 14, 2021, 08:37:09 PM
So,

According to the patent there's 3 different ways to apply relaxin to your penis:

"Relaxin can be administered at a dosage of 0.02 to 10 micrograms/kg body weight/day by intracavernosal injection.
Relaxin might be for topical administration at a dosage of 25 to 400 micrograms/kg body weight/day.
The relaxin might be for administration at a dosage of 0.02 to 1 micrograms/kg body weight/day by injection into the dense connective tissue surrounding the erectile tissue of the penis."

I'm not sure that topical administration would be much help. I'm also not sure if you could mix it with DMSO, I'm not sure what relaxin's molecular weight is.

I'm not brave enough to inject relaxin to my penis. I'm not sure if one should avoid the Neuro Vascular Bundle or something. Even though i regularly inject PGE-1 and apply DMSO to my penis.

Would be interested to see how this works, just won't do it on myself.

Have you heard of a place where it can be purchased as a topical cream?