Peyronies Society Forums

Peyronies Disease TREATMENT Discussion Boards => Developmental Drugs & Treatments => Topic started by: LMP on January 31, 2013, 07:33:11 AM

Title: Hybrid H-100
Post by: LMP on January 31, 2013, 07:33:11 AM
Has this ever been mentioned or discussed on here - can't see that it has. Treat with a large dose of salt I assume???

The Hybrid Medical invention for the treatment of Peyronie's disease is a new viscous, oil based tissue delivery system called H-100 which combines an effective carrier agent with proven plaque reducing compounds.


(link deleted by administrator)
Title: Re: Hybrid H-100
Post by: Hawk on January 31, 2013, 10:09:45 AM
It is more of the transdermal Verapamil treatment or scam.  You decide which.

What is clear they put up a slick website and yet will not tell you the drug they use even though they say it is proven effective.  They also do not disclose their the transdermal delivery agent.  Buyer Beware!
Title: Re: Hybrid H-100
Post by: james1947 on January 31, 2013, 04:08:30 PM
I can just second Hawk and add:
In my opinion is a scam like many other miracle cures!!!
They will became rich 8), you will became poor :( and you Peyronies? in best case no change to worse ;)

James
Title: Re: Hybrid H-100
Post by: Angus on January 31, 2013, 06:33:47 PM
    Members young and old, male and female, be advised:
The internet is full of fishermen. Their web sites are the hooks and the "wonderful" treatment they offer is the bait. These fishermen have no problem preying on men afflicted with Peyronies Disease and offer "hope" to the desperate men who they KNOW are surfing the web for HOURS looking for the magic cure for Peyronies. I know that surfing the web for a cure lets you feel better because you're doing SOMETHING to try and help your affliction. There is not one of us here, including moderators and the forum owner, that has not been through this.
   These people wanting to sell you a tub of hand lotion with some herbs and things in it have NO problem taking money from the ill and desperate. They go to sleep at night with no problem and feel NO remorse over their scam.
   I won't ask you to stop surfing the web for information on a cure because I know it is something you are compelled to do. But I can tell you, from experience, to do your best to try and have some objectivety when you land on one of these sites and ask yourself what are they offering. Read with reason and constraint, and you will discover that they offer.... nothing. Members here have explored every type of treatment, both logical ones and the rediculous ones, many times over. The scams and ineffective treatments have been posted about many, many hundreds of times here.
   Please ask yourself do I really want to pad some web sites PayPal account with my hard earned money for a product that may not even have a list of ingredients? Men will always be willing to try ANYTHING to rid themselves of Peyronies. The scammers know this. It is up to you to read with caution and make smart decisions.
Title: Re: Hybrid H-100
Post by: TomP on February 02, 2013, 05:37:00 PM
I agree.

But I read that levine is their chief medical advisor. Is someone can  ask him what do we have to think about h-100 ?

Tom
Title: Re: Hybrid H-100
Post by: Hawk on February 02, 2013, 10:00:16 PM
I have never known Dr. Levine to prescribe TV. The verdict against TV is so well established that I would question his motives if he ever attached his name to such a treatment.  At this point I am not convinced that he has.
Title: Re: Hybrid H-100
Post by: funnyfarm on February 02, 2013, 10:10:49 PM
I won't paste the link but he is listed on their website as Chief Medical Advisor, as Tom pointed out.    The site itself does not give any specifics about what the product contains or when it will be available.  My personal impression is that they are trying to get seed money to fund the venture rather than find customers right now.  Perhaps one of his patients can ask him about this during the next visit.   If it is indeed TV, I agree with Hawk, it would very likely be a huge waste of time for everyone involved including investors, clinicians, and patients.
Title: Re: Hybrid H-100
Post by: Hawk on February 02, 2013, 10:12:52 PM
Paste the quote in full context if you will.

Thanks
Title: Re: Hybrid H-100
Post by: Hawk on February 02, 2013, 10:29:12 PM
FF,
I just want the quote in context not the link so I removed your post.  Here is the Quote _________________________________________________
Laurence A. Levine, MD, FACS

Chief Medical Advisor

Professor of Urology, Rush University, Chicago, Illinois. Dr. Levine has made a substantial contribution to the medical press in the form of peer- reviewed articles, abstracts, book chapters, and Internet publications regarding Peyronie's disease, male sexual dysfunction, fertility, chronic orchialgia and reconstructive urology. He is an ad hoc reviewer for The Journal of Urology, Urology, Journal of Sexual Medicine, Journal of Andrology, Asian Journal of Andrology, British Journal of Urology, European Journal of Urology and International Brazilian Journal of Urology.

Dr. Levine is the editor and contributor to the first textbook on Peyronie's disease published by Humana Press in December 2006 and a patient guide entitled "Understanding Peyronie's disease" published by Addicus Books in 2007. He also has an active involvement in basic science research on Peyronie's disease at Rush University Medical Center where he and his colleagues are looking for the causes and new treatments for this distressing medical problem.
_____________________________________________________________________

They get his bio right but seem a little vague on his actual association.  I too wish a patient would get a straight answer from Dr. Levine.  If they are misusing his name he will no doubt want to know and he will stop it in its tracks.
Title: Re: Hybrid H-100
Post by: funnyfarm on February 02, 2013, 10:34:00 PM
Thanks Hawk, also I emailed Hybrid Medical requesting more info on the product.  I will share it with the forum if they reply.
Title: Re: Hybrid H-100
Post by: dvdmaven on February 05, 2013, 07:54:31 PM
Just because a person is listed on a site as being connected with a company does not mean they know about it.

Since there isn't any treatment out there that has FDA approval* (my standard of effective) I'll call this a scam.

*Soon there will be one, but it ain't H100.
Title: Re: Hybrid H-100
Post by: funnyfarm on February 06, 2013, 01:27:56 AM
I think it is just in the conceptual stage.  The website is short on info, and offers nothing for sale. 

They did not reply to my inquiry either so I will write it off as a lost cause. 
Title: Advice on new trial
Post by: fxt on April 25, 2013, 08:38:26 AM
I was recently diagnosed with Peyronies Disease but the condition likely began 9-12 months ago.  My urologist is recruiting for a double blind study on a new topical compound that he thinks is likely to produce positive results.  I can choose to participate in the study but can't use any other form of treatment while waiting for it to start and until it ends and there is also a 50% chance I will be in the placebo group.  The study doesn't start for another month and a half and runs 3 months.  There is a possibility that by participating in the trial, I may miss the opportunity to treat the symptoms while still in the inflammatory stage. (I will have had Peyronies Disease for 13-18 months by the end of the study.)

My urologist won't tell me exactly what the compound is, only that it is likely to absorb better than verapmil gel and has shown to be effective on other types of scar tissue.  He also mentioned that Dr. Levine is the independent advisor but I have been unable to get a response from Dr. Levine to get his opinion first hand.

Would I be better off starting pentox/arginine/coQ10/cialis right away and skipping the study or holding off on other treatments so that I can participate in the study? Is it more important to treat it early or are current treatments fairly ineffective to the point where I should take the 50/50 risk of either having no treatment for 4.5 mo (placebo) or trying something new (which may or may not work)?


Title: Re: Advice on new trial
Post by: GS on April 25, 2013, 11:50:20 AM
Obviously, this is only one man's opinion.  But, I would start treatment right away with stuff that's proven to help.  Let other guys that have had the condition for a longer time be in the trials.

GS
Title: Re: Advice on new trial
Post by: funnyfarm on April 25, 2013, 01:21:21 PM
This sounds like the mysterious H-100

Innovation | Hybrid Medical (http://www.hybridmedicalmn.com/?page_id=8)

I have emailed them several times for info and never heard back.   There are a few other threads about this you can find here on the forum.  I was hoping someone would ask Dr Levine about it at their appt., but this never happened.

If it were me I would take pentox first since to date there are no topicals with a good track record and this company has provided very little useful information about H-100 safety and efficacy.  I guess that is why they need test subjects.. 
Title: Re: Advice on new trial
Post by: james1947 on April 25, 2013, 06:23:59 PM
Fxt

Welcome to the forum.
It is very difficult to give you an advice in the subject as we are talking about your body and not mine or someone else.
I am proposing you to get much as possible information (on the forum and on the web) before you are deciding what to do.

James
Title: Re: Advice on new trial
Post by: skunkworks on April 25, 2013, 10:02:47 PM
Yeah more info on the substance would be useful. If it is this h-100 stuff I'd say skip it and go with what you know works, that product does not look very promising.
Title: Hybrid Medical H-100 Topical Cream
Post by: Youngdude22 on August 23, 2015, 12:30:44 AM
Hybrid Medical | Treatment for Peyronie's Disease (http://www.hybridmedicalmn.com/)

Anyone know about this products active ingredients? I was initially skeptical of it until I found out that Dr. Levine is a medical advisor for the company. Thoughts?
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: skunkworks on August 23, 2015, 12:58:33 AM
https://www.google.com/patents/EP2804606A1

https://clinicaltrials.gov/ct2/show/NCT02072018
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: goodluck on August 23, 2015, 09:12:01 AM
Interesting!  Emu oil and a calcium channel blocker(likely Veraprimil) are its main listed ingredients.  They also mention other items may be used in a generic sense.  Carriers, fragrances etc.

I have no personal experience with Emu oil.  But, I know Emu oil is used as a skin moisturizer, anti inflammatory and anti bacterial/fungal.

Has anyone heard of using Emu oil for Peyronies or even tied it?  For any reason.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: skunkworks on August 23, 2015, 09:37:11 AM
Not with Peyronie's but it has been used as a successful transdermal vehicle for other treatments, progesterone for one and some other lipid soluble steroids. From memory I think verapamil is lipid soluble.

That said, this has been around for a while it seems - Hybrid H-100 - Peyronies Society Forums (https://www.peyroniesforum.net/index.php/topic,3118.0.html)

According to the clinicaltrial info, if it was ever completed it was completed a year ago, so either results were bad therefore not published or the study was never completed.

I'm a bit sceptical of a company seeking FDA approval who don't even have a product pipeline on their website and don't mention the active ingredients. That is quite shady.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: goodluck on August 23, 2015, 01:37:38 PM
Their website has very little information.   It looks like the company was formed just for this product and pending its approval.

They do mention one doctor's name who is affiliated with the company.

Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Youngdude22 on August 23, 2015, 07:50:07 PM
I have not been able to get in contact with them. I will continue to try to get ahold of them to find out the latest on this product.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on August 27, 2015, 05:56:47 PM
Just wanted everyone to know I did reach out to them and got this reply...FWIW

Thank  you for your inquiry regarding H-100 and for volunteering to participate in a clinical study.

Hybrid Medical (hybridmedicalmn.com) is testing H-100 and we have seen positive results. However, it is not available for commercial use at this time. Please continue to monitor the website for updates and suggest the same to your urologist.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Dros on December 30, 2015, 05:49:05 PM
"Safety and efficacy of topically applied gel H-100 composed of Nicardipine, superoxide dismutase and emu oil for treatment of acute phase Peyronie's disease (Peyronies Disease) was evaluated. Twenty-two patients (Peyronies Disease <12 months duration) were studied in a prospective, randomized, double-blind, placebo-controlled study. Eleven patients received H-100 and 11 patients received placebo for 3 months. All 22 patients then received H-100 for the final 3 months. Flaccid-stretched penile length, degree of penile curvature, pain level and side effects were assessed monthly. H-100 showed significant improvement in all Peyronies Disease parameters at 6 months: mean stretched penile length increase (22.6%, P=0.0002), mean curvature reduction (40.8%, P=0.0014), and mean pain level reduction (85.7%, P=0.004). Placebo group showed no significant improvement except for mean stretched penile length increase (6.8%, P=0.009). Crossover patients from placebo to H-100 showed significant improvement in all parameters: mean stretched penile length increase (17.5%, P=0.000007), mean curvature reduction (37.1%, P=0.006), and mean pain level reduction (40%, P=0.17). Treatment was well tolerated. A self-limited rash was the only side effect in three patients. Statistically significant improvements in flaccid-stretched penile length, curvature and pain suggest that H-100 is a safe and possibly effective non-invasive, topically applied treatment for acute phase Peyronie's Disease."

http://www.nature.com/ijir/journal/vaop/ncurrent/full/ijir201522a.html
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on December 30, 2015, 06:26:59 PM

[Full quote removed by admin]

FreeMason....  please use the 'Reply' button instead of 'Quote'.

Great news early at least. I'm wondering if they are developing this for actor phase and not chronic phase? Seems as though a gel or product would be easier to get results during acute phase rather than an established chronic phase like 5 years down road.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: krazylord on December 30, 2015, 11:27:26 PM
This is great news. I wonder if this also helos with general fibrosis, not only tunica, even if it is small, and both in the tunica and the corpora. That being said, it is a pity that they don't say the amount of each component. If we had that data, we could order it and try ourselves.

Thanks for the link!
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: nemo on December 31, 2015, 10:50:12 AM
Everything about the website causes me to be very suspicious (including the fact that the address listed for the company is a residential house in Minnesota), but the fact that Dr. Levine is associated with the product definitely gives it credibility. Here's hoping the results from the test bear out in real world application, whenever that comes.

Will be interesting to see how the treatment is priced. The closest comparison is the infamous Topical Verapamil from PDLabs in San Antonio, Texas, which was thoroughly abandoned by forum members years ago as being a ridiculously expensive waste of time (if not total scam). I would also note, though, that PDLabs had their own "study" showing TV's efficacy, conducted in San Antonio, so just because there's a study doesn't mean it's rock solid - you have to look at the details, who conducted it, etc.

But as I say, Dr. Levine's participation brings credibility, as besides being at the front of the field, he's also the one who showed through testing how little TV actually penetrates the tunica (virtually none). So one assumes he's confident this new medication actually penetrates.

For now I'll be guarded but hopeful.

Nemo
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: LWillisjr on December 31, 2015, 11:19:21 AM
I saw Doctor Levine in November and he shared this new treatment approach with me. I haven't posted much on it because I haven't had much time to research it. But the Doc was very positive towards it.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on December 31, 2015, 11:38:41 AM
Sorry about hitting Quote button before. Thought it was reply..lol.

Hope this is ok but I did some research on H-100 product. Seems like the key ingredient is SOD or super oxide dismutase.  Emu oil and a blood pressure med are the other active ingredients in their cream or gel it seems.  If you do some research on SOD you can see that it's a pretty powerful enzyme that counter acts...well...super oxide, a free radical most common in our bodies.

A definition of SOD:
Superoxide Dismutase (SOD) is an enzyme that repairs cells and reduces the damage done to them by superoxide, the most common free radical in the body. SOD is found in both the dermis and the epidermis, and is key to the production of healthy fibroblasts (skin-building cells).

So I looked further and found that years or decades ago SOD was used to look at treating all kinds of arthritic and skin scarring issues.  A Bovine version of SOD was first used in many trials outside the US. There are two types..Bovine and Human. Apparently there really isn't really any efficacy differences in the two...but I found this information interesting on a SOD patent for peyronnies and using Bovine SOD:
Outcome of bovine SOD (orgoteine) therapy for Peyronie's Disease
Bartsch,   23 pts   Excellent (≈100%) resolution of pain
Europ. J. Rheumatol.      7/15 patients penile deviation
Inflamm., 1981      disappeared
Danner   39 pts.   75% pain improved
Prog. Reprod. Biol.      78% decrease of plaque size
Med., 1983      53% deviation improved
Gustafson,   22 pts.   18/22 patients significantly improved
Europ. J. Urol.,   
1981 Berlin   31 pts.   50% pain improved
J. Urol., 1986      50% improved
De Vries,   35 pts.   21/25 patients significantly improved
Akt. Urol.,1988      10 patients treatment discontinued
Schilling        78 pts.      72% pain improved
Symposium 1985      33% decrease ofplaque size
                                         33% deviation improved
Pisani, 1985   70 pts.   90% pain improved
                                       50% decrease of plaque size
                                        50% deviation improved

This is some remarkable results at least in these studies with SOD. Again this was Bovine version which is no longer used due to serious side effects I guess. But human version seems same.

reading up on SOD it appears that you need a carrier to get it into skin obviously. I wonder ve ever looked at DSMO and SOD together.

Any way...this product from H-100 is prob a few years away if all goes well but based on what they are using and past success that I can see with SOD it is at the least encouraging.

Hope it's ok that I provided this info.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on December 31, 2015, 11:54:06 PM
Out of curiosity I looked up the patent for this future drug. I've got it book marked but the describe in detail exactly what is used as ingredients and the formulations used, how much, and compounding pharmaceutical instructions! Lol.  I'm thinking Of taking it to my local compounding pharmacy and having them make me some cream?  One hiccup is it requires Veraprimil cream or another calcium channel blocker. Other than that it's basically Super Oxide Dismutase(very powerful anti inflammatory and scar destroyer), Emu Oil. Those are it basically.  As some on here have probably found out..Veraprimil cream was worthless...by itself..but added with SOD and Emu oil and a strong carrier like DSMO and there might be something here.  It's been proven that SOD can reduce plaque and improve this curvature in Peyronies Disease it's just no one has come out with a product. Well this could be it.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on January 01, 2016, 12:13:10 AM
I have a ? About Veraprimil cream for those that have used? Maybe this is wrong area if so sorry. But I've read the large studies done with it and it's quite impressive results? What's the deal? So many on here have claimed it does nothing. I've not tired it. Any thoughts?
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Douglas Hall on January 01, 2016, 12:26:00 AM
Quote from: LWillisjr on December 31, 2015, 11:19:21 AM
I saw Doctor Levine in November and he shared this new treatment approach with me. I haven't posted much on it because I haven't had much time to research it. But the Doc was very positive towards it.

Did he say when it might be released?
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on January 01, 2016, 10:28:18 AM
Looks like they just might have completed phase 1/2 study. This drug is prob at least 2 years away.  Just depends on how long it takes to do phase 3.  What I'd actually like to see them do is a triple arm study. H-100, control arm, Veraprimil cream.  I don't know why Veraprimil cream has studies that show literally thousands of men wh had significant improvements yet on this board less than 1% have. 
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: nemo on January 01, 2016, 10:31:39 AM
Can you link to these studies you're referring to on Verapamil cream?  The only study I remember from back when TV from PDLabs  was even part of a relevant discussion was a study in San Antonio, literally conducted by the company, so obviously pretty questionable.  You keep referring to multiple studies showing tremendous results. Can you provide links?

Thanks,
Nemo
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on January 01, 2016, 11:08:57 AM
Heres the one on 15% Veraprimil.  I wonder how many on here tired the original 8% and didn't see much and didn't try the 15%?  This is a smaller study but if a new cream came out today with these results people on here would be ecstatic.

Topical verapamil HCl, topical trifluoperazine, and topical magnesium sulfate for the treatment of Peyronie's disease--a placebo-controlled pilot s... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/17367443)
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on January 01, 2016, 11:16:00 AM
But yea I see what you are saying. The data appears to be conflicting results. Could mean the company just falsified the data...could be possible that many who tried Veraprimil didn't try it long enough? It appears that the longer you use it the more effective..takes 9 months or more. I don't know.  Clearly Verprimil works to reduce scaring and plaque it's a matter of actually reaching the tunica...maybe this new drug being studied, that uses Veraprimil in its compound, uses other carriers to finally get the drug where we need it to go?  If you read up on Superoxide Dismutase and peyronnies..you can see that it's been studied for Peyronies Disease with success but it was with Bovine SOD. Although human SOD seems to be same.  I think one could create his own compound with a compounding pharmacy. They give instructions on how to compound their new drug on the patent.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on January 01, 2016, 11:17:53 AM
Off topic...but it would be nice if the moderators were able to conduct polls on here.  It's so difficult to sift thru what has worked for folks etc..
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on January 01, 2016, 01:45:06 PM
What's encouraging about this early study is two things...1- Levine was part of the investigators...and 2- the crossover group(meaning they took placebo group who showed no improvement and then gave them the compound) showed almost as good of improvements.

Also...where are the guys who used this stuff!!!?? Get on this board..lol. Probably signed a NDA:(
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: nemo on January 01, 2016, 03:50:25 PM
That Verapamil study you point to is several years old and I can guarantee you, if real world results echoed what they claim in the study (which I believe is the study conducted by PDLabs) you'd hear about it on this forum.  I realize you're frustrated by the belief that topically applied verapamil should work, but overwhelming anecdotal experience of this forum is that it does not. And Levine's research on tissue excised surgically showed that verapamil applied topically simply did not penetrate the tunica.  The ridiculous prices charged by PDLabs only made this treatment looks more and more like a lose/lose proposition.

Nemo
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: user of no names on January 01, 2016, 09:27:46 PM
This is very interesting.  The business address is 8 miles from my house.  Dr Jeffry Twidwell seems to be a decent urologist from a google search.  I am going to call on Monday and see if there is any trials I can get into.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: itsme on January 01, 2016, 10:05:03 PM
Simplespress is the best forum platform with more than 100000 thousands wordpress plugins to be integrated with. This platform is really bad. Its easy to migrate though.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on January 02, 2016, 01:22:29 PM
User of no names...lol..good name btw...I too live wishing 4 hours of them and what I thought about doing is going into Moudry RX compounding pharmacy..they are the pharmacy that's made the drug for the trial and see if I can talk them into making some for me.  Only ingredient of ? Would be Veraprimil but I actually think they used narcidine? Another calcium channel blocker. Would require a rx but Emu Oil and SOD no problem. I think I mentioned in a previous post but the patent is online if u look and they go into detail different formulations and rational along with actual compounding instructions...which seems odd they would do that.  No need to wait a couple years.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: james1947 on January 03, 2016, 07:45:20 AM
Nemo, I agree with you 100% that if Dr. Levine is involved it may be more in it than snake oil.
Freemason, I hope you are really excited by the subject and not a part of the marketing of the product.

James
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on January 03, 2016, 02:03:38 PM
lol. I wish I were part of it.  If I were part of it I wouldn't be looking to have some local pharmacy compound me some, I'd just ask them.

So I read the abstract of H-100 presented by Dr Tidwell in Nov 2014. Their Phase 1 study was done on acute phase Peyronies Disease. I'm sure Phase 2-3 will include chronic but maybe they are just looking to launch a product that has bigger impact on Acute Peyronies Disease patients.  Makes me wonder if Peyronies Disease in its chronic stage has simply reached point of no return for topical applications?
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: nemo on January 03, 2016, 03:21:34 PM
We have yet to see that even the acute stage is treatable with a topical application. Fingers crossed, but it remains to be seen. Topical Verapamil certainly failed to impress. 

Nemo
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Dros on February 18, 2016, 06:23:11 AM
Freemason, did you end up getting a cream? And have you tried it yet?
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Freemason on February 18, 2016, 12:13:53 PM
Ha. No I haven't yet. But I am planning on trying.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: Dros on February 18, 2016, 12:40:01 PM
Where did you find the ingredients? Might be interedted in trying it for myself.
Title: Re: Hybrid Medical H-100 Topical Cream
Post by: NeoV on February 18, 2016, 04:36:32 PM
It's quite easy to make, at least the emu oil and SOD could be bought anywhere and combined. The Nicardipine would be hard to get which is the calcium blocker. Maybe I'll try the SOD and emu oil for fun.

Keep in mind that emu oil is very likely to do nothing, or be entirely a scam. There is little research on it, and even if it does work, something like olive oil or grapeseed oil should work as well. I do not think anyone knows the mechanism behind its transdermal effects, and again, it's just an expensive olive oil most likely.

As for SOD, this is interesting, Antifibrotic action of Cu/Zn SOD is mediated by TGF-β1 repression and phenotypic reversion of myofibroblasts (http://www.sciencedirect.com/science/article/pii/S0891584900004317)

I guess the question is still up in the air, as to whether or not topical SOD can effect Peyronie's, but there are a few studies now showing that it might.
Title: Re: Hybrid H-100
Post by: skunkworks on February 28, 2016, 07:24:57 PM
This was mentioned in the paper Dros found:

Topical treatment for acute phase Peyronie's disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study. - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/26700214)

QuoteAbstract

Safety and efficacy of topically applied gel H-100 composed of Nicardipine, superoxide dismutase and emu oil for treatment of acute phase Peyronie's disease (Peyronies Disease) was evaluated. Twenty-two patients (Peyronies Disease <12 months duration) were studied in a prospective, randomized, double-blind, placebo-controlled study. Eleven patients received H-100 and 11 patients received placebo for 3 months. All 22 patients then received H-100 for the final 3 months. Flaccid-stretched penile length, degree of penile curvature, pain level and side effects were assessed monthly. H-100 showed significant improvement in all Peyronies Disease parameters at 6 months: mean stretched penile length increase (22.6%, P=0.0002), mean curvature reduction (40.8%, P=0.0014), and mean pain level reduction (85.7%, P=0.004). Placebo group showed no significant improvement except for mean stretched penile length increase (6.8%, P=0.009). Crossover patients from placebo to H-100 showed significant improvement in all parameters: mean stretched penile length increase (17.5%, P=0.000007), mean curvature reduction (37.1%, P=0.006), and mean pain level reduction (40%, P=0.17). Treatment was well tolerated. A self-limited rash was the only side effect in three patients. Statistically significant improvements in flaccid-stretched penile length, curvature and pain suggest that H-100 is a safe and possibly effective non-invasive, topically applied treatment for acute phase Peyronie's Disease.International Journal of Impotence Research advance online publication, 24 December 2015; doi:10.1038/ijir.2015.22.
Title: Re: Hybrid H-100
Post by: NeoV on February 28, 2016, 08:02:51 PM
That study was very recent (posted in pubmed in December 2015).

In the review Dros posted,

"Recently, a small placebo controlled trial of topical nicardipine and superoxide dismutase
compounded with emu oil in 22 men with untreated acute phase Peyronies Disease demonstrated
significant improvement in multiple Peyronies Disease parameters (length gain, curvature reduction,
pain scores) compared to placebo"
Title: Re: Hybrid H-100
Post by: Freemason on February 28, 2016, 09:47:39 PM
Neo...yea I've done lots of reading on their compounds..I think all 3 have potentially a synergistic affect...but SoD has been studied alone with Peyronies Disease patients a while ago with moderate success in all parameters.  SOD is highly powerful anti oxidant and anti inflammatory.  As for the Emu Oil it's commonly used in expensive skin/face creams for wrinkles/scars etc..has transdermal effects.  I just haven't taken time to have a pharmacy compound me some. I'm sure u could get a Uro to prescribe the calcium channel blocker...pretty harmless on our penis.  Any way...you'll have to have a compounding pharmacy with the rx for calcium compound u a gel with these ingredients. If u look enough on their product you can find the patent and they list out the ingredients and percentage of each used.
Title: Re: Hybrid H-100
Post by: Dros on March 01, 2016, 04:03:57 AM
Here's the patent: http://www.google.com/patents/EP2804606A1?cl=en

H-100 is:
20% Nicardipine
0.2% SOD
1% gelling agent (e.g. fatty acids)
78.8% Emu Oil

I will ask my Uro to prescribe me this :-)
Title: Re: Hybrid H-100
Post by: skunkworks on March 01, 2016, 05:07:11 AM
Was there ever a definitive answer on how important (or not important) DHT is in an adult penis? The  linolenic acid in emu oil is a reasonably potent 5 alpha reductase inhibitor, so it could decrease the levels of DHT in the penis.

DHT is essential to development of the penis, but I am not sure how important (if at all) it is for an adult penis.
Title: Re: Hybrid H-100
Post by: Jack1909 on March 01, 2016, 08:31:00 AM
I think DHT is important to preserve the tissues integrity. I don't have any scientific proof of it but I know for sure that some people who take finasteride/propecia for hairloss develop tissue changes, scarring and sometimes a real Peyronie.
Title: Re: Hybrid H-100
Post by: NeoV on March 01, 2016, 03:16:26 PM
That's interesting to note, however the results of the trial seemed to suggest the formula can overcome this. Still could be a reason to be wary.

It looks like it has quite a lot of the nicardipine, and not much SOD, unless 0.2% is a lot.

I have been reading online about emu oil, and I cannot find any information regarding it's mechanism of action for being a trans-dermal carrier, though it is repeatedly touted as one on emu oil websites. One writer thought olive oil or any fatty acid would and should do the same thing.

It would be important to see a good study on how the stuff works. Because I might as well just use grape seed oil and SOD and see how that goes.

Anyway, I guess this stuff really is mostly nicardipine. I hope we can use it and see how we feel in not too long.
Title: Re: Hybrid H-100
Post by: Freemason on May 07, 2016, 03:15:08 PM
It's a lot of SOD..doesn't take much. Just read up on SOD a little and you begin to realize that this compound is prob the most powerful antioxidant scavanger there is to date. One interesting thing I read recently is h2o2 a lot of doctors don't want people using it for cuts etc because it prohibits scaring over to take place, it's really just a debriding agent..intersting. Peroxide inhibits fibrosis from forming...at all. So in theory using peroxide in the acute and very early phase might do something?  If only u could discover a way to get it into the skin..idk.
Title: Re: Hybrid H-100
Post by: skunkworks on May 08, 2016, 01:48:58 AM
That is really interesting Freemason re peroxide. I will be reading up on that.
Title: Re: Hybrid H-100
Post by: Freemason on May 08, 2016, 10:54:28 AM
Yea I was just reading online an old text book on oxidizing compounds and stuff...it seems older texts, when all these compounds were discovered, have a lot of interesting info and I came across Peroxide.  There's a cult group of folks who firmly believe in drinking very small amounts of it to cleanse and do various things. I'm not advocating that. I had a friend who was into it decades ago and I tried it for a week or so. Nasty nasty tasting. We are talking a couple drops in a full glass of water and it completely alters the water.  Some theorize that by raising oxygen levels you eliminate bad stuff etc..

One other thing I thought about...Liposuction..there are all kinds of diff types and techniques but I wonder if one could have it done on the plaque? Lol. Seems crazy prob. There is Air lipo dome by the top guys in Beverly Hills but it just under skin in fat layers. I guess no plastic surgeon is skilled enough to get thru the nerve bundle into the plaque without destroying your dick.  Any way..dumb idea never mind.
Title: Re: Hybrid H-100
Post by: skunkworks on May 08, 2016, 12:14:22 PM
Google any lipo video and you'll forget that idea very quickly. It's basically a person getting stabbed with a metal straw hundreds of times.
Title: Re: Hybrid H-100
Post by: Freemason on May 08, 2016, 12:51:19 PM
Lol. Yea I've seen it. Idk I just thought there's got to be a way of just sucking out the plaque without damaging stuff..I guess u have to replace it with something though. Hence the graft.
Title: Re: Hybrid H-100
Post by: Pey-penis on May 17, 2016, 03:05:07 AM
Quote from: Freemason on May 08, 2016, 10:54:28 AM
There's a cult group of folks who firmly believe in drinking very small amounts of it to cleanse and do various things. I'm not advocating that. I had a friend who was into it decades ago and I tried it for a week or so. Nasty nasty tasting. We are talking a couple drops in a full glass of water and it completely alters the water.  Some theorize that by raising oxygen levels you eliminate bad stuff etc..
For a long time I am drinking hydrogen peroxide 3% every day in the form of "lemonade" consisting of 1/2 cup of water, a tablespoon apple cider vinegar, a teaspoon of honey or syrup of pine shoots, and 50 drops of pure hydrogen peroxide 3%. To this amount of H2O2 I was slowly went up for several months. The only visible effect of this is a regrowth of black hair instead of gray and not actually fall back on any type of  catching cold disease for several years. I support this way the bacteria e-coli, where the byproduct of the activities in the large intestine is the production of H2O2. It is indispensable for macrophages, which uses it to perform "oxygen explosions" thus destroying pathogens.
Title: Re: Hybrid H-100
Post by: jim morrison on July 27, 2016, 05:49:34 PM
At least orally, they do not think SOD can be absorbed in the body unless coated and carried through liposomes. Here are a couple links to products that I found with topical liposomic SOD and how it is beneficial for anti inflammatory diseases. The last link is a report stating that SOD may be beneficial for peyronies. In this instance they use iontophoresis to drive it home.  Also, this narcidipine is a calcium channel blocker just like Verapamil so I wander if it would be beneficial to use SOD while using a topical Verapamil if you can get it to penetrate? Maybe it will give a similar or even better outcome of the H-100. Just a thought.

[I removed the commercial links as we don't want to promote sales for these products. I left the book link for information purposes]

https://books.google.com/books?id=07ucAgAAQBAJ&pg=PA194&lpg=PA194&dq=can+i+mix+verapamil+and+superoxide+dismutase&source=bl&ots=NLyvl9sCbp&sig=cdP1CokcuLF9RyMbDII4FsA-F5I&hl=en&sa=X&ved=0ahUKEwijotjUpJTOAhUi7YMKHaFhCe4Q6AEIYDAJ#v=onepage&q=can%20i%20mix%20verapamil%20and%20superoxide%20dismutase&f=false
Title: Re: Advice on new trial
Post by: Arabia on November 21, 2016, 02:48:45 AM
Results on the infamous H-100 cream.  Results look promising for acute Peyronie's.

International Journal of Impotence Research - Abstract of article: Topical treatment for acute phase Peyronie/'s disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study (http://www.nature.com/ijir/journal/v28/n2/abs/ijir201522a.html)

Title: Re: Advice on new trial
Post by: peyter on November 21, 2016, 07:36:24 AM
Dear all,

I have found:

Innovation | Hybrid Medical (http://www.hybridmedicalmn.com/products/)
http://www.nature.com/nrurol/journal/v13/n2/full/nrurol.2016.6.html Study about H-100 trials.

Any info about a comercial launch?

Is that the same H-100 product?

Thanks!!!
Title: Re: Advice on new trial
Post by: james1947 on November 21, 2016, 09:12:49 PM
The link posted by Peyter yesterday November 21, 2016
&
The link posted by Funnyfarm on April 26, 2013
Is the same link.
So what happened during 3 & 1/2 years?
If it is such a miracle cure, they were billionaire already from the sales of this cream

James
Title: Re: Advice on new trial
Post by: spyrosg on November 22, 2016, 05:37:04 AM
May i point out that the two recent posted liks refer to some hopefull indications out of the performed study, that were published almost 11 months ago...

Let us all hope that some more positive info will soon flow in ...

Member ''Freemason'' was supposed to try mixing his own version of H-100, but I don't recal seeing any updates
Title: Re: Advice on new trial
Post by: Lucketts on November 22, 2016, 07:07:47 PM


Outstanding research, gentleman.  Please keep up apprised of anything further you learn.
Title: Re: Advice on new trial
Post by: Freemason on November 24, 2016, 01:26:17 AM
Quote from: spyrosg on November 22, 2016, 05:37:04 AM
May i point out that the two recent posted liks refer to some hopefull indications out of the performed study, that were published almost 11 months ago...

Let us all hope that some more positive info will soon flow in ...

Member ''Freemason'' was supposed to try mixing his own version of H-100, but I don't recal seeing any updates


Correct..but I never got around to it:(. But boy I would love to.  I do live somewhat near Minneapolis i could just make an appt with the Urologist who is heading this and tell him to just write me a RX compounded..the Pharmacy they used for the formulation is in Minneapolis..My question would be how come none of these 22 men have come on this forum?  I mean I'm very happy if this product works for Acute phase patients but how about the millions that aren't in the Acute phase anymore?
Title: Re: Advice on new trial
Post by: Lucketts on November 24, 2016, 10:16:44 AM


Freemason, you are a prophet ahead of your time!

Perhaps when they do trials, they have to be very selective and well defined, and just focussed on the acute phase as a starter.

Just learning about compounding pharmacies.  By making a lot of drugs themselves, they seem to be a lot more flexible, and can sell drugs (i.e. cialis) at a fraction of the price of a drug store.
Title: Re: Hybrid H-100
Post by: pizzaman on November 30, 2016, 02:09:12 PM
A quick google search shows a bunch of oil-based SOD creams. I may try one as an experiment.
I am no longer in the acute phase, but still get some pain/irritation and palpable inflammation.
Title: Re: Hybrid H-100
Post by: Paul52 on January 30, 2017, 06:45:31 AM
Hi all,

Has anybody tried making and applying the H-100 gel? Any results?

I'm in the acute phase and willing to make/try it.

Best,
Paul
Title: Re: Hybrid H-100
Post by: Paolo on January 30, 2017, 11:07:48 AM
Paul52, I think this has all gone quite, if you are willing to try it please update when you can

Emu Oil, SOD and narcidine where the main ingredients, think this gel is dead in the water (scam)  :(
Title: Re: Hybrid H-100
Post by: Freemason on March 03, 2017, 06:30:16 PM
It's not dead in the water yet..I haven't gotten around to having a pharmacy mix it myslef..But they are in phase 3 trials I believe..Have a feeling it will be more beneficial for those in acute phase rather than chronic phase..based on the ingredients it a lot of anti inflammatory stuff etc..

But hey if it works some that's great for anyone..

Oh...and I hate this f ing disease..
Title: Re: Hybrid H-100
Post by: pey ron on February 05, 2018, 12:01:28 AM
I can easily compound stuff. Where to source the SOD though?
Title: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: MJohn on March 04, 2018, 06:00:45 PM
Now to find a doc that will prescribe it! 

Hybrid Medical – H100 Peyronie's Disease Treatment (http://hybridmedical.org/)

Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 04, 2018, 08:30:25 PM
Any idea on the cost?
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: NeoV on March 04, 2018, 08:59:48 PM
Oh man... Here we go. How to get our hands on this... The science looks incredibly simple, but I like simple. Very exciting.
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 04, 2018, 10:05:30 PM
Looks like the compounding pharmacy is promoting it, just fax a prescription.  Please let us know the cost.
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: Paolo on March 05, 2018, 06:54:49 AM
A very exciting development, any member trying this please post back with testimonials in 3-6 Months.

Why hasn't Hybridmedical made contact with this forum of 1'000s of members????  ???

Hope it rolls out internationally  :)
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: swiss on March 05, 2018, 10:04:02 AM
If anyone gets prescribed this in Illinois please let me know what doctor did it for you.

Thanks!
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: Crooked_Stick on March 05, 2018, 10:29:18 AM
I guess it bothers me that they haven't released the results of the 'trial' that included a whopping 22 people. This treatment has not been approved by the FDA to treat anything. My uro won't prescribe unapproved treatments and no ones insurance will cover it. Just seems sketchy to me. They also mention on their site that H 100 is more effective for those in the acute phase so that eliminates 98% of the members here as far as max benefit. Sorry, can't get too excited about this
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: diehardpatriot on March 05, 2018, 12:28:01 PM
It's not available in California, damn. Anyone know why it's omly available for certain states even tho it all comes from the same pharmacy ?? Also, wasn't there a guy who ended up making his own H-100 using the exact formula a while back with no results ?? Anyway, still kind of exciting
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: MJohn on March 05, 2018, 01:01:23 PM
Ya I hear you on the 22 people in the study.  they do say it works best in the acute phase but anyone can benefit from it.  The ingredients are fairly innocuous, the Nicardipine being the only ingredient needing a prescription.  Like most of us on here, I will try it if the cost isn't too crazy and I can get my doc to prescribe it.  I will be printing out the documentation and prescription form and going to give it a whirl and see if I can convince my Doc to give me a script.   
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 05, 2018, 04:28:17 PM
If we have the formulation, any compounding pharmacy can do it.  I suspect that particular pharmacy marketing it does not have a license in CA
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: pey ron on March 06, 2018, 01:16:38 AM
Quote from: diehardpatriot on March 05, 2018, 12:28:01 PMa guy who ended up making his own H-100 using the exact formula a while back

who's that? I'd love to send them a message and ask them where they procured the ingredients, to try it myself
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: diehardpatriot on March 06, 2018, 01:51:45 AM
Yo, we do have the formulation. I have a screenshot of it from a post in the forum a while back . The problem is getting a doc to prescribe it. Since it sounds crazy giving him a list of crap to compound you. Now that it actually Has a name and brochure, and someone who actually perfected the compound, it's much easier to pbtain IMO. But us Californians aren't so lucky this time. The compound I saw was. Anyway , isn't Hybrid medial the only pharmacy that can make this now? Did they put a patent on it?

20 percent Nicardipine
.2 percent SOD
1 percent geling agent
78.8 percent emu oil
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: pey ron on March 06, 2018, 02:46:08 AM
I can easily make it if I manage to get the ingredients. I have precision scales, a magnetic stirrer and the stir bars and the borosilicate bekers. Just like in a lab :P
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: swiss on March 06, 2018, 08:59:59 AM
Is your name Heisenberg?
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: MJohn on March 06, 2018, 01:06:07 PM
Ya know if you read the studies they cite as evidence for their formula, only the SOD and the EMU oil have studies to show topically they help fibrosis and inflammation.  The Nicardipine study they tout is for injectable version not topical.  And if you think about it, there are many things that have been shown to be effective when injected.  Even saline injected has been shown to help and they surmise the physical injection in the scar tissue actually helps to break down and remodel the scar.  MY point of all this is it really seems that the EMU and SOD are the only things that possibly could make a difference topically.  PLUS, they mention manually tugging on your member multiple times per day.  I am thinking about getting EMU oil and SOD cream and tugging on it for 30 seconds multiple times per day. 
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: Paolo on March 06, 2018, 01:32:20 PM
MJohn, I love your eagerness here but I think you would also need a calcium channel blocker, that would be the Nicardipine, by all means give emu and SOD a go meantime but I presume H-100 should become available soon  :-\
If a calcium channel blocker increases oxygen by widening arteries I presume the SOD is required to mitigate or limit damage resulting from this  :-\ I wish I understood this better.
Presume the manual stretching along with H-100 breaks up the plaque over 3-6 Months??????
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 06, 2018, 02:04:01 PM
 The beauty of a compounding prescription is any compounding pharmacy can make it themselves. The study is published by Dr. Levine out of Chicago
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: JS1991 on March 06, 2018, 08:50:56 PM
Awesome news!! Can't wait to add this to my current regimen. I actually had my first urologist appointment today and got referred to a Peyronie's/ED specialist, so I plan on printing out the brochure and bringing it with me when I go to see him. Will update as things happen!
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: pey ron on March 06, 2018, 10:17:49 PM
Tsanchez12369: how to find a compounding pharmacy in the US???
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 07, 2018, 09:30:07 AM
Just google compounding pharmacy
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: Freemason on March 08, 2018, 02:18:02 PM
you could try your own Emu Oil mix and SOD but they have looked at the pharmacology of all the ingredients combined to give maximum penetration and effectiveness...hence the studies.  SOD is arguably the strongest anti inflammatory compound known..

I'm def going to use it..cant hurt..I don't care about cost..I'd spend $20,000 for a straight penis. Heck more...

I'm guessing it is more effective for acute phase bc in that phase lowering inflammation is critical, however those wiht pain (fortunately im not one) might benefit from this compound i'd Guess..

Hope so.


Guess we will know in 6 months right.
Title: Re: Hybrid H-100
Post by: TonySa on March 08, 2018, 02:31:29 PM
The patent has multiple formulations, any idea which formulation they landed on?
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 08, 2018, 02:33:25 PM
Is Dr Levine using it as he was one of the original authors?
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: skunkworks on March 08, 2018, 06:48:52 PM
Are there not many different kinds of SOD available? Which one are they using?
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: pey ron on March 09, 2018, 01:45:15 AM
where do you buy SOD in powder form?
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 09, 2018, 04:38:26 PM
Freemason, how much was it?
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: Paolo on March 10, 2018, 06:06:38 AM
It appears the SOD required would be LrhSOD, known as Lipoxysan, 1.4 mg SOD/day ,see an old study below;

http://www.europeanurology.com/article/S0302-2838(05)00256-3/fulltext

Note the following;
Response to other disease parameters was assessed at week 12: plaque size was reduced in 47% of patients, as was plaque consistence in 38%. Penile curvature was improved at 5–30 degrees in 23% of patients. Very effective for pain reduction.

It was demonstrated that a significant amount of lrhSOD reaches deep layers of the skin and also adjacent deeper tissue

A total of 39 patients were evaluated in the study.
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: pey ron on March 10, 2018, 05:02:33 PM
thanks Paolo!

unfortunately, I don't even see it on Alibaba... :(
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: diehardpatriot on March 10, 2018, 06:46:15 PM
Has anyone ordered H-100 yet? If it was available in Cali I would've filed a prescription already
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: Freemason on March 11, 2018, 01:52:41 PM
I haven't gotten it yet but I'm gonna call Levine office for a RX.. I saw him about 2 years ago..my first real appt.  but I elected to not have grafting.  I have upward bend about 45 degrees. Lost inch at least..

So if I can use this I'll use it for year or more i don't care it's non invasive and can't hirt and has been studied so..

Heck of it improves my curve by 10-20 degrees I'll be happy.. I'm also gonna do some light traction with it as well and ask for low does Cialis.
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 11, 2018, 04:26:20 PM
Can you ask him the formulation? % of each ingredients for those of in CA who can't order directly?
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: swiss on March 13, 2018, 09:55:39 AM
Can you just call Levine and he'll give you an RX??
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: Freemason on March 14, 2018, 07:46:22 PM
I called Monday but they havent called me back..lady said on phone since its been 2 years i might have to have another appt..which is bs..nothing has changed and I live 4 hours away. Stupid.

I can prob just make an appt wiht the Dr. in Minnesota who helped create it..im 5 hours from there but actualy do work up there so can stay for free.
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: Crooked_Stick on March 15, 2018, 12:48:41 PM
any word on the cost of the H-100 treatment? Thinking about emailing my uro to see if he has/would prescribe (which is doubtful since it's not approved)
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 16, 2018, 01:39:36 PM
This pharmacy doesn't even have a phone number—very suspicious to me, but I've emailed them....
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: Crooked_Stick on March 16, 2018, 03:16:18 PM
Messaged my Uro here in Houston, TX.....he is "not prescribing H-100 at this time".  >:(
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: swiss on March 16, 2018, 03:40:40 PM
Send that dude a letter full of glitter for his help
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 16, 2018, 04:32:13 PM
I just requested Dr Lue to prescribe it.  If he does i'll Let folks know the price and any progress after using.
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: franklee on March 17, 2018, 12:55:15 PM
The cost for H-100 is 290.00 per month based on a 3 month supply. They will discount 50.00 per month if you complete survey which seems easy enough. This is from Hybrid Medical directly. Dr. Twidwell is listed as inventor. I did patent search. Levine is not mentioned.
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 17, 2018, 01:43:15 PM
They both wrote the medical article.
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: pey ron on March 17, 2018, 04:23:20 PM
@franklee: wait, how many months does one need to apply this for???

@paolo: we really need to find a source for LrhSOD/Lipoxysan...
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: diehardpatriot on March 17, 2018, 05:27:58 PM
So it's mad expensive . Anyone think it's worth trying? Or maybe anyone know where to get it for cheaper or make your own? How much cheaper would it be to just ask ur uro to write an RX for the same ingredients and take it to a compounding pharmacy? I luckily can afford H-100 , should I guinea pig it ?
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: TonySa on March 17, 2018, 05:31:02 PM
If we can get the exact concentrations of the three components there are much more reasonably priced compounding pharmacies.  Does anyone know, the patent lists multiple formulations so I don't know which one they used.  Maybe I'm not reading it correctly?
Title: Re: Hybrid H-100
Post by: diehardpatriot on March 17, 2018, 05:53:28 PM
It's on their website tsanchez in the brochure. Has all the ingrefients
Title: Re: Hybrid H-100
Post by: TonySa on March 17, 2018, 10:11:10 PM
The ingredients yes, but I'm wondering the strengths of each.
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: franklee on March 17, 2018, 10:12:48 PM
my understanding is it is a 3 month prescription. Recommended use is 6 months.I can afford it but I'm wondering if any of my Drs. will fill out RX form. Also, not having the experience of many members I'm not as confident it's anywhere near the answer we have all been waiting for. I know Dr Levine was involved in the study but isn't involved with the roll out of this highly anticipated drug. Does anyone know if he is using it for his patients?
I'm probably going to use it if I can get a Dr. to fill out RX. I'm trying everything else I read about on this forum. :D
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: pey ron on March 18, 2018, 02:34:49 AM
is it the same as this? Some additional information on lrhSOD and Peyronies Disease - Peyronies Society Forums (https://www.peyroniesforum.net/index.php?topic=1680.0)

also, can't we merge these two threads?

Hybrid H-100 - Peyronies Society Forums (https://www.peyroniesforum.net/index.php/topic,3118.0/topicseen.html)
H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!! - Peyronies Society Forums (https://www.peyroniesforum.net/index.php/topic,9677.0/topicseen.html)
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: pey ron on March 18, 2018, 02:42:15 AM
Impact of Superoxide Dismutase-Gliadin on Radiation-induced Fibrosis: An Experimental Study (http://iv.iiarjournals.org/content/30/4/451.full)
Title: Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
Post by: LWillisjr on March 19, 2018, 07:51:09 PM
Quote from: pey ron on March 18, 2018, 02:34:49 AM

also, can't we merge these two threads?


Done
Title: Re: Hybrid H-100
Post by: Brookfield56 on March 20, 2018, 09:14:42 AM
My doctor is ignoring my request for a prescription.  Any other way to get this?
Title: Re: Hybrid H-100
Post by: Crooked_Stick on March 20, 2018, 10:12:39 AM
Maybe contact the company and ask them who in your area is prescribing, my Uro will not since it is not approved......some docs will prescribe just about anything...
Title: Re: Hybrid H-100
Post by: Freemason on March 22, 2018, 03:23:07 PM
$300 month is Meh..i spend $200 month on cable and internet.  I'll give it a shot for 6 months if i can get a RX.  I'll take the chance of it working some.  If it can improve me by 20-30% i'll Be thrilled.
Title: Re: Hybrid H-100
Post by: pey ron on March 22, 2018, 04:30:49 PM
has anyone started using this?

I am about to get it prescribed. I am planning to use my HSA debit card to cut the cost in half by using pre-tax money.

Given it would still be pretty expensive I am already wondering how to maximize its absorption and how to minimize how much gets rubbed into my underwear...

I have been trying the following with the diclofenac/voltaren gel: right after I apply it, i wrap my weiner into king film. The problem is that the cling film tends to roll up into a ring. But under that ring the gel stays fresh for hours. Outside of the ring covered by the cling film, it dries up pretty quickly and probably that means that my underwear absorb most of it, instead of my weiner. I don't want this to happen with the $300/mo H-100 gel... I need to find a better way...

Title: Re: Hybrid H-100
Post by: Freemason on March 23, 2018, 12:39:53 PM
Pey ron....outermost layer of our dick is extremely thin and highly absorbable..it is the inner layers that stuff cannot really penetrate well.  My point is when i get it im just going to use as directed and see what happens.  Guess i dont know how long it takes to dry after application.  Just dont put on underwear directly after applying...you might have to wait 5-10 minutes.
Title: Re: Hybrid H-100
Post by: pey ron on March 24, 2018, 12:14:09 AM
Quote from: Freemason on March 23, 2018, 12:39:53 PM
outermost layer of our dick is extremely thin and highly absorbable..it is the inner layers that stuff cannot really penetrate well

That's what makes me skeptical it's gonna work for me. I have scarring of the septum. All along the septum. These topicals (both H-100 and the diclofenac gel) may work best for people that have a sharp bend or a dent. Those people must have scarring on the "outside" part of the tunica. I have scarring on the "inside" part of the tunica. That's also probably why doctors don't want to do injections on me: the curve is not very sharp and there's a lot of healthy tissue that could be damaged between the "entry points" of the needle and the target scar tissue. I think I am a tad out of luck...
Title: Re: Hybrid H-100
Post by: skunkworks on March 24, 2018, 12:33:10 AM
Yeah it is a pretty safe bet that my scarring is septal also.

I have been looking at this cream/lotion and I think improvements could be made. One thing is emu oil actually inhibits 5 alpha reductase, an enzyme which converts testosterone into the far more potent dihydrotestosterone. I do not think inhibition of 5ar enzyme types is a good idea in the penis.

Penetration could be improved either with msm (cheap) or mayb some of the newer and more high tech transdermal penetration enhancers, I'd have to read up on what is available now.
Title: Re: Hybrid H-100
Post by: pey ron on March 24, 2018, 02:13:06 AM
Quote from: skunkworks on March 24, 2018, 12:33:10 AM
Yeah it is a pretty safe bet that my scarring is septal also.

Haven't you had it checked via ultrasound?

Quote from: skunkworks on March 24, 2018, 12:33:10 AM
emu oil actually inhibits 5 alpha reductase

I wouldn't say "actually"... it's a conjecture by folks that purport it as a hair loss topical. No-one has had success with it, AFAIK, so I really doubt it is a 5ar inhibitor.

Quote from: skunkworks on March 24, 2018, 12:33:10 AM
Penetration could be improved

they use lyposomal encapsulation... I believe it'd be hard to beat that...
Title: Re: Hybrid H-100
Post by: skunkworks on March 24, 2018, 09:17:03 AM
Quote from: pey ron on March 24, 2018, 02:13:06 AM
I wouldn't say "actually"... it's a conjecture by folks that purport it as a hair loss topical. No-one has had success with it, AFAIK, so I really doubt it is a 5ar inhibitor.

I would say actually.

https://www.ncbi.nlm.nih.gov/pubmed/1637346

https://www.ncbi.nlm.nih.gov/pubmed/3260860

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132824/

https://www.ncbi.nlm.nih.gov/pubmed/19353546

NB.

Composition (%) of Fatty Acids from the Emu Oil
Fatty Acid

Oleic          47.4%
Linoleic      15.2%
Linolenic   0.9%

Quotethey use lyposomal encapsulation... I believe it'd be hard to beat that...

Emu oil is a penetration enhancer, msm is as good or better. Removing emu oil (and one should) would possibly require the addition of a different penetration enhancer to make sure the active ingredient achieves the same penetration as with emu oil. Re liposomal encapsulation, how are people who are getting this made at compounding pharmacies achieving that? Can compounding pharmacies do that now?


Re ultrasound, results were inconclusive twice and I had zero luck finding anyone experienced with Peyronie's anywhere near me. Pretty common sadly.

Re merging threads, will do so as soon as I have time to check that it won't screw up flow of questions/answers etc.
Title: Re: Hybrid H-100
Post by: pey ron on March 24, 2018, 02:51:58 PM
Quote from: skunkworks on March 24, 2018, 09:17:03 AM
I would say actually

I stand corrected. Sorry, I've seen so many random claims in the hairloss community about this or that natural compound being anti-5ar I was assuming this was yet one of those claims going around...

Quote from: skunkworks on March 24, 2018, 09:17:03 AM
Emu oil is a penetration enhancer, msm is as good or better.

I tried adding MSM to hairloss topicals before and had the *impression* -there's nothing scientific about this observation of mine- it was making them very similar to those with the addition of DMSO... which makes me wonder: will adding MSM cause the vehicle to become a harsh solvent?

Quote from: skunkworks on March 24, 2018, 09:17:03 AM
Re liposomal encapsulation, how are people who are getting this made at compounding pharmacies achieving that? Can compounding pharmacies do that now?

They aren't. One could try at home with an ultrasonic cleaner and lecithin granules. See "recipes" floating around the internet about liposomal vitamin C.

Quote from: skunkworks on March 24, 2018, 09:17:03 AM
Re merging threads, will do so as soon as I have time to check that it won't screw up flow of questions/answers etc.

thanks, but it looks like @LWillisjr has already done that and was able to preserve the order...
Title: Re: Hybrid H-100
Post by: skunkworks on March 24, 2018, 09:50:40 PM
Re MSM, I have used it at a high % in topical solutions before with zero issues from skin irritation. Is that what you'd be worried about with MSM? Obv n=1 is not of much use but from doing some reading about it I have not come across much mention of skin irritation.
Title: Re: Hybrid H-100
Post by: pey ron on March 24, 2018, 10:32:53 PM
I'm more worried that it may bring in bacteria a la DMSO, or that it may partially melt the cling film I wrap around my penis and bring some of the plastic in... who knows? is there any expert here?
Title: Re: Hybrid H-100
Post by: diehardpatriot on March 25, 2018, 12:23:14 PM
My doc sent the RX on Friday. I'm guessing hybrid medical will call me for billing? I'm gonna call Monday if I don't receive a call by noon
Title: Re: Hybrid H-100
Post by: x2 on March 26, 2018, 09:07:04 PM
Could you folks clarify please?

"Scar tissue in septum "-- septum is the tissue in between of the 2 corpora (or the two chambers of the penis). It looks like a "T" that separates the  corpora on either side.

The scar tissue or the Peyronie's plaque is usually on dorsal, meaning on top of the septum (upward curvature), or, on either side of the corpora ( left or right curve) or on the bottom (downward curve). Can the scar be on the septum itself?

I have a 30+ degree upward curvature. My plaque is a cord like structure that covers the entire dorsal. Feels like the scar is on top of the "T" , the septum. Does it mean that it is  "scar tissue in septum"?

I hope the H-100 can help me,  but if it is considered "scar in septum", it sounds unlikely.

Thank you!
Title: Re: Hybrid H-100
Post by: TonySa on March 26, 2018, 10:21:56 PM
With upward curve you have plaque on the upper/dorsal side of the shaft—may be septal as well.  If going to help should do so with upward curve.
Title: Re: Hybrid H-100
Post by: pey ron on March 27, 2018, 01:33:20 AM
x2: we are on the same boat... I have upward curvature with a slight twist. Septal scar, feels hard on the dorsal side, but only when erect. Feels very soft and rubbery when flaccid.
Title: Re: Hybrid H-100
Post by: JustAnotherMember on March 29, 2018, 07:16:27 AM
Just so others can see this.  I contacted Polymun the company who create the liSOD to see if personal purchase available and they replied with "Unfortunately liposomal Dismutase is not available for purchase.".  I know it was a long shot but at least there is a concrete answer.

Link to commercial site deleted by moderator

If anyone uses Hybrid H-100 if they could keep up updated on progress I (as I'm sure others) would greatly appreciate it. 
Title: Re: Hybrid H-100
Post by: diehardpatriot on March 29, 2018, 02:01:34 PM
My rx is filled. The pharmacy said they won't be shipping out till late April. They're short on one of the ingredients . So I'm guessing it'll be early May when I receive it. When I do I'll keep everyone updated with any improvement or lack of improvement
Title: Re: Hybrid H-100
Post by: Paolo on March 29, 2018, 02:11:55 PM
Great, so we should know by October if H-100 is beneficial along with stretching with some honest reviews and testimonials  :)
Title: Re: Hybrid H-100
Post by: diehardpatriot on March 29, 2018, 02:59:23 PM
Yeah . I wish the people in the trial were forum visitors. Seems weird that not one of them visits here. For xiaflex trials many were on here and I'm hoping some forum members get picked for dr Atala's Tunica and corpora replacement. I'm not sure how much stretching I'm going to be able to get done as I have a new lump I just got 2 weeks ago that's pretty tender and causes erect pain. That's my 3rd plaque site already...  I'm hoping the H100 reduces the pain and maybe can get the lump to go down and prevent it from causing any new deformity. That'll make it 1,000 percent worth the money. I can live with the 10 up/ 20 right curve I have already. I'm hopimg by September/October I have good news for myself and everyone else. It seems I'd be 1/3 people who will have the cream ASAP
Title: Re: Hybrid H-100
Post by: curved on March 29, 2018, 04:22:32 PM
My dr signed off on the script today as well, and it has been sent to Hybrid Medical. I imagine the timing of delivery for me will be similar to diehard.  I will keep everyone posted on delivery as well as progress reports throughout
Title: Re: Hybrid H-100
Post by: Freemason on March 29, 2018, 08:23:20 PM
I have an Appt. with Dr. Tidwell in few weeks...FYI..I'll be up there on business anyway.

So i'll Get my RX from him...Hopefully :D ..lol.

I'll come back and see what info he can provide me as well.
Title: Re: Hybrid H-100
Post by: x2 on April 04, 2018, 12:25:34 AM
Quote from: pey ron on March 27, 2018, 01:33:20 AM
x2: we are on the same boat... I have upward curvature with a slight twist. Septal scar, feels hard on the dorsal side, but only when erect. Feels very soft and rubbery when flaccid.

Pey ron,
Thank you for the info. From Dr. Levine's book on Peyronie's, he indicated that the cord like plaques meant mild cases. However, it is troubling me a lot since I was diagnosed 5 years ago. I do hope H-100 will be available and helpful to us. I have had Xiaflex - it reduced to 32 degrees upward from 42 degrees. My uro told me that there is nothing else he could do for me.
Title: Re: Hybrid H-100
Post by: TonySa on April 12, 2018, 03:15:02 PM
I'm being told the H-100 is still not yet available, expected end of month.  Quoted $270/month if ordering 3 month supply.  I wish someone could get the formulation so we could order it from any compounding pharmacy, probably at a lower price.
Title: Re: Hybrid H-100
Post by: pey ron on April 12, 2018, 06:24:01 PM
I had been told it was expected for mid April... :(
Title: Re: Hybrid H-100
Post by: TonySa on April 12, 2018, 07:19:56 PM
They told me end of the month.
Title: Re: Hybrid H-100
Post by: Gabriel on April 28, 2018, 11:17:42 AM
Hello guys,

Just to make things clear on this topic: do we or do we not possess the exact composition of H-100 ? I remember someone posting that, according to the patent, H-100 would be :

20% Nicardipine
0.2% LRHSOD
1% gelling agent (e.g. fatty acids)
78.8% Emu Oil

--> Based on these informations, I convinced my urologist to give me a prescription that mimics H-100 for a compounding pharmacy. I currently have the prescription in hands, buy did not try yet to contact with a proper pharmacy.

What do you guys think about that :)?
Title: Re: Hybrid H-100
Post by: TonySa on April 28, 2018, 11:49:24 AM
I'd like to do the same.  The google patent website lists different possible percentages but no way of knowing which one they went with that I know of.  Also, they're still waiting for one of the ingredients before shipping, so not sure if other pharmacies will even have it on hand.
Title: Re: Hybrid H-100
Post by: pey ron on April 28, 2018, 01:21:09 PM
@Tsanchez12369: can you please quote the percentages from the patent? I think we just need to make sure we use the highest possible ones.

I was told the H-100 will start shipping in early May... delays keep on accumulating. I still haven't ordered it.
Title: Re: Hybrid H-100
Post by: TonySa on April 28, 2018, 02:23:29 PM
See: https://patents.google.com/patent/EP2804606A1
Title: Re: Hybrid H-100
Post by: pey ron on April 28, 2018, 08:24:59 PM
have you found where to source the nicardipine and superoxidismutase?
Title: Re: Hybrid H-100
Post by: TonySa on April 29, 2018, 12:37:08 PM
That's probably the problem as even the compounding pharmacy selling H-100 is having difficulty dooing so.
Title: Re: Hybrid H-100
Post by: pey ron on April 29, 2018, 02:19:12 PM
how do you know they are not finding it?
Title: Re: Hybrid H-100
Post by: Freemason on May 01, 2018, 08:32:41 PM
Hey guys...Wanted everyone to know I had an appt recently with Dr Tidwell in MSP.  Couple things:

1- He said product should start shipping in week or so that part of the ingredients was in customs from China.

2- He mentioned that Nicardipine in the RX is a special blend made specifically for our penis.  So those wanting to do their own compounding i guess it might not be exactly like the RX.

3- He did start out by saying that the study and the RX itself is more intended for acute phase when scar tissue is forming and collagen is building up etc..

4- I mentioned to him that i had only tried traction a couple times and previously having never experienced any pain until starting traction (so i stopped) that the pain might actually be viewed in his theory as not a bad thing as it could indicate the scar tissue is changing. Interesting.

That was about it that i can think of right now.  I'll be starting on H 100.  Oh the pharmacy called me same day and upfront cost for 3 months is like $800.  Dr. Tidwell told me to try traction (which im ordering RestoreX soon) and H 100 and after 3 months of consistent therapy if i dont see any change or improvement that it wouldn't make sense to continue wiht H 100...
Title: Re: Hybrid H-100
Post by: curved on May 02, 2018, 10:37:09 AM
Just spoke to compounding pharmacy and if you have sent in your prescription the H100 will be shipping out today or tomorrow.
Title: Re: Hybrid H-100
Post by: alec on May 02, 2018, 02:13:10 PM
is there a scientific explanation for the mechanism behind this h100?
Title: Re: Hybrid H-100
Post by: TonySa on May 02, 2018, 09:34:06 PM
They called me too, $390/mos or $890 for 3 mos supply.  $50 mos rebate is through hybrid medical doing the research, not the pharmacy.
Title: Re: Hybrid H-100
Post by: Gabriel on May 03, 2018, 01:14:59 PM
Thank you very much for keeping us up-to-date Freemason  :)

God I hope this thing does work and comes to Europe soon  ::)...
Title: Re: Hybrid H-100
Post by: curved on May 04, 2018, 10:15:39 AM
Received my H-100 yesterday. The pharmacy fed exed which was great.  I do have a few questions if anyone can help.

1-  Does the cream have to be rubbed in completely or just applied.  This may seem like a silly question but once the cream is applied I wasn't able to get it all "absorbed"... there remained a slight film on the outside.

2-How long does one wait until you can get dressed.... I recall DMSO being fully absorbed in 5-7 minutes and wasn't sure if there was a similar requirement with this.

3- Is there any advantage to immediately employing traction or VED after application to stretch the damaged tissues and enhance absorption?

Many thanks!
Title: Re: Hybrid H-100
Post by: Freemason on May 04, 2018, 10:27:05 AM
Curved,

Good ?'s..don't know..lol...But i'd Say once you have applied the dosage it says after a few minutes what needs to be asbsorbed should be.  The film i'd Guess is prob Emu oil which is a majority of the compound. 

As for soemone that asked about evidence of the compounds...As the study indicated it is mostly beneficial and tested, i believe, on acute phase pts.  H-100 compounds are all heavily anti inflammatory and inflammation during acute phase is what causes all that colleges build up early on and then scar tissue.
Title: Re: Hybrid H-100
Post by: curved on May 04, 2018, 10:45:14 AM
Thanks Freemason!  I also sent an email into Hybrid Medical with these questions... if/when I hear back will let everyone know.
Title: Re: Hybrid H-100
Post by: Paolo on May 04, 2018, 10:54:15 AM
Good luck, hope to hear some positives in near future.
I would imagine to use less than you would initially think but ensure you use it on the whole shaft (excluding glans) and rub in with gentle/moderate pressure, ideally let it air dry before dressing.

Perhaps introduce traction after 4-5 days use, good luck  :)
Paul
Title: Re: Hybrid H-100
Post by: curved on May 04, 2018, 10:57:08 AM
Thanks Paul appreciate the suggestions.
Title: Re: Hybrid H-100
Post by: Paolo on May 04, 2018, 11:00:30 AM
No problem, just a thought, in 3 months post a 'separate' post titled something like 'H-100 honest testimonial' please, that would be great if you would  :)
Paul.
Title: Re: Hybrid H-100
Post by: curved on May 04, 2018, 11:28:34 AM
will do.
Title: Re: Hybrid H-100
Post by: diehardpatriot on May 04, 2018, 12:45:14 PM
Ordered my h100 yesterday . Should be coming in soon. Curved, I have the same questions. I was also wondering if putting it in my own container and only applying it where I need it would make it last longer
Title: Re: Hybrid H-100
Post by: curved on May 04, 2018, 04:57:53 PM
Diehard- The container it comes in is quite unique... at least I hadn't seen one like it before for a topical cream. It is analogous to a deodorant bottle that twists from the bottom to push up the cream.  You simply turn the bottom slowly until you hear 2 clicks and the correct dosage of the cream (I want to say .5ml... but could have that wrong.) materializes on top to be applied.  the cream comes out through a tiny hole and you apply it using the top of the bottle to massage it in.  The recommendation is to use it all over the shaft even if you do not detect plaque as a preventative measure for those areas of the shaft that do not have detectable plaque.
Title: Re: Hybrid H-100
Post by: pey ron on May 04, 2018, 09:00:04 PM
how do you guys plan to do after you have applied it? Unless you can stay naked for hours at a time while it absorbs and dries?

with topical diclofenac i've been wrapping my best friend in food-grade cling film, but most of the times it tends to curl up into a thin ring and so most of the diclofenac goes wasted into my underwear.

Now, a month of diclofenac costs $10.

A month of H-100 costs $300.

We need to find a better way...
Title: Re: Hybrid H-100
Post by: diehardpatriot on May 05, 2018, 02:28:39 AM
Best thing I can think is apply immediately after a shower then pick your outfit and do everything else while naked, put your clothes on last
Title: Re: Hybrid H-100
Post by: curved on May 05, 2018, 10:40:43 AM
I sent questions on absorption rate into hybrid medical on Friday but have not heard back yet...
Will let everyone know what I hear
Title: Re: Hybrid H-100
Post by: pey ron on May 05, 2018, 03:01:37 PM
TLDR; occlusion increases absorption because it helps hydrate the skin, disrupting the lipid barrier. Careful though, instructions for the H-100 mention it can cause irritation, so go easy at first and see how well you tolerate it.

Here are some sources and some quotes I took from them (with my emphasis added).

https://www.livestrong.com/article/149181-what-is-skin-occlusion/

«If you have eczema on your hand, for instance, you would soak your hand for 15 to 20 minutes, apply your normal medication, cover the area affected by eczema with plastic, seal that plastic with an elastic bandage and leave your hand wrapped as such for approximately six hours».

https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.0909-752x.2001.10311.x

«Application of chemicals/drugs under occlusion can increase penetration of chemicals and antigens into the skin and therefore can increase dermatitis (1, 2). Local reactions (i.e. irritation and/or sensitization) of TDDS, typically occlusive patches placed on the skin surface for 1–7 days to deliver the drugs into the systemic circulation, have been widely reported (57–61). However, reactions can be minimized with immunosuppressive agents, [a]antioxidants, local anaesthetics, and other anti-irritant technologies[/b] (62).».

zhai2001.pdf - DocDroid (http://docdro.id/B1XhZZQ)

«Skin occlusion can increase stratum corneum hydration, and hence influence percutaneous absorption by altering partitioning between the surface chemical and the skin due to the increasing presence of
water, swelling corneocytes and possibly altering the intercellular lipid phase organization, also by increasing the skin surface temperature, and increasing blood floww [2–4]. Occlusion may enhance drug efficacy [5–10]. tually, skin occlusion is a complex event producing profound changes and influencing skin biology as well as wound healing processes [11–27]. In general, occlusion can, with exceptions
[2, 4, 28, 29], increase percutaneous absorption of topically applied compounds [30–42]; even a short-time (30 min) occlusion can result in significantly increased penetration and horny layer water content [43]».

https://www.verywell.com/how-to-use-topical-steroids-1068830

«A topical steroid can be absorbed into the skin more quickly through a process known as occlusion. Occlusion involves applying the topical steroid to the affected area and wrapping it in plastic wrap or cloth and securing it with tape. The plastic wrap keeps perspiration close to the skin and hydrates the stratum corneum, the top layer of the epidermis. Hydrated skin is able to absorb topical medication much more efficiently than dry skin, providing faster relief.

Occlusion dressings need to be left on for at least 2 hours at a time. Because of this, they are usually applied at bedtime. The occlusion method should only be used under the care of a health care provider since it significantly increases the potency of a topical steroid. Because occlusion promotes a moist environment, it increases the risk of developing bacterial infections and should not be utilized more than 3 days in a row».
Title: Re: Hybrid H-100
Post by: diehardpatriot on May 07, 2018, 05:45:36 PM
So is that what you guys are gonna do, try wrapping it? Let me know how it works out. My cream should come in the mail soon
Title: Re: Hybrid H-100
Post by: TonySa on May 07, 2018, 08:09:22 PM
I'll try wrapping it, or just air dry while doing traction for 1-3 hours.
Title: Re: Hybrid H-100
Post by: alec on May 08, 2018, 01:30:31 PM
How big is one tube of H100 and for how long?
Title: Re: Hybrid H-100
Post by: diehardpatriot on May 09, 2018, 02:20:22 AM
They're like the size of a deodorant. I have 3. One for each month of treatment
Title: Re: Hybrid H-100
Post by: alec on May 09, 2018, 03:40:52 AM
Like 50 or 100ml?
Title: Re: Hybrid H-100
Post by: NeoV on May 09, 2018, 05:23:26 AM
A study showed that Emu oil ranked LAST for being a transdermal among olive oil, coconut oil, and a bunch of other oils. I do not really think it's better than any other oleic acid (omega 9) containing fat for being a transdermal. SOD is another problem I suppose, but I wouldn't worry about overpriced emu oil.

https://www.tandfonline.com/doi/abs/10.3109/03639045.2015.1047847?src=recsys&journalCode=iddi20
Hydrogel >>>> olive oil >> liquid paraffin >> coconut oil > grape seed oil >> Avocado oil ≥ Crocodile oil >> Emu oil.

It is said that Emu oil does not contain phospholipids, and therefore is a better transdermal carrier than other fats, yet this has never been demonstrated in any study I can find, it is simply touted by the makers from what I can tell. Actually, emu oil has LESS oleic acid (the actual transdermal carrier) than olive oil or other fats.

I'm very excited to have a product for Peyronie's, I just hope this is worth our money.
Title: Re: Hybrid H-100
Post by: diehardpatriot on May 09, 2018, 10:25:50 AM
Hello everyone . I have a questions regarding the use of H100. I have had a recent injury almost 2 months ago that has not healed 100 percent yet. (Check this post for more info on it) Androcur or antierection meds for healing minor fracture? - Peyronies Society Forums (https://www.peyroniesforum.net/index.php/topic,9872.msg94059.html#msg94059)  Is using the H100 on it safe? Will it prevent healing ? Or will it help cut down inflammation and promote healing? what's y'all opinion ? Thanks
Title: Re: Hybrid H-100
Post by: Paolo on May 09, 2018, 11:07:25 AM
IMO I would go with using it, good luck and hope this H-100 stuff works out for you, no masturbation though, right.
Paul  :)
Title: Re: Hybrid H-100
Post by: pey ron on May 09, 2018, 12:00:28 PM
@diehardpatriot: i think it's great that you get to apply it so early after the injury. Also make sure you are on pentox.

Last night I applied H-100 for the first time. Given the price, it feels like I was smothering my weiner in gold. I decided to think of it in a positive way. I tell to myself «I am taking care of my penis with expensive products», rather than «I am wasting so much money for this little bastard that sometimes even dares to let me [and the girl] down». Hopefully the positive attitude will also leverage the healing power of the mind...
Title: Re: Hybrid H-100
Post by: TheTollundMan on May 09, 2018, 12:35:25 PM
How would one even go about getting this if they're Canadian?
Title: Re: Hybrid H-100
Post by: diehardpatriot on May 09, 2018, 04:45:55 PM
@Paolo: No masturbation. I have a plan now, I'm really not scared of the future as much as I was.

@the tollund man: email hybrid medical or call the pharmacy who makes the stuff

@Neo: I pray to God my father didn't just waste 800 dollars on this stuff. One promising thing is that it has SOD, which has a study outlining its benefits for Peyronie's when just used ALONE. H100 has SOD, and nicardipidine (which also has studies showing its benefits when injected into Peyronie's scarring). So I really really hope this can at least make the scarring smaller or impalpable. I guess we won't know until 3-6 months when we report back.

Another question and maybe more people can benefit off doing this. I have some topical magnesium oil, should I mix a little with the H100 or maybe apply a little mag oil on top of the H100 on my penis? Would it penetrate with the other ingredients ? Would the benefits be good?
Title: Re: Hybrid H-100
Post by: curved on May 09, 2018, 05:16:37 PM
Along the same lines as diehard.... was wondering if applying some 70% DMSO on top of the H100 might help it get absorbed a bit better. I know Emo is considered a transdermal agent but know DMSO is as well.  Any thoughts?  Thanks.
Title: Re: Hybrid H-100
Post by: pey ron on May 09, 2018, 06:28:18 PM
Quote from: diehardpatriot on May 09, 2018, 04:45:55 PM
I have some topical magnesium oil, should I mix a little with the H100 or maybe apply a little mag oil on top of the H100 on my penis? Would it penetrate with the other ingredients ? Would the benefits be good?

I'd rather apply it on top. And if possible a few hours later.

For example,

in the morning:

1) wake up
2) shower
3) apply H-100

12 hours later than (3):

4) Apply H-100 when you wake up.

3, or if possible 4 hours later than (4):

5) apply mag oil.

It may push further in the H-100 you applied earlier, but you've at least given it four hours to penetrate without being disturbed.

The next morning you wash away any mag oil residue in the shower, so it won't impede the absorption of the H-100.

Mag oil is cheap. H-100 is expensive. Don't F^@% it up and waste it :)

Quote from: diehardpatriot on May 09, 2018, 04:45:55 PM
SOD, which has a study outlining its benefits for Peyronie's when just used ALONE

Can you please upload it on docdroid and link it?

Quote from: diehardpatriot on May 09, 2018, 04:45:55 PM
nicardipidine (which also has studies showing its benefits when injected into Peyronie's scarring)

idem please :)

thank you!

Quote from: curved on May 09, 2018, 05:16:37 PMapplying some 70% DMSO on top of the H100 might help it get absorbed a bit better

it might, but emu should be already pretty good at it... The problem with DMSO is that then you cannot do occlusion with PVC cling film. You'd need to find some teflon wrap.

Also, I'd only use DMSO right after I'm squeaky clean from a shower. And then I'd wear underwear that is fresh out of the laundry. I think I'm leaving the DMSO for homemade concoctions and I am not going to be messing with this very expensive compounding pharmacy formulation.
Title: Re: Hybrid H-100
Post by: curved on May 09, 2018, 08:39:08 PM
Thanks Pey  Ron....think I will stick with H100 as is for now and skip the dmso (only 1 week in on the H100). Will keep everyone posted at the 1 month, 2 month and 3 month mark
Title: Re: Hybrid H-100
Post by: Freemason on May 09, 2018, 08:45:00 PM
I received mine yesterday as well..I'm going to start on Saturday..One thing I wanted to say aside from applying it after a nice hot shower is to use latex or the like gloves..Just to not have any absorb into your finger if u rub it in...Just a thought.

Yes it is expensive..but i'll Gladly pay $800 for 3 months of something that has at least been studied some with moderate success.  At the very least we are putting a whole bunch of anti inflammatory compounds on our shaft.

I do know after meeting with Dr. Tidwell that they are continuing to look for ways to increase absorption even further..not just this compound but others as well.
Title: Re: Hybrid H-100
Post by: WhatNext81 on May 09, 2018, 10:31:24 PM
Many people seem to be using several different products, pills, etc for treatment.  How will we know if this stuff is legit? Especially since pentox is used by many on here. That coupled with this only being useful in the acute phase.

Some mention of putting another oil on before to absorb better. Wouldn't the experts have that covered and could it possibly interfere with the effectiveness of the creme? I recall reading about castor oil and ppl making castor packs. Could one apply h-100, wait, wrap a small piece of 100% cotton cloth and then wrap it with plastic wrap? None of it gets wasted, nothing on your clothes, leftover can absorb throughout the day, and the added bencit of keeping your penis warmer?

All that being said, I really hope that this stuff is proven effective. It would be a great alternative to pentox. Best of luck to everyone trying this and hope to hear great things!

Title: Re: Hybrid H-100
Post by: WhatNext81 on May 09, 2018, 10:48:59 PM
That's kind of a bummer that it's not FDA approved.
Title: Re: Hybrid H-100
Post by: NeoV on May 10, 2018, 05:05:33 AM
I'm excited you guys are trying this despite what I think about Emu oil! I like everything I read about SOD and am very curious if you guys will have results. Seriously : )
Title: Re: Hybrid H-100
Post by: treeza1 on May 10, 2018, 06:05:11 AM
Are you guys trying this in the active or chronic phase?
Title: Re: Hybrid H-100
Post by: curved on May 10, 2018, 10:15:37 AM
Hybrid Medical was pretty clear that the best results from this will come during the acute phase.  I am in the chronic/stable so not expecting miracles but Hybrid said even in the chronic phase there would be some relief.  Will keep everyone posted.
Title: Re: Hybrid H-100
Post by: Freemason on May 10, 2018, 12:59:24 PM
I've only tried traction for a few days..and this was maybe 18 months ago..i stopped bc i experienced the "pain" for first time ever and man did that suck..I' figured it was from traction so i jus stoped and pain never came back..

But after talking with Dr. Tidwell he seemed to theorize that pain in a chronic Peyronies Disease actually might be not a bad thing as the scar tissue might be changing...This was his theory anyway.

I've got the H-100 but im just going to use H-100 alone for 3 months...See if anythign at all changes..THen I'm going to do another 3 months with traction regularly.

Since I've not done traction before really much i dont wanna start doing traction with H-100 and if i see improvement won't know which one did it.

I'm not expecting some miracle 90% change for the better wiht my Peyronies Disease on H-100 but if i get any improvement i think that would be huge.
Title: Re: Hybrid H-100
Post by: Paolo on May 10, 2018, 01:07:03 PM
Great Idea to stagger the treatment, hope it helps, after 3 months you could even include careful manual stretches.
In 3 months post a 'separate' post titled something like 'H-100 honest testimonial'

Good Luck  :) :)
Title: Re: Hybrid H-100
Post by: pey ron on May 10, 2018, 01:43:12 PM
I wonder if I could have billed this through my insurance. It would have helped hit my max-out-of-pocket for the year. I have HSA, so I'd have been the one paying for it anyway.
Title: Re: Hybrid H-100
Post by: alec on May 13, 2018, 02:54:52 AM
This might be interesting for everyone taking H-100:

"The patient can be instructed to avoid vitamin C supplements and anthocyanins while using the medication. Furthermore, patients can be instructed to take at least about 500 mg of a calcium supplement twice a day with food with water, and to take about 50 mg of a zinc supplement once a day with food."

Title: Re: Hybrid H-100
Post by: pey ron on May 13, 2018, 12:47:58 PM
Alexander88: where did you get that quote from?

Any idea why we should quit the anthocyanins? I have been taking bilberry extract according to the multimodal treatment paper...

And why should one take calcium? Zinc is probably good to raise testosterone, which probably helps with Peyronie...
Title: Re: Hybrid H-100
Post by: alec on May 13, 2018, 01:05:53 PM
It is from the patent, which someone posted here before

I do not know why and it doesnt say why in the patent
text
Title: Re: Hybrid H-100
Post by: curved on May 14, 2018, 11:59:49 AM
Just circling back on H100 absorption rate.  I just got off the phone with CustomRX (compounding pharmacy) and they had a conference call with Hybrid Medical last week to discuss several questions customers had on absorption timing.  CustomRX indicated that the cream will be absorbed over several hours and that it is important to space the application of the cream by at least 4 hours.  They also said you could get dressed whenever you felt comfortable after the application and that it wouldn't interfere with absorption.  For what it is worth I have been wrapping in cling wrap if for no other reason then to avoid getting any residue on my clothes.  They also indicated that the stretching protocol outlined by Hybrid Medical was important to efficacy of the treatment.
Title: Re: Hybrid H-100
Post by: Freemason on May 17, 2018, 12:40:36 AM
I started using H100 on Monday..so day 3 complete now..fortunately i'm Not getting any irritation..at least not yet.  I apply and run it in all over shaft really well for idk about 3-4 minutes until my shaft is just shiny glow..that is the emu oil assume left over.  I have noticed that after application maybe an hour later my shaft is little red like blood flow or something which i assume is the blood pressure med in it..

I'll use 2x day for 3 months and see how it goes.

Yea after i rub it in for 3-4 minutes i put clothes on.  I also take hot shower prior to application.
Title: Re: Hybrid H-100
Post by: Paolo on May 17, 2018, 01:47:06 AM
Appreciate post, good luck continuing with this protocol  :)
Paul.
Title: Re: Hybrid H-100
Post by: alec on May 17, 2018, 01:54:35 PM
I can not wait for it to be shippable to Europe  :'(
Title: Re: Hybrid H-100
Post by: Gabriel on May 17, 2018, 04:34:35 PM
Yep, thanks guys keep us up to date :-)
Title: Re: Hybrid H-100
Post by: pey ron on May 18, 2018, 04:21:07 AM
i have been applying two clicks in the morning and two clicks at night.

Is it just me or it really looks like the stick is not gonna last for 30 days???
Title: Re: Hybrid H-100
Post by: Freemason on May 18, 2018, 12:12:13 PM
Well if it doesnt last 30 days then i'll Certainly ask for more to make up for it..

I have noticed that when i go to do my 2nd application and open the lid that some has oozed out on top every time...but I just use it up.
Title: Re: Hybrid H-100
Post by: Freemason on May 20, 2018, 07:57:31 PM
Idk I'm on day 8 and seems like should be enough..

One thing I have noticed is my flaccid hang is bigger slightly and this is hours after application.

Not that I care cause I don't Idk maybe it's increased blood flow
Title: Re: Hybrid H-100
Post by: Freemason on May 25, 2018, 07:09:51 PM
On day 13 of H-100..no rash or advers affect so that's good.  If anythign it is forcing me to do manual stretching twice a day for 4-5 minutes which is prob a good thing.

nothing new to report really just thought i'd Update.
Title: Re: Hybrid H-100
Post by: WhatNext81 on May 25, 2018, 11:16:58 PM
Appreciate the update. Hopefully you'll see some benefits.
Is anyone else using this?
Title: Re: Hybrid H-100
Post by: diehardpatriot on May 26, 2018, 03:48:25 AM
Hello everyone. I've been using h100 for I think 3 weeks now. No change in curve but I haven't been doing traction due to a penis injury about 2 months ago. I think to combat curve traction must be done together with the ointment for max results. Anyway , the ointment has almost completely rid me of the penis pain from the injury, it may just be natural healing, but coincidentally the pain improvement was shortly after I began using the H100. It's very anti inflammation so I do not doubt it's ability to kill pain. Still can feel some weird tissue inflammation at the spot of injury though and erections still aren't what they used to be. I'll update again in about another 2-3 weeks
Title: Re: Hybrid H-100
Post by: Christopher1 on May 26, 2018, 11:54:23 AM
Fascinating thread.

Keep us updated!!
Title: Re: Hybrid H-100
Post by: blackdiamond on May 26, 2018, 03:29:56 PM
Actually my Doc was at a convention this past week and knows Dr. Levine who endorses the product. They spoke.
He said that the H-100 can and should moderately improve Peyrones but is still too expensive.......I guess like 300$ per month.
IDK Xiaflex and all the other stuff I had to do did the trick for me.........75 degrees to 15.......
Title: Re: Hybrid H-100
Post by: hope794 on May 27, 2018, 08:13:56 AM
Any news guys? Do you think that H100 can be useful to reverse a tunica fibrosis, or at least reduce it?
Title: Re: Hybrid H-100
Post by: Freemason on May 27, 2018, 03:49:44 PM
[Full quote remove]

Yea I agree with you on doing traction with H-100..but i decided to just use H-100 alone for first 3 months..just to see if i see any improvement at all with just this nothing else..After my 3 months is up I'm going to do another 3 months but with traction..kinda my own comparative study.

Good to hear on pain reduction..that doesnt surprsie me as every ingredient in this compound has a lot of anti inflammatory properties..I've not had any pain fortunately but that has to be a relief for you.

heck if anything if all this compound does is relieve pain and help more those in acute phase then its prob worth being in our bag.
Title: Re: Hybrid H-100
Post by: TonySa on May 27, 2018, 04:41:08 PM
Good to hear Dr Levine feels it results in moderate improvement!
Title: Re: Hybrid H-100
Post by: hope794 on May 27, 2018, 04:56:50 PM
So, H100 has effects on pain only? What about the fibrosis reabsorption? Please keep in touch guys.
Title: Re: Hybrid H-100
Post by: TonySa on May 27, 2018, 05:18:23 PM
Some curve reduction found in study.
Title: Re: Hybrid H-100
Post by: hope794 on May 27, 2018, 06:50:40 PM
Quote from: Tsanchez12369 on May 27, 2018, 05:18:23 PM
Some curve reduction found in study.

Thanks for the info. Has anyone got a review about this gel?
Title: Re: Hybrid H-100
Post by: TonySa on May 27, 2018, 08:17:59 PM
https://www.nature.com/articles/ijir201522
Title: Re: Hybrid H-100
Post by: WhatNext81 on May 28, 2018, 03:51:46 AM
This sounds promising in terms of pain.
Freemason-that's awesome that you're splitting it up, using it by itself and then with traction.

As one could speculate that 6 months of traction can make a difference alone, especially in the accute phase. I understand the logic behind this, but one has to wonder if it's more effective than injections. It would be great if it did prove to as I feel with injections, there are many factors that play into its success rate. If this stops it early on, then peyronie's awareness would be very important. I had no clue what peyronie's was or early symptoms/signs. As with anythting else, it takes time and people. It seems more options are being explored and I'm sure there's more things in the works that we don't know about yet. Thanks to those using this and keeping all of us in the know.
Title: Re: Hybrid H-100
Post by: Limping Along on May 28, 2018, 05:39:38 AM
Traction takes time.  I'm in the Mayo Restorex traction device clinical trial, seeing some benefits after 8 wees, have about 16 morre weeks to go (the study is 9 mos long for each individual participant),  I tried the extra vitamins and supplements mentioned, did not see any change.  With traction, about a 10% difference to date (original measurement 55-60 degrees)

Anecdotal findings from the study are 1) traction works well with 1 round (2 injections) of Xiaflex and 2) better results if you can get to 3rd level or more on traction device (settings are about 15/30/45 & 90 degrees)  For those doing manipulation and modeling, I suspect you don't realize how much force needs to be applied to see results.   While the curve is improving, I can't testify that traction has made me longer.  Thenegative side effect is that a have a 'turkey neck' behind the head that wasn't there before.
Title: Re: Hybrid H-100
Post by: WhatNext81 on May 28, 2018, 01:32:53 PM
"For those doing manipulation and modeling, I suspect you don't realize how much force needs to be applied to see results."

I was quite surprised as well. I had my first crash course on it after my first xiaflex injection. Dr Trost did it and explained everything in great detail. It helped put things in perspective as I was also using RestoreX. He further explained how much force I could safely apply with RestoreX along with some tips here and there.
Title: Re: Hybrid H-100
Post by: Gabriel on May 29, 2018, 01:10:55 PM
Hey Limping Along,

Could you please be more specific about what you call the "turkey neck" you got from using traction ? I'm asking you because for a few months I have had a circular lump that looks like a ring, located just 1cm beneath the glans; my 3 uros, including Dr Sussman which is said to be the best penis echographist in France, were wondering what this would be. Dr Sussman thinks it might be a inflamed lymph vessel, but she's not sure, and although she told me not to worry too much about it, I must confess I'm starting to have some concerns. Could this be related to the Andropeyronie I use ?

Thanks a lot !
Title: Re: Hybrid H-100
Post by: jusirmi on May 29, 2018, 04:56:17 PM
I think it could be a possibility. I also have some vein or lymp inflamed after using traction. this is a shame because penile traction is the only option to try to restore our original length. When you read medical literature you find that mondor's disease and sclerosing lymphangitis could be caused by a traumatic damage to vein or lymp node at the penis and mondor's disease could be caused by vacuum pump. For this reason i think that this inflamed lymp could be a side effect of using penile traction. In addition, i read in forums of people that do penile exercises that mondor's disease is a common problem between this people that is doing a more agressive type of streching.
Title: Re: Hybrid H-100
Post by: Gabriel on May 30, 2018, 03:55:01 PM
Thanks for the answer jusrimi!

I wasn't aware of the existence of Mondor's disease, but after checking I'm pretty sure I have it (with the dorsal vein grewing very thick and hard; according to the studies, it doesn't seem too bad a condition though).

Nevertheless, about the "turkey neck", I was actually speaking of a structure which is exactly like a ring 0,5cm wide, all around the circumference of the penis, just 1cm beneath the glans. I'm not sure I'm making myself clear in English, sorry ! Anyone else can relate to this mysterious ring ??

PS to moderators: maybe we are trolling here; should we start another topic ?

Anyway, thanks to you all H-100 testers for your posts which are so many glimmers of hope!!
Title: Re: Hybrid H-100
Post by: franklee on June 02, 2018, 12:19:54 PM
Began H-100 4 days ago. Doing VED 15 mins once a day plus traction. I hate traction, always have discomfort after so some days modeling/stretching instead. No noticeable change but will keep you updated.
Title: Re: Hybrid H-100
Post by: Christopher1 on June 11, 2018, 02:40:26 PM
Traction irritates my plaque, too.

Always gives me scar pain afterwards. Pentox helps it though.
Title: Re: Hybrid H-100
Post by: Gabriel on June 11, 2018, 04:00:09 PM
Franklee, thanks for the update!

So you guys confirm that traction can actually make the plaque worse?? I was wondering if the disconfort/pain under the glans was coming from a mere irritation, or from a more serious and deep agression caused by the traction device... Could we even imagine that it can be the cause of the two growing dents I have juste under the glans?

Sorry but after 9 months of this crap and only worsening I'm beginning to feel a little lost and annoyed  >:( ;)
Title: Re: Hybrid H-100
Post by: Freemason on June 13, 2018, 04:16:15 PM
I've had Peyronies Disease for over 7 years...tried traction about 2 years ago and for the first time since getting Peyronies Disease i experienced the pain everyone was always talking about on here..and it sucked..I couldnt' figure out what the pain was from adn then realized that i'd Started traction and that was it.  So i stopped traction and pain went away.

Now...my Uro Indicated that he felt that new pain might not be a bad thing as he theorized taht the plaque was changing.

I am one month in using H-100..Havent seen any difference yet.  But he did say you wont see any change if any until around 3 months.  I think u have to build up a level of SOD and absoption affecting the plaque which takes months.  But we will find out.
Title: Re: Hybrid H-100
Post by: HybridMedicalOrg on June 14, 2018, 09:13:18 AM
Hello, everyone.  I'm Dr. Jeff Twidwell, a 30-year practicing urologist and co founder of Hybrid Medical. I wanted to craft a brief response to some of the comments I have seen on the forum site.

We understand that this forum is an important place for patients to dialogue. We don't want to interfere with this dialogue, so we ask that any future questions for Hybrid Medical be posted through "Contact Us" on the company website, hybridmedical.org.  There you can also see our published study abstract, video and other information.

Peyronie's Disease has been a very frustrating condition for patients and doctors alike.  Over three decades of practice, I've seen very little advancement in treatment. 

Our motivation at Hybrid has always been to find a treatment that could help with this disease.  The acute phase is when the disease is developing, so that was the focus of the research and treatment.  Peyronie's involves a cascade of events in which trauma leads to inflammation which leads to scar tissue.  Changing the natural course of this cascade was the focus of our research.

After much research, we developed a treatment that should target inflammation, scar tissue remodeling, and plaque development.  As documented in prior independent studies, Nicardipine and Superoxide dismutase can accomplish this.  We combined these ingredients with ultra-purified emu oil which contains the fatty acids necessary to be an effective carrier agent.  Emu oil also has been used for centuries by the Aborigines for scar tissue remodeling.

To make sure we were on the right track, we performed a proof of concept / safety study that was double blind, randomized, and placebo-controlled.  The results were very positive with statistical improvement in curvature, stretched penile length and pain reduction.  Rash was the only side effect for about 10% of patients.

The study size was relatively small, but its design was done under the guidance of Dr. Larry Levine, a world expert in Peyronie's Disease.  The study only included acute phase patients because those are the ones that should be helped most with H100, due to H100's mechanism of action.

H100 is a patented and proprietary compound.  At this time, only Custom Rx in Wichita, Kansas, has the sole rights to legally produce this product in the US.  Other compounders may claim to use the "same" ingredients; however, the exact formula and quality standards are unlikely to be the same - so you cannot expect the same results or safety as documented in our study.

Hybrid Medical plans to continue research on patients using H100 and will be using the Peyronie's Disease questionnaire found on our website to assess improvement in a larger group of men.  This data will be published once it is gathered and analyzed.

In summary, we have created a breakthrough treatment option for men with acute phase Peyronie's disease.  Based on our study data, I recommend a patient tries H100 for 3 months and if you improve or remain stable, continue for a total of 6 months.
Again, if you have any further comments or questions for us, please use the Contact Us function on our website.

[Link removed to comply with forum rules - those interested can easily find HybridMedical - Admin]

Thank you, and we wish you all the best.
Title: Re: Hybrid H-100
Post by: james1947 on June 14, 2018, 08:09:50 PM
Hi Dr. Jeff Twidwell

We are appreciating you posting on our forum and also Dr. Larry Levine is much esteemed here  :)
Because your website is a commercial one and you are inviting members to contact you, please be kind and contact our Administrator LWillisjr.
Links to commercial sites or invitations to contact commercial sites are not allowed on our forum

James 
Title: Re: Hybrid H-100
Post by: HybridMedicalOrg on June 14, 2018, 10:04:52 PM
James,
Thank you very much for the direction.  We noticed Norm was the board moderator.  We reached out to him on Friday asking his blessing to post a reply to all the comments in hopes to clear up any misconceptions.  We did not hear back from Norm, thus in interest of all, we posted this today.  Given your instructions, we will now reach out to LWillisjr. 

Thank you,
Dr Jeff Twidwell
Title: Re: Hybrid H-100
Post by: LWillisjr on June 15, 2018, 08:30:21 PM
Dr. Jeff did contact me. I did modify the post to comply with forum rules. But anyone interested can easily find HybridMedical. Our forum has been following H-100 progress over some time now.
Title: Re: Hybrid H-100
Post by: alec on June 18, 2018, 04:33:29 AM
How is it going with H-100? Any changes? Any problems?

I am thinking about taking a flight to the US just to get it prescribed and have it send to an US-address. Can someone recommend a doctor who prescribed it? Thank you! I do not want to sit here and just wait...
Title: Re: Hybrid H-100
Post by: WhatNext81 on June 18, 2018, 04:48:05 AM
Could members who are sending questions directly to Hybrid Medical please post their questions and the medical companies responses in this thread? It only seems fair and it would also be beneficial to others that are using the product and those who are considering trying it.
Title: Re: Hybrid H-100
Post by: diehardpatriot on June 18, 2018, 04:56:01 AM
Dr Goldstein in San Diego prescribed it to me
Title: Re: Hybrid H-100
Post by: TonySa on June 18, 2018, 10:26:39 AM
For other countries, perhaps consider a compounding pharmacy to make up a similar formula with the ingredients?
Title: Re: Hybrid H-100
Post by: WhatNext81 on June 18, 2018, 01:24:08 PM
"H100 is a patented and proprietary compound.  At this time, only Custom Rx in Wichita, Kansas, has the sole rights to legally produce this product in the US.  Other compounders may claim to use the "same" ingredients; however, the exact formula and quality standards are unlikely to be the same - so you cannot expect the same results or safety as documented in our study."

According to the company, one cannot expect the same results or safety if not provided by Custom Rx.
Title: Re: Hybrid H-100
Post by: philtered on June 18, 2018, 01:34:18 PM
  Doesn't seem fair that something is available that could help me in the acute stage i'm in and i can't get my hands on it because i'm in england. Shame you can't do online prescription and postage for something like this.
Title: Re: Hybrid H-100
Post by: tiagofil on June 18, 2018, 04:20:40 PM
.

Title: Re: Hybrid H-100
Post by: alec on June 18, 2018, 04:54:20 PM
@Tsanchez12369

All the pharmacies and doctors I asked couldn't help, because the formula is not precise enough or ingredients are not available in my country.

@diehardpatriot

thank you for sharing. I will look Dr.Goldstein up. Maybe that is an option to fly to San Diego!
Title: Re: Hybrid H-100
Post by: franklee on June 26, 2018, 07:29:02 PM
Hello all. Update.....began H-100 on May 30th. On June 8th, I awoke seriously dizzy. Vertigo type dizzy, lasted about 4 hrs and continued to feel slightly dizzy all day. I called Customer RX and spoke to pharmacist who stated could be H-100, possibly low Blood Pressure. He said reducing amount may eliminate issue but call my Doctor. My doctor seemed concerned but understood I wanted to continue treatment. I continued use at half amount until June 15th. The lightheadedness and lethargy had continued and now I was having difficulty walking up stairs. Completely winded. I was horribly disappointed because in such a short time (16) days I had noticeable improvement.
Plaque pain was reduced considerably, some plaque was clearly softening, I had added more than 1 CM to my traction length and was having nocturnal erections. There was no change in curvature.
On June 18th I emailed Hybrid Medical and informed them of my situation.I received a response in short order and was informed that Dr. Twidwell would be calling me at 9 pm central time if that was OK. Duh....yes. Lol.

Dr. Twidwell called and spent a lot of time, asking questions, giving anecdotal information, and while reminding me I was not his patient he explained a protocol he would have a patient of his try. He said he would call the compounding pharmacy ( Customer RX ) to ensure all was right on that end and that he would call me in the morning. And he did, leaving me a detailed and precise message part of which was that I should see my doctor to ensure I have no underlying issues before restarting H-100 at a lower dose. I was greatly impressed with Dr. Twidwell, the amount of time he gave me, his obvious concern and his belief in what he has developed.

Since I was away from home I decided to leave earlier than planned so I could see my GP in FL but not immediately. Surprise....on June 20th I was using my VED and was sure the large indent on the left side of my penis was much smaller. You guys know....don't believe anything you see today cause tomorrow it will look different. Lol. Yesterday, I said what the heck, let's see what this mess of a dick looks like. I was very happy, for those that don't know I have a hinge at base which makes erection unstable, 80 degree left curve maybe worse with very large indent on left side. I also curve up about 20 degrees which came on much later about 7 month into this horrible disease.

I have tried everything I knew to try since I was diagnosed, Pentox, Verapamil cream, all the known supplements discussed on this board, traction, VED and I just kept getting worse.
Yesterday my erection was much more stable. Indent has lessened. I am back on H-100 at a much lower dose and for the first time since this started feeling somewhat hopeful. I pray I can handle this dose or eventually increase it. At my age, I'm not looking for anything but pain free and old man intercourse. ;)


Title: Re: Hybrid H-100
Post by: TonySa on June 26, 2018, 09:39:07 PM

"According to the company, one cannot expect the same results or safety if not provided by Custom Rx."

Compounded Rx's are not proprietary, if we can get the percentages of each ingredient any compounding pharmacy w access to these meds can recreate it.
Title: Re: Hybrid H-100
Post by: WhatNext81 on June 26, 2018, 10:44:00 PM
Tsanchez-I'm not disagreeing, as I'm not familiar with the logeistics. But, that's what the representative said in their post on here. Maybe try emailing them as they've instructed us to do so and see what they say?

Franklee-thanks for keeping the line of communication open and sharing your expierence. That sounds kind of scary. Best of luck to you.

Whoever was asking for someone to fill the script and ship it-I'm guessing that would be illegal? We have laws against that kind of stuff in the US.
Title: Re: Hybrid H-100
Post by: Gabriel on June 27, 2018, 10:39:25 AM
Hi Franklee,

Thanks a lot for this report! I want to believe that your side effects are not so worrying compared to the tremendous progress you did recently. Your post is the kind that gives all of us some f**ing hope back!!!

Did we finally know if/when they intend to sell H-100 to Europe?? I'm getting confused with the RestoreX which I'm so looking forward to using too....
Title: Re: Hybrid H-100
Post by: bjelorad on June 30, 2018, 07:52:17 PM
How much does H100 cost?
For example therapy for 1 month.

Has anyone suceded to buy it in Europe?
Title: Re: Hybrid H-100
Post by: Freemason on July 01, 2018, 02:39:25 PM
Its around $250 a month...little bit pricey but i figured worth it for 3 months to at least try it since its non invasive.
Title: Re: Hybrid H-100
Post by: TonySa on July 01, 2018, 04:20:37 PM
I've been on it one month now in addition to Xiaflex, and no changes yet
Title: Re: Hybrid H-100
Post by: JasperTJ on July 04, 2018, 10:03:29 AM
I dont know if this is the real deal or not, but seems promising.
It's not available in my state (NJ)...does anyone have ideas how to get this? PM me if needed.
Any other results to speak of on here?
Title: Re: Hybrid H-100
Post by: P1992 on July 05, 2018, 12:16:28 PM
Hi jasperTJ,

                  Enter the hibryid medical website that has guidelines on how to get the drug, since you live in New Jersey that is a state that does not have coverage for h-100. A urologist must prescribe the drug and send it to the RX Custom pharmacy in Wchita, Kansas. The figure looks like it costs $ 290 a tube for a month. Hybrid Medical recommends using it for at least 6 months to have some effect. I am from Brazil and I have a friend who lives in your state in the city of Milltown and he was willing to help me if I wanted to go there to get the H-100 since only a urologist from the United States can prescribe, as I am already in the chronic phase, I do not know if it would be worth doing this. In addition I would have to go to NY city to consult with some urologist since this state has coverage for H-100. As you live nearby, you could do the same.
Title: Re: Hybrid H-100
Post by: LWillisjr on July 08, 2018, 03:19:14 PM
Whatever you do like this you do at your own risk. The forum is not responsible in any way.
Title: Re: Hybrid H-100
Post by: WhatNext81 on July 09, 2018, 02:11:21 PM
The product is already very expensive. Sounds like a lot of money to invest in something that isn't yielding much, if any results, by the members on this site.
Title: Re: Hybrid H-100
Post by: TonySa on July 09, 2018, 09:58:17 PM
I'm trying it but wouldn't recommend going to such great lengths when one will probably have as good if not better results from treatments that have been around such as xiaflex, VED, traction, low dose daily cialis and anti-oxidants.
Title: Re: Hybrid H-100
Post by: WhatNext81 on July 10, 2018, 12:49:46 AM
Agreed. I didn't mean to come across as negitive. I really hope that after 3 months we start to hear positive results. I just don't know how to separate the results as traction is strongly encouraged in conjunction with its use. 

Title: Re: Hybrid H-100
Post by: SF99 on July 24, 2018, 09:18:31 AM
Would anyone who was perscribed H100 mind giving the name of the doctor who helped them? I have been unable to recieve a script from any of the uros I saw. I live in the Northeast US, but any names would be appreciated  :)
Title: Re: Hybrid H-100
Post by: Pancreata on July 25, 2018, 08:13:16 AM
A reliable source for peyronie's specialists by state.

Peyronies | Peyronie's Disease, Syndrome Cure, Treatment, Surgery | ADPA (http://www.peyroniesassociation.org/)

Title: Re: Hybrid H-100
Post by: SF99 on July 25, 2018, 09:10:50 AM
Quote from: Pancreata on July 25, 2018, 08:13:16 AM
A reliable source for peyronie's specialists by state.

Peyronies | Peyronie's Disease, Syndrome Cure, Treatment, Surgery | ADPA (http://www.peyroniesassociation.org/)

Yes I have seen a specialist on this list. He did not recommend H100
Title: Re: Hybrid H-100
Post by: diehardpatriot on July 25, 2018, 01:26:32 PM
Okay. So I'm like 2 months into H100. Ive only been using 1 click each application (directly to the injured area) and it made 1 of my bottles last two months instead of one. It actually dulled my pain right away. I'm gonna go put an a limbxand say that I can only see H100 being effective once he active phase. Chronic phase maybe not.
Title: Re: Hybrid H-100
Post by: SF99 on July 25, 2018, 02:44:06 PM
[Full quote removed, please read rules regarding quoting - Admin]

That's great news! The pain has been killing me. Could you give the name of the doctor who perscribed you?
Title: Re: Hybrid H-100
Post by: diehardpatriot on July 25, 2018, 11:19:52 PM
Hey Sam. His name is DR Goldstein in San Diego. I honestly don't recommend him. Not that he's bad but he's not a skilled surgeon and he doesn't even prescribe pentox.  and if you know you may need surgery down the line I recommend another doctor. If surgery is out of the question Goldstein does xiaflex.  I know dr Levine in Chicago prescribes and advocates for it and maybe dr Lue in San Fran will prescribe it.
Title: Re: Hybrid H-100
Post by: TonySa on July 26, 2018, 10:01:54 PM
Dr Lue prescribed pentox for me until he could get the Xiaflex approved and started.  But since my primary doc was prescribing it as well it wasn't an issue.  I'd just ask your primary for it if the uro won't prescribe.
Title: Re: Hybrid H-100 - Loss of erection rigidity
Post by: Pancreata on August 11, 2018, 08:46:20 AM
Hi,

I have been applying H-100 2x/day for 4 weeks and have developed a noticeable drop in the rigidity of my erections. 

Am on 5mg of Cialis daily so before H-100 had no issue with ED or rigidity.

One of the components nicarpidine is a calcium channel blocker and can cause loss of erectile rigidity by lowering blood pressure. 

Has anyone experienced this?

I know Peyronies Disease also can cause ED, so this might be difficult to ascertain in some men, but any relative change might still be noticeable

Thanks!
Title: Re: Hybrid H-100
Post by: diehardpatriot on October 13, 2018, 12:17:34 AM
Pancreata: hey I haven't noticed a drop in my erection quality due to H100

UPDATE: all I can attribute H100 to is a reduction in pain. I do not have a normal case of Peyronie's like everyone else here so do not take my testimonial as something that'll apply to everyone. I have an injury that re occurs over and over... I believe that H100 keeps my mind off the pain for the most part.
Title: Re: Hybrid H-100
Post by: TonySa on October 13, 2018, 11:10:35 AM
It's very expensive if only addressing the pain.  Diclofenac sodium gel is generic and inexpensive.  Low dose available over the counter, and higher dose w prescription.
Title: Re: Hybrid H-100
Post by: diehardpatriot on October 13, 2018, 11:15:48 AM
Tsanchez. Thank you, I might benefit from using that once my H100 expires
Title: Re: Hybrid H-100
Post by: pey ron on October 14, 2018, 08:06:16 PM
After 4-5 months since starting the H-100 I have had some sudden progress. Not a 100% sure it's the H-100 though, given there are a lot of things I have been trying in parallel.

First I suddenly could no longer feel a large and hard plaque right below the glans, then my septum started feeling softer.
Title: Re: Hybrid H-100
Post by: diehardpatriot on January 22, 2019, 10:29:28 AM
I have some leftover expired h100. Should I still use it?
Title: Re: Hybrid H-100
Post by: Bent Ding Dong on February 24, 2019, 12:05:38 AM
With the lack of excitement in this thread about H100, is it safe to assume that it's not very effective in treating peyronie's? I'd love to give it a go but they only sell to certain US states and no other countries which is really limiting their sales reach and they only prescribe it to peyronie's in the acute phase so that rules me out completely.
Title: Re: Hybrid H-100
Post by: TonySa on February 25, 2019, 01:46:17 PM
I'm not excited about it, haven't heard any great outcomes and I think they are way to greedy in their pricing as it is a simply generic compounded medication made in the pharmacy.
Title: Re: Hybrid H-100
Post by: Bent Ding Dong on February 26, 2019, 04:50:53 AM
Yes and they state that it's only for the acute stages as they probably know it has no effect on the chronic stage.
Title: Re: Hybrid H-100
Post by: taller on June 15, 2019, 11:05:51 AM
I've been using it for a couple months and it's almost entirely washed away any pain I was dealing with. Felt like I'd bedded a blow torch one day and pain was gone in 30 minutes. It seems like it's slowed down progression of Peyronies Disease, at least, or maybe even stopped it. But I could be wrong. I have been only using the H-100 for treatment of my Peyronies Disease and my main dent is still minor 2 months later, while dents in areas that can't really be reached by the topical have appeared and nearly overtaken its severity. I'm no scientist, but I figure if the pain meds are getting that deep then the nicardipine must be too, which would be excellent.

But sometimes soon after application I get a cold tingly sensation that's pretty minor, but still concerned me a bit, seeing how this is a medication that has an impact on the vascular system I had concerns that it was doing something bad to the veins. I contacted the drug's developer and he said they'd never had this side effect reported before. Said to report any changes, and might have to stop if it gets much worse. But it hasn't really. This is prescribed for bends, but I only have dents and the scar isn't really that palpable so maybe that's resulting in too much absorption into regular tissue? One of their primary selling points is that it's totally safe, and you'd think that makes sense since this is probably a lower dose than having this all injected and I haven't read of many bad outcomes to that not having to do with the needle itself.

The first week I started it, I would get an erection every time I rolled onto my side to sleep, and still have one when I woke up. Must have been the veins opening up. The urologist who prescribed it for me didn't seem very knowledgeable about peyronies at all, and was pretty much just prescribing me whatever I asked for. Had to go to a specialist two hours away just to get it diagnosed so he would listen.

By the way.. I think it's making my nails softer too from handling it. My thumb nails are almost a centimeter now, and they haven't frayed or chipped yet like they usually would. But maybe it's just a diet change or something. Anyways...
Title: Re: Hybrid H-100
Post by: Christopher1 on June 15, 2019, 12:57:18 PM
Very interesting. Thank you for sharing.
Title: Re: Hybrid H-100
Post by: Gabriel on June 16, 2019, 03:18:18 AM
Yep, thanks a lot Taller, that's pretty good news!

Do we finally know when the stuff will be available to Europe?? Two years now and I'm still in pain, I'd try everything...
Title: Re: Hybrid H-100
Post by: Bent Ding Dong on June 16, 2019, 06:22:24 AM
I would like to try it too and have emailed them previously but they are not interested in selling to anyone who is not a US citizen. Also, they require a prescription now and only prescribe it to those who have peyronie's in the acute stage so it is impossible to use a parcel forwarding service to try it.
Title: Re: Hybrid H-100
Post by: TonySa on June 16, 2019, 02:19:53 PM
For pain, you can purchase the diclofenac sodium gel. 
Title: Re: Hybrid H-100
Post by: taller on July 05, 2019, 06:36:33 AM
An update. It seems like my condition may be starting to settle down. I've been fapping once a day for three days now, and not suffered the usual excruciating pain I would otherwise be dealing with. No noticeable increase of pain at all, actually. Gonna back off anyways to play it safe. Still feeling almost bruised between my legs, where it feels like there's a dent over half centimeter deep, but the pain isn't as bad as it had been the previous couple weeks. Tough getting the lotion down there, so not sure there's much I can do about it. The widest dent hasn't gotten worse than 3mm deep, so the size has been pretty much consistent despite the past month of excruciating pain and occasionally more severe sensations of tightness, which would eventually fade. I had even been wearing pajamas out everywhere because anything remotely constricting would cause more pain, and had been forced to jog indoors because I needed to hold my junk to keep it from bobbing around. Car rides.... hell. The pain relief of H-100 goes a long way, but sometimes I'm not sure there's a pain reliever in the world strong enough for certain cases.

My primary treatment up to this point has primarily involved the H-100, and maintaining an erection for between 30 minutes and a couple hours most days as a substitute for stretching and traction, which had grown too painful to do.

Hard to say how much H-100 has actually been helping my case though, after over two months of use which I started on my 5th month. It seemed to be slow-progressing to begin with, but then I'm not really sure how my progression compares to the average case. I went to see the same urologist a week ago who diagnosed me before I started H-100 treatment and he said that he couldn't find the plaque this time, but maybe it'd be easy to miss since my deformity was never that bad to begin with.

So in conclusion, I want to believe that it's been helping, but my inner skeptic doesn't want to convince people to buy this expensive product if it actually hasn't and maybe my case would've turned out minor anyways (not that I'm out of the water yet). I'm sitting on two extra months of doses right now, and depending on how things go from here I'm not sure what I'll do with them at $290 a pop. Though if I remember correctly, active phase can continue for a while after the pain has resolved right?
Title: Re: Hybrid H-100
Post by: taller on August 16, 2019, 09:50:41 PM
Fresh update. I can see why H-100 stresses the importance of daily stretching now. Went a week without getting an erection and when I tried to again, it was excruciatingly painful. The scar tissue had mostly built up in the latter half of the crease between my urethra and shaft, where the lotion has a hard time getting to. Took a week of forcing myself to get erections through the pain (of which the H-100 was unable to directly help with, unfortunately) before it went away. But it did go away. Things feel a bit tighter now, but I get the feeling that will resolve. I think the dent developed a bit more around the bottom around that time, but my fear of this disease and any long-term consequences from it are still at an all-time low. My dents have not gotten smaller, but seem to be otherwise stable for the most part.

That must have been the painful erections that other people have, where the scar tissue feels like it's ripping flesh from the tension. If that's the case, then it's a miracle that I was able to just make it go away like that. If anything, the H-100 was actually doing what it was supposed to do and made the scar tissue softer and more stretchy. I've been using the H-100 for about 3 months now I think. I'm at the point now where I feel like I can recommend this to people, particularly those earlier in the acute phase since I'm unable to testify to its ability to pierce through a thicker layer of scar tissue. I'd like to see more of what other people have to say about it. I've been the primary poster in this thread for a while now.
Title: Re: Hybrid H-100
Post by: Bent Ding Dong on August 16, 2019, 10:22:02 PM
I'd like to give it a try and post about it here but don't have access to it unfortunately.
Title: Re: Hybrid H-100
Post by: diehardpatriot on August 17, 2019, 12:47:17 AM
Taller. Glad to hear it worked for you, it did absolutely nothing for me in the pain department. But then again my diet was horrible, I was massively stressed out, and I was very acute.
Title: Re: Hybrid H-100
Post by: Alibaba on August 17, 2019, 01:06:57 AM
Quote from: TonySa on October 13, 2018, 11:10:35 AM
It's very expensive if only addressing the pain.  Diclofenac sodium gel is generic and inexpensive. 

Good information to know. I have it in tablet form but had no idea it cam in a get. Might be helpful to have around. Thanks Tony.
Title: Re: Hybrid H-100
Post by: taller on August 17, 2019, 09:38:02 AM
Diet could have something to do with it. I'm usually pretty strict with mine.
Title: Re: Hybrid H-100
Post by: diehardpatriot on August 18, 2019, 10:34:01 AM
What does "strict mean" strict so some people can mean whole wheat bread, oatmeal, and low fat foods. What kind of diet do you eat
Title: Re: Hybrid H-100
Post by: taller on August 19, 2019, 12:17:41 PM
I mean I eat a fruits and salad kinda diet..  eggs, tuna, oatmeal, stuff. occasionally slip underweight from it. But I've been pretty far off it lately.

Also short term update: my urethra appears to be sinking into my shaft fairly quickly now, and it feels mega weird. It's been freaking me out to the point of causing some Erectile Dysfunction, which is exacerbating the issue. Never thought I'd find myself viewing porn as a medical necessity.
Title: Re: Hybrid H-100
Post by: diehardpatriot on August 19, 2019, 01:59:51 PM
Dude you should consider cutting carbs and sugar completely, or living a fasting focused lifestyle (OMAD, 48 hours, ect)
Title: Re: Hybrid H-100
Post by: taller on September 12, 2019, 07:20:50 AM
Started keto. There has still been noticable, but trivial hourglassing over the past month. I'd say I'm still in the green, overall. This is probably the fastest its progressed. I'm half way through my last tube, and I'm not sure I'll buy another. Budget is pretty tight. I've been using a half dose on concentrated areas, and stretching it with regular emu oil (hopefully to some effect) when it dries up.
Title: Re: Hybrid H-100
Post by: taller on September 13, 2019, 07:10:08 PM
I thought I'd noticed the H-100 getting dryer over time as I used it, and I was right. It seems some of the emu oil has been leaking out of the bottom of my last bottle excessively as it separates from the rest of the lotion. It's been getting on my hands for a while now when I picked it up and I had no idea where it was coming from, but I put my hand on the bottom and it was pretty wet. I checked the bottom of my second to last bottle and sure enough there was some there too, but not nearly as much. Seems that it happens over time, hence why my last bottle is the worst since I ordered 3 month supply all at once. I'm concerned that the medication has had a reduced effectiveness as a result of the slightly noticeable dryness of it, and I'll be contacting Custom Rx about it soon. It's too expensive not to. I'll be buying some high quality emu oil from amazon to mix it myself as I apply it, and scraping some of it off the bottom. For a while I was under the impression that I was becoming immune to its pain-reducing effects, but maybe it's because there was less of the ingredient required for absorption.

Just set it on its side hoping to keep more from leaking and it left a small puddle on my table. Big oof. I mixed the lotion with the emu oil and was surprised to watch the white lotion disappear and leave just the oil behind as it completely absorbed into the skin, rather than eventually drying up on the surface. I forgot that was even supposed to happen since it's been so long.

Update: Custom Rx is replacing a full month supply for me, and having me ship back the old ointment. Wouldn't recommend getting more than 2 months at a time, despite the discount.
Title: Re: Hybrid H-100
Post by: taller on October 05, 2019, 11:45:44 AM
Uh... don't leave your H100 on the floor. Woke up to ants swarming it, same as they did my regular emu oil bottle a while back. Guess I know now why I keep finding lone ants in my bed. Can't imagine waking up to a couple dozen ants on my dick. YIKES. Luckily I haven't had any bites yet. Think I'm going to be elevating my bed again...
Title: Re: Hybrid H-100
Post by: diehardpatriot on October 11, 2019, 07:05:50 PM
Taller, ahaha ants on dick. Good call. Love the updates
Title: Re: Hybrid H-100
Post by: james1947 on October 16, 2019, 05:08:02 AM
QuoteThink I'm going to be elevating my bed again...
Just put anti ants powder around the bed legs.
A more serious solution, flood your room 8)

James
Title: Re: Hybrid H-100
Post by: pey ron on February 12, 2020, 03:58:42 AM
They quit issuing rebates. Now it's gonna be even more expensive :'(
Title: Re: Hybrid H-100
Post by: drew67 on July 12, 2020, 07:09:36 PM
has this worked for anyone?
Title: Re: Hybrid H-100
Post by: TonySa on July 12, 2020, 09:37:06 PM
I haven't heard any positive outcomes yet.
Title: Re: Hybrid H-100
Post by: Anbil on August 16, 2021, 01:20:26 AM
this is so stupid, it's 2021 and these moronic manufacturers still have not figured out a way to deliver medications into the tunica

if million dollar companies end up making such essentially useless products

then what hope do patients have of compounding an effective cream themselves