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Peyronies Disease TREATMENT Discussion Boards => Developmental Drugs & Treatments => Topic started by: kendotx on April 24, 2010, 11:15:15 AM

Title: Tissue Engineering
Post by: kendotx on April 24, 2010, 11:15:15 AM
Hey Guys – My name is Ken and this is my first post on the site. I'm 48 years old and was diagnosed with Peyronies in 1989 therefore I'm encouraged by some of the advances that are on the horizon such as tissue regeneration. Tissue engineering technology is here today! The technology exists today to fabricate and replace a complete corpora cavernosa using your own cells thus eliminating any tissue rejection issues. I base my statement on the following:

1.   Dr. Atala and his team from Wake Forest Institute for Regenerative Medicine has fabricated and surgically implanted functional Corpora Cavernosum into rabbits. The corpora cavernosum were generated by building a scaffold and spraying the scaffold with the smooth muscle and endothelial cells, and then allowed to grow. The new rabbit penises are functional and operated well.
2.   Dr. Atala's team has been surgically implanting functional bladders into humans for the past four years, thus reducing some of the learning curve associated with human subjects and tissue engineering.
3.   Dr. Badylak from the McGown Institute of Regenerative Medicine has a different approach to regenerating body parts. His team uses a substance called ECM, Extra Cellular Matrix, extracted from pig bladders. The substance is places on the injured body part and it provides signals and instructions to jolt the cells into regenerating themselves. Amazing

I think we should use networking and a collective writing effort to encourage further research including human subjects as soon as feasibly possible. There are a lot of us with damaged organs and psyches that have been waiting a long time for good news, I really think this could be it. One can go to the Wake Forrest Institute of Regenerative Medicine site for more info. CBS News also has a couple or three pieces on tissue generation, two on 60 Minutes, and one on CBS Sunday Morning. I attempted to post the links however this site will not permit posting links.
Title: Re: Tissue Engineering
Post by: Tim468 on April 24, 2010, 01:34:05 PM
Atala's work is amazing - I saw him speak when he came to my city and was so excited about it.

Unfortunately, there is limited funding for this research. I wrote to Dr. Gonzalez-Cadavid who is one of the best basic science researchers in this field and he is leaving it for a lack of funding.

If you have bladder cancer and a resection of the bladder and urinary incontinence, a reconstructed bladder (and the research into it) gets funded as "Cancer Research" - lots of money. "Sexuality Research" doesn't stand up next to "Cancer". For Bladder cancer, the numbers are: New cases: 70,980 per year; Deaths: 14,330 per year.

Peyronies affects anywhere between 0.5% to 8.9% of all men - meaning anywhere from 1.4 to almost 20 million men have Peyronie's Disease (this is prevalence - the number who have it - not the number who develop it in a given year, which is the incidence).

One could well argue that death is worse than Peyronie's, and so bladder cancer is more "important". I would argue that the importance of one disease does not mean that another disease is not important - both can be worthy of funded research.

I have long argued here that we need a separate funding mechanism for Peyronie's Disease, similar to how Cystic Fibrosis is studied through independent mechanisms funded through the CF Foundation. Of course, cute little kids dying of their disease get more donations than cranky older men who can't have sex the way they used to (and, yes, Noway, I know that you are young, as was I when I developed Peyronies - I am talking about perceptions).

Still eventually Peyronies will benefit from Atala's work. He did the rabbit penis studies as a "proof of principle" when I asked him why it had been done - he did it to show it could be done. Now, if we can only find a good post-doc in his lab who wants to work on it...

Imagine - one smart PhD funded by us (and paid a little more than the other young docs in Atala's lab)... We develop a fund and call Atala and say "Get one smart doc there to start working on this and we will fund him for 5 years". Do direct and indirect costs - make it 750,000-1,000,000 over five years, with the goal of developing a protocol that can be used to help men who have lost their penis to trauma (not rabbits), and we would be off and running.

Or, encourage the DOD to fund the trauma research (lots of soldiers have lost their private bits to explosive devices) and ask if we can fund a separate pathway for research on fixing Peyronies, and piggyback it to the DOD project(s) (I think Atala gets money from the DOD).

Dreamily,

Tim
Title: Re: Tissue Engineering
Post by: Fred22 on April 24, 2010, 03:47:23 PM
Quote from: Tim468 on April 24, 2010, 01:34:05 PM
Of course, cute little kids dying of their disease get more donations than cranky older men who can't have sex the way they used to .....Tim

Tim,

I know you realize from your own experience that Peyronie's creates more suffering for some than was implied by the above quote.  I could deal with not being able to "have sex the way I used to" if I could just be pain free.  I know for many, pain is a minor and temporary issue , or in many cases not an issue at all, but some of us have endured years of pain.  This is my primary issue, and from our discussions I know it's also an issue with you.  If not for the pain, my wife and I could have a relatively "normal" sex life (she actually prefers oral sex anyway).  I wonder every day why there is such a variation in this condition from one person to the next.  Some never have any pain, some for a number of months and it goes away (the "textbook" scenario), and then those of us who experience almost daily pain/discomfort for years.  I hope that those conducting research in this area are made aware that there are many who do experience varying degrees of pain (sometimes excruciating) on a daily basis. 

Fred 
Title: Re: Tissue Engineering
Post by: ComeBacKid on April 25, 2010, 02:25:14 AM
Fred,

I think this disease varies greatly from person to person from everything I've heard over the last decade.  Some people have indentations, others bends, twists, thinning, venous leakage.  It just causes deformities of all kinds.  Right now I've got a huge stock of pentox and intend to stay on it over the long haul.  We can garner the interest of the medical community by growing our membership to show there are many sufferers, and catch the attention of the private market research companies, looking to make a product and make a profit doing so.  All the more reason to get involved in our mass mailing campaign to recruit new members.  This month we are at a pace to beat last months numbers for new registrations.  We are registering almost 3 people per day, which is a good clip, but escalated to 4 or 5 per day would be incredible growth for the PDS.  I think its hard for us to be called legitimate in size until we hit the 10 thousand member mark.

Comebackid
Title: Re: Tissue Engineering
Post by: kendotx on April 30, 2010, 05:10:09 PM
I wrote a letter to the Wake Forest Institute for Regenerative Medicine basically asking when they expect human trials to begin on penile regeneration. They responded in less than a week with a personally signed letter. The letter stated that the institute continues to actively work in this area however it is impossible to provide a time estimate for bringing the technology to widespread clinical use. I was very pleased they responded in such a quick fashion and I want to contribute to their progress therefore, I made a recurring credit card donation on the institute's website. I have provided the web address in the event anybody else is interested in donating. Perhaps if the majority of this site's members were to contribute, it may help with that funding problem that was mentioned earlier.

I am simply fascinated with this new technology and I think everybody would have to agree that new working corpora cavernosa generated from one's own cells is far superior to anything else available today. So pass the word - Donate. The website is:

wfubmc.edu/wfirm/ - The  link for donations is on the right side titled "Ways to Give."
Title: Re: Tissue Engineering
Post by: Manrico on May 04, 2010, 07:05:08 PM
I'm a little confused by this.  How much of a solution to our problem would this be?  It sounds to me like it might solve it.  Maybe a little unpleasant, but it seems the end product might be as good as new?  If this is the case, why aren't we more excited by it?  Is it just a matter of a little money and poof we have a solution? 
Title: Re: Tissue Engineering
Post by: kendotx on May 06, 2010, 05:28:48 PM
Hi Manrico - I agree, I am also puzzled at the lack of enthusiasm. Perhaps its due to the funding problem for Peyronies that Tim mentioned earlie, or perhaps it simply that tissue regeneration still seems like science fiction to most, I don't know. Dr. Atala is the chief of the Department of Urology at Wake Forest Baptist Medical Center so you know he's seem many Peyronie's patients who are desperately seeking a solution to their curved penis problems. Dr. Atala is also the director for the Wake Forest Institute for Regenerative Medicine, thus he has a lot on his plate and I'm sure that many other projects take priority over Corpora Cavernosa. Having said that, I'm also sure that as the chief of Urology, he seeks a solution for patients with penile problems. That's my best guess anyway, who knows I could be way off base. I'll say this, I certainly have hope and I really think this new technology could solve our problem.  - Ken
Title: Re: Tissue Engineering
Post by: ComeBacKid on May 06, 2010, 05:47:22 PM
I'm not confused by lack of enthusiasm, most people don't even know what peyronies disease is, or laugh off a bent penis joke.  Penis reconstruction surgery isnt that common int he united states.  On the other hand surgeries on women are much more common. We need to show the market there is a demand for a product to cure peyronies and DC and then you will see more investment in a solution to try to cure it.  No one will lay down capital to build a housing development if there isnt a demand for housing.  The higher the demand, the more developers and developments spring up.  The PDS can be a tool to help facilitate interest by showing a huge membership.  The bigger our membership, the more credit we will get when we write government agencies, doctors, institutions, and research labs, drawing more attention to ourselves.  You have to remember, people don't do things for the hell of it, they do it to make money.  They are gong to build/create/construct things which can make them money. Thats the whole point of our mass mailing project, to get every single possible person registered on here , including doctors, and spread word of our existence, and offer a place for support and education.  I'm kind of puzzled people are confused that doctors and companies AREN'T interested in investing millions in research for a rare disease. ???

Comebackid
Title: Re: Tissue Engineering
Post by: ocelot556 on May 10, 2010, 03:13:51 AM
I'm surprised. If they have learned how to regenerate the tissue in the penis, and implanted new working tissue in rabbits -- couldn't they regenerate the tissue in the penis to be... oh, say... 5 or 6 inches longer than the original member?

I suppose this can't be true, because if it were -- how hard would it be to find an investor for that? If it worked, you'd be the world's richest man! :D
Title: Re: Tissue Engineering
Post by: ComeBacKid on May 10, 2010, 03:58:48 AM
If my memory serves me correct, this was a rabbit penis right?  Thats still a bit off from regrowing a human male penis and attaching it however they would do such a thing, and not having the body reject it.  I also thought they could inject cells or genes into the penis to regrow over the old tissue, thats just a theory though...

Comebackid
Title: Re: Tissue Engineering
Post by: j on May 10, 2010, 01:21:59 PM
I think the liability issue would be a huge barrier.  In fact that may be a big reason why more reasearch isn't happening.   I'm somewhat surprised that Auxilium had the guts to try penile injections of Xiaflex, even though I'm sure the patients signed more waivers than a Space Shuttle pilot.   

If some surgical group decided to do this, the cost would be astronomical. Would insurance pay it, just to 'improve' the sex lives of baby boomers? I doubt it.

In my opinion this sort of treatment is decades away.  Disclaimer: I tend to be a pessimist.
Title: Re: Tissue Engineering
Post by: Skjaldborg on May 10, 2010, 02:59:53 PM
Quote from: j on May 10, 2010, 01:21:59 PM
Would insurance pay it, just to 'improve' the sex lives of baby boomers? I doubt it.


As a 31 year-old with Peyronie's, I would hope that the medical establishment knows that old men aren't the only ones dealing with this disease. I also hope that they know that some men have such terrible curvature, pain, deformity or Peyronie's-induced ED that sex is impossible, so allowing them to have a functioning organ is not just "improving" their sex life, it's about improving their quality of life.

-Skjald
Title: Re: Tissue Engineering
Post by: ComeBacKid on May 10, 2010, 05:45:14 PM
They don't care if your suffering, the question is can money be made selling the product?  As for J's assessment of xiaflex, if it works I don't care if insurance covers it or not, I mean obviously I'd like them to, cause thts the purpose of insurance, but if they don't I'll pay out of pocket for it. 

Comebackid
Title: Re: Tissue Engineering
Post by: Tim468 on May 11, 2010, 09:55:14 AM
Fred,

I completely agree about the suffering engendered by Peyronie's. But if you go look at the cute kids on the CFF site (www.cff.org) and you then go look in the mirror what do you see? I see an average looking middle aged man staring back at me compared to a beautiful baby.

So how would we market this? I think one goes to the people with the problem - the men with Peyronie's Disease. I may not get others to contribute, but if every man with Peyronies Disease gave a dollar, there would be 20 million bucks to spend gathered in one day (in the US alone - just imagine a global effort).

My point is that these goal are not mutually exclusive. We should be able to pay for cancer research and also for research into sexual functioning.


ComeBackKid,

Some of us would settle for a rabbit penis if it worked! I am not quite there yet at least!


Ocelot,

Actually, given that my own tissue used as a source of stem cells to generate a new penis would theoretically be at risk for developing Peyronies all over again, I think it is *entirely* reasonable to start out a few inches longer and thicker than I ever was!

Just saying...

Tim
Title: Re: Tissue Engineering
Post by: Skjaldborg on May 12, 2010, 12:42:28 PM
Research into regrowing tunica will probably have to be "piggy backed" on to some other research, such as growing other forms of tissue in the body. If they figure out how to reliably grow bone and nerve tissue over some form of matrix and safely place it in the body, it stands to reason that doing the same thing for the penis would be in the realm of possibility.

On a side note, I wonder how many young men have lost sexual functioning due to IED blasts in Iraq and Afghanistan. It's got to be a significant and sad number. You get a wounded warrior with no legs sitting next to his wife and the funding problem would not be so bad as it is now. Regrowing penile tissue would be a boon to many forms of penile trauma, not just Peyronie's, or you know "The hilarious bent penis disease that only old men get™".

-Skjald

PS The quotation marks indicate sarcasm.
Title: Re: Tissue Engineering
Post by: newguy on May 12, 2010, 12:59:14 PM
This certainly does seem like an area of promise. If real attention was paid to it, I'm sure that rapid progress could be made in the field of peyronie's. Of course for reasons stated, we're probably going to be playing a waiting game. It seems to me that progress is being made in various areas, just not very fast.

Once a emthod like this is available, I wonder how many men will come out of the woodwork and seem treatment for peyronie's.

Title: Re: Tissue Engineering
Post by: Fred22 on May 13, 2010, 02:51:53 PM
Tim,

If this treatment pans out, what is your professional medical opinion as to when it might be offered to the general public? It's my guess it would take years , but I'm not familiar with the procedure.  Also, how would it work?  Would they have to remove the diseased tissue and inject stems cells to grow new tissue or......?

Fred
Title: Re: Tissue Engineering
Post by: ComeBacKid on May 14, 2010, 03:18:36 AM
Quote from: Tim468 on May 11, 2010, 09:55:14 AM



Ocelot,

Actually, given that my own tissue used as a source of stem cells to generate a new penis would theoretically be at risk for developing Peyronies all over again, I think it is *entirely* reasonable to start out a few inches longer and thicker than I ever was!

Just saying...

Tim

Possibly not for everyone though, as my peyronies disease started from a severe trauma, I didn't just get it!

Comebackid
Title: Re: Tissue Engineering
Post by: kendotx on May 23, 2010, 11:41:30 AM
There seems to be confusion about exactly what parts are regenerated and how the process works. If one reads the article titled "Laboratory-Grown Replacement of Penile Erectile Tissue In Animals Suggests Potential to Benefit Patients," on the Wake Forest Institute of Regenerative Medicine website, you can get a brief explanation of what happens. I will attempt to paraphrase the content.
The process only regenerates the Corpora Cavernosa, other penile tissue such as the glans, urethra, and skin remain intact.
-   Smooth muscle and endothelial cells are harvested from the existing erectile tissue.
-   Cells are multiplied in the laboratory
-   A 3D scaffold is molded using biodegradable material designed to dissipate after the organ has developed.
-   The scaffold in implanted into patient.
-   Cells are injected into the scaffold using a two step process allowing a great number of smooth muscle cells to be introduced.
-   The Corpora Cavernosa begins to develop and continues to do so until maturity level is reached. The entire process took about a month in the rabbit model.
According to an April 14, 2010 "Wired Science," Article, the rabbits had fully functional penises at the conclusion of the experiment. Using logical thinking one could conclude the following;
-   A rabbit, although not human, has the same basic penile structure; Corpora Cavernosa, urethra, etc.
-   Functional human bladders have been regenerated and implanted for several years now, why is it so difficult to believe that the same is not possible with erectile tissue.
-   The cell's origins are from one's own body therefore eliminating rejection issues.
I believe the procedure is certainly feasible and I think the technology already exists. It's simply a matter of refining the process to ensure safety and effectiveness.  Perhaps funding for this type of research is a concern, but given the large number of men with Peyronie's disease, seems like donations alone could account for significant progress; just a thought.
Title: Re: Tissue Engineering
Post by: Fred22 on May 25, 2010, 03:13:30 PM
Quote from: kendotx on May 23, 2010, 11:41:30 AM
There seems to be confusion about exactly what parts are regenerated and how the process works. If one reads the article titled "Laboratory-Grown Replacement of Penile Erectile Tissue In Animals Suggests Potential to Benefit Patients," on the Wake Forest Institute of Regenerative Medicine website, you can get a brief explanation of what happens. I will attempt to paraphrase the content.
The process only regenerates the Corpora Cavernosa, other penile tissue such as the glans, urethra, and skin remain intact.
-   Smooth muscle and endothelial cells are harvested from the existing erectile tissue.
-   Cells are multiplied in the laboratory
-   A 3D scaffold is molded using biodegradable material designed to dissipate after the organ has developed.
-   The scaffold in implanted into patient.
-   Cells are injected into the scaffold using a two step process allowing a great number of smooth muscle cells to be introduced.
-   The Corpora Cavernosa begins to develop and continues to do so until maturity level is reached. The entire process took about a month in the rabbit model.
According to an April 14, 2010 "Wired Science," Article, the rabbits had fully functional penises at the conclusion of the experiment. Using logical thinking one could conclude the following;
-   A rabbit, although not human, has the same basic penile structure; Corpora Cavernosa, urethra, etc.
-   Functional human bladders have been regenerated and implanted for several years now, why is it so difficult to believe that the same is not possible with erectile tissue.
-   The cell's origins are from one's own body therefore eliminating rejection issues.
I believe the procedure is certainly feasible and I think the technology already exists. It's simply a matter of refining the process to ensure safety and effectiveness.  Perhaps funding for this type of research is a concern, but given the large number of men with Peyronie's disease, seems like donations alone could account for significant progress; just a thought.


Id gladly contribute if I knew the money would go to the correct place.  I saw the program on 60 Minutes and these doctors were performing miracles.  If we can organize a way to help fund this count me in!
Title: Re: Tissue Engineering
Post by: SSmithe on May 26, 2010, 01:59:07 AM
Dito... I would gladly donate to an organization if I knew it was going directly to Peyronie's research.
SSmithe
Title: Re: Tissue Engineering
Post by: Fred22 on May 26, 2010, 03:54:14 PM
Quote from: SSmithe on May 26, 2010, 01:59:07 AM
Dito... I would gladly donate to an organization if I knew it was going directly to Peyronie's research.
SSmithe

I was speaking specifically of this tissue engineering work.  I really believe it can be done.  If they can make a bladder why not a penis.  If you didn't see the 60 Minutes show here's the link.  It's amazing.  http://www.cbsnews.com/stories/2009/12/11/60minutes/main5968057.shtml
Title: Re: Tissue Engineering
Post by: SSmithe on May 27, 2010, 03:13:53 AM
Fred22,
That 60 minute video is freaking amazing!  That second segment where the powder helps the body regrow organs is really cool.  I agree with you, of course they can help with Peyronies Disease.... How do we  bring our cause to their attention??
Title: Re: Tissue Engineering
Post by: Fred22 on June 01, 2010, 03:04:17 PM
Quote from: SSmithe on May 27, 2010, 03:13:53 AM
Fred22,
That 60 minute video is freaking amazing!  That second segment where the powder helps the body regrow organs is really cool.  I agree with you, of course they can help with Peyronies Disease.... How do we  bring our cause to their attention??


Told you it was amazing!  Tim might know more about how to bring our cause to their attention.  If I remember correctly he said he either met Dr. Attala (sp.?) or heard him speak.  To me this is the most promising research going on.

Fred
Title: Re: Tissue Engineering
Post by: kendotx on June 02, 2010, 05:18:56 PM
Fred,
Dr. Atala is the director for Wake Forest Institute for Regenerative Medicine and he is also the Chief of Urology at Wake Forest University Baptist Medical Center. During Dr. Atala's urological career, I'm sure he has seem many Peyronies patients thus he should be very well aware of our plight. Anyway I simply wrote a letter indicating my interest in the program, and I'm happy to report they responded within a week. Perhaps we could all contribute to our own well being by doing the same. Conceivably, WFIRM administrators would realize how much demand there is for this research simply by receiving letters from Peyronies sufferers. I could be wrong but it certainly couldn't hurt for many of us to write and express our interest in the program. The address for Wake Forest Institute for Regenerative Medicine is listed below, I encourage everybody to write. Thanks

WFIRM
Richard H. Dean Biomedical Building
391 Technology Way
Winston-Salem, NC  27157-1083
Title: Re: Tissue Engineering
Post by: SSmithe on June 02, 2010, 06:47:15 PM
Kendox,
I will definitely write a letter about my interest in the WFIRM as a Peyronie's patient.  Thanks for providing the address.  Any advise on how you think is best to word the letter?  IE What will get their attention, take me seriously, etc.  Do I write it to Dr Atala or Richard Dean?  Perhaps their response to you would shed some light on their thinking.
Thanks,
SSmithe
Title: Re: Tissue Engineering
Post by: kendotx on June 03, 2010, 09:27:50 PM
I wrote a letter to Dr. Atala and his staff responded. I simply said that I was interested in the corpora cavernosa regeneration program and asked if he could predict when human trials would begin. Dr. Atala's staff responded by saying that the program is active and research continues however, it is not possible to predict when the technology will be widely available in a clinical setting. I believe the more of us that write the more interest will be devoted to the project, providing hope for the future. Thanks

Ken
Title: Re: Tissue Engineering
Post by: ComeBacKid on June 03, 2010, 11:00:53 PM
Ken,

Would you be interested in drafting a letter on behalf of the PDS, we could reach out to him as a site, after we kick around the idea, if people think it is something worth pursuing. Please post any replies in the Advocacy, Awareness, and Activism section if your interested.

Comebackid
Title: Re: Tissue Engineering
Post by: Fred22 on June 04, 2010, 12:00:59 PM
Quote from: ComeBacKid on June 03, 2010, 11:00:53 PM
Ken,

Would you be interested in drafting a letter on behalf of the PDS, we could reach out to him as a site, after we kick around the idea, if people think it is something worth pursuing. Please post any replies in the Advocacy, Awareness, and Activism section if your interested.

Comebackid

Pardon my ignorance, but where is the Advocacy, Awareness and activism section?
Title: Re: Tissue Engineering
Post by: newguy on June 04, 2010, 01:40:56 PM
Quote from: Fred22 on June 04, 2010, 12:00:59 PM

Pardon my ignorance, but where is the Advocacy, Awareness and activism section?

https://www.peyroniesforum.net/index.php/board,11.0.html
Title: Re: Tissue Engineering
Post by: Fredca on June 15, 2010, 05:49:27 PM
This seems to be the most interesting news in some time on the subject we care so much for.

Apart from poor marketing situations, which I am not so convinced of, likely another factor is at hand as to why this technique is not implemented in humans yet. First of all we do not know whether the rabits were in pain or not and how the 'functionality' was achieved. Also there are no reports of tissue asphyxiation and other complications or the prevalance rate of it.
The Doctor in question has proven that it 'can be done' but that on its own doesnt mean anything. We are missing a lot of information that would justify becoming enthusiastic.
Title: Re: Tissue Engineering
Post by: peyroninsidepglans on September 18, 2010, 01:49:23 PM
Okay so I think if they can regrow a finger they can regrow a penis i am a graphic artist and make websites so i have had enough of not getting it up i want some some suppor in trials in this subject in theory you should be able to regrow a penis

http://www.youtube.com/watch?v=AppsEtEGzSA
Title: Re: Tissue Engineering
Post by: newguy on September 18, 2010, 05:56:59 PM
This thread on tissue engineering might be of interest to you:
https://www.peyroniesforum.net/index.php/topic,1191.msg25912/topicseen.html
Title: Re: Tissue Engineering
Post by: skunkworks on September 19, 2010, 12:07:52 AM
Quote from: peyroninsidepglans on September 18, 2010, 01:49:23 PM
Okay so I think if they can regrow a finger they can regrow a penis i am a graphic artist and make websites so i have had enough of not getting it up i want some some suppor in trials in this subject in theory you should be able to regrow a penis

http://www.youtube.com/watch?v=AppsEtEGzSA

They did not regrow a finger, they regrew a small pad of flesh that was cut off the tip.
Title: Re: Tissue Engineering
Post by: UK on March 09, 2011, 02:17:42 AM
Breakthtrough in engineering urethra, so interesting to see what they can do for Peyronie's, would still involve surgery most likely.

http://www.bbc.co.uk/news/health-12666171
Title: Re: Tissue Engineering
Post by: fubar on March 09, 2011, 01:56:45 PM
UK

Thank you for posting the article link. Just yesterday I was reading a different article about this regeneration growing cells from the rabbit's to restore or grow a penis.It took them 18 years to accomplish this.

After they do what ever they actually do they eventually returned the rabbits to the cages.They immediately do what bunnies do procreate.They were successful as a few of the females became pregnant.

So bunnies and human bladders and ureathras. I did read that the cells in erectile tissues are more complicated to grow. That the cells are more complexed.Hopefully in the near future we will know more.Everthing I read is a couple years old.

I imagine regenerative medicine will make great progress because it could treat so many issues. Diseased organs the heart, kidneys, and liver These seem to be the major organs they are interested in.So a cure may not be to far away.However I'm sure it will take time and I have alot of that.

Fubar
Title: Re: Tissue Engineering
Post by: fubar on March 09, 2011, 09:37:35 PM
Uk

Found another article on organ regeneration this afternoon on the national geographic magazine site titled miracle grow.It begins telling the reader How there are over 100,000 people alone in the US waiting for organ transplants.18 of them die every day.The donor and the patient have to be closly matched and often as we know the body rejects the organ.Somthing new incubating in Labs could be a solution. Bioartificial organs grown from the patient's own cells.Thirty people have received lab grown bladders and other organs to be produced in the future.

Anthony Atala developed the technique for growing a human bladder.Then the article tells how the process begins and how it works pretty cool stuff.How it is all started by normal cells from the patient's diseased organ,  then multiply them in a petri dish then apply them to a scaffold made of protien and collagen. Then. The bladder is incubated at body temperature for 6 to 8 weeks.

Atala's team is now working on 22 organs and tissues  including the ear something some of are soldiers are missing.Other labs are also working on growing organs so at least we know there are at least a several or many working with this science.

This article is interesting and there is   more to read of value its not a long article. It is relevant as its this months National Geographic magazine.


Fubar
Title: Re: Tissue Engineering
Post by: Hawk on March 12, 2013, 11:00:52 AM
This entire area of Wake Forrest's website is pretty interesting.  Click around and check it out.  Our Story - WFIRM - Wake Forest Baptist Medical Center (http://www.wakehealth.edu/Research/WFIRM/Our-Story/Our-Story.htm)
Title: Re: Tissue Engineering
Post by: damian on May 07, 2013, 06:00:56 PM
I had no idea how far science has come. I was shocked as I saw literally a printer for cells on some youtube video. That's very promising. If I only had this disease later and not with 24 :( . When I'm 40 (in 15 years) , I'm sure peyronie's will be a disease to laugh at. :D


I found an interesting article about tissue engineering. They made grafts which can replace the TA of dogs. After half a year of implant, I think,  these grafts could barely be differentiated from normal tunica. Dogs seems to have a cure for Peyronies Disease :D
Title: Re: Tissue Engineering
Post by: Nescio on May 11, 2013, 07:35:34 PM
Could you please post the link? That should be an interesting read. I think I have found the article. From what I have read so far, I do not think it is, strictly speaking, a form of tissue engineering. The researchers harvested TA tissue from healthy dogs, decellularized it and used the Extra Cellular Matrix that was left as grafts. Even if it proves to be an ideal graft for humans, where would one get healthy TA tissue except from cadavers?
PS. I have attached the article to this post.
Title: Re: Tissue Engineering
Post by: lgrace on May 23, 2013, 05:20:00 PM
Check out this amazing article in the "hope dies last" category.

I am well aware that a treatment derived from these findings is still years or possibly decades away. It is one thing to isolate one component that plays a role in an amphibian's regenerative abilities, but it is definitely another to find a way to use it as a treatment for mammals/humans.
The article does however state its possible use for fibrosis.

Humans may soon regenerate damaged body parts like salamanders (http://io9.com/humans-may-soon-regenerate-damaged-body-parts-like-sala-509269956)


Title: Re: Tissue Engineering
Post by: stavraki on May 29, 2013, 09:50:26 PM
Quote from: kendotx on June 03, 2010, 09:27:50 PM
Quote edited by moderator

Hey there fellas,

I wrote to Dr Atala and like everyone got a really quick reply, within a week.  He said just what he said to all of you.

I also read that he's applied for FDA approval for human trials somewhere (saw it here, too, although the posts were dated 2009).

Organ printing is looking like big business, and I've noticed corporations and research organisations spawning over the world.  We just got one here in Melbourne, Oz.  I'm not so sure the technology is that far away.

cheers
stav
Title: Re: Tissue Engineering
Post by: Nescio on June 08, 2013, 09:46:17 AM
Thanks for sharing, Igrace.
Title: Re: Tissue Engineering
Post by: hopeful7 on June 13, 2013, 12:39:32 PM
Current technology grafting surgery (which I have experienced) has limitations because the venous graft does not retain the properties of the cavernosa.  It does not expand/contract the same way as the original CC; does not respond to the chemical signals. However, it can sometimes work because the rest of the CC is undamaged.

Doctors are able to manufacture many kinds of tissue outside the body and currently do so for grafting in heart and GI tract. 

Rather than regenerating CC tissue in the body, the next (easier) step should be to take a cell culture and grow CC tissue in a dish, then use it as grafting material in conventional surgery.  This will improve the success rate of grafting.

This makes perfect sense for people who have injury to the CC.  However, peyronies puts a wrinkle in this because there is a predisposition of the tissue towards scarring, so initial trials would be complicated by that. 

IMO, there is no reason they should not use manufactured tissue as grafting material, and I do not see any reason they would need special trials or studies, as they use a variety of materials in this surgery, technique/materials that were borrowed from other kinds of reconstructive surgery.  Manufactured CC tissue should be the standard of care in grafting surgery.
Title: Re: Tissue Engineering
Post by: funnyfarm on June 13, 2013, 08:06:53 PM
This may be true but isn't stem cell treatment about 10yrs ahead of manufactured CC ? 
Title: Re: Tissue Engineering
Post by: MarcPierre on January 07, 2014, 04:32:09 AM
Thanks for this valuable information, Because I never heard this types of thing and information.
Title: Re: Tissue Engineering
Post by: 29mUK on October 07, 2014, 03:50:45 PM
My spidey senses detect this is probably further away than the article suggests, but nonetheless it's potentially exciting news... Laboratory-Grown Penises Ready To Be Tested In Humans | IFLScience (http://www.iflscience.com/health-and-medicine/laboratory-grown-penises-ready-be-tested-humans)
Title: Re: Tissue Engineering
Post by: james1947 on October 07, 2014, 04:18:33 PM
Good catch 29mUK.
A big step forward by Dr. Atala. We have a topic regarding his activity:
Letter To Dr. Atala (Tissue Engineering) - Peyronies Society Forums (https://www.peyroniesforum.net/index.php/topic,1227.0.html)
Hope he is working also to fix Peyronies without the need of a transplant.

James
Title: Re: Tissue Engineering
Post by: stopthismadness on October 07, 2014, 10:48:24 PM
An update on Wake Forest's quest to regenerate penile tissue. Very encouraging and hope very much that it proves to be safe.

The penises grown in a lab: Scientists say organs could be tested on humans within five years 

The lab-grown penis: approaching a medical milestone | Science | The Observer (http://www.theguardian.com/education/2014/oct/04/penis-transplants-anthony-atala-interview)
Title: Re: Tissue Engineering
Post by: mrg91 on November 01, 2014, 09:24:10 PM
Hello,2years ago my penis get damage cause stupid pump device.my penis nerves damaged a lot like this story
Link to commercial site deleted by moderator - James
. my situation is different with you that suffer peyronies . now i wanna know is penis regeneration really possible or it is just science fiction?? and did you send email to dr.atala for more information? i am just 23 and my horror situation occured when i was just 21 years old... thank you a lot.
Title: Re: Tissue Engineering
Post by: edzo67 on November 02, 2014, 01:00:42 AM
When I first heard about this about a year ago, I sent them an email volunteering for any human trials when the time comes.
The following day I received a phone call from the Dr's assistant and she asked me for my backround with Peyronies disease and told me that they would add me to their list of potential candidates for trials. They are doing wonderful work. I hope they come up with a positive solution in my lifetime. Knowing that they are hard at work to help people with severe penial injuries gives me some ray of hope and something to keep my chin up. You all can relate to that kind of desperation and the ups and downs of keeping faith. I f I had a million dollars? I would put it into their research....Gladly and without hesitation
Title: Re: Tissue Engineering
Post by: mrg91 on November 02, 2014, 01:55:17 PM
thank you Mr.edzo67 for answer and i hope like you that in near future they do it and your answer encourage me although i know this medicine search is very complicated and really hard.
Title: Re: Tissue Engineering
Post by: Lollaro on November 11, 2014, 04:23:50 AM
I read this post .. is very interesting...

Do you think this could be a way to cure Peyronie's final?
Title: Re: Tissue Engineering
Post by: Jack1909 on February 17, 2015, 05:21:01 AM
I read a lot about Atala's studies..the most important obstacle to overcome is obtaining FDA's approval to start human trials for lab-grown penises. As far as I know, He already created successfully more than a dozen of human penises...the next step is trials. We are close. He already created and implanted two vaginas in two girls who suffered from a disease that prevented them from growing it. Practically they were without vaginas. Now they live a perfect normal life and they have intercourse with feeling.
About men, He created urethras in some guys who did not have them perfectly grown and it works as our urethra work.
Title: Re: Tissue Engineering
Post by: mrg91 on February 22, 2015, 12:26:25 PM
drea jack1909.like many of other person at this forum i suffer sever penis injury(not peyronies but nerve and sever b.c muscle injury cause wrong penis pump use). i really have very horrible situation and i lost my hope about every thing.every day i just sit and think about my stupid mistake for making my penis bigger and i cant found anything to calm me down.i contact with wakeheath by email and they told me we are continue our research but they never told me when it will be possible.only at news i see it could be possible near future like 5 years later.i am tired of being waiting since 2 years ago till unknown possible future(that i even dont  know regenerative medicine can solve my problem or not).i really dont know what should i do.. i ever think to total phallo(my penis is now just useful for urination)as i know its not functional and cant solve my physical and psychological problem and its very expensive.if you know something new and hopeful about dr.atala please tell us.thank you my friend.
Title: Re: Tissue Engineering
Post by: james1947 on February 22, 2015, 05:12:19 PM
mrg91

Can you say more regarding your symptoms?
Did you see already a Peyronies specialist?
Why you think that the only solution for you is Tissue Engineering?
If you will give us some more details regarding your symptoms and what you have done to treat them, other members will be able to give you they opinion.

James
Title: Re: Tissue Engineering
Post by: mrg91 on February 22, 2015, 08:24:19 PM
hello dear james. ok,please see these addresses(i know its a lot but these describe my problem)
1. Link to commercial site deleted by moderator - James  (this includes another peson and my post that i describe,number8 comment is my describe) 
2. Link to commercial site deleted by moderator - James 
3. Link to commercial site deleted by moderator - James 
  in one sentence i suffer sever penis nerve damage and b.c muscle injury.
also another site that i can tell is:
Link to commercial site deleted by moderator - James 
sorry for these lots of sitse but you can read some of them fast and know what is my problem and some others like me.

thank you james for your reply.
   
Title: Re: Tissue Engineering
Post by: james1947 on February 23, 2015, 06:39:45 AM
mrg91

I asked a few simple questions from you to understand better your problems and the answer was 4 links to commercial site.
And then, reading again all your posts, I found that you had one more link to the same site.
Links to commercial sites are not allowed on this forum, please read the forum rules and obey them!!!


James
Title: Re: Tissue Engineering
Post by: mike jones on June 10, 2015, 09:12:00 PM
I was wondering if anyone knows if regenerating the erectile tissue will also mean regenerating the dorsal vein as I am afraid mines might be damaged
Title: Re: Tissue Engineering
Post by: drew67 on June 10, 2015, 10:06:09 PM
Looks like Atala will be able to replace the fibrous tissue much sooner than the predicted 5 years before they'll be able to replace an entire penis.
Title: Re: Tissue Engineering
Post by: mike jones on June 11, 2015, 03:21:19 AM
Dr. Atala said they will perform clinical trials within 5 years. I'm not to sure where but I have read somewhere that they will perform these trials in the summer of 2016. However, even after these trials take place it will be a couple of more years before the treatment will be clinically available.
Title: Re: Tissue Engineering
Post by: Jack1909 on June 11, 2015, 04:01:48 AM
I can understand that everybody here is focused on Atala's work, probably because no one as him has pronounced about engineering tissues, but, I have to point out that no many in here need a total renew of their penis. And, as Atala told many times, he is working on misses parts to replace rather than fixing them. This what does it means? This means that we should expect to overcome our problems sooner.
Title: Re: Tissue Engineering
Post by: Jack1909 on June 11, 2015, 04:03:11 AM
I mean, don't forget the old sweet Europe.
Title: Re: Tissue Engineering
Post by: mike jones on June 11, 2015, 05:09:04 AM
Yes that it true they might be able to replace the tissue within the next 5 years but it mostly likely won't be widely available until later on. For example they can regenerate bladders however only a hand full of people that needed a bladder transplant actually got a regenerated bladder.
Title: Re: Tissue Engineering
Post by: Pfract on June 11, 2015, 12:59:44 PM
Mike Jones: but are you sure there is something new on Dr. Atalla? Could you please try to find the link? i thought we still needed to wait 5 years at least....
Title: Re: Tissue Engineering
Post by: mike jones on June 11, 2015, 03:30:08 PM
There wasn't a new article what I had saw was a email from  Dr Atala that said they expected the trials to begin in the summer of 2016
Title: Re: Tissue Engineering
Post by: drew67 on July 16, 2015, 09:32:06 PM
Was in touch with the principal investigator for the Atala trials.  Here is the transcript:

Will you be involved in Dr. Atala's trials of repairing parts of the penis using the 3D printing technique? 

--

I am the principal investigator on the trials to which you are referring. We won't be using the printed constructs. We will be engineering tissue in decellularized cadaveric tissue. Our first aim is treating wounded soldiers, and later rolling it out to civilians.

--
Would this technique be able to fully repair damaged tissue caused by peyronies or does it depend on the case?  When do you anticipate treating wounded soldiers and how soon after that civilians?

--
Every case is different. We are still working with the U.S. DOD and the FDA on our timeline.
Title: Re: Tissue Engineering
Post by: james1947 on July 16, 2015, 09:44:32 PM
Thanks for the information Drew.
It seems we are very far from getting something for us :(

James
Title: Re: Tissue Engineering
Post by: drew67 on July 16, 2015, 10:02:59 PM
So as opposed to replacing parts of the penis using 3D printing the decellularized cadaveric tissue will be used as a scaffold for tissue reconstruction.  I suppose the results must be pretty good or they wouldn't be going forward with this technique.
Title: Re: Tissue Engineering
Post by: Jack1909 on July 17, 2015, 02:53:16 AM
The results are outstanding as far as I know..this the basement of the regenerative medicine. A scaffold is from where all begins..and let me say that most of people here need just a new tunica so it would be very feasible. I mean..they are about to commence the total replacement trials..at this point we should already have heard about someone with partial replacement.
Title: Re: Tissue Engineering
Post by: kuaka on July 17, 2015, 09:04:04 AM
Definitely watch this...and report here.
Title: Re: Tissue Engineering
Post by: Pfract on August 03, 2015, 08:16:17 PM
thank you for providing us with such an insight on the subject. Although we are super impatient, things "seem" to be heading towards a better understanding of the peyronies disease. Who knows how things will be in 5 years from now? Positive i hope.. :)
Title: Re: Tissue Engineering
Post by: Jack1909 on December 04, 2015, 08:17:14 AM
Any news from those guys who said they'd have underwent a procedure in Mexico led by Atala's team? I think it was in October..
Title: Re: Tissue Engineering
Post by: krazylord on December 22, 2015, 01:24:50 AM
Hi Jack,

I messaged one of them and he didn't reply. Looks like he last connected on Oct 20th. I hope everything went ok for them. I called the Wake Forest Institute and talked to the person in charge of the regenerative medicine department, and they put me on a list, but apparently this list is to regrow penis or parts of the penis. It has nothing to do with stem cell. So I will try to call again and find out who is the doctor involved on this.

After doing some research, I found the name of a professor involved with the stem cell, but I am unsure as if he is a doctor or not. Here is the link: AFIRM: Research Programs: Genitourinary and Lower Abdominal Research Leaders (http://www.afirm.mil/index.cfm?pageid=research.research_areas.genitourinary.research_leaders) His name is John Jackson.

By the way, I also ask to see Dr. Atala, but apparently he only sees pediatric patients, not adults for Urology issues...
Title: Re: Tissue Engineering
Post by: Jack1909 on December 22, 2015, 11:38:00 AM
Thank you very much for the reply,
let's hope to have some news in a little time, some update that shows us we are close to something.
Title: Re: Tissue Engineering
Post by: drew67 on February 23, 2016, 08:38:10 PM
apologies if this was already posted.  Atala update: 

http://www.journalnow.com/business/business_news/local/regenerative-medicine-at-wake-forest-reaches-milestone-with-tissue-research/article_d30bb115-3938-5397-9743-e5ec9b0bb7a4.html#.VspvrZQ2xH8.twitter
Title: Re: Tissue Engineering
Post by: Pfract on February 24, 2016, 01:54:23 AM
"The institute has identified at least 29 tissues and organs for their regenerative potential, some of which they already have had success such as the bladder, ear, penile tissue, skin and vagina"

Thank you so much for sharing this! so much!
Title: Re: Tissue Engineering
Post by: NeoV on February 24, 2016, 02:59:06 AM
Very interesting and hopeful indeed.
Title: Re: Tissue Engineering
Post by: Freemason on February 24, 2016, 09:57:39 PM
This is truly amazing research...5 years or so fellas...5 years...15-20 years and you can prob forget about worrying about heart disease. This technology will print you a new heart to be transplanted with zero rejection..amazing.
Title: Re: Tissue Engineering
Post by: james1947 on February 25, 2016, 03:35:59 AM
I suppose that I will not be around 15, 20 years from now, let's hope is not 150, 200 years
Here we are 9 years after the first post on the forum regarding Dr. Atala (September 05, 2007) and we are still in the "HOPE" stage

James
Title: Re: Tissue Engineering
Post by: popopo on March 04, 2016, 05:51:51 AM
I agree James, it's all taking way too long. I'm 21 so I have some time left, but even then I can't stand the wait. Are there any updates on Atala, because personally tissue engineering seems the only REAL cure to me. I heard about human trials in the summer of 2016, but I'm not 100 percent sure.
Title: Re: Tissue Engineering
Post by: Jack1909 on March 04, 2016, 08:13:50 AM
Just consider that most of us in here need ''just'' a tunica replacement and in general a partial replacement. That's get the things easier and closer than having a total penis replaced as all these articles are about. They speak about a total replacement of complex organs.
Title: Re: Tissue Engineering
Post by: james1947 on March 04, 2016, 04:35:08 PM
I am not talking about penis replacement.
I am talking about "simple parts" replacement.
We are not closer to that than 9 years ago!!!
Sorry sounding so pessimistic, but let's be rational. Sadly, no any advances in the horizon :(
Posting opinions in the media is done for sealing purposes.
Bu it is just my opinion, the future will say if I am wrong.

James
Title: Re: Tissue Engineering
Post by: james1947 on March 12, 2016, 01:37:49 AM
So now I am optimistic regarding stem cell therapy for restoring vision for blind people.
Miracle cells to cure blindness - CNN.com (http://edition.cnn.com/2016/03/07/health/using-stem-cells-to-cure-blindness/index.html)
No, it is not off topic as it is an example how stem cell therapy going fast forward.
The research started at 1998, trials started in 2015, 17 years of fast track!!!
Still trials, but what a progress for people that yesterday were blind and today can see :)
Hope it will help other researches in the stem cell therapy, including restoring penis tissues :)

James   
Title: Re: Tissue Engineering
Post by: Brunobald on March 13, 2016, 07:40:27 AM
I have a feeling stem cell treatment and tissue regeneration will take off very soon. Every bio lab feeds off each other and the progress seems fast. Tunica replacement sounds doable even now.
Title: Re: Tissue Engineering
Post by: Billionaire on March 16, 2016, 08:45:17 PM
The basis for all tech, from imaging, to stem cells, to tissue engineering, to robotic surgery is ALL already here.

What holds us back is cultural attitudes towards male sexuality that insist on shame and excessive secrecy.

The disorder know as MRKH in women is pycho-emotionally very similar Peyronie's in that it structurally prevents penetrative sex and limits partner options. They however, have global support groups and non-profits, pull in Washington, media coverage and societal awareness... because they talk about it.

What we need is to ally ourselves with them and others, because as far as tissue engineering and regenerative medicine, the tech solutions are very similar for males, females, intersex, and trans people.

To put it into context, entire vaginas have been grown in labs and implanted already, a far more complex procedure than what most of us need. At this rate, we're going to print entire penises before we master the comparatively small regenerative remodeling of Peyronies Disease scar tissue.

In the advocacy group I've presented one strategy complimentary but different to the mission of this group.

Quote from: Brunobald on March 13, 2016, 07:40:27 AM
I have a feeling stem cell treatment and tissue regeneration will take off very soon. Every bio lab feeds off each other and the progress seems fast. Tunica replacement sounds doable even now.
Title: Re: Tissue Engineering
Post by: Billionaire on March 16, 2016, 08:51:05 PM
Some people here have alluded to the difference between Tissue Engineering and Regenerative Medicine.

While it's true that Tissue Engineering deals primarily with the manufacture and transplanting of new body parts, and Regenerative Medicine with coaxing the body to heal itself beyond the norm...

both borrow every heavily from each other, require each other, and share the exact same materials science.
Title: Re: Tissue Engineering
Post by: Dared on March 23, 2016, 03:38:57 AM
Billionaire, if what you say is true and we already have the technology available. How long do you think it'll be until we see the treatment made available to the public for peyronies? By the way, I totally agree with you about the shaming of male sexuality. But even women suffer from it in many instances too. Consider that no one even knew about ed until the drugs like viagra came out in the 90's.
Title: Re: Tissue Engineering
Post by: popopo on March 31, 2016, 03:13:51 AM
When I mail Wake Forest Urology they don't reply to me? Anybody got an update on how long this will take? I don't have much motivation left so it would.be nice to know what I'm waiting for and for how long. Theraphy doesnt help me, it just want to be able to get laid again dammit.
Title: Re: Tissue Engineering
Post by: Billionaire on April 04, 2016, 09:25:44 PM
Gentleman. The regenerative medicine technologies have already been manifested.

The non-profits and patient advocacy groups are fighting in D.C. to clear the way for every imaginable Stem Cell / Regenerative Medicine Application worldwide.... except for Peyronie's Disease.

Patients for Stem Cells | It is our right to access our own stem cells for potential life saving therapies (http://www.patientsforstemcells.org/)

- FasterCures (http://www.fastercures.org/)

The regulatory and standard bearing agencies are familiar with and expecting companies to emerge.

Foundation for the Accreditation of Cellular Therapy (http://www.factwebsite.org/)

The investment firms focused on Stem cells have also arisen, and will even work with crowdfunding in addition to angels, seed, etc. (Run by industry eminences I might add)

http://www.poliwogg.com/

And that's just in in the US. There's movement in the UK, Australia, and don't get me started on China where anything goes.

Only two things are missing:

1. For the leadership of this organization to build a relationship with patient groups and D.C. lobbying entities like FasterCures.
And for us as as the Peyronies Disease Society (not individually) to "come out of the closet" and tell the public, market and government we exist in vast numbers,
as have done women for analogous vaginal conditions like MRKH with huge success.

2. For a team of firebrands to start a company in stem cell applications specialized for Peyronies Disease.

Also, what's being done at Wake by Dr. Atala is incredible, and we will surely transfer over knowledge from it, but tissue engineering of entire organs is overkill for the comparatively simple Peyronies Disease.
Dr. Badylak's I'll be analyzing in depth.

Title: Re: Tissue Engineering
Post by: popopo on April 06, 2016, 03:08:01 PM
Are you surebBillionaire? I mean PRP is also called "stem cell treatment" by some but the effexlct isnt perfect. Also,what can we do about this? Inallready liked the fb page you asked us to like, but what next?
Title: Re: Tissue Engineering
Post by: Billionaire on April 07, 2016, 02:22:50 PM
Quote from: popopo on April 06, 2016, 03:08:01 PM
Are you surebBillionaire? I mean PRP is also called "stem cell treatment" by some but the effexlct isnt perfect. Also,what can we do about this? Inallready liked the fb page you asked us to like, but what next?

The infamous P-Shot.The limitation is that all independent, anecdotal procedures have retrofitted existing technologies to this condition to "see what happens", rather than created a new procedure to suit Peyronies Disease.

The next step is for us to fund the work of a Doctor-Institutional Researcher. There's a perfect candidate in mind but I'm reluctant to say his name because I don't want us all emailing him at the same time.

Popopo if what I'm saying makes sense, help me reach the administrators of this group. We would need them in the near future to help us send a call to action to every member of PDS to raise funds.

It would be done through a legitimate non-profit like Experiment.com and they'd head directly to a University Research Center.
All details and involved parties would be transparently displayed.

The Study would be Mesenchymal Stem Cells for Peyronie's Disease.

Title: Re: Tissue Engineering
Post by: james1947 on April 08, 2016, 12:32:28 AM
Billionaire

You don't need no one help to reach the active Administrator of this forum.
His forum name is LWillisjr and you may write him a PM

James
Title: Re: Tissue Engineering
Post by: drew67 on April 17, 2016, 07:34:34 PM
In case this hasn't been posted: 

Stem Cell Technique Could Regenerate Any Human Tissue Damaged By Aging or Disease

trials start late 2017

Stem Cell Technique Could Regenerate Any Human Tissue Damaged By Aging or Disease (http://futurism.com/game-changing-stem-cell-technique-developed/)

Title: Re: Tissue Engineering
Post by: james1947 on April 17, 2016, 09:23:24 PM
Thank you for the information Drew
I don't know who is managing futurism.com, hope they are serious people as not just sales advertisers.
Who will make the human trials? How can enroll? No information in the article in the subject.

James
Title: Re: Tissue Engineering
Post by: Billionaire on May 02, 2016, 12:45:51 PM
If you go to the original source listen on the bottom of the article, you'll see it's UNSW.


Quote deleted by moderator
Please read the forum rules!!!
Title: Re: Tissue Engineering
Post by: AphexTwin on October 13, 2016, 12:05:49 AM
Where do i sign up for this? This is my last hope.
Title: Re: Tissue Engineering
Post by: AphexTwin on October 13, 2016, 12:19:08 AM
If anyone could give info on how to get in on the trials, i would greatly appreciate it.
Title: Re: Tissue Engineering
Post by: nastyone on November 03, 2016, 08:31:58 PM
This conversation caught my eye and I'm in the process of contacting Dan Wheelahan, seems he may run medicine there. I'll keep this updated with anything I hear regarding iMS(induced multipotent stem cells) clinical trials and research. I'm so sick and tired of all the suffering and pain I see on these boards. It's exhausting. We as a group need to come together and actively recruit more members that are willing to push for some change. It's so easy to give up simply from lack of treatment options. If nothing else, pushing toward treatments and an eventual cure will provide hope to those that need it most. I have no doubt there will be a permanent fix for peyronies, all we can do is try and hasten it.
Title: Re: Tissue Engineering
Post by: nastyone on November 03, 2016, 10:50:53 PM
Well I emailed him as his title was under medicine..But I got an automated response that he is the media director, and on leave until november 9th.  I did request that he forward the message to whoever is in charge of stem cell research. I think I asked alot of good questions, so unless I find a better person to contact, I'll be playing the waiting game.
Title: Re: Tissue Engineering
Post by: popopo on November 04, 2016, 05:42:04 PM
You might want to contact dr.Atala and his team too. I have a mailadress so anyone who wants to at least give them a heads up that we are here waiting for developments PM me.
Title: Re: Tissue Engineering
Post by: AphexTwin on January 12, 2017, 09:15:22 PM
No success on getting hold of dr atala?  I havent emailed him yet, im just assuming trials have not started? Dont know how much patience i have either, im severely depressed.
Title: Re: Tissue Engineering
Post by: DELETED on February 02, 2017, 11:27:36 AM
Nobody still haven't contacted with Dr. Atala or Dr. Yoo?
Title: Re: Tissue Engineering
Post by: rellisacct on March 02, 2017, 03:16:13 PM
I went and saw the doctor who works under Dr Atala about 3 weeks ago and they are waiting for FDA approval to go ahead with trials. It's only available to military, but trials should be starting by summer-fall. Urethra trials have been given clearance though.

The most painful thing is knowing that the technology exists to cure all of us but our government is too corrupt to let things happen. Read Dr. Robert Becker's book called "The Body Electric". If I knew anything about Electromagnetism I would have tried his experiment.
Title: Re: Tissue Engineering
Post by: popopo on March 03, 2017, 02:31:41 AM
That sounds like a good development.
Title: Re: Tissue Engineering
Post by: DELETED on March 05, 2017, 09:06:45 AM
[Full quote removed]

What else do you know about laboratory-grown penises human trials in Wake Forest? Maybe you've seen this pic?

http://i11.pixs.ru/storage/0/6/8/KopiyaScre_9335718_23419068.png

In this screenshot you can see that Terri Bowen (secretary of Dr. Atala) said that they are confident they will start human trials in mid-late 2016 (this screenshot pic was made in July 2015), but now is March 2017, and they're still not started trials, so what is a main problem? Is it because FDA still not approve trials or what?

Also, maybe this doc with whom you spoke, has said something about how many time may take human trials? I mean, is it possible, to see this technology in widespread clinical practice, say, in next 5 or 10 years?

Thanks.
Title: Re: Tissue Engineering
Post by: popopo on March 05, 2017, 10:28:44 AM
The problem is the FDA. It's not that Atala isnt doing his job, it's just a loooooooonnnng proces for the fda to approve anything. Same goes for a substance called androxal that could be an absolute game changer in testosterone replacement theraphy. HECK, the substance is already an ingredient in a pill called clomiphene so it is easy as cake to make it, but the FDA doesn't care. It's all about money and adrogel is expensive so why change a winning team?
Title: Re: Tissue Engineering
Post by: popopo on March 05, 2017, 10:30:01 AM
Sorryfor being off topic, just making a point and making clear it's not the doctors fault, it's the system that's not working well.
Title: Re: Tissue Engineering
Post by: rellisacct on March 10, 2017, 04:05:34 PM
AlexSamo - That is a very interesting pic and is exactly what I was told in 2015 from this same doctor. Just a few weeks ago he basically flat out said that the technology is there and they have had GREAT results in animals as well as regrowing human penises, however, it is strictly in the hands of the FDA to go ahead with approvals. The whole project that they are working on now is called "AFIRM", which means it is only for the military right now. When will it become widespread in clinics? I have no clue. I would hope that it would not take another 10 years to get to us, but it is really up to the FDA and how well the human trials go.

Popopo - Absolutely agree...I wish they could do these trials somewhere in Europe or something, but it's our government that's funding this so it has to be done here.



Title: Re: Tissue Engineering
Post by: Brunobald on March 21, 2017, 04:53:55 AM
Thinking about this method more. Would it not come with the same problems as standard graft operations for example ED?

Also for those worrying about slow progress try to console yourself with the fact that there are multiple emerging technology that will work together to bring this new procedure to reality and that the basic tech will transfer from one body part to another. Flat material like skin or tunica are the easiest.

I do not under stand how this doctor can say he is growing a full penis as this would involve the prinintg or growing of veins which is a piece of the puzzle which is far from solved??

Examples of technology you can research that I think might speed things up are. Machine learning and genetic editing for example the discovery of crispr.
Title: Re: Tissue Engineering
Post by: DELETED on March 21, 2017, 04:38:55 PM
@rellisacct

Please, delete some messages from your PM box, I can't sent you PM
Title: Re: Tissue Engineering
Post by: lessor on March 22, 2017, 05:03:31 AM
This post was opened in 2010, we are now almost in april of 2017 and everything remains the same, then when we are in 2020 or 2027 Will anything have changed? wth!

I am very tired of people who give false hopes
Title: Re: Tissue Engineering
Post by: popopo on March 22, 2017, 07:49:52 AM
Me too, and I feel so powerless because of it, but what can we do? The only way would be to go into politics or become a doctor yourself and change the rules. What can we do? The only thing I'm doing well is going from doctor to doctor complaining about this crap and telling them to F~@< off with "psychological help" that doesn't really help. People do not understand how something like this takes away the will to live. Most healthy men are just not "wired" to never have satisfying sex and no matter what you do this will haunt you for the rest of your life. I can trick myself into thinking I'm happy by being active, but everything lost meaning. I wanna be heard. I want us all to speak out and make sure we're heard by the others who don't even think about these things right now. But even THAT isn't true. ALL men know these insecurities and most non-expert people I spoke to understand the pain we're dealing with. The only one's who don't are left winged feminists who think having a dick is just "macho BS" anyway. you got hands and a mouth, right? But whatever the future might bring and no matter how long I'll be able to fight the suicidal thought, I will NOT go unnoticed. If I ever give into these thoughts I'll make sure it's not for nothing and I hope to raise awareness for this issue. Now people might "laugh" at issues like this, but I'll make F^@$!ng sure people will feel my pain. OUR pain.
Title: Re: Tissue Engineering
Post by: james1947 on March 22, 2017, 08:04:52 AM
lessor

I am not answering to your question because If I, many members will blame me for discouraging forum members. :(

James
Title: Re: Tissue Engineering
Post by: popopo on March 22, 2017, 01:48:21 PM
You can just tell the truth James, I think most people can handle the truth and no hope is better than false hope in my opinion anyway.
Title: Re: Tissue Engineering
Post by: lessor on March 22, 2017, 02:18:17 PM
Totally agree with you mr popopo, You've read my mind
Im very tired about the doctors, seriously i dont know why I keep seeing doctors, they dont have solutions, apart from those that we all already know and that in many cases do not serve..

And many people, many women, will say you have mouth, you have legs, you are live but for me the life right now is empty, no have any sense. I dont want to be all my life working, alone , seeing other men enjoying of the life with her wife, or with others girls, while I m feeling like a crap every time I see that and i cant avoid feel like a crap.

I cant be with the people because when they talk about woman, sex my sensation will be horrible, and i dont want feel so
And then you read something like this, a thread of 2010 which gave hope to the people about a cure which would arrive in a short-medium term, and now you realize is 2017! and this treatment hasnt been tried in any person since so, People can not even test it to see if it works or not, is that there isnt even that possibility after 7 years.

WTF and I will say more i hate the actual situation with the medicine, when a woman has a breast cancer or a woman want to be a man the doctors will  do everything possible to help them, support them from all walks of society, from the media, will make many campaigns to support them, for the transsexuals will build a new penis that will cover insurance, BUT if a man has a real problem with the penis Oh friend in that case the society will tell you How can you be depressed by that, you're still alive! but with the others examples dont tell the same. In a particular case, the doctors specialized in veins know all about the veins of the body, veins in legs, veins in arm, veins in vagina but OH WAIT they dont know about the veins in the penis and  havent interest in knowing F***. The doctors they do not take this problem seriously, most of them have no interest in researching about it, and this is the guilt of the current society and I no longer say since the viagra or cialis appeared the urologist think that prescribing that they do not have to do anything else , No longer investigate, They will always say take a pill, if it does not work they say take an injection, but I have peroyne / venous leak, that is not a solution, and in many cases it does not help and can make things worse

In conclussion i feel impotent, f'^+'ing impotent that is the word

Sorry for this post i express all my crap here LOL
Title: Re: Tissue Engineering
Post by: Brunobald on March 22, 2017, 02:42:52 PM
Lots of negative posts but I do not agree that nothing has changed since 2010. Any of these advanced technique like regrowing organs is not specific to peyronies. Organ regeneration is a broad subject and the field is making progress everyday.

Some of the biggest advances in the field since 2010 are the following.

Discovery of crispr cas9, I think its a protein (google crispr for more info there is some great YouTube videos) that can edit any genome with relative ease. It's important as it allows rapid and accurate changes to our dna. It can be used as a tool to grow peyronies scars in a petrie dish for example the scar could be used to test and discover new drugs. It has also been used to remove the genes in pigs that cause our bodies to reject their doner tissue.

Printing DNA, this one is pretty cool. It is now possible to print dna using a computer and special equipment. In combination with crispr it is now possible to print dna and then copy and paste that DNA sequence into almost any living organism. The possibilities are endless, there are research groups right now trying to make the first 100% synthetic yeast cell which is mind blowing. We are moving into the age we we cab actually code for life.

This lead me on to machine learning. It's prob best to search YouTube for this one as well as its a big complex subject. Machine learning cab be used to try and decide our genome. If we can find out what sequence of genetic code, codes for peyroines we can use crispr to deliver a genetic edit to the tissue effected by peyronies. This is the basis of gene therapy. The crispr gene changer would be delivered by a synthetic virus. Gene therapy could be a 100% cure for peyronies progression but not a physical fix.

This is not science fiction, all three are receiving massive investment.

I would guess a decent cure for peyroines is about 10 years away.

We might get better fixes along the way. Possibly a better way to dissolve the scar tissue.
Title: Re: Tissue Engineering
Post by: lessor on March 22, 2017, 02:52:25 PM
I would guess in 10 years i will write in this board the same again
But hey i could be in a wrong  Just my two cents
Title: Re: Tissue Engineering
Post by: james1947 on March 22, 2017, 05:20:07 PM
Lessor
QuoteI have peroyne / venous leak, that is not a solution
My problem same as yours. VED, Pentox, low dose Cialis helped me to some extent, Viagra helping me for intercourse, not much strong an for not long time.
We have two solutions:
* Veins surgery, very complicated, very few specialist surgeons, low rate of success
* Implant, not so complicated, many good surgeons, high rate of success
Did you ever check out FT? Serious website, a lot of information about implants

Brunobald
I agree with you about the researches but non of them Peyronies/ED oriented
Regarding:
QuoteI would guess a decent cure for peyroines is about 10 years away
I know will be some members that don't like my answer, but:
I was given shorter time 9 years ago, less than 5 years
So now, my previous 9 + 10 yours it gives 19 for me. And the 10 years is just a wild guess :)

Solutions have if nothing else helps, see my two lines above with *
If you will ask why I didn't make an implant yet, I have no insurance and have more important targets right now for my finances as I am 69 and my daughter 7 :)

James
Title: Re: Tissue Engineering
Post by: lessor on March 22, 2017, 05:58:11 PM
Quote deleted by moderator. Please read the forum rules regarding quotes
Yes i check FT  many times
I am thinking about the implant seriously, but first I will try something like embolization or ligation possibly, if it doesnt work(the most probably really) i would go for the implant

James if you go for the implant and you can go to the USA Dr Eid have a guarantee for 10 years for his work in the implant, maybe you already know this
Title: Re: Tissue Engineering
Post by: james1947 on March 23, 2017, 02:52:34 AM
Lessor

I didn't know about Dr Eid insurance, but in my priority list I have two doctors that will be before him :)
Anyhow, he will be the third I suppose.

James
Title: Re: Tissue Engineering
Post by: lessor on March 23, 2017, 03:12:50 AM
But I mean Dr Eid guarantees if your implant fails in the next ten years to the operation, the replacement for the doctor will be free, the work of the doctor will be free, and as the implant is cover for the whole life time for AMS or Titan, the unique cost in the replacement would be the cost of anesthesia.

I say this because i havent seen any other doctor who guarantees this. It is interesting
Title: Re: Tissue Engineering
Post by: Brunobald on March 23, 2017, 03:18:48 AM
Actually the implant is a decent working solution. I would maybe go with the implant over a lab grown penis. It has a track record of success. The idea of an implant horrified me a first but now if my peyronies progressed I would almost feel relieved to have such a device and be somewhat cleared of the mental worry of peyronies progression.

Also in response to the comments that people have been told we are ten years away in 2007 and still nothing, I agree progress has been slow. Let's hope things will change, I truly believe we have new tools now that actually give is a shot at a better solution.

I also believe that young peyronies sufferes have it the worst and we are the smallest group. In the grand scheme of things peyronies is not a big problem to the research and medical world. Let's hope that some big research group makes some strides in their work that can migrate to fight our disease.
Title: Re: Tissue Engineering
Post by: popopo on March 23, 2017, 07:26:31 AM
Let me just add one positive thing about the way society is changing. In my honest opinion I really see people change. I feel like society is more superficial and even a little more individualistic and cold. Maybe that's not a good thing, BUT I also feel more people are insecure and open about their insecurities. If I say "I feel like crap because I'm an almost impotent 22 year old, people genuinly feel bad, especially young folks." If I did the same a 100 years ago people would probably wash my mouth wit soap and tell me to shut up. xD my point is that because of porn, the media, etc etc it's less of a taboo to talk about these issues, and I'm sure at some point men (even healthy ones) will not settle for having just some dick and want to be able to choose for something else like women can with breasts or lips or vaginal lips and what not. And the acceptance of homsexuality is good too! Not trying to stereotype, but be real.. the is no other group that fetisjises penises more than gay men. I can't imagine that no man will even be able to enlarge his penis even though deep down ALL men want to be at least "above average" if he's being true to himself.
Title: Re: Tissue Engineering
Post by: james1947 on March 23, 2017, 07:37:04 AM
I may change Dr. Eid to be the number 1  :)

James
Title: Re: Tissue Engineering
Post by: KoffeeKup on March 25, 2017, 05:51:23 PM
Guys I know the future looks bleak. But we can't stop fighting. The FDA is a big pile of crap, I know, but there is a good damn reason why. Here is a good example. Back in the day they believed radiation could cure all sorts of aliments. There was a common believe that radiation could reverse aging, cure wrinkles and rejuvenate skin.

A clinic opened up and promoted miraculous skin treatments involving X-Rays, newly discovered at the time. Dozens of women paid good money to turn back the clock and look younger, more beautiful, remove hair and erase their blemishes. They would put these women in a room and blast them with high intensity X-ray radiation.

I'm sure you can imagine the effects of radiation bathing a persons skin. If any of you have played Fallout, can you say Hiroshima Maiden syndrome boys and ghouls?

So while yes, the FDA may be corrupt and has people working for their own interests, but they also don't want people selling bogus treatments and quick fixes for things and causing more health issues. And I am sure many of you have had a run in at least once in your life with a snake oil sales man.
Title: Re: Tissue Engineering
Post by: DELETED on April 20, 2017, 10:20:43 AM
Hey rellisacct, please delete some messages from your PM box, I have a few questions for you.
Title: Re: Tissue Engineering
Post by: AphexTwin on June 16, 2017, 07:06:17 PM
Ten years for any kind of hope? Ive already had this disease for 17 years and im only 30. This issue needs to be taken seriously, people are commiting suicide over it. What kind of quality  of life will a man have if he cant have sex. 
Title: Re: Tissue Engineering
Post by: AphexTwin on June 16, 2017, 07:12:22 PM
If a woman can completely have her uterus and vagina replaced, why isnt it an option for men yet?

Title: Re: Tissue Engineering
Post by: james1947 on June 20, 2017, 10:27:56 PM
QuoteThis issue needs to be taken seriously, people are commiting suicide over it
You are right, but I suppose the researchers/doctors don't think will be big money from it :(

James
Title: Re: Tissue Engineering
Post by: AphexTwin on June 26, 2017, 11:25:19 PM
[Full quote removed - Use 'Reply' instead of 'Quote']

That is truly disgusting , we are dealing with human lives here. Do it out of the goodness of your heart , not for your bank account. A sad world we live in.
Title: Re: Tissue Engineering
Post by: AphexTwin on June 26, 2017, 11:29:43 PM
[Full quote removed - Use 'Reply' instead of 'Quote']

Tbh, i would pay millions for a cure  if i had that kind of money. Money means absolutely nothing with no peace of mind. Quality of life over money ANYDAY.
Title: Re: Tissue Engineering
Post by: popopo on June 27, 2017, 08:00:28 AM
I'm sure others feel the same way aphextwin. I dont think doctors purposely NOT find a cure, it's probably just way harder (no pun intended)  than we think. You, me and thousands of other men are willing to pay for ways to improve size and function of the penis, aphextwin. Even just for vanity men would be willing to pay with or without peyronies. The lack of demand or money to be made clearly isnt the issue, it just doest exist now and hopefully that will change.
Title: Re: Tissue Engineering
Post by: popopo on June 27, 2017, 08:07:37 AM
On the other hand.. there is still a stigma around the issue and that really frustrates th progression. I keep going to doctors and I hope you all do the same. Yeah yeah, it sucks hqvig to admit you have an issue, but in my opinion it's worse to keep it secret and keep your "pride" and aft like nothing is wrong, than openly admit this to a doctor. I mean when I say that part of the problem are the men that are too "proud" to get help. I wouldnt be surprised if like 50% of men with peyronies never ever even sees a urologist for it.

Then again, I did go to a urologist and many others as well and those that do arent getting th help they need either. It's still easier and a stupid "trend" to always seek th answer in "cognitive behaviour theraphy, mindfullness and other psychological help". I just hope some day the docs can actually help us instead of just tryig to make us feel better about the situation.
Title: Re: Tissue Engineering
Post by: DELETED on July 04, 2017, 01:06:49 PM
Quote from: rellisacct on March 10, 2017, 04:05:34 PM
Just a few weeks ago he basically flat out said that the technology is there and they have had GREAT results in animals as well as regrowing human penises, however, it is strictly in the hands of the FDA to go ahead with approvals.
Rellisacct, if you read this post, please delete some of messages from your PM box, because it's full. I'll be waiting your reply. Thanks.
Title: Re: Tissue Engineering
Post by: popopo on July 04, 2017, 02:10:30 PM
Whatever you guys know about this, please keep me informed I'd be glad to hear all about it.
Title: Re: Tissue Engineering
Post by: AphexTwin on July 15, 2017, 07:29:07 PM
So you can delete the quote yourself, don't wait for moderator :)
They did the exact same thing when i got the nesbit plication surgery at mayo clinic, i really regret having surgery. I went back about a year later to tell them things were still wrong, and they gave me a referal to a psychologist, how rude. Im not crazy, i know i have a problem. I have a hard chord in my penis even when im soft . It drives absolutely nuts because it shrivels up and feels light. Im praying they come up with a successful tissue regeneration, because im losing the will to live. I have gone with this disorder long enough, im tired of fighting. Im tired of it all, i want my life back.
Title: Re: Tissue Engineering
Post by: AphexTwin on July 15, 2017, 07:32:27 PM
Opps i hit quote instead of reply again
Title: Re: Tissue Engineering
Post by: Jack1909 on July 16, 2017, 01:33:58 AM
Aphex I feel fo you. It's happened the same to me and I was "suggested" to take care of the psychological component of that. That's ridiculous. Unfortunately it looks like there is still poor awareness around how dangerous and invasive straightening surgeries are. I think all the concept behind them is wrong..let's hope medicine will step forward soon.
Title: Re: Tissue Engineering
Post by: kuaka on September 11, 2017, 10:34:19 AM
There is definitely a psychological component to dealing with persistent pain of any severity, but a Dr. who suggests that as the ONLY course of action is not doing his job.
Title: Re: Tissue Engineering
Post by: lessor on September 11, 2017, 10:50:56 AM
Quote from: AphexTwin on June 16, 2017, 07:12:22 PM
If a woman can completely have her uterus and vagina replaced, why isnt it an option for men yet?
Because the society despises our problem, because society is deeply feminist (at least in Europe) because if you are a man the stupid doctors will tell you to live with it, love and anothers BS, because women will often say it is just a penis, (but in the background they will never be with an man so and being with a woman does not make sense unless you want to commit suicide) In short because society is hypocritical
Title: Re: Tissue Engineering
Post by: james1947 on September 14, 2017, 11:58:59 AM
Quote...because society is deeply feminist...In short because society is hypocritical
Good said lessor!!! I am with you 100% ;D But of course, people will say that I am an old chauvinist, racist, etc' etc'. They may be right, I am really old, relatively, at almost 70 8)

James
Title: Re: Tissue Engineering
Post by: lessor on September 14, 2017, 06:33:12 PM
Quote from: james1947 on September 14, 2017, 11:58:59 AM
I am with you 100% ;D But of course, people will say that I am an old chauvinist, racist, etc' etc'.
I do not care what people say anymore, and you probably do not care what people can say.
Everything is too correct in society. If you tell the truth, if you do not act politically correct you are a bad person, a racist, chauvinist and more crap .. I do not care anymore what they think, my life is over or near so I will tell things as they are
Title: Re: Tissue Engineering
Post by: DELETED on October 01, 2017, 02:05:21 PM
Any news&updates for tissue engineering clinical trials?

P.S. Rellisacct, if you read this post, please delete some of messages from your PM box, because it's full. Or PM me. I'll be waiting your reply. Thanks.
Title: Re: Tissue Engineering
Post by: Werther on January 17, 2018, 01:14:20 PM
Hey guys, I've been a lurker on this forum for a long time and I have finally decided to register to post on this subject.

I've been following every kind of news and updates about Atala's work on penile tissue engineering ever since I came to know about it and I read here that some users contacted WFIRM asking them when they intended to begin with clinical trials on humans. It appears that they should have begun recruiting people last year's fall (I assume this by user treeza1's words in this thread: Anythig new? - Peyronies Society Forums (https://www.peyroniesforum.net/index.php/topic,8632.0.html)). However no update was reported.

So I've decided to write to WFIRM via e-mail by myself and this is the response that I've received:

"Good afternoon,


I was forwarded your e-mail inquiry.



We do have a research study that is about to begin for engineered corporal tissue to treat peyronie's disease.  The goal will be to correct curvature but we can't guarantee that it will or that it will correct ED.



If you are interested in being evaluated by Dr. Ryan Terlecki at Wake Forest Baptist Health Urology, please call 1-888-716-9253 to make an appointment.



Thank you for contacting us
".

I answered them back, asking for more details, regarding the precise day of the study's beginning and its duration, also adding that I can't be personally evaluated by them right now, since I don't live in the USA. Unfortunately, they didn't reply.

So now I am writing on this forum to know if anybody here have actually been personally to WFIRM in order to get evaluated to find out if they're eligible or not for this kind of surgery; if that's not the case, could anyobody here (US resident) go personally to the Institute and report back on what's actually happening with this study? I'd go by myself, but, as I've mentioned before, it's not possible for geographical reasons.

I'd be very glad if all of us could know something more on a treatment that could potentially be the cure for our damned disease.

Thank you all for your attention and sorry for any misspell, but english in not my motherlanguage.
Title: Re: Tissue Engineering
Post by: TonySa on January 17, 2018, 03:54:57 PM
Do you have their website or know where they are located?
Title: Re: Tissue Engineering
Post by: Werther on January 17, 2018, 05:40:06 PM
Their website's link is Wake Forest Institute for Regenerative Medicine (WFIRM) - Wake Forest School of Medicine (http://www.wakehealth.edu/WFIRM/)

Here's the link to the study: Engineered Penile Erectile Tissue - Urology Research - Wake Forest School of Medicine (http://www.wakehealth.edu/Research/Urology/Regenerative-Medicine/Engineered-Penile-Erectile-Tissue.htm) and then an older one, again on their website: Lab-grown Replacement of Penile Erectile Tissue In Animals (http://www.wakehealth.edu/penile-erectile-tissue-replacement.htm)

They are located in Winston-Salem, North Carolina. Are you willing to reach out to them?

It seems to me that this Dr. Ryan Terlecki, who was mentioned in the e-mail they sent to me, is going to be the urologist that will perform these surgeries; in fact Peyronie's disease and erectile dysfunction are his clinical interests, based on the description of his profile in WFIRM's website (Ryan Terlecki, MD, Urology - Wake Forest Baptist, North Carolina (http://www.wakehealth.edu/Faculty/Terlecki-Ryan.htm)). Maybe someone could get an appointment with him and report to the forum what he will say about this study?
Title: Re: Tissue Engineering
Post by: Jack1909 on January 19, 2018, 06:41:16 AM
I think I'll be there in a couple of months. Don't feel like doing btw flying around the world due to health reasons is a nightmare.
Title: Re: Tissue Engineering
Post by: Werther on January 19, 2018, 11:11:14 AM
Thank you so much Jack! Keep us updated!
I too think it's a shame that somebody is forced to travel to the other side of the world just to get infos and maybe discover that the study won't even start anytime soon or there's no eligibility for tissue replacement in that specific case.

Isn't there an advocacy group on this forum? It would take literally nothing for a US resident (even better if North Carolina's resident) to go there, maybe on behalf of the whole PDS, and get things clear with regards to the beginning of these trials, their duration and the parameters of eligibility and exclusion for this kind of surgery.

The fact that we still know nothing is beyond ridicolous, considering that Atala's work's main aim is to recreate an entire penis but, as declared by himself, in order to reach this goal first they'll have to begin with partial replacement; and guess what? only people with scar tissue in the penis (tunica albuginea and/or corpora cavernosa) need partial replacement and here we are. If we're not going to urge them to - at least - declare what they intend to do, nobody else will do it for us.

The absence of activism is killing the possibility of getting what could be a real and effective therapeutic option and - I bet - an alternative to prosthesis.
Title: Re: Tissue Engineering
Post by: DELETED on January 19, 2018, 01:41:21 PM
Werther,

Thank you so much for information. User "rellisacct" (link: https://www.peyroniesforum.net/index.php?action=profile;u=6718 ) living in North Caroline, but he was not active on this site since March 20, 2017.

As for clinical trials at Wake Forest, regarding penile tissues, I've found only one at this moment, here it is: https://clinicaltrials.gov/ct2/show/NCT03240822
But I think it's not that we need, it's a trial for full penile transplantation, not partical and nor regarding tissue engineering.

In article by october 2014 (link: https://www.theguardian.com/education/2014/oct/04/penis-transplants-anthony-atala-interview ) Dr. Atala have said that they hoping it will be available in next 5 years i.e. in 2019, but what does he mean saying this? It's seems like he talked about approval this technology by US FDA and first human trials in 2019, not about use this technology in widespread clinical practice in the next 5 years for all patients who need that.

I'm also have a question and would appreciate if someone will explain just one thing. Atala and his team started this project in 1992 (more than 25 years ago), in 2002 they've performed first succesfull animal trials, then another successful animal trials in 2008 (it's already was 10 years ago), but this technology still not tested on humans! Isn't it sounds a bit suspicious? We talking about timelines literally of 25 years, but we still haven't this technology on medical market. So why this is taking so long? Why even after 10 years after second successful animal trials, human trials still not even started? Moreover, still not clear when they will starts.
Title: Re: Tissue Engineering
Post by: popopo on January 19, 2018, 05:04:05 PM
I agree it takes long alex, but consider this: cancer has been around for ages, it's among the most deadly and well known diseases, people spend millions on research and there still is no fool proof cure for cancer. It's not uncommon for these things to take some time and especially getting your treatment FDA approved and being able to start human trials takes time.
Title: Re: Tissue Engineering
Post by: Werther on January 19, 2018, 08:17:19 PM
[Full quote removed - Please read the forum rules for posting]

I had alreay read the article of The Guardian and I agree with you with regards to Wake Forest's trials for full penile transplantation: it has nothing to do with tissue engineering (in fact Peyronie's disease and ED are both mentioned as exclusion criteria for recipients).

There seems to be nothing new on their site or in the newspapers concerning the subject of penile erectile tissue engineering; I have just found this link about a conference that was held in Boston in May 2017: https://www.urotoday.com/conference-highlights/95611-aua-2017-regenerative-medicine-where-do-we-stand.html

Anyway the information are, again, vague. I quote what's written: "With respect to genitourinary organs, they have reverse engineered a vagina, from a remnant vagina biopsy, and successfully implanted it into a patient with vaginal agenesis. In patients with contracted, noncompliant bladders (end stage bladders) they have implanted bladders that over time increased in compliance and capacity. This is proof of the recipient truly "accepting" these refurbished organs. Following this, they moved on to the more complex solid organs. Their team has successfully regenerated a penile implant in a rodent model with the ability to sustain erection and ejaculate. Based on these studies, they are planning preliminary human studies".

The fact is, however, that a lot of people here tried to contact them and lately (beginning from last year) they have always been responded that they were just about to begin; but when they were asked for more precise details, they didn't answer. So, plain and simple, I think that they'll actually begin very soon (maybe this year), but we'll never know for sure if nobody's willing to go there in person and talk face to face with someone who's involved in this project (one of these people could be Dr. Terlecki, since he was mentioned in the response they sent to me). We could keep sending tons and tons of e-mails, but if they simply don't answer we'll keep remaining in a limbo.

Damn, isn't there a single North Carolina's man who have Peyronies Disease (except for "rellisacct") and is interested in discovering what the hell is going on with this study? It looks like North Carolina's male inhabitants are immune to this disease.
Title: Re: Tissue Engineering
Post by: Brunobald on January 21, 2018, 05:24:07 PM
As far as I'm aware we are still a long way from regenerating, growing or printing a penis outside of the body for transplantation. I did find a company called polarityte that claims to use the body's own cell to make a healing matrix which they fill into a tissue void. This uses the body as a bio reactor. I contacted them and they say that fascia is also in their pipeline. There skin results should be published first half of 2018.
Title: Re: Tissue Engineering
Post by: Jack1909 on January 22, 2018, 01:33:19 AM
No one is in need to have something done it's just about having a small piece of tunica replaced..
Title: Re: Tissue Engineering
Post by: DELETED on January 22, 2018, 12:54:12 PM
Jack1909,

I'm not agree. In some cases patients need in both tunical and cavernous tissue replacement, especially when we talking about patients with ED.
Title: Re: Tissue Engineering
Post by: Werther on February 19, 2018, 09:43:11 PM
FYI

I wrote again to WFIRM asking for more precise details with regards to their trials and here's what they answered: "We are hoping to begin recruiting for the engineered corporal tissue study in May.  The study will be for a corpora injury/deformity of 5 cm or less in length.  There are 2 surgical procedures (a biopsy and then the implant) about 3-5 weeks apart, and follow-up visits at 1 week, 3 weeks, 6 months, 9 months and 1 year post-implant.  When the engineered corpora is ready for implant we will have about 2 days to get the implant surgery scheduled. This is a phase 1 safety study.  we have not performed this surgery before".

They had to begin recruiting last year (and maybe even the previous one) and now they "hope" to commence in May; well, I hope even more than them that this will be the time (but I have to say that I still didn't find any new record on ClinicalTrials.gov).

Anyway I think this is a positive progress, since they described the procedure and an exclusion criteria (plaque of 5 cm or less in lenght)... It kinda makes me hope that they're getting serious and they'll finally begin before the end of this year.
Title: Re: Tissue Engineering
Post by: diehardpatriot on February 20, 2018, 02:17:38 AM
Holy ****, so you're telling me WFIRM is going to do corporal replacements ?? That's insane. I think we're about 5 years,  10 tops from being able to replace a tunica or corpora
Title: Re: Tissue Engineering
Post by: popopo on February 20, 2018, 02:45:16 AM
Well, in 2016 they said they'd be able to replace whole penises in 5 years max, so let's just wait and see about that.
Title: Re: Tissue Engineering
Post by: Sadguy on February 20, 2018, 03:09:18 AM
Can they cure ED ? I think for ED it would need a complete replacement of the penis ( corpus cavernosum, tunica and the fascias)

Do you see this possible? What it would take? 10 years maybe?
Title: Re: Tissue Engineering
Post by: Jack1909 on February 20, 2018, 04:33:32 AM
I might be super eligible for it as most of my problems come just from that fibrotic stitch. Probably the most eligible considering I'm not at risk of any flare up (don't have peyronie).
Title: Re: Tissue Engineering
Post by: Werther on February 20, 2018, 12:32:03 PM
I hope that people with ED caused by fibrosis (mainly venous leakage) will be recruited, so we can know if these surgeries actually restore sexual function, a part from straightening the dick. And I think it will work like this, since they declared that they aim at solving selected cases of erectile dysfunction with tissue engineering.

Hopefully we won't have to wait for other 5 or 10 years; maybe it will take these many years (or more) for whole tunica and/or corpora replacement, but these trials deal with partial replacement and they've been planning on beginning for a very long time.

I'm no doctor, but I think that partial replacement of engineered tissue could solve ED without having a whole new tunica and/or corpora, if ED onset is due to scarring.
Title: Re: Tissue Engineering
Post by: DELETED on March 01, 2018, 12:31:49 PM
Today I received an update from Wake Forest

"Thank you for contacting use regarding lab-grown penile tissue.  We will be starting a clinical trial in the next few months for engineered corporal tissue mainly for men with Peyronie's Disease.  This is a phase 1 study for safety.  If the study goes well, we hope to be able to advance to a Phase 2 study, looking at incorporating more penile tissue and for other indications.

Regards,
Mary-Clare Day

Mary-Clare Day, RN, BSN, CCRC
Research Nurse Manager"


P.S. @"rellisacct", where are you man?
Title: Re: Tissue Engineering
Post by: DELETED on March 07, 2018, 10:16:04 AM
Does anybody else received any information about upcoming clinical trials in Wake Forest?
Title: Re: Tissue Engineering
Post by: jusirmi on March 16, 2018, 01:21:46 PM
this clinical trial appeared to clinicaltrials.gov recently
https://clinicaltrials.gov/ct2/show/NCT03463239?cond=corpora+cavernosa&rank=5
Title: Re: Tissue Engineering
Post by: Werther on March 20, 2018, 07:03:54 PM
Finally! It's the one people have been talking about since this thread had opened.
It looks like they are really moving forward.
Title: Re: Tissue Engineering
Post by: AlmostBlue on April 30, 2018, 10:48:29 PM
Happy Phase 1 is beginning.

A little confused here... they constantly mention engineered corporal tissue. To me this means the spongey tissue, specifically the smooth muscle tissue, inside the corporas that relaxes to let blood in. There is no mention of engineered tunica nor replacement of pieces of the tunica by WF.

I get that replacement of corporal tissue can help ED, but what we really need is engineered tunica tissue in order to replace our plaques. Is WF not doing this yet?


*EDIT*
I stand corrected... Brief Summary:
"The primary objective of this clinical trial is to evaluate the safety of autologous engineered corpora cavernosa + albuginea constructs for treatment of complex penile deformities. Autologous endothelial and smooth muscle cells obtained from enrolled subjects' corpora cavernosa biopsy sample, will be culture expanded in vitro and used to seed decellularized corpora cavernosa + albuginea obtained from cadaveric-donors to create autologous bioengineered corpora cavernosa/albuginea constructs for repair of damaged penile tissues."

https://clinicaltrials.gov/ct2/show/NCT03463239

So they take the tissue from a cadaver, strip it off all its cells, so what's left is the structure/empty scaffold. Then they add your cells to it and they multiply them. Then they replace. Makes sense now. I am happy to find that they are doing the Tunica Albuginea and not just cavernosa tissue.
Title: Re: Tissue Engineering
Post by: diehardpatriot on April 30, 2018, 11:02:03 PM
It's a whole penis replacement bro. They take biopsy stem cells from the corpora , that's what they use to regrow the penis. Can you post a link stating phase 1 is starting? How do you know? I wonder if any forum members were able to volunteer
Title: Re: Tissue Engineering
Post by: DELETED on May 01, 2018, 02:12:57 PM
Does anybody contacted with WF? Any news or updates about upcoming human clinical trials?
Title: Re: Tissue Engineering
Post by: AphexTwin on May 10, 2018, 12:30:34 AM
Im still interested in this. Any leads would be so appreciated
Title: Re: Tissue Engineering
Post by: Jack1909 on July 08, 2018, 07:28:11 AM
I actually went down there the last week and had a consultation with Terlecki who is the principal investigator of the trial. He got around the point, but basically we are not veterans injured so we are not considered as candidates  and don't know when we will ever be. He didn't give me any info about this. He just offered me the same treatments we all know they are knocking people's penis out around the world. He told me it would be helpful getting into this in first place but lately I was not considered qualified for it (via mail).

Think we should turn ourselves  to something else, even if this would be pretty much a cure to me.
Title: Re: Tissue Engineering
Post by: Jack1909 on July 08, 2018, 07:39:59 AM
Alex Samo you posted this..



"Thank you for contacting use regarding lab-grown penile tissue.  We will be starting a clinical trial in the next few months for engineered corporal tissue mainly for men with Peyronie's Disease.  This is a phase 1 study for safety.  If the study goes well, we hope to be able to advance to a Phase 2 study, looking at incorporating more penile tissue

...I think it's not true that's will be on veterans unless they wanna find veterans with peyronies..that answer is misleading unfortunately. Otherwise I wasn't told how things are going..
Title: Re: Tissue Engineering
Post by: hope794 on July 08, 2018, 09:29:15 AM
I didn't understand properly:
this studies which you all are talking about, the one which involves "veterans", aim to replace the penis TOTALLY (new penis from another guy) or only small parts of tissue?

I am not a doctor, but i can't understand why is so much complicated to grow with stem cells + 3D printer some little parts of tissue. For example, i have got some fibrosis in the TUNICA ALBUGINEA. Why should this be complicate to solve with actual technology?

I'ts only a matter of removing a small part of TA (some millimeters) and replace it. Am i missing something?
I read that there are many studies about growing parts of organs to replace only the 'bad parts' and not the entire organ, and they seem really promising. For some organs, it is still possible. So what's the matter with tissue engineering?

P.S. = Someone in this post said that, 10 years ago, we were "10 years from the target". Today i can't understand if we are near or not. What's the truth? Can someone REALLY well informed explain to me where we are now, please?
Title: Re: Tissue Engineering
Post by: swiss on July 08, 2018, 11:14:18 AM
so...join the army. Claim you hurt your pee pee there and get new pee pee.
Problem solved.
Title: Re: Tissue Engineering
Post by: Jack1909 on July 08, 2018, 12:03:20 PM
They can but they don't want to. That's the fact. The technology already exists but we are not allowed to get there. Waiting for this to wild open in any clinic will take years.

I think I explained myself. They are sponsored and funded by the difence so they are focusing on them rather than people with "real" diseases.
Title: Re: Tissue Engineering
Post by: Jack1909 on July 08, 2018, 12:07:38 PM
Small parts for veterans..I know it sounds strange but that's what I ve been told.
Title: Re: Tissue Engineering
Post by: Thomas2 on July 08, 2018, 02:59:56 PM
For what i remember, medical research through history has always gone through veteran studies... It's about standardization...
Title: Re: Tissue Engineering
Post by: hope794 on July 12, 2018, 05:17:56 PM
Hi all, i have got a question. I read in this post many people talking about a "total penis replacement", but IMHO only some people suffering from Peyronies Disease really needs this. For many people, a little piece of tunica replacement would be enough, and this doesn't seem so hard to do. (i'm talking about the piece of tunica which is covered by fibrosis)
So i'm writing this post because i would like to hear the opinion of someone in the forum which is expert in this field and is following the progresses of Tissue Engineering; it would be fantastic if someone could explain to me why a little piece of tunica albuginea, grown on a scaffold and then transplanted on a patient, is so hard to do, and which results you would obtain with this procedure.

Thank you very much
Title: Re: Tissue Engineering
Post by: DELETED on October 01, 2018, 02:42:59 PM
Quote from: Jack1909 on July 08, 2018, 07:39:59 AM
Alex Samo you posted this..

...I think it's not true that's will be on veterans unless they wanna find veterans with peyronies..that answer is misleading unfortunately. Otherwise I wasn't told how things are going..

Yes, I was told exactly this. She mentioned that this trials would be available for Peyronies Disease patients. I don't know if she was wrong or something. It was half-year ago. You can ask her: mday@wakehealth.edu

Quote from: Jack1909 on July 08, 2018, 12:03:20 PM
They can but they don't want to. That's the fact. The technology already exists but we are not allowed to get there. Waiting for this to wild open in any clinic will take years.

Skip the fact that this is not available for us yet, but "The technology already exists"? Are you sure about this part of your message?
Title: Re: Tissue Engineering
Post by: DELETED on February 01, 2019, 02:15:45 PM
Any news&updates?
Title: Re: Tissue Engineering
Post by: shrunken_dick on November 11, 2020, 10:05:41 AM
Looking for an Update.
Title: Re: Tissue Engineering
Post by: GaussRifle on March 19, 2021, 12:02:45 AM
Finally! The trials begin this month and we will have primary study completion by Summer of next year. This site was updated January 2021 so it is accurate.
https://clinicaltrials.gov/ct2/show/record/NCT03463239?cond=corpora+cavernosa (https://clinicaltrials.gov/ct2/show/record/NCT03463239?cond=corpora+cavernosa)
Title: Re: Tissue Engineering
Post by: Fubar94 on March 19, 2021, 05:59:50 AM
Finally some good news. I am doing PRP for now, keep fcking with viagra in my system as long as I can and hopefully will see this happening and get cured in my lifetime.
Title: Re: Tissue Engineering
Post by: GaussRifle on March 26, 2021, 01:53:06 AM
Fubar,  prp results ?
Title: Re: Tissue Engineering
Post by: Jack1909 on March 26, 2021, 03:36:15 AM
10 years away.....
Title: Re: Tissue Engineering
Post by: Jack1909 on March 26, 2021, 05:03:13 AM
Why just no pursuing the cadaveric tissue implanting, building up a penile tissue bank...nowadays would be feasible and it would not require immuno suppressants. I read some articles urging this thing to be set up..
Title: Re: Tissue Engineering
Post by: GaussRifle on March 26, 2021, 05:33:54 AM
You can't directly implant tissue from a dead body (cadaver). Your body will reject it without immunosuppression. You need to use it as a scaffold on top of which your cells grow and then implant. Hence the clinical trials.
Title: Re: Tissue Engineering
Post by: Jack1909 on March 26, 2021, 12:52:12 PM
That's not necessary true, not nowadays at least..I know the overall purpose of the trial (I think I'm the only one went down in Notth Carolina to speak with the guy leading the trials), but the point is we are 10 years away..
Title: Re: Tissue Engineering
Post by: GaussRifle on March 26, 2021, 01:06:01 PM
10 years atleast ... lol
Title: Re: Tissue Engineering
Post by: Fix This on April 06, 2021, 02:23:11 PM
This sounds very promising

Did they actually give a timescale when they were contacted ?

Title: Re: Tissue Engineering
Post by: Godisreal on April 07, 2021, 05:23:24 PM
I sincerely hope they are doing something. We all know this whole forum would come to a beautiful end if it worked, and the pain and suffering for us all, would be done.
Beautiful f*cking thought lol
But it's far away. No doubt.
I can promise you that I will finance the entire research one day if a beautiful soul does not do it before me. I hope one does.
Title: Re: Tissue Engineering
Post by: Student000 on August 02, 2022, 07:06:43 PM
Hey there!

Since this topic has been quite inactive for a while, I'd like to put my two cents in. This whole peyronie stuff is so devastating especially if you are in your early twenties...  :'(

I hope that I can one day help others and myself with tissue engineering (I started medical school in Germany 3 years ago and now have a great internship in this field), but for the meantime I contacted Wake Forest a few weeks ago and got this response:

"Thank you for your interest in our research at Wake Forest Institute for Regenerative Medicine. We are excited that after many years of research in our lab, and after rigorous review by FDA,  we will begin enrolling into 2 clinical trials – one for bioengineered urethra for males with urethra stricture, and for bioengineered corpora for males with a defect to corporal tissue.
These are both safety trials, and we hope once completed we will be able to advance our research in both areas, and one day be able to combine both technologies in the same surgery.  As safety studies, we do not guarantee any new function with the implanted tissue - our goal at this point is the implants' safety.
Both studies may begin recruiting in the Fall of 2022."

That means they didn't abandon this project and will continue to work on it! Will it be widely available in the next few years? - probably not. There are still important questions which will be crucial for a successful clinical application that I think we need answers to, like the following:

Let's say we were able to create a perfect replica of the native tunica albuginea and cavernosal tissue how would an erection be possible? There are tiny nerves that contact the endothelial cells via molecules to send signals to relax and allow more blood to flow in the penis, if we would insert such a transplant those peripheral nerve endings would be certainly missing... You could get erections via injections though or maybe molecule diffusion might be sufficient...
On the other hand there is also a possibility for your own nerves to grow into the new tissue, but that will probably also take some time on its own.
I researched this topic since there are a few reports about complete penis transplants and severed penises, they mentioned successful reattachment, but few described their functionality in detail. Were erections spontaneous? Etc.

I would genuinely like to get an answer to this question... but this just shows how difficult tissue engineering is overall...
Don't give up there is always some hope left, without questions there would be no answers to solve difficult problems.

Take care.




Title: Re: Tissue Engineering
Post by: Trapper on January 10, 2023, 11:14:38 AM

Hey Student,

This is really exciting news! Glad they are finally moving on this. Regarding your comment on the nerves I find it hard to imagine they would touch the neurovascular bundle of the penis during the surgery. I think they would probably leave it intact just like IPP surgery.