Hello guys. I don't write anything here since a lot of time, but i think it's worth for me to come back and write my own experience.
Long story short, in these months i've been feeling lethargic, tired and began to smoke a little bit. My doctor told me that i could take Bupropion (commercial name: Wellbutrin), an "atypical" antidepressant which is used for those kind of depressions which bring tiredness, lethargy and so on. The drug is also used to stop smoking, and many say that it work wonders.
But why am i writing all of this here?
I was really panicked about taking an antidepressant, for two reasons: the first one is that i don't feel "depressed" actually, but i want to trust my doctor. And this is my business. The second one is that i've read on this forum that many antidepressants make inflammation way worse, for example the SSRIs.
So i've decided to make some research. Long story short, this "Buproprion" molecule seems to have ANTI-INFLAMMATORY effects to a great extend. I'll give you some papers, you can dig to find others:
https://pubmed.ncbi.nlm.nih.gov/16644475/
https://www.gastrojournal.org/article/S0016-5085(03)01316-7/fulltext
https://journals.lww.com/psychosomaticmedicine/Citation/2003/07000/Bupropion_in_Psoriasis_and_Atopic_Dermatitis_.35.aspx
.. and many, many others.
I needed the final proof. I took it myself about 2 weeks ago. I've taken 150mg, once a day, extended release version.
Please note that i have a diffuse fibrosis of the dorsal area of the shaft, and i'm in a permanent high inflammation state, with pains, ED and shortening of the shaft.
I didn't obviously got cured from Peyronies, but my inflammation has improved DRAMATICALLY. I would say that it is 75% off. When i masturbate a lot or have sexual intercourse, i still have some increase in the inflammation, but it subsides fast 1-2 days after and my penis becomes really soft, well blood-irrorated, and i feel it's good.
My ED did improve a little bit. Unfortunately all this fibrosis gave me venous leak, so even if my penis gets more blood now (i can feel it) its still hard to mantain the erection. But i feel like my glans engorges a lot more and its better now than before. And it has only been 2 weeks.
Now.. As a conclusion.. i want to say 2 things.
1) Im not saying Bupropion is a cure, but crap, this thing lowers the inflammation by a great extend. Maybe this just works on me, but it works and scientifical literature confirms it.
2) This molecule can't reverse fibrosis, but at a dosage of 300mg or 450mg per day for some months i am sure that it can beat this F^@$!ng disease. It can at least "turn off" the inflammation acute phase. Unfortunately i'm pretty sure that it can't reverse fibrosis, but ehy, even a medicine which can turn off the inflammation would be a real game changer.
So i've decided to share for the good of the community. If you have tried or will try this and notice the same effects, please comment here and let me know.
Thanks and.. good luck.
I've been taking Wellbutrin 150 mg for about 5 years now and I haven't noticed anything anti inflammatory about it; things are much the same for me down there. I would caution taking larger doses just because you think it might have some sort of secondary anti inflammatory effect; it'll have much more pronounced effects on your mental state and it will increase the risk of seizure, possibly anxiety, and may thin your hair. 150 mg is the sweet spot for me, 300mg made me forgetful and too stimulated which brought on anxiety, which increases cortisol, which actually feeds into more inflammation. It has made me much more able to cope with the psychological aspects of this disease and actually live my life without feeling sorry for myself everyday like I used to though. There are better anti inflammatory options out there.
Quote from: stopthismadness on May 14, 2021, 01:39:23 AM
I've been taking Wellbutrin 150 mg for about 5 years now and I haven't noticed anything anti inflammatory about it; things are much the same for me down there. I would caution taking larger doses just because you think it might have some sort of secondary anti inflammatory effect; it'll have much more pronounced effects on your mental state and it will increase the risk of seizure, possibly anxiety, and may thin your hair. 150 mg is the sweet spot for me, 300mg made me forgetful and too stimulated which brought on anxiety, which increases cortisol, which actually feeds into more inflammation. It has made me much more able to cope with the psychological aspects of this disease and actually live my life without feeling sorry for myself everyday like I used to though. There are better anti inflammatory options out there.
I respect your experience and your opinion, but it is making wonders for me. WONDERS. My theory is that there are many "Kinds" of Peyronie's disease, and each kind requires a different treatment. The origin of my peyronie's is a strong, ongoing and lasting inflammation. Probably my genetics is crap in dealing with inflammation, and my TNF-alpha and my IL-6 and so on are too high, and my body just cant regulate them easily and correctly.
Seems like buproprion fixes this kind of issues. At least, for me.
I all due respect, when a guy with no medical background, no research background, who has never conducted one study, comes up with his idea of many kinds of Peyronies Disease, that is not a theory.
We refer to that as wild baseless speculation.
The part about "many kinds of peyronie disease" might be baseless speculation, but how about the action of buproprion on TNF-alpha and IL-6? Isn't that in line with the action of pentoxyfilline on the same, only way more powerful - or conversely with much fewer side effects for the same efficacy on those parameters, allowing for higher therapeutic doses? I once read a paper where they were showing that the ideal dosage of pentox for antifibrotic effects would be so high it would be unpractical and would come with serious side effects. Maybe pentox acts on a few other synergistic pathways, and it would benefit from a little help on the TNF-alpha and IL-6 front? I'd be interesting on adding low dose buproprion to my pentox+cialis+citrulline daily regimen.
Dear Hawk,
Point 1: You got no clue who i am in real life and outside this forum. So the only wild baseless speculation is your statement about my background.
Point 2: You got no clue what my theory is. I sintetized it by saying "there are many types of Peyronie's disease" but there's an idea behind it.
Point 3: Baseless or not, i didn't say "I'm right and others are wrong", i just said "It's my theory". Luckily, in this country (as well as in yours, as far as i know) there's freedom of think and speech. I stress once more that it's just MY THEORY, my opinion, an idea. just this. Nothing established.
Cheers. And thanks to @pey ron for defending me.
Hey Hope,
Just a word to tell you that I'm very glad to see that you found such a good relief from this molecule! As our cases are very similar, I added your post to my "to-try Peyronies Disease treatment list", and it it's precisely this kind of stuff that keeps me full of hope and energy to always try new stuff and never give up :).
For the moment I'm still very happy with my Hirudoid results, although I would like to 100% definitely beat that inflammation/pain response I get after sex/masturbation or when I'm not applying the cream. I'll try chondrointin/msm from next week, and will post you a review after a few weeks of as much objective assesment as possible, as always :).
Take care all of you guys, cheers,
G