I would ask for a referral to urologist.  But be prepared for a long wait.  I have Peyronies, urologist didn't use ultra sound but give diagnosis based on photos I provided. I have been given prescription for Somacorrect.  Yet to collect it

I check my morning BP daily since taking Cialis and L-Arganine.

I started with 95/60, then after taking both dropped to 90/55. With my lifestyle changes and and especially daily morning sport my BP stabilised more around 100/60 now.

It definitely has an effect on my BP c. A. -5 points, but long term it feels like the body is adapting.

By GP says my low BP is OK. I should drink lots of water and eat regular soup to get electrolytes.

Again great work; Don't let the last 5% stress you out. Focus on the 95% that you fixed with your hard work!

another correction: I contacted peptide sciences and they do not offer custom synthesis. So, only B7-33 can currently be sourced from them.

Hi, I was diagnosed with flaccid US + bringing images of erect penis. Maybe this option is something to discuss to avoid the injections.

Quote from: pey ron on October 20, 2025, 09:47:35 PMCurrent price is 90 USD.

correction: 70 USD.

I tried asking AI which one is more powerful between B7-33 and E4 and I didn't get a conclusive answer:

«Based on current scientific literature, it is not possible to state which peptide is "more powerful" because they have not been tested against each other in a head-to-head study."Power" or potency in this context is not a single measure. It depends entirely on the specific type of fibrosis (e.g., heart, lung, skin), the animal model, and the dosage used. Both B7-33 and E4 are considered highly potent, but they work in completely different ways.Here is a breakdown of what is known about the potency of each:B7-33 (Relaxin-based peptide)How its power is measured: Its potency is typically compared to the natural hormone, H2 Relaxin.1What studies show: In the cells responsible for fibrosis (native fibroblasts), B7-33 is considered equipotent to the full H2 Relaxin hormone at triggering the anti-fibrotic pathway (pERK).2Context of power: It has shown significant anti-fibrotic effects, particularly in models of cardiac fibrosis (heart scarring).3 One animal study noted it reduced heart tissue fibrosis by approximately 50% after a myocardial infarction.4 Its "power" comes from its selective nature—it provides the anti-fibrotic benefits of relaxin without activating other pathways that could cause side effects.5E4 (Endostatin-based peptide)How its power is measured: Its potency is measured by its ability to reverse existing, established fibrosis.6What studies show: E4 has demonstrated "remarkable" anti-fibrotic effects in preclinical models, particularly for dermal (skin) and pulmonary (lung) fibrosis.Context of power: Its unique strength is its reported ability to reverse even late-stage fibrosis.7 In one mouse study, it was able to reverse the scarring in "end-stage fibrotic lungs," which represents a very high bar for an anti-fibrotic agent.Summary: Why can't they be compared?Different Mechanisms: B7-33 works by activating the RXFP1 receptor, while E4 works by activating the urokinase pathway.8 This is like comparing two different tools (a hammer and a wrench) that both achieve a similar goal (reducing fibrosis).Different Research Focus: B7-33 is heavily researched for cardioprotection, while E4 has gained attention for its dramatic effects on lung and skin fibrosis.No Direct Comparison: No scientific paper has published a direct, quantitative comparison (like an $IC_{50}$ value) of B7-33 and E4 in the same experiment.Conclusion: Both are powerful anti-fibrotic peptides. B7-33's power is in its selective mimicry of relaxin for heart-related fibrosis, while E4's power is in its ability to reverse severe, established fibrosis in tissues like the lungs and skin»

Peptide sciences is said to be reputable and IIRC offered custom peptide synthesis... I can't seem to find the custom peptide synthesis page anymore though, and I have no idea how pricey it might be to request a custom peptide since I have never even dared asking them for a quote for E4.

But they have been offering 6mg of B7-33 for several years now. Current price is 90 USD.

I personally have never dared to purchase B7-33 because I am scared of injecting my willy.

They describe B7-33 the following way:

«B7-33 exibits potent anti-fibrotic effects. It is under active research and investigation as a means of reducing fibrosis in acute and chronic diseases like heart failure, lung inflammation, kidney and more.

In animal studies, B7-33 has reduced fibrosis by roughly 50%, leading to prolonged survival following injury and offering the first new means of treating heart failure in 20 years.

It has been shown to reduce excessive scar formation following cardiac injury. It has also shown promise in the treatment of certain vascular disorders as well as preeclampsia of pregnancy.»

Quote from: Ukguy1234 on October 19, 2025, 07:53:21 PMGet off here, spammer.

What?

Get off here, spammer.

Thanks for the responses!  Signature updated (apparently I forgot to hit "save" on that the other day lol).

I think the point of the verapamil is to increase bloodflow to the penis, but they have to compound it and mail it to me, and it is too expensive for me ($70/month out of pocket).  I stopped getting refills on that and saved up for the device instead.

I might try wrapping just the clamp instead of the glans next time to see how that works.  Removing the tape from the glans does not feel good.  I've tried using makeup pads that came with it, but I get slippage unless I still use self adherent tape also. 

I had never considered using a VED until reading these forums, but I did discover early on that getting an erection right after a session does make things feel better.  My friend asked me "What if you get an erection while using it?"  I said "I never thought of that, but I imagine something like 'The Incredible Hulk' but with less green."