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#1
Hi guys,

I still have my New curvature on the left and a hard painful area on the left side as if my penis was not filling with blood on the left side, this has appeared since my last surgery with Dr Gelman. At the base I had a curvature only downward.

The urologists don't know where my problem comes from, either an old suture that broke, or a problem with the corpus cavernosum after surgery.

All the urologists I've seen, including Dr Gelman, tell me that the only solution is another surgery.

All except Dr Trost, who says that the best solution would be Xiaflex injections, bearing in mind that I don't have Peyronie's, and according to the Doppler I recently had done, there's no fibrosis except for slight scars around the old sutures.

I was also able to chat by e-mail with Dr Djinovic in Serbia who also recommends surgery, but he didn't inspire confidence in me, it seems too easy for him and he's not very explanatory, plus the price for my surgery is much higher than other guys I've talked to.

So I'm very confused by the lack of consensus between doctors. What do you think? Has anyone had Xiaflex for congenital curvature with Dr. Trost?

Currently, I'm going to try VED soon, as recommended by a local urologist.
#2
April

Spirito L, Manfredi C, La Rocca R, Napolitano L, Preto M, Di Girolamo A, Arcaniolo D, De Sio M, Creta M, Longo N. Long-term outcomes of extracorporeal shock wave therapy for acute Peyronie's disease: a 10-year retrospective analysis. Int J Impot Res. 2024 Apr;36(2):135-139. doi: 10.1038/s41443-023-00673-w. Epub 2023 Feb 14. PMID: 36788352.

Maremanda AP, Du Comb W, Able C, Kohn TP, Unal S, Burnett AL. Erectile dysfunction and Peyronie's disease diagnosis rates after penile fracture-a retrospective claims database cohort analysis. Int J Impot Res. 2024 Apr;36(2):125-128. doi: 10.1038/s41443-023-00746-w. Epub 2023 Aug 4. PMID: 37542153.

Zugail AS, Alshuaibi M, Lombion S, Beley S. Safety and feasibility of percutaneous needle tunneling with platelet-rich plasma injections for Peyronie's disease in the outpatient setting: a pilot study. Int J Impot Res. 2024 Apr;36(2):140-145. doi: 10.1038/s41443-023-00744-y. Epub 2023 Aug 7. PMID: 37550385.

Loloi J, Schuppe K, Reddy RV, Rahman F, Bernstein A, Reddy P, Kulkarni N, Masterson T, Ramasamy R. A survey of exposure to the use of Xiaflex for the treatment of Peyronie's disease among United States urology residency programs. Int J Impot Res. 2024 Apr;36(2):155-159. doi: 10.1038/s41443-023-00781-7. Epub 2023 Oct 21. PMID: 37865716.

Kadıoğlu A, Gürcan M, Rakhmonovich AF, Dursun M. Surgical management of complex curvature in Peyronie's disease. World J Urol. 2024 Apr 30;42(1):276. doi: 10.1007/s00345-024-04936-z. PMID: 38689034; PMCID: PMC11061042.

Schneider D, O'Leary M, Amini E, Miller J, Hassas N, Nguyen J, Hammad MAM, Barham D, Yafi FA. Peyronie's disease response to intralesional collagenase clostridium histolyticum therapy is independent of baseline testosterone. Andrology. 2024 May;12(4):830-834. doi: 10.1111/andr.13532. Epub 2023 Sep 27. PMID: 37753943.
#3
February

Larson H, Warner J, Savage J, Kohler T, Ziegelmann M, Trost L. Changes in Point of Maximal Curvature During Collagenase Clostridium Histolyticum Injections for Peyronie's Disease. Urology. 2024 Feb;184:122-127. doi: 10.1016/j.urology.2023.11.024. Epub 2023 Dec 6. PMID: 38061610.


Cilio S, Rocca R, Celentano G, Marino C, Creta M, Califano G, Manfredi C, Russo GI, Morgado A, Falcone M, Capece M; YAU Working Group Sexual and Reproductive Health. Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie's disease: a retrospective single-center experience. Asian J Androl. 2024 Feb 2. doi: 10.4103/aja202371. Epub ahead of print. PMID: 38305689.


Wang X, Bao X, Liu H, Cui Y. Exploring the pharmacological mechanism of Herba Epimedii (yinyanghuo) for Peyronie's disease with network pharmacology strategy. Asian J Surg. 2024 Feb 20:S1015-9584(24)00270-7. doi: 10.1016/j.asjsur.2024.02.012. Epub ahead of print. PMID: 38383197.

Garaffa G, Traunero F, Claps F, Pavan N, Rossin G, Piasentin A, Rizzo M, Biasatti A, Zorzi F, Trombetta C, Liguori G, Ongaro L. Plication surgery does not produce additional loss of length in Peyronie's disease patients. Int J Impot Res. 2024 Feb 22. doi: 10.1038/s41443-024-00852-3. Epub ahead of print. PMID: 38388784.

Levine LA, Desouky E, Elist JJ, Moon D, Wilson SK. Use of Himplant® for correction of residual deformity following prior treatment of peyronie's disease: a case series. Int J Impot Res. 2024 Feb 23. doi: 10.1038/s41443-024-00840-7. Epub ahead of print. PMID: 38388785.

Ledesma BR, Velasquez DA, Egemba C, Molina M, Ibrahim E, Costantini-Mesquita F, Deebel NA, Han S, Reis IM, Saltzman R, Ramasamy R. A phase 2 randomized, placebo-controlled crossover trial to evaluate safety and efficacy of platelet-rich plasma injections for Peyronie's disease: clinical trial update. Int J Impot Res. 2024 Feb 29. doi: 10.1038/s41443-024-00844-3. Epub ahead of print. PMID: 38424354.


March

Thach S, Pommier B, Soulier V. The impact of Peyronie's disease on couples. Fr J Urol. 2024 Mar 4;34(4):102595. doi: 10.1016/j.fjurol.2024.102595. Epub ahead of print. PMID: 38442548.

Rassweiler JJ, Scheitlin W, Goezen AS, Radecke F. Long-term experiences with high-energy shock wave therapy in the management chronic phase Peyronie's disease using two different electromagnetic lithotripters. World J Urol. 2024 Mar 7;42(1):124. doi: 10.1007/s00345-024-04792-x. PMID: 38453751; PMCID: PMC10920406.

Şahin A, Babayev H, Cirigliano L, Preto M, Falcone M, Altıntas E, Gül M. Unveiling the molecular Hallmarks of Peyronie's disease: a comprehensive narrative review. Int J Impot Res. 2024 Mar 7. doi: 10.1038/s41443-024-00845-2. Epub ahead of print. PMID: 38454161.

Institute for Quality and Efficiency in Health Care (IQWiG). Penile traction therapy for induratio penis plastica: IQWiG Reports – Commission No. N22-01 [Internet]. Cologne (Germany): Institute for Quality and Efficiency in Health Care (IQWiG); 2024 Mar 8. PMID: 38574187.

Hatzichristodoulou G, Gültekin MH, Özkara H, Akkus E. First worldwide correction of ventral Peyronie's disease utilizing rigicon inflatable penile prosthesis combined with plaque incision & grafting with collagen fleece (PICS-technique) for residual curvature. Int J Impot Res. 2024 Mar 13. doi: 10.1038/s41443-024-00873-y. Epub ahead of print. PMID: 38480871.

Jin DC, Luo Y, Wang P, Zhang Y, Bi G, Tong DL, Wang YY, Zhou WY, Li YF. Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease. J Vis Exp. 2024 Mar 15;(205). doi: 10.3791/66305. PMID: 38557978.

Paulis G, De Giorgio G, Paulis A. Ultrasound Elastography as a Diagnostic Tool for Peyronie's Disease: A State-of-the-Art Review. Diagnostics (Basel). 2024 Mar 21;14(6):665. doi: 10.3390/diagnostics14060665. PMID: 38535085; PMCID: PMC10969672.

Giagulli VA, Lisco G, De Tullio A, Guastamacchia E, Triggiani V, Jirillo E. The pathogenic role of the immune system in erectile dysfunction and Peyronie's disease: focusing on immunopathophysiology and potential therapeutic strategies. Sex Med Rev. 2024 Mar 26;12(2):210-220. doi: 10.1093/sxmrev/qead055. PMID: 38196188.

"This study is to our knowledge the first analysis of temporal gene expression associated with the regulation of the transformation of resident fibroblasts to profibrotic myofibroblasts in Peyronies Disease. Further research is warranted to investigate the role of the MAPK-Hedgehog signaling pathways in reversibility of Peyronies Disease.'

Spirito L, Manfredi C, La Rocca R, Napolitano L, Di Girolamo A, Capece M, Trama F, Sciorio C, Sokolakis I, Creta M, Arcaniolo D. Daily low-dose tadalafil may reduce the penile curvature progression rate in patients with acute Peyronie's disease: a retrospective comparative analysis. Int J Impot Res. 2024 Apr;36(2):129-134. doi: 10.1038/s41443-022-00651-8. Epub 2022 Dec 13. PMID: 36513814.
#4
Hello and welcome to the forum. Please take a couple minutes to fill in your signature under your profile settings. This will help keep you from having to repeat why your here in the forum when you post.

I have sent a PM explaining how and giving you some guidelines for the forum. We are happy you are here and look forward to helping

Stabler
#5
I am 29 and i have had a strange pain on the left side of my penis, kind of where the glands meets the shaft for about two weeks now. The best way to describe it is that it feels like when you have a bruise and you press on it, but it's not really that painful. The pain is localized to a small spot and does not radiate.

I can't really feel the pain when I press on it while it's flaccid or erect. I feel it most when my erection presses against my clothes, or when i put pressure on my penis like if i were to masturbate. It feels like a bruise, but there are no obvious signs of bruising. I would rate it at a 1 out of 10 on a pain scale. It's not really painful, but it has been there long enough for me to be concerned. It doesn't feel like it's getting worse, but it also doesn't feel like it's getting better. There are no signs of any curving, indentation or plaque. The erection itself does not hurt my penis, just when pressure is applied to it at that specific spot.

The reason I am a little worried is because I have been on a very low dose of beta blockers (20mg propranolol) for just over a year now and I read that a rare side effect of long term use is Peyronie's. I have no recollection of injuring my penis. However, I have noticed that I have been getting potent nocturnal erections recently and I think maybe I bruised my penis sleeping on my stomach somehow?

My GP has no idea what could be causing the pain, as she didnt see or feel anything wrong when she inspected me, but she did share my concern a bit when i brought up the propranolol side effects, so she wants me to see a urologist. It will be a while before i can get an appointment, but does anyone have any insight on what the pain could be from in the meantime?
#6
Hello Alex,

I am John in Seattle, USA.  Are you in France?
Do you want to exchange some ideas regarding treatments?
I am using the Restorex now for one month and I can already see improvement.

My email is cernfan@protonmail.com

Merci!
John
#7
I tried this last week and it was a GAME CHANGER!  I had only used my machine once or twice and it was so painful even with the wrap that it felt like medieval torture clamping my glans in that device.  I tried the makeup pads and BINGO!  I also made an adjustment to the clamps and moved the screws one position wider.  BINGO!  My glans was too plump to fit in the paddles the way it was configured and no amount of wrapping it with that thin gauze coban tape helped.  It felt like I was trapped in a mousetrap.  Now I actually look forward to my stretching and bending with the device.  I also apply heat packs and then I use the VED.  I am already seeing some reduction in my curve and it's only been a week!  HONESTLY!!!!
#8
I know the soma is recommended by many on this forum however it does not have a gauge so I don't know why it is recommended. I have been led to believe over pumping is the biggest reason ppl hurt themselves.

I just bought a glass cylinder from la pump with a gauge and it has been working well so far.

The soma also fogs up much easier because the cylinders are a cheap plastic
#9
Penile Implants / Re: Is stretched out flacid yo...
Last post by Lostand Looking24 - Yesterday at 10:14:52 PM
Quote from: ohnoohno on Yesterday at 05:01:20 PMAlso @lostandlooking - how much have you gained since using the pmp?

I dont track length since I haven't lost any, but I've noticed since doing traction I can consistently stretch my flaccid to pretty much the same length as when erect. Before it wasn't that stretchy at all.

Also I personally much prefer the Restorex (more a convenience thing) and only use the PMP every now and then at this point so can't really say. 
#10
Penile Implants / Re: Is stretched out flacid yo...
Last post by ohnoohno - Yesterday at 05:01:20 PM
Thanks all. I'm getting a penimaster pro (plus the weighted set) to try regain some length and life into my todger.

Also @lostandlooking - how much have you gained since using the pmp?