Abstract Effects of sildenafil treatment on patients wit... [Ir J Med Sci. 2013] - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/24190613)
INTRODUCTION:
It has been shown on experimental rat models that type 5-phosphodiesterase isoenzyme (PDE5) inhibitors have anti-fibrotic effects for Peyronie's disease (Peyronies Disease); however, this issue has not been addressed clinically. The aim of this study was to document the effects of PDE5 inhibitors used for erectile dysfunction (ED) seen in Peyronies Disease patients on the main course of the Peyronies Disease clinically.
METHODS:
A total of 39 Peyronies Disease patients with ED were divided into two groups. Patients in Group 1 (n = 18) served as controls and received 400 IU vitamin E per day. Those in Group 2 (n = 21) received 50 mg sildenafil per day for 12 weeks. Penile plaque volume was assessed by palpation and by duplex ultrasound. Erectile capacity, penile deformity and plaque characteristics were assessed by the International Index of Erectile Function questionnaire form (IIEF-5) and penile duplex ultrasound.
RESULTS:
Statistically significant improvement in all parameters was observed within both groups except for IIEF score in Group 1 when compared with the initial values. Significant reduction in plaques and pain were observed in 7 (33.3 %) and 14 (66.6 %) patients in Group 2 and 6 (33.3 %) and 9 patients (42.8 %) in Group 1, respectively. At the end of the therapy, improvement in IIEF score and reduction in pain were statistically significant in Group 2 compared with Group 1 (p = 0.028 and p = 0.045, respectively).
CONCLUSION:
We conclude that continuous administration of oral PDE5 inhibitors may be a candidate for medical treatment of Peyronies Disease; however, more controlled studies are needed.
My own interpretation and thoughts:
So 1/3 of people will see significant reduction in plaque if they take 50mg of viagra for 3 months.
But also 1/3 of people will see significant reduction in plaque if they take 400iu of Vitamin E for 3 months.
I'd like to be hopeful about this, but the impact they found from Vitamin E is troubling to me. I've never heard anyone who thought Vitamin E did squat (other than generations of Urologists who push it like its state of the art). Makes me wonder what's going on in the minds of these participants or researchers.
Nemo
Improvement on vit E could be due to placebo or spontaneous improvement, which supposedly occurs in about 10% of Peyronie's cases.
-Skjald
Right. But that would apply to the Sildenafil group, as well—could be placebo or spontaneous resolution. Thus, for me, the study really doesn't prove much of anything I'd like to hear. Clouding the study with Vitamin E was needlessly confusing.
Nemo
Nemo:
I think you are right about vitamin E doing anything much for Peyronies Disease symptoms, nor ED for that matter. My uro prescribed it for me way back in the 1950s and I took jars full of the stuff. Never saw any good results even taking it along with 45 3 minutes bombardments of radiation on the young tool (at that time!).
Maybe there is some effect for some folks, but not for me.
Old Man
This is an interesting and worthy topic but I have a few comments, some about the study and some about posting in the resource library.
First, the study is such a very tiny study, and it apparently was neither double blind or even blind. I don't know that we can draw much from it.
Next, the resource library clearly says in the heading
QuoteThis area is only for viewing: Articles, Images, Links and other educational resources. Discussion must take place on the main Peyronies Disease Discussion Boards.
It is for posting significant resource information for taking to doctors, and information members may have to refer back to over and over again.
Because of this I will be moving this entire topic to the Oral Treatment board.
My theory is that it helps with peyronies cause of the increased blood flow to the tissues..
melting
Again you are not complying with the forum rules!!!
Hawk stated very clear in his post bellow that this board is not a conversation board.
James