Peyronies Society Forums

Peyronies Disease TREATMENT Discussion Boards => Developmental Drugs & Treatments => Topic started by: Whyisthishappening on April 19, 2019, 09:43:32 AM

Title: mycophenolate mofetil
Post by: Whyisthishappening on April 19, 2019, 09:43:32 AM
Anti-fibrotic effect of mycophenolate mofetil on Peyronie's disease experimentally induced with TGF-β

https://www.nature.com/articles/s41443-019-0138-7?error=cookies_not_supported&code=3a30c172-d60f-4c5f-a3ea-2d3bd1317c8d

  "The histochemical analysis revealed the fragmentation and degradation of elastin in the tunica albuginea. This process was partially reversed in the MMF-7d group and a situation very close to normality was observed in the MMF-30d group"
Title: Re: mycophenolate mofetil
Post by: Paolo on April 19, 2019, 09:59:30 AM
Interesting drug used for Chemotherapy and prescription only  :o
Question is for the layman (us) would be getting access to it.
Paul.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on April 19, 2019, 10:05:17 AM
 used for immunosupression in transplants but it is something and allready in use
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on May 19, 2019, 01:06:16 AM
guys if my herbal treatments fail i would consider to start mycophenollate mofetil after getting doctors advice
Title: Re: mycophenolate mofetil
Post by: pey ron on May 19, 2019, 06:31:34 PM
This is an awesome find. I see they sell it for cheap. And they even sell it in powder form to be reconstituted for injection. Ideally this would work well with iontophoresis, I wonder whether it should go on the anode or the cathode...
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on May 20, 2019, 12:24:44 AM
i believe if someone would experiment with mofetil should do it under medical advice and supervision
Title: Re: mycophenolate mofetil
Post by: pey ron on May 21, 2019, 01:49:35 AM
if only i could get my hands on some MMF in powder form...
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on May 21, 2019, 05:21:28 AM
mofetil acts as an inosine inhibitor but   i found that SAPPANONE A  can selectively inhibit inosine
  Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530702/
and sappanone a is a component of a herbal tea popular in some parts of the world
  what do you think guys?
Title: Re: mycophenolate mofetil
Post by: jj21 on May 21, 2019, 06:07:04 AM
WhyIsThisHappening - bro I love how you aren't giving up and trying to find a solution no matter what. KEep it up man i'm not giving up either we will find a solution together and conquer this.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on May 21, 2019, 06:27:54 AM
thanks jj we are together in this bro everybody of us no matter our differences
  i do not want to be disturbing but  please everybody read about mofetil and Peyronies Disease publication it may offer the solution
they managed to have a better collagen I/III ratio even than controls and mofetil targets inosine so i believe we should pay attention on inosine inhibitors i invite every experienced or not member of this forum to find safe mofetil alternatives
Title: Re: mycophenolate mofetil
Post by: Patientxyz1992 on May 21, 2019, 08:31:26 AM
Interesting, do you guys think this would work, also how could we obtain it and would it needed to be injected?
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on May 21, 2019, 09:27:01 AM
    it worked in animal studies only 5 DAYS of ORAL administration.The MMF7d and MMF30d is reference to the days post TGF administration not mofetil therapy.
     where  i live it costs 60 dollars a package of 50x500mg tabs
Title: Re: mycophenolate mofetil
Post by: Patientxyz1992 on May 21, 2019, 03:40:27 PM
Do you know are there much sideeffects, also do you think people are getting cured of peyronies and we dont know?
Title: Re: mycophenolate mofetil
Post by: pey ron on May 21, 2019, 05:13:08 PM
Can you get it without a prescription? Back in my home country (Italy) I could get a lot of stuff without a prescription even though it would be legally required.
Title: Re: mycophenolate mofetil
Post by: hope794 on May 21, 2019, 06:44:25 PM
Great find bro.
Title: Re: mycophenolate mofetil
Post by: jj21 on May 21, 2019, 09:40:00 PM
Patientxyz1992 - I think some people do get cured as many members have not returned to this forum. Check the improvements section as well..... Some members who were experimenting with growth hormone and peptides never returned either - I presume they were healed?
Title: Re: mycophenolate mofetil
Post by: pey ron on May 22, 2019, 03:55:30 AM
Quote from: jj21 on May 21, 2019, 09:40:00 PM
Patientxyz1992 - I think some people do get cured as many members have not returned to this forum. Check the improvements section as well..... Some members who were experimenting with growth hormone and peptides never returned either - I presume they were healed?

which peptides? can you please link their posts?
Title: Re: mycophenolate mofetil
Post by: Bubba dawg on May 22, 2019, 05:44:16 AM
 Nobody doing experimental treatments on me! Now if I were terminally ill with no other options, then experiment away. Some of these methods maybe good ones. Yall test them first and get back to us  ;D
Title: Re: mycophenolate mofetil
Post by: Crooked_Stick on May 22, 2019, 02:39:14 PM
If I read the report correctly there was no improvement in deformity  :-[
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on May 22, 2019, 10:40:05 PM
 you interpreted wrong crooked

"The analysis of the penile angle revealed a reduction in the mean angle after the induction of Peyronies Disease with TGF-β. This angle was increased after treatment in the MMF-7d group and increased even further after treatment in the MMF-30d group"
            mmf 30d brought rat Peyronies Disease penis closer to control
 
"The histochemical analysis with the different methods revealed atypical distribution of the connective fibres in the tunica albuginea. Using fluorescence microscopy with hematoxylin-eosin, the degradation and fragmentation of elastin was found in the TGF-β group. This process remained in the MMF-7d group and a situation close to NORMALITY was found in the MMF-30d group"
 
Title: Re: mycophenolate mofetil
Post by: jj21 on May 22, 2019, 10:40:50 PM
Pey ron - I've lost the links but try a forum search, I think one of them was BPC 157. I found a few posts of people starting or talking about starting their course on growth hormone and peptides then they never returned to the forum. Not sure if they just stopped coming here or were actually healed.
Title: Re: mycophenolate mofetil
Post by: JohnnyDoe on May 25, 2019, 02:30:13 PM
Quote from: Patientxyz1992 on May 21, 2019, 03:40:27 PM
Do you know are there much sideeffects, also do you think people are getting cured of peyronies and we dont know?

There is a list of side effects. It basically weakens your immune system, but should come back to normal after you stop using it. This medicine is normally used for organ transplants, so your body does not reject the new organ.

https://www.rxlist.com/cellcept-side-effects-drug-center.htm

So yeah, who is willing to try? 😅
Title: Re: mycophenolate mofetil
Post by: Hontas on May 27, 2019, 01:25:16 PM
Whyisthishappening

Check your pms mate
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on June 18, 2019, 11:43:51 AM
guys i am currently having a tea of 6g of HEARTWOOD everyday which contains sappanone an inosine inhibitor the name of the tea is SU MU it is very cheap reddish and has no taste.i rinse 6g of heartwood in water for 10min. then boil for 10min. and after is not hot i drink it.take it while fasting for better results, i had improvements and do not know if is reish,i boswellia or heartwood but try yourself 
also alpha -carotene is an inosine inhibitor try to eat foods that contain a lot of it (carrots,sweet potatos,avocados,broccoli)
     
PASS-Predicted Hepatoprotective Activity of Caesalpinia sappan in Thioacetamide-Induced Liver Fibrosis in Rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950979/
"The antifibrotic effects of traditional medicinal herb Caesalpinia sappan (CS)"

" CS treatment was noted to normalize the expression of TGF-β1, αSMA, PCNA, MMPs, and TIMP1 proteins"

" Several studies have shown that CS has antimicrobial and bactericidal activity [8] and antiallergic [9], neuroprotective [10], and hypoglycaemic effects [11]. Others found that extract from CS can be used for treating ascites, tumour, leukaemia [12], and arteriosclerosis [13]. This could be due to its antioxidant activity and its capability to inhibit malondialdehyde (MDA) and scavenging of superoxide anions, hydrogen peroxide, and hydroxyl radicals"


Title: Re: mycophenolate mofetil
Post by: projectpd on June 18, 2019, 02:29:48 PM
@pey ron, that is a good point

it is available as a hydrochloride salt,
https://www.drugbank.ca/drugs/DB00688

from reading the below then it could be amenable to iontophoresis:
https://www.ncbi.nlm.nih.gov/pubmed/25482587
"Therefore, in this project, ITR was converted to hydrochloride salt (ITR-HCl) to improve its solubility and to render it amenable to iontophoresis."

in addition the molecular weight is 433g/mol , low enough to be likely transportable by DMSO

I wonder, ultrasound could also enhance transdermal delivery; heat , ethanol also can increase transdermal delivery. 

it would be understandable to try to avoid a large systemic dose as it is a powerful immune suppressor.
Title: Re: mycophenolate mofetil
Post by: projectpd on June 18, 2019, 02:52:03 PM
@pey run , so I think it would be the anode that you would then use as the active node , see
https://www.freece.com/Documents/Transdermal_Monograph.pdf

however, what does anyone think about whether there is any reason this would be helpful when not in the acute phase.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on June 19, 2019, 03:19:18 AM
why do you overcomplicate things and why local administration cannot act systemically?  it was administered for 6 months  to IPF patients with no side effects we have to take it only for 5 DAYS .the rat study was 30mg/kg body weight/day FOR 5 DAYS if your weight is only 70 kilos you are in the recommended dose of IPF study patients and also the rat study analog dose.
i will try to contact a reumatologist who did research with mofetil toSS patients
  you can also try su mu tea which is heartwood of caeselpinia sappan no side effects and many systemic benefits i will make a post for it in alternative treatments
 
Title: Re: mycophenolate mofetil
Post by: projectpd on June 21, 2019, 07:58:47 AM
if anyone tries it, note the statement in the same paper:
In contrast, analysis of fibrosis parameters in vivo revealed
a biphasic pattern: MMF reached a maximal antifibrotic effect at 5 mg/kg
(equivalent of 500mgiday in humans), which declined at 20 mgilcg (human
dose 1.5g/day) and the drug became profibrogenic at 100mg/kg.

I guess that would make estimating a reasonable transdermal dosage more problematic.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on June 21, 2019, 08:29:39 AM
projectpd can you please cite this mention?
   it is very important that we may need an even smaller dose thank you
   also tried to contact with no success yet a mofetil researcher
Title: Re: mycophenolate mofetil
Post by: projectpd on June 21, 2019, 12:34:35 PM
sorry, not one of the papers above, but referenced here, still seems worth noting https://www.journal-of-hepatology.eu/article/S0168-8278(07)61934-5/pdf
THE ANTIFIBROTIC EFFECT OF MYCOPHENOLATE
MOFETIL IS LOST AT CLINICALLY RELEVANT DOSE,
IN LIVER FIBROSIS
FOLLOWING A BlPHASlC DOSE-DEPENDENT PATTERN

In contrast, analysis of fibrosis parameters in vivo revealed
a biphasic pattern: MMF reached a maximal antifibrotic effect at 5 mg/kg
(equivalent of 500mg /day in humans), which declined at 20 mg/kg (human
dose 1.5g/day) and the drug became profibrogenic at 100mg/kg,...
Conclusions: 1, MMF demonstrates strong antifibrotic properties in vivo
only at low dose (equivalent to less than 500mgiday in a patient), while
higher doses are ineffective or even profibrogenic

Title: Re: mycophenolate mofetil
Post by: Werther on June 22, 2019, 12:19:58 PM
Quote from: projectpd on June 18, 2019, 02:52:03 PM
however, what does anyone think about whether there is any reason this would be helpful when not in the acute phase.

Projectpd and Whyisthishappening, can you please both clarify on this?

Based on your understanding, might mycophenolate mofetil be helpful for the chronic phase? If so, why?

Post sources in order to support your statements, if you can.

Thanks
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on June 22, 2019, 02:46:55 PM
yes it may   be more helpful in the chronic phase because the 30 days rat group after tgf injection saw much more benefits(close to normality) than the 7d after tgf injection group,if you read the pub it says tissue regeneration properties bringing the affected tissue close to normality
if you see the microscope fotos collagen 3/1 ratio looks even better than control (less collagen 3) also elastin structure is almost completely restored
just read very carefully the whole pub its easy to see by yourself the fotos also(collagen 3 black fibers, collagen 1 brown, elastin green )
if you dont understand something specific lets discuss it here because proejctpd mentioned above something about mofetil dosing that was a great find so lets made  loads of question and answers here by many members,maybe someone finds something more the better for all of us
i thank you too bro
ps to everybody please  try su mu tea and reishi especially if in pain
Title: Re: mycophenolate mofetil
Post by: projectpd on June 22, 2019, 03:50:04 PM
Hi Werther,
I can't see that anyone suggested that would be the case,  I already raised the question in #25. The study seems to add to the existing view in the forum on the potential effectiveness of early treatment, in the acute phase,  as opposed to the wait-and-see advice that has been the norm. Then again the study did not collect data that might have been more relevant to a chronic phase.
Title: Re: mycophenolate mofetil
Post by: projectpd on June 22, 2019, 04:02:53 PM
sorry @Whyisthishappening, I had not seen your message above.  The problem is the rats' condition was probably still developing after 30 days even allowing for their faster life cycle vs humans.  In the Discussion section they made the below statements but I found difficult to interpret:

This characterises an improvement in the acute phase of the disease and may interrupt and even attenuate or reverse the formation of fibrotic plaque. The lower collagen III and collagen ratio values in the MMF-30 group than the control group suggests that MMF treatment may not reverse the fibrosis effect, but acts in another way.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on June 22, 2019, 09:48:36 PM
projectpd i find difficult to interpret also the same statement
what do you guys think to contact the researchers?
Title: Re: mycophenolate mofetil
Post by: Werther on June 23, 2019, 12:23:13 PM
Quote from: projectpd on June 22, 2019, 04:02:53 PM
In the Discussion section they made the below statements but I found difficult to interpret:

This characterises an improvement in the acute phase of the disease and may interrupt and even attenuate or reverse the formation of fibrotic plaque. The lower collagen III and collagen ratio values in the MMF-30 group than the control group suggests that MMF treatment may not reverse the fibrosis effect, but acts in another way.

It's indeed difficult to understand clearly what the authors are trying to say. IMO it looks like they're stating that the drug might be helpful in the acute phase but not in the chronic one, as you stated; I base my thinking on the fact that they speak of reversal with regards to "the formation of fibrotic plaque" which happens during the acute phase but then they add that "MMF treatment may not reverse the fibrosis effect" which is the late stage of peyronie's (i.e. the chronic phase).

I may be wrong though.

I agree with your idea Whyisthishappening: maybe it could be of help getting in touch with the authors of this study and ask them specifically about this passage.

If anybody get to know anything, please post it here.

Thanks again.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on June 24, 2019, 08:12:26 AM
i just talked to a mofetil researcher not the one of Peyronies Disease study but a reummatologist
he read the Peyronies Disease publication and told me that for 5 days in the smallest dose 500mg cannot hurt anybody but that we should consider its immunosuppresive properties,also he told me for scleroderma they took it for 3 to 6 months in higher doses and that 5 days for him is not long enough to have any effect(he was surpprised that the mice study showed results in just five days) maybe the solution is just a drugstre and 5 away who knows?
so accordind to projectpd mention of 500mg/day showing maximum antifibrotic effect i will try it for 5 days in the dose of 500mg/day after some blood test i will do this week or the next one
if anybody is willing to talk to the brasillian researchers of mofetil Peyronies Disease study please do
Title: Re: mycophenolate mofetil
Post by: JohnnyDoe on June 26, 2019, 06:15:58 AM
Good luck man, respect for trying it. Looking forward to read the results.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on June 28, 2019, 03:39:13 PM
thank you johhny i will keep everybody informed
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on July 05, 2019, 07:43:37 AM
guys they stopped selling mofetil in my country from july 1st i cannot take it i would talk again to the reummatologist
Title: Re: mycophenolate mofetil
Post by: Werther on July 06, 2019, 12:33:00 PM
I'm sorry to hear this man. Does this mean that you won't get to experiment with this drug?
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on July 06, 2019, 10:40:48 PM
no i will try to get it man
Title: Re: mycophenolate mofetil
Post by: Patientxyz1992 on July 07, 2019, 09:37:40 AM
Im in north carolina now, do you now maybe can i buy this drug over the counter?
Title: Re: mycophenolate mofetil
Post by: Werther on July 07, 2019, 10:33:57 AM
@Whyisthishappening:

Good luck then and please keep us updated.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on July 08, 2019, 06:54:25 AM
i found it with the name CELLCEPT but i need prescription so i will try to get it
Title: Re: mycophenolate mofetil
Post by: Patientxyz1992 on July 08, 2019, 06:23:21 PM
https://medicalxpress.com/news/2018-07-metformin-reverses-lung-fibrosis.html
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on August 27, 2019, 03:10:32 PM
i just talked to my urologist(one of many) he cannot prescribe mofetil it needs special prescription from a reummatologist i also tried my luck to three pharmacists today but they told me that they have to order it with the special prescription in hand so will try my luck with reummatologists i hope someone  will understand and give a prescription
   
 
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on August 29, 2019, 02:38:41 PM
i called the reummatologist of the scleroderma study today and he does not prescribe it to me.next week i will try other reummatologists .he told that it is used for organ transplantation and reummatologic use is off label but very common for lupus.
  there are people in this sub forum that are very active searching for crazy compounds,guys what makes you believe that a compound in a lab which we cannot buy and they use it for other conditions and not Peyronies Disease could be more effective than  mofetil
i will say it again mofetil its our only realistic option and even  that may  not work on human subjects
Title: Re: mycophenolate mofetil
Post by: JohnnyDoe on August 29, 2019, 07:42:34 PM
Doctors are responsible for the medicine they prescribe, therefore it might be hard to find someone who gives this based on an animal study, but I admire you trying! Who knows, it might work.

But I am sure so many things have not been tested yet for this disease. From what I read, seems like the medical world has not yet figured out to properly treat scar tissue in general.
Title: Re: mycophenolate mofetil
Post by: Hontas on August 30, 2019, 09:01:38 AM
Whyisthishappening,

This isn't an autoimmune disease, it is an autoinflammatory one. The best bet is drugs like Colchicine or biologics that are used to lower certain types of inflammatory cytokines. I have had problems communicating with the doctors in that retrospect and taking immune suppressive drugs will not be the solution from what i know theoretically, as there isn't any antibody being produced if you have a negative autoimmune marker test. Its all about DAMP and PAMP overreaction and response and a bit of underlying genetics that makes you vulnerable to mutation and myofibroblast differentiation. But you can at least try it. Colchicine is a mixed drug for me as i am not sure if it actually helps, as i had severe side effects and had to stop the treatment right now for my own life's sake and i am not even sure if lower doses help by lowering inflammation or make it worse over time by delaying healing. I have realised while taking colchicine that i have a lot of minor scar spots in other places and i am not sure if colchicine is actually returning them back to acute to dissolve them or simply just creates them. First one has a higher chance of happening and i am just betting right now to be honest.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on August 30, 2019, 01:58:43 PM
mofetil healed rats in just 5 days  and not in a crazy dose but human therapeutic one
Title: Re: mycophenolate mofetil
Post by: jj21 on September 01, 2019, 12:21:43 AM
any update?
Title: Re: mycophenolate mofetil
Post by: Fix This on September 01, 2019, 02:51:46 PM
Yes I've just seen this and I'm very interested to hear of an update on this now too!...
Title: Re: mycophenolate mofetil
Post by: Fix This on September 01, 2019, 06:27:09 PM
Also, whyhisishappening. Can you tell me where exactly you get thie SU MU tea from?  I have found several MU teas, but no SU MU?


Thanks

Fix
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on September 02, 2019, 11:45:08 AM
bought it from a chinese traditional medicine shop  su mu (caesalpinia sappan)
https://tcmwiki.com/wiki/su-mu
please take reishi powder 1 tea spoon two times a day very helpful
Title: Re: mycophenolate mofetil
Post by: Fix This on September 02, 2019, 11:54:26 AM
Thanks Whythisishappening. I'll look at that for sure

Have you had any success treating your peyronies with this tea?

Any news on the Mofetil yet ?
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on September 02, 2019, 01:31:27 PM
i do not know man my TWO DENTS ARE smaller but STILL THERE i had an MRI and i have NO FIBROSIS at the moment while a year ago  i had ,so reishi or my body helped i stoped su mu after a month of use and i am on reishi powder only
considering mofetil today i called another reummatologist and is willing to prescribe it so i hope in a few days to have it
Title: Re: mycophenolate mofetil
Post by: Fix This on September 03, 2019, 05:09:14 AM
Do you think the reishi poweder might have helped ratehr than the su mu tea?

I've looked on Amazon here in the UK and there are quite a few reishi options - tablets, powder etc. But I'm not sure what doseage we shoud be looking at ? I haven't heard of this as a treatment or supplement before.

Whic country are you in Whythisishappening? If you don't mind me asking? It may be that some Easter countries such as China have different methods of dealing with peyronies which we in the West and even on this forum may not have such general knowledge of
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on September 03, 2019, 06:34:13 AM
i do not know Fix maybe both ,try them they do not harm you,just take reishi up to a gram per day not less .Buy reishi in bulk powder form costs less and take a tea spoon twice a day
Title: Re: mycophenolate mofetil
Post by: Fix This on September 08, 2019, 05:32:15 AM
Thanks, Su Mu in powder form or the red bark is better?

Also any update on the Mofetil?..
Title: Re: mycophenolate mofetil
Post by: Hope77 on September 09, 2019, 01:30:49 PM
Quote from: Whyisthishappening on September 02, 2019, 01:31:27 PM
i do not know man my TWO DENTS ARE smaller but STILL THERE i had an MRI and i have NO FIBROSIS at the moment while a year ago  i had ,so reishi or my body helped i stoped su mu after a month of use and i am on reishi powder only
considering mofetil today i called another reummatologist and is willing to prescribe it so i hope in a few days to have it

Hello, I have 3 lumps amd with pain around the area. Are these lump/swelling the same as plaques? Could I be in acute peyronie? What do u recommend at this stage apart from survival guide.

Thank you
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on September 10, 2019, 09:40:49 AM
fix this i took bark ,i also just got mofetil today but will wait for some days before i take it
hope 77 try reishi mushroom powder apart from that i do not know this is the mofetil thread.. ,take care man and welcome to the forum
Title: Re: mycophenolate mofetil
Post by: JohnnyDoe on September 10, 2019, 05:19:38 PM
Good luck with the Mofetil. I look forward to read about your results!
Title: Re: mycophenolate mofetil
Post by: Fix This on September 10, 2019, 06:42:06 PM
Thanks Whythis , I'll try the bark :)

Also looking forward to your results with Mofetil

Are you going to try a 5 day course as per the rat tests?


Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on September 12, 2019, 05:30:28 PM
 i will try  500mg  for 5 days and if does not work 2000mg for 5 days like the rat study
Title: Re: mycophenolate mofetil
Post by: JohnnyDoe on September 13, 2019, 04:17:31 AM
Make sure to take before/after photos! In case it works, it would be good to have some proof :)
Title: Re: mycophenolate mofetil
Post by: pey ron on September 17, 2019, 01:10:43 AM
@Whyisthishappening: can you send me a private message with the source you bought it from?
Title: Re: mycophenolate mofetil
Post by: Fix This on September 18, 2019, 04:12:45 AM
Have you completed the 5 days at 500mg yet Whythisishappening?  Any improvements?

Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on September 18, 2019, 01:14:48 PM
hi ron i bought mofetil from a pharmacy in my city with a special prescription from a reummatologist
fix i have not started my treatment yet i am planning to start tomorrow or monday
Title: Re: mycophenolate mofetil
Post by: samsung on September 23, 2019, 11:13:46 AM
Anything to report?
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on September 25, 2019, 02:04:19 PM
hi guys i am on mofetil treatment  day 2 nothing so far to report i will finish my treatment on saturday
Title: Re: mycophenolate mofetil
Post by: pey ron on September 27, 2019, 04:11:00 AM
best of luck!!!!!

what country are you in?
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on September 28, 2019, 06:45:57 AM
mofetil day 5 i have switched yesterday to 2 grams per day so will take it for 4 more days and report about the results ,so far no results.
Title: Re: mycophenolate mofetil
Post by: Hontas on September 28, 2019, 08:31:01 AM
Just don't overuse it man, there are serious risks of rare uncurable cancers with the use of mofetil. From my perspective its not a risk worth taking however i give you props for being the one with the biggest balls. I just think thrice before using something potent since it can also make you worse in theory... Now i am gonna mix up raloxifene and tadalafil and will let you know about the results. We gonna get through this man
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on September 30, 2019, 08:04:04 AM
guys it did nothing so far so i quit it
Title: Re: mycophenolate mofetil
Post by: JohnnyDoe on September 30, 2019, 04:00:13 PM
Respect for trying. Who knows, it will take some time to have an effect.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on October 01, 2019, 01:00:41 AM
guys i want to thank everybody for your best wishes mofetil at least in theory sounded promising the doctor told me that it takes time to build in your system and work but i followed the rat study protocol with no results and didn't want to try it longer
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on October 03, 2019, 02:42:29 PM
guys great news

   i have no curvature while i had minimal curvature before
    and my two dents are better

i should mention that i had NO FIBROSIS established on MRI BEFORE I TOOK MOFETIL
  i have soft non palpable plaques so my case is considered very mild

also i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day
i will try again for five days at 2000mg per day in the near future and report back
Title: Re: mycophenolate mofetil
Post by: JohnnyDoe on October 03, 2019, 04:50:42 PM
Great to hear. So after 2 days you saw improvements happening?
How many degrees are we talking about?
Title: Re: mycophenolate mofetil
Post by: samsung on October 03, 2019, 05:18:23 PM
Pickatures
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on October 04, 2019, 06:10:33 AM
i saw improvement 3 days after the last pills i had 5-10 degrees curvature i have no pictures
Title: Re: mycophenolate mofetil
Post by: hope794 on October 04, 2019, 05:03:15 PM
Hello, can you please be more accurate bro?

Answer these questions please..

1. Curvature degrees BEFORE and AFTER the treatment?
2. How long did the treatment last?
3. How were your erections BEFORE and AFTER the treatment?
4. Which effects did you notice (if you had any) on other deformities, like dents, hourglassing, and so on?
5. What about penile lenght and girth? any improvements?

Thank you!!!
Title: Re: mycophenolate mofetil
Post by: samsung on October 04, 2019, 05:21:01 PM
Sorry for me saying to provide pics. Don't mean to be aggressive. You understand we are all just anxious for any positive results.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on October 05, 2019, 09:11:05 AM
 i have no curvature while i had minimal curvature before (5-10 degrees)
   
my two dents are better

i had NO FIBROSIS  on MRI BEFORE I TOOK MOFETIL

i have soft non palpable plaques so my case is considered very mild

i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day

i never had and i do not have any erection problems

i will try again for five days at 2000mg per day in the near future and report back
Title: Re: mycophenolate mofetil
Post by: JohnnyDoe on October 05, 2019, 03:52:24 PM
I assume by "dents are better" you mean not completely healed yet, but better than before.
Do you want to do it again because you believe you can get further improvements?
Did you experience any side effects during or after this treatment?
And most importantly, would you recommend this treatment to the rest of us?

I believe this sounds pretty amazing.
As you can imagine, 5 days of taking a few pills sounds to good to be true.
But I am open to trying if it works this well, especially because my case sounds very similar to yours.
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on October 06, 2019, 06:21:53 AM
I assume by "dents are better" you mean not completely healed yet, but better than before
yes
Do you want to do it again because you believe you can get further improvements?
yes i will for 5 days at 2000mg per day
Did you experience any side effects during or after this treatment?
no nothing
And most importantly, would you recommend this treatment to the rest of us?
i CANNOT RECOMMEND A DANGEROUS DRUG I AM NOT A DOCTOR VISIT ONE BEFORE YOU TAKE IT
  WHEN ON MOFETIL YOU HAVE TO AVOID UV AND SUN EXPOSURE AND MANY OTHER THINGS LIKE INFECTIONS AND SORE THROAT READ THE MANUAL
Title: Re: mycophenolate mofetil
Post by: JohnnyDoe on October 07, 2019, 04:17:40 PM
Thanks for answering, yeah speaking to a doctor makes sense.
If I understand correctly, if you went from 10 degrees to 0, that means your plaque must have softened or (partially) went back to normal tissue.
Which both sounds pretty impressive.

MMF weakens the immune system, could halt auto immune processes, therefore could stop myofibroblasts.
Also it restores the collagen ratios according to the article. But why does it have an anti-fibrotic effect though?
Restoring the balance of the different elements initiates the process of restoring the damaged tissue?
Title: Re: mycophenolate mofetil
Post by: Dabbydu on October 15, 2019, 09:36:56 PM
Quote deleted by moderator. Please read the forum rules.

I'm eager to see what the follow up run will do, any idea how soon you'll do it? And are you planning to take pictures?
Title: Re: mycophenolate mofetil
Post by: samsung on October 22, 2019, 11:29:02 AM
Any plans on doing additional dose? Anything to report?
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on October 22, 2019, 11:56:41 AM
as of today nothing new to report guys do not know when i am going to take it again
Title: Re: mycophenolate mofetil
Post by: Patientxyz1992 on October 22, 2019, 12:44:56 PM
Hey whyisthishappening im closely watching on this thread, congratulations on improvement and on balls to do this, did you finished second round and if you can calculate what was your percentage of improvement before and after drug if 100% is perfect healthy erection, thank you and i hope that soon enaugh we will get rid of peyronies..
Title: Re: mycophenolate mofetil
Post by: pey ron on October 23, 2019, 03:20:05 AM
Whyisthishappening, this is so exciting to hear!!!

do you have:
1) an old ultrasound?
2) before pictures?
3) after pictures?

...

4) suppose you get to the point where you believe you are 100% healed, will you go and do a follow-up ultrasound?

thank you!!! and good luck!
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on October 23, 2019, 07:11:55 AM
guys i have no pictures

had an MRI with NO FIBROSIS  BEFORE i took  MOFETIL

I BELIEVE REISHI MUSHROOM OR MY BODY DID THE JOB FOR FIBROSIS I CANNOT TELL

I WILL TRY CHLORELLA BECAUSE OF WOUNDVITE

MOFETIL DID SOMETHING FOR MY MINIMAL CURVATURE AND IMPROVED SLIGHTLY MY TWO DENTS
 
reply#83
 
" i have no curvature while i had minimal curvature before (5-10 degrees)
   
my two dents are better

i had NO FIBROSIS  on MRI BEFORE I TOOK MOFETIL

i have soft non palpable plaques so my case is considered very mild

i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day

i never had and i do not have any erection problems

i will try again for five days at 2000mg per day in the near future and report back"
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on October 31, 2019, 07:00:51 AM
i just finished mofetil treatment 2000mg per day for 5 days will report back if i have any benefits
Title: Re: mycophenolate mofetil
Post by: Dabbydu on October 31, 2019, 07:03:02 PM
Look forward to your report whyisthishappening. Did you notice any I'll effects from the dosage with this run vs last run or still relatively easy on the body?
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on November 01, 2019, 07:16:09 AM
i noticed no side effects
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on November 04, 2019, 08:18:01 AM
guys no gains so far and i do not believe i will have any
Title: Re: mycophenolate mofetil
Post by: melting on November 04, 2019, 08:33:58 AM
mycophenolate mofetil
Molecular Weight‎: ‎433.5 g/mol
Theoretically possible to shuttle in via transdermal application.(ask your doc)
Title: Re: mycophenolate mofetil
Post by: Whyisthishappening on November 04, 2019, 10:43:29 AM
melting you believe its going to have an effect as a topical treatment and why better than oral the rat study was oral
Title: Re: mycophenolate mofetil
Post by: melting on November 04, 2019, 02:39:27 PM
mycophenolate mofetil is also indicated as treatment being injected into a vein(don't do that without a doctor!) so I guess it will work transdermally too.

Most supplements around "Molecular weight 500 g/mol" (I think it gets hard beyond 1000 g/mol) can be transported transdermaly via DMSO directly to the plaque site. (searching google with "Supplement XYZ + molecular weight gives you the weight)

Why Transdermal? Side effects are often high with oral medication. 
But the most important reason for transdermal is the PLACE where the Peyronies plaques sit! Penis has not as much blood circulation as let's say your heart, biceps, brain, arms, legs, even your knee.. The plaque also often is right in the Penis tunica which has even less blood circulation than the Penis smooth muscles. The plaque itself has no direct blood supply..
That's why pde5 can help a lot, it increases blood circulation to the penis and allows supplements to go there..

Now imagine you take orally a supplement and it's half life in the blood is 20 minutes.. and your penis is just normal flaccid, no blood in it.. the medication will float through your body getting used up, degraded, secreted into your bladder/urine.. possibly nothing reaching the plaque/fibrosis.

So transdermaly applied at and around your plaque area it will be right there(yes, some will miss/transported away by blood too)
Doing that 1 to X times daily you can see how this is much more effective than oral. IMO this is also why oral has such wide range of results between people and studies. Hit or miss! (It still can be good to do both oral and transdermal -WATCH toxicity obviously)

That said..

QuoteThe mean maximum plasma mycophenolic acid concentration (Cmax) after a mycophenolate mofetil 1g dose in healthy individuals was around 25 mg/L, occurred at 0.8 hours postdose, decayed with a mean apparent half-life (t1/2) of around 16 hours, and generated a mean total area under the plasma concentration-time curve
So not that bad of a chance but imo orally you would still need to take is often as possible(and healthy!) to get good concentrations to the plaque site.

I'm no doctor though and maybe this logic only makes sense to me ;)

I'm not sure on mycophenolate mofetil generally, sounds promising, I would have to investigate more(I won't cause I'd need a prescription to use it)


Title: Re: mycophenolate mofetil
Post by: projectpd on May 12, 2020, 12:02:03 PM
the problem with this transdermally could be that it's biphasic - I posted about it, see https://www.journal-of-hepatology.eu/article/S0168-8278(07)61934-5/pdf, so transdermally we wouldn't have any idea on safe dosage.
also @WhyThis, according to that, 500mg was optimal, 2000mg was slightly too much for an average human.
Title: Re: mycophenolate mofetil
Post by: melting on May 12, 2020, 12:10:08 PM
I would always go with the lower dose transdermally. 
So much we intake orally get's lost in the stomach and other transfers through the blood and organs, that a 1-1 comparison might not apply. Though with most substances toxic amounts are known.

Quote from: projectpd on May 12, 2020, 12:02:03 PM
the problem with this transdermally could be that it's biphasic

Could you say what biphasic in relation to transdermal delivery means in a rather simple way? ;)
Title: Re: mycophenolate mofetil
Post by: projectpd on May 12, 2020, 12:35:40 PM
biphasic means that at sufficiently low doses, it is effective, but as the dose increases, the response changes, it starts to have the opposite effect and gets worse. Like alcohol (maybe)  ;) Transdermally, if it works, you would be delivering a vastly higher tissue concentration to the local tissue for a dose meant to be used orally. So it would need to be scaled down, but how much is impossible to quantify.
Title: Re: mycophenolate mofetil
Post by: melting on May 12, 2020, 04:23:37 PM
Thx! Learned something! Makes complete sense.
Title: Re: mycophenolate mofetil
Post by: drew67 on May 20, 2020, 06:52:24 PM
Just wanted to see if anyone is considering this either orally or transdermally.
Title: Re: mycophenolate mofetil
Post by: Michiganguy19 on August 31, 2020, 09:44:29 PM
For a lot of us it is an autoimmune disease causing it.

Quote from: Hontas on August 30, 2019, 09:01:38 AM
Whyisthishappening,

This isn't an autoimmune disease, it is an autoinflammatory one. The best bet is drugs like Colchicine or biologics that are used to lower certain types of inflammatory cytokines. I have had problems communicating with the doctors in that retrospect and taking immune suppressive drugs will not be the solution from what i know theoretically, as there isn't any antibody being produced if you have a negative autoimmune marker test. Its all about DAMP and PAMP overreaction and response and a bit of underlying genetics that makes you vulnerable to mutation and myofibroblast differentiation. But you can at least try it. Colchicine is a mixed drug for me as i am not sure if it actually helps, as i had severe side effects and had to stop the treatment right now for my own life's sake and i am not even sure if lower doses help by lowering inflammation or make it worse over time by delaying healing. I have realised while taking colchicine that i have a lot of minor scar spots in other places and i am not sure if colchicine is actually returning them back to acute to dissolve them or simply just creates them. First one has a higher chance of happening and i am just betting right now to be honest.
Title: Re: mycophenolate mofetil
Post by: Michiganguy19 on August 31, 2020, 09:45:22 PM
What dose do I ask my doc for? I will try it. What about the IPF drug Ofev? Reversed my friends pulmonary fibrosis
Title: Re: mycophenolate mofetil
Post by: Michiganguy19 on August 31, 2020, 09:51:57 PM
A lot of success treating pulmonary fibrosis with nintedanib and pirfenidone. Also ACE drug Lofarin been shown to stop and reverse fibrosis. Why no one trying it for Peyronie's?
Title: Re: mycophenolate mofetil
Post by: Bent Ding Dong on September 01, 2020, 07:33:13 AM
@Michiganguy19, I don't have access to those drugs otherwise I would try them but I bet they have nasty side effects also?

I've tried monk fruit extract which is supposed to reduce pulmonary fibrosis but that didn't do anything for my peyronies.

Here is the study: https://pubmed.ncbi.nlm.nih.gov/28280123/
Title: Re: mycophenolate mofetil
Post by: hope794 on September 01, 2020, 04:53:38 PM
Anyone else have tried this?
Title: Re: mycophenolate mofetil
Post by: Michiganguy19 on September 01, 2020, 07:44:36 PM
I just messaged my doctor. He said he'd put me on it.
Title: Re: mycophenolate mofetil
Post by: pey ron on September 02, 2020, 05:17:24 AM
Did you have an easy reason to get it, or did you find a very understanding doctor who was willing to experiment?
Title: Re: mycophenolate mofetil
Post by: pey ron on September 02, 2020, 05:21:05 AM
but do you have any condition for which mycophenolate mofetil has an on-label use?

also: how do you spell Lofarin? I can't find it...
Title: Re: mycophenolate mofetil
Post by: Bent Ding Dong on September 02, 2020, 06:14:12 AM
@Michiganguy19, can you keep this post updated about how the drug goes for your peyronie's?
Title: Re: mycophenolate mofetil
Post by: Asphyxia on April 09, 2021, 02:24:58 PM
can i use mycophenolic acid instead?
anybody knows the difference?
Title: Re: mycophenolate mofetil
Post by: westerntown on November 08, 2021, 12:24:33 PM
Any updates?