Ellagic acid and corilagin selectively inhibit TGF-β1 in fibroblasts by targeting LOXL2:
https://www.jci.org/articles/view/94624
This is in the context of lung fibrosis, but might well be applicable to us -- if perhaps only those of us in the early stage.
"These studies reveal, for the first time to our knowledge, a pathway of inhibition of the TGF-β1–induced collagen program selective to the cells that are most accountable for pathological collagen deposition, tissue fibroblasts and fibroblast-like tumor cells. The surprising finding that such selectivity depends on active LOXL2/3 and appears to operate in a cell-autonomous manner largely abrogates inhibition by trihydroxyphenolic-containing compounds of TGF-β1 signaling in epithelial or immune cells that don't express LOXL2/3. This selectivity likely avoids the toxicities of long term general TGF-β1 inhibition in chronic disease processes such as fibrosis and cancer progression. ... Although selective, the combined inhibition of LOXL2 and TGF-β1 signaling in fibroblast-like cells results in potent in vivo antifibrotic activity that has untapped but promising potential as a therapeutic approach for chronic diseases [...] dominated by progressive collagen accumulation."
Nice find Cacogen :)
Hopefully they will go forward and get to us also.
James
I include this here because corilagin is just a polyphenol -- an ellagitannin, more specifically -- which can be found in a number of plants. Extracts of Phyllanthus niruri contain corilagin (along with other polyphenols, I'm sure), and are available for purchase. These extracts appear to be non-toxic in rats at doses of 5,000mg/kg bw:
https://www.ncbi.nlm.nih.gov/pubmed/22319255
Pomegranate leaves also contain corilagin.
Active stage sufferers who are inclined towards self-experimentation might want to give it a try. Corilagin also appears to be a fairly potent inhibitor of a number of different cancel cells, in vivo.
Hmm, apologies if this post is miscategorized. Possibly it should be in the Oral Treatments section.
Cacogen
Your topic is on the correct board
James