CASE REPORT
A 40-years male patient of Kolkata metro region, attended Hospital OPD of National Research Institute of Ayurvedic Drug Development, Kolkata, with complain as follows: Unusual angulation of the penile shaft when erect, pain during erections and/or during sex. Patient felt difficulties while on sexual activity and gradually developed plaques with slightly bending since 6 months. Patient did not have any history of injury. On examination he revealed; height 1.7 m, body weight 71 kg (BMI 24.57 kg/m2), Scarring or plaque palpated at the abnormal bend or angle of the penis, palpable of an indentation of the penis shaft at the site of the plaque or scarring & inability to have intercourse. He had a treatment history of vitamin 'E' supplementation along with some Non-steroidal anti-inflammatory drugs and anti-biotic for 15 days. He found euglycaemic and normotensive. He was habituated to take non-veg diet, and smoking 3-4 cigarette per day. He had an irregular bowel problem with normal bladder and adequate sleeping habits. Family history was not suggestive.
Manual examination revealed; 10 no. of plaques on ventral part and 7 no. of plaques on dorsal part of the penis by stretching it with one hand and gently compressing the shaft between the fingers and thumb of the other hand. Localized tenderness elicited on superficial palpation and 20 to 30 degree of the penile curvature has been observed and the presence of penile shortening was not remarkably identified. There was no established abnormality disclosed during systemic examination.
Laboratory investigation : A Biopsy sent for study and found to be scar tissue and diagnosed as Peyronie's disease. Human cell antigen, HLA-B7 has not been associated with the disease. USG of penis with high frequency (7.5-12MHz) linear high transducer suggested penile plaques, seen as focal hyper echoic thickening of the tunica albuginea, exhibiting strong echogenicity with substantial attenuation of the acoustic beam.
Treatment plan :The case was prescribed with Kanchanar Guggulu at a dosage of 1 gm. thrice daily with Luke warm water after food for 6 weeks and followed up for another two weeks. He also advised to attend the OPD at an interval of one week.
RESULT : Based on the schedule of the administration of drug and assessment criteria the case was clinically assessed on every week till the end of 8 weeks. There was reduction in the number and size of plaques observed after 2 weeks of treatment and remarkably reduction noticed at the end of 6 weeks. Pain during erection of penis observed after 1 week of treatment. Curvature of penis reduced remarkably up to 10 degrees after 6 week of treatment. Correction of erection also found improved after 6 weeks of treatment. USG done after 6 weeks of treatment revealed the two corpora cavernosa are homogenous in echo texture and identified as two hypo echoic circular structure. The tunica albuginea is visualized as linear as hyperechoic structure covering the corpora cavernosa.
The various actions attributed by the drug are due to analgesic and anti-inflammatory, anti-microbial, Hypolipidemic, fibrinolytic and anti-tumor activities of various ingredients present in the formulation. The main pathogenesis involved in the Peyronies Disease is atheroma, vasculitis and auto immune factors. The drug might have reversed the exact path way involved in the genesis of disease. From this investigation, it observed that, there is a significant progress noticed in respect of overall clinical assessment criteria.
FULL Article Link : https://www.researchgate.net/publication/301646956_CLINICAL_EFFICACY_OF_A_TRADITIONAL_AYURVEDIC_COMPOUND_ON_PEYRONIE'S_DISEASE_A_CASE_STUDY
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Two things are to be noted : 1. These morons are too lazy so tested this on only one man. 2. He took vitamin E and some other medicines for 15 days before this anceint treatment, so may be this result can be due to those medicines also.
But still we should give it a try. When i searched the medicine on google, its one dollar $1 medicine for one month, LOL. Unfortunately its not available in my country.
Any early intervention w an anti inflammatory may have had the same effect, but still interesting. Probably only one patient as a doc just wrote up his patient as a case study because there was some success. Next step would be a study.
Interesting. I might add this to my treatments, just because! Can't hurt.
Hey Asian Eagle,
Very interesting, thank you!!!
This may be definitly worth the try.
Just made a few researches about it: it's ayurveda so obviously very discussed, etc. etc. Comercial or scientific-ish (?) sites claim that it helps A LOT with inflammation and even fibroids:
- https://www.ayurtimes.com/kanchanar-guggulu-or-kanchnar-guggul/
- Ayurvedic intervention in the management of uterine fibroids: A Case series Dhiman K - Ayu (http://www.ayujournal.org/article.asp?issn=0974-8520;year=2014;volume=35;issue=3;spage=303;epage=308;aulast=Dhiman)
Also, results seem to vary greatly from person to person...
--> Just as always, each one will have to try and make its own opinion! If I can find it, I will add it to my daily regimen next month. Will report if anything good happens!
Kanchanar Guggulu
Can find on Amazon as Energizing Ayurvedic Herbs for Thyroid & Lymphatic Wellness.
$28 for 90 tablets.
Found here where I am living now in the far east.
$13 for 80 tablets
Thyroid and skin problems, also certain kind of cancers
James
I ordered that exact thing from Amazon. I started taking it yesterday, I'll keep everyone updated.
Here's an ingredients list from an Amazon listing for Banyan Botanicals - Kanchanar Guggulu:
Guggulu resin (Commiphora mukul)+, Kanchanara herb (Bauhinia variegata)+, Amalaki fruit (Emblica officinalis)+, Bibhitaki fruit (Terminalia belerica)+, Haritaki fruit (Terminalia chebula)+, Silicon dioxide, Pippali fruit (Piper longum)+, Ginger root (Zingiber officinale)+, Black Pepper fruit (Piper nigrum)+, Varuna bark (Crateva nurvala)+, Cardamom seed (Elettaria cardamomum)+, Cinnamon bark (Cinnamomum verum)+, Bay leaf (Cinnamomum tamala)+. +Certified Organic
I suppose it's safe to say that the whole concoction contains a bunch of flavonoids and other polyphenols. The "guggulu" component is a resin from the plant Commiphora wightii -- the major flavonoid component of which is quercitin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637499/
The "kanchanara" herb contains kaemferol.
https://www.researchgate.net/publication/5468873_Antiinflammatory_activities_of_flavonoids_and_a_triterpene_caffeate_isolated_from_Bauhinia_variegata
There could be a significant amount of piperlongumine.
So definitely should have anti-inflammatory and anti-oxidant effects, at least.
Hey guys,
I saw the product you ordered, but they couldn't ship it to France; so I bought a cheaper version (5 bucks!) which seemed to have success in the commentaries, seemingly authentic and crazy-high dosed... And which was shipped for free from India! It will arrive around the 15th of november, and according to some (real? fake?) falks who are taking it, it also increase your metabolism and generate a great energy boost -very cool for sport and weightlifting... I hope I didn't buy a scam and that will have some effet; I will report too obviously!
Cheers,
PS: Cacogen, according to some website I read, it should also be "guggulsterones" which confers its amazing metabolism booster properties and inflammatory lesions healer to kanchanar guggul...
Quote from: Gabriel on October 23, 2018, 03:57:34 AM
PS: Cacogen, according to some website I read, it should also be "guggulsterones" which confers its amazing metabolism booster properties and inflammatory lesions healer to kanchanar guggul...
Yeah, I noticed the presence of that substance after I posted. Hmm ... phytosteroids ... might plausibly have some sort of effect.
Quercitin does have some legitimate science behind it, but it is usually in too small quantities when occuring naturally.
Quote from: skunkworks on October 23, 2018, 08:54:22 PM
Quercitin does have some legitimate science behind it, but it is usually in too small quantities when occuring naturally.
And supplemental quercitin in common forms has rather low bioavailability, IIRC. It *might* be the case that piperlongumine is increasing the bioavailability of the quercitin.
Also -- this is very, very wild speculation -- I would not be surprised if senescence ends up being implicated in pathological fibrosis associated with Peyronies Disease, with senescent fibroblasts being fibrogenic. I would have to look up the paper, but I recall this being suggested to be the case in pulmonary fibrosis. Quercitin + piperlongumine may be a sufficiently powerful senolytic, selectively destroying senescent fibroblasts. And maybe this concoction also contains fisetin, which was recently shown to be a fairly strong senolytic.
Love the way you talk Cacogen... That would be great indeed!!
I have to say, this supplement smells and tastes very pleasant. Very fruity with lots of ginger and undertones of other spices.
Quote from: Cacogen on October 24, 2018, 08:25:36 PM
And supplemental quercitin in common forms has rather low bioavailability, IIRC. It *might* be the case that piperlongumine is increasing the bioavailability of the quercitin.
Interesting, particularly because some members are fasting, see https://joshmitteldorf.scienceblog.com/2017/04/07/is-fasting-senolytic/
Very interesting Paolo! We'll have to shed light on this...
@JS: along most of my researches I've read that kanchanar guggulu had to be not yellowish powder (weak concentration and effect), but brown and smelly powder (seemingly like the strange-packaged one I ordered on Amazon)... So maybe it's a good sign??
It looks like it's used for fatty liver, which is a symptom of high carb diets. There is one case of liver injury by taking this stuff but one case is nothing. Anyway seriously interesting, I'll keep reading about this stuff tonight. Anything that helps metabolic syndrome will help Peyronie's. Just like the famous CoQ10 study. But I am interested in quercitin.
Here's an article on dupuyten's and Indian medicine
Dupuytren's Contracture - Ayurvedic Herbal Treatment (http://ezinearticles.com/?Dupuytrens-Contracture---Ayurvedic-Herbal-Treatment&id=2071072)
Hello guys,
Update: I just received my Amazon crazy-cheap free-shipped from India kanchanar guggulu (god this is hard to write down)... The package seems quite professionnal after all (sealed, with a list of ingredients in English, etc.); even better, the tablets inside are made of very dark brown matter, also very smelly (like spices or berries).
I'm a little scared about starting taking it now, as I don't want to mess this soon with my hormones levels which I just found to be desastrous (they say kanchanar guggulu can have a HUGE impact on your thyroid, for the best of course, but I don't want to play with that yet).
JS, have you already started taking this stuff? What do you say about it man?
Anyone else??
I've started taking it, yes. So far no remarkable improvements, but no side effects either. I think I got the same brand as you (Banyan Botanicals) because your description of pill and packaging is identical to mine. But as far as I know, my hormone levels are good.
Hey JS,
My brand is Patanjali Baba Ramdev, not the same as yours (I was it and wanted to order it because it looked more secure, but they couldn't deliver to France), but I'm happy to see that our products look similar.
I'll let pass my total hormonal check-up + 5th round of PRP/HA injections (next week), and I'll try it too!!
Quote from: Cacogen on October 24, 2018, 08:25:36 PM
Also -- this is very, very wild speculation -- I would not be surprised if senescence ends up being implicated in pathological fibrosis associated with Peyronies Disease, with senescent fibroblasts being fibrogenic. I would have to look up the paper, but I recall this being suggested to be the case in pulmonary fibrosis. Quercitin + piperlongumine may be a sufficiently powerful senolytic, selectively destroying senescent fibroblasts. And maybe this concoction also contains fisetin, which was recently shown to be a fairly strong senolytic.
This is a suspect -- or at least highly simplistic -- line of thinking perhaps. Apparently in some bodily locations, a senescent (myo)fibroblast phenotype may actually suppress fibrosis:
Skin:"Mammalian wound healing involves the rapid synthesis and deposition of extracellular matrix (ECM) to maintain tissue integrity during repair. This process must be tightly controlled, as its deregulation may result in fibrosis, scarring, and loss of tissue function. Recent studies have uncovered an efficient and parsimonious mechanism for rendering fibrogenesis self-limiting in wound healing: in such diverse organs as the liver and skin, the myofibroblasts that initially proliferate and produce ECM are themselves eventually driven into senescence, blocking their further proliferation and converting them into matrix-degrading cells. Myofibroblast senescence in skin wounds is triggered by a dynamically expressed matricellular protein, CCN1/CYR61, which acts through integrin-mediated induction of oxidative stress. We propose that the onset of myofibroblast senescence is a programmed wound healing response that functions as a self-limiting mechanism for fibrogenesis, and this process may be regulated by the ECM microenvironment through the expression of CCN1/CYR61." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984611/
Heart"In this study, we presented comprehensive evidence for an essential role of premature cellular senescence as a mechanism to restrain cardiac fibrosis (Central Illustration). We showed that senescent cells accumulate in fibrotic myocardial tissue and identified myofibroblasts as the predominant cardiac cell population undergoing senescence. Mechanistically, we demonstrated that the cellular senescence program of CF is dependent on both p53/p21 and p16/Rb pathways, and that genetic ablation of Trp53/Cdkn2a resulted in diminished senescence that is associated with aggravated fibrosis and functional impairment of the heart after TAC. Conversely, induction of the cellular senescence program in CF by cardiotropic expression of the matricellular protein CCN1 had cardioprotective effects and led to reduced fibrosis and improved cardiac function after TAC. Collectively, our results revealed senescent fibroblasts as critical regulators of cardiac fibrogenesis and established the cellular senescence program as a potential target for antifibrotic therapies."https://www.sciencedirect.com/science/article/pii/S0735109716009153
But on the other hand, senescence may be driving fibrosis in IPF:
Lung"IPF hLFs [human lung fibroblasts] have increased cellular senescence with higher expression of β-galactosidase, p21, p16, p53, and cytokines related to the senescence-associated secretory phenotype (SASP) as well as decreased proliferation/apoptosis compared with age-matched controls. Additionally, we observed shorter telomeres, mitochondrial dysfunction, and upon transforming growth factor-β stimulation, increased markers of endoplasmic reticulum stress. Our data suggest that IPF hLFs develop senescence resulting in a decreased apoptosis and that the development of SASP may be an important contributor to the fibrotic process observed in IPF. These results might change the existing paradigm, which describes fibroblasts as aberrantly activated cells, to a cell with a senescence phenotype."https://www.ncbi.nlm.nih.gov/pubmed/28860144
Biology sure is complicated.
Some herbs can damage your liver , kidney and/or other vital organs. I know some of them cause my bowels to inflame. Most of them are diuretics so you have to drink a lot of water. I would be careful taking them. Very careful mixing them. They are not harmless
I tried the "kanchanar guggulu" oral medicine for a month or two, didn't work.
@JS1991: a month or two is nothing. You need to do 6+ months experiments.
Thymoquinone from black seed oil seems to be antifibrotic as well.