Anti-fibrotic effect of mycophenolate mofetil on Peyronie's disease experimentally induced with TGF-β
https://www.nature.com/articles/s41443-019-0138-7?error=cookies_not_supported&code=3a30c172-d60f-4c5f-a3ea-2d3bd1317c8d
"The histochemical analysis revealed the fragmentation and degradation of elastin in the tunica albuginea. This process was partially reversed in the MMF-7d group and a situation very close to normality was observed in the MMF-30d group"
Interesting drug used for Chemotherapy and prescription only :o
Question is for the layman (us) would be getting access to it.
Paul.
used for immunosupression in transplants but it is something and allready in use
guys if my herbal treatments fail i would consider to start mycophenollate mofetil after getting doctors advice
This is an awesome find. I see they sell it for cheap. And they even sell it in powder form to be reconstituted for injection. Ideally this would work well with iontophoresis, I wonder whether it should go on the anode or the cathode...
i believe if someone would experiment with mofetil should do it under medical advice and supervision
if only i could get my hands on some MMF in powder form...
mofetil acts as an inosine inhibitor but i found that SAPPANONE A can selectively inhibit inosine
Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530702/
and sappanone a is a component of a herbal tea popular in some parts of the world
what do you think guys?
WhyIsThisHappening - bro I love how you aren't giving up and trying to find a solution no matter what. KEep it up man i'm not giving up either we will find a solution together and conquer this.
thanks jj we are together in this bro everybody of us no matter our differences
i do not want to be disturbing but please everybody read about mofetil and Peyronies Disease publication it may offer the solution
they managed to have a better collagen I/III ratio even than controls and mofetil targets inosine so i believe we should pay attention on inosine inhibitors i invite every experienced or not member of this forum to find safe mofetil alternatives
Interesting, do you guys think this would work, also how could we obtain it and would it needed to be injected?
it worked in animal studies only 5 DAYS of ORAL administration.The MMF7d and MMF30d is reference to the days post TGF administration not mofetil therapy.
where i live it costs 60 dollars a package of 50x500mg tabs
Do you know are there much sideeffects, also do you think people are getting cured of peyronies and we dont know?
Can you get it without a prescription? Back in my home country (Italy) I could get a lot of stuff without a prescription even though it would be legally required.
Great find bro.
Patientxyz1992 - I think some people do get cured as many members have not returned to this forum. Check the improvements section as well..... Some members who were experimenting with growth hormone and peptides never returned either - I presume they were healed?
Quote from: jj21 on May 21, 2019, 09:40:00 PM
Patientxyz1992 - I think some people do get cured as many members have not returned to this forum. Check the improvements section as well..... Some members who were experimenting with growth hormone and peptides never returned either - I presume they were healed?
which peptides? can you please link their posts?
Nobody doing experimental treatments on me! Now if I were terminally ill with no other options, then experiment away. Some of these methods maybe good ones. Yall test them first and get back to us ;D
If I read the report correctly there was no improvement in deformity :-[
you interpreted wrong crooked
"The analysis of the penile angle revealed a reduction in the mean angle after the induction of Peyronies Disease with TGF-β. This angle was increased after treatment in the MMF-7d group and increased even further after treatment in the MMF-30d group"
mmf 30d brought rat Peyronies Disease penis closer to control
"The histochemical analysis with the different methods revealed atypical distribution of the connective fibres in the tunica albuginea. Using fluorescence microscopy with hematoxylin-eosin, the degradation and fragmentation of elastin was found in the TGF-β group. This process remained in the MMF-7d group and a situation close to NORMALITY was found in the MMF-30d group"
Pey ron - I've lost the links but try a forum search, I think one of them was BPC 157. I found a few posts of people starting or talking about starting their course on growth hormone and peptides then they never returned to the forum. Not sure if they just stopped coming here or were actually healed.
Quote from: Patientxyz1992 on May 21, 2019, 03:40:27 PM
Do you know are there much sideeffects, also do you think people are getting cured of peyronies and we dont know?
There is a list of side effects. It basically weakens your immune system, but should come back to normal after you stop using it. This medicine is normally used for organ transplants, so your body does not reject the new organ.
https://www.rxlist.com/cellcept-side-effects-drug-center.htm
So yeah, who is willing to try? 😅
Whyisthishappening
Check your pms mate
guys i am currently having a tea of 6g of HEARTWOOD everyday which contains sappanone an inosine inhibitor the name of the tea is SU MU it is very cheap reddish and has no taste.i rinse 6g of heartwood in water for 10min. then boil for 10min. and after is not hot i drink it.take it while fasting for better results, i had improvements and do not know if is reish,i boswellia or heartwood but try yourself
also alpha -carotene is an inosine inhibitor try to eat foods that contain a lot of it (carrots,sweet potatos,avocados,broccoli)
PASS-Predicted Hepatoprotective Activity of Caesalpinia sappan in Thioacetamide-Induced Liver Fibrosis in Rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950979/
"The antifibrotic effects of traditional medicinal herb Caesalpinia sappan (CS)"
" CS treatment was noted to normalize the expression of TGF-β1, αSMA, PCNA, MMPs, and TIMP1 proteins"
" Several studies have shown that CS has antimicrobial and bactericidal activity [8] and antiallergic [9], neuroprotective [10], and hypoglycaemic effects [11]. Others found that extract from CS can be used for treating ascites, tumour, leukaemia [12], and arteriosclerosis [13]. This could be due to its antioxidant activity and its capability to inhibit malondialdehyde (MDA) and scavenging of superoxide anions, hydrogen peroxide, and hydroxyl radicals"
@pey ron, that is a good point
it is available as a hydrochloride salt,
https://www.drugbank.ca/drugs/DB00688
from reading the below then it could be amenable to iontophoresis:
https://www.ncbi.nlm.nih.gov/pubmed/25482587
"Therefore, in this project, ITR was converted to hydrochloride salt (ITR-HCl) to improve its solubility and to render it amenable to iontophoresis."
in addition the molecular weight is 433g/mol , low enough to be likely transportable by DMSO
I wonder, ultrasound could also enhance transdermal delivery; heat , ethanol also can increase transdermal delivery.
it would be understandable to try to avoid a large systemic dose as it is a powerful immune suppressor.
@pey run , so I think it would be the anode that you would then use as the active node , see
https://www.freece.com/Documents/Transdermal_Monograph.pdf
however, what does anyone think about whether there is any reason this would be helpful when not in the acute phase.
why do you overcomplicate things and why local administration cannot act systemically? it was administered for 6 months to IPF patients with no side effects we have to take it only for 5 DAYS .the rat study was 30mg/kg body weight/day FOR 5 DAYS if your weight is only 70 kilos you are in the recommended dose of IPF study patients and also the rat study analog dose.
i will try to contact a reumatologist who did research with mofetil toSS patients
you can also try su mu tea which is heartwood of caeselpinia sappan no side effects and many systemic benefits i will make a post for it in alternative treatments
if anyone tries it, note the statement in the same paper:
In contrast, analysis of fibrosis parameters in vivo revealed
a biphasic pattern: MMF reached a maximal antifibrotic effect at 5 mg/kg
(equivalent of 500mgiday in humans), which declined at 20 mgilcg (human
dose 1.5g/day) and the drug became profibrogenic at 100mg/kg.
I guess that would make estimating a reasonable transdermal dosage more problematic.
projectpd can you please cite this mention?
it is very important that we may need an even smaller dose thank you
also tried to contact with no success yet a mofetil researcher
sorry, not one of the papers above, but referenced here, still seems worth noting https://www.journal-of-hepatology.eu/article/S0168-8278(07)61934-5/pdf
THE ANTIFIBROTIC EFFECT OF MYCOPHENOLATE
MOFETIL IS LOST AT CLINICALLY RELEVANT DOSE,
IN LIVER FIBROSIS
FOLLOWING A BlPHASlC DOSE-DEPENDENT PATTERN
In contrast, analysis of fibrosis parameters in vivo revealed
a biphasic pattern: MMF reached a maximal antifibrotic effect at 5 mg/kg
(equivalent of 500mg /day in humans), which declined at 20 mg/kg (human
dose 1.5g/day) and the drug became profibrogenic at 100mg/kg,...
Conclusions: 1, MMF demonstrates strong antifibrotic properties in vivo
only at low dose (equivalent to less than 500mgiday in a patient), while
higher doses are ineffective or even profibrogenic
Quote from: projectpd on June 18, 2019, 02:52:03 PM
however, what does anyone think about whether there is any reason this would be helpful when not in the acute phase.
Projectpd and Whyisthishappening, can you please both clarify on this?
Based on your understanding, might mycophenolate mofetil be helpful for the chronic phase? If so, why?
Post sources in order to support your statements, if you can.
Thanks
yes it may be more helpful in the chronic phase because the 30 days rat group after tgf injection saw much more benefits(close to normality) than the 7d after tgf injection group,if you read the pub it says tissue regeneration properties bringing the affected tissue close to normality
if you see the microscope fotos collagen 3/1 ratio looks even better than control (less collagen 3) also elastin structure is almost completely restored
just read very carefully the whole pub its easy to see by yourself the fotos also(collagen 3 black fibers, collagen 1 brown, elastin green )
if you dont understand something specific lets discuss it here because proejctpd mentioned above something about mofetil dosing that was a great find so lets made loads of question and answers here by many members,maybe someone finds something more the better for all of us
i thank you too bro
ps to everybody please try su mu tea and reishi especially if in pain
Hi Werther,
I can't see that anyone suggested that would be the case, I already raised the question in #25. The study seems to add to the existing view in the forum on the potential effectiveness of early treatment, in the acute phase, as opposed to the wait-and-see advice that has been the norm. Then again the study did not collect data that might have been more relevant to a chronic phase.
sorry @Whyisthishappening, I had not seen your message above. The problem is the rats' condition was probably still developing after 30 days even allowing for their faster life cycle vs humans. In the Discussion section they made the below statements but I found difficult to interpret:
This characterises an improvement in the acute phase of the disease and may interrupt and even attenuate or reverse the formation of fibrotic plaque. The lower collagen III and collagen ratio values in the MMF-30 group than the control group suggests that MMF treatment may not reverse the fibrosis effect, but acts in another way.
projectpd i find difficult to interpret also the same statement
what do you guys think to contact the researchers?
Quote from: projectpd on June 22, 2019, 04:02:53 PM
In the Discussion section they made the below statements but I found difficult to interpret:
This characterises an improvement in the acute phase of the disease and may interrupt and even attenuate or reverse the formation of fibrotic plaque. The lower collagen III and collagen ratio values in the MMF-30 group than the control group suggests that MMF treatment may not reverse the fibrosis effect, but acts in another way.
It's indeed difficult to understand clearly what the authors are trying to say. IMO it looks like they're stating that the drug might be helpful in the acute phase but not in the chronic one, as you stated; I base my thinking on the fact that they speak of reversal with regards to "
the formation of fibrotic plaque" which happens during the acute phase but then they add that "
MMF treatment may not reverse the fibrosis effect" which is the late stage of peyronie's (i.e. the chronic phase).
I may be wrong though.
I agree with your idea Whyisthishappening: maybe it could be of help getting in touch with the authors of this study and ask them specifically about this passage.
If anybody get to know anything, please post it here.
Thanks again.
i just talked to a mofetil researcher not the one of Peyronies Disease study but a reummatologist
he read the Peyronies Disease publication and told me that for 5 days in the smallest dose 500mg cannot hurt anybody but that we should consider its immunosuppresive properties,also he told me for scleroderma they took it for 3 to 6 months in higher doses and that 5 days for him is not long enough to have any effect(he was surpprised that the mice study showed results in just five days) maybe the solution is just a drugstre and 5 away who knows?
so accordind to projectpd mention of 500mg/day showing maximum antifibrotic effect i will try it for 5 days in the dose of 500mg/day after some blood test i will do this week or the next one
if anybody is willing to talk to the brasillian researchers of mofetil Peyronies Disease study please do
Good luck man, respect for trying it. Looking forward to read the results.
thank you johhny i will keep everybody informed
guys they stopped selling mofetil in my country from july 1st i cannot take it i would talk again to the reummatologist
I'm sorry to hear this man. Does this mean that you won't get to experiment with this drug?
no i will try to get it man
Im in north carolina now, do you now maybe can i buy this drug over the counter?
@Whyisthishappening:
Good luck then and please keep us updated.
i found it with the name CELLCEPT but i need prescription so i will try to get it
https://medicalxpress.com/news/2018-07-metformin-reverses-lung-fibrosis.html
i just talked to my urologist(one of many) he cannot prescribe mofetil it needs special prescription from a reummatologist i also tried my luck to three pharmacists today but they told me that they have to order it with the special prescription in hand so will try my luck with reummatologists i hope someone will understand and give a prescription
i called the reummatologist of the scleroderma study today and he does not prescribe it to me.next week i will try other reummatologists .he told that it is used for organ transplantation and reummatologic use is off label but very common for lupus.
there are people in this sub forum that are very active searching for crazy compounds,guys what makes you believe that a compound in a lab which we cannot buy and they use it for other conditions and not Peyronies Disease could be more effective than mofetil
i will say it again mofetil its our only realistic option and even that may not work on human subjects
Doctors are responsible for the medicine they prescribe, therefore it might be hard to find someone who gives this based on an animal study, but I admire you trying! Who knows, it might work.
But I am sure so many things have not been tested yet for this disease. From what I read, seems like the medical world has not yet figured out to properly treat scar tissue in general.
Whyisthishappening,
This isn't an autoimmune disease, it is an autoinflammatory one. The best bet is drugs like Colchicine or biologics that are used to lower certain types of inflammatory cytokines. I have had problems communicating with the doctors in that retrospect and taking immune suppressive drugs will not be the solution from what i know theoretically, as there isn't any antibody being produced if you have a negative autoimmune marker test. Its all about DAMP and PAMP overreaction and response and a bit of underlying genetics that makes you vulnerable to mutation and myofibroblast differentiation. But you can at least try it. Colchicine is a mixed drug for me as i am not sure if it actually helps, as i had severe side effects and had to stop the treatment right now for my own life's sake and i am not even sure if lower doses help by lowering inflammation or make it worse over time by delaying healing. I have realised while taking colchicine that i have a lot of minor scar spots in other places and i am not sure if colchicine is actually returning them back to acute to dissolve them or simply just creates them. First one has a higher chance of happening and i am just betting right now to be honest.
mofetil healed rats in just 5 days and not in a crazy dose but human therapeutic one
any update?
Yes I've just seen this and I'm very interested to hear of an update on this now too!...
Also, whyhisishappening. Can you tell me where exactly you get thie SU MU tea from? I have found several MU teas, but no SU MU?
Thanks
Fix
bought it from a chinese traditional medicine shop su mu (caesalpinia sappan)
https://tcmwiki.com/wiki/su-mu
please take reishi powder 1 tea spoon two times a day very helpful
Thanks Whythisishappening. I'll look at that for sure
Have you had any success treating your peyronies with this tea?
Any news on the Mofetil yet ?
i do not know man my TWO DENTS ARE smaller but STILL THERE i had an MRI and i have NO FIBROSIS at the moment while a year ago i had ,so reishi or my body helped i stoped su mu after a month of use and i am on reishi powder only
considering mofetil today i called another reummatologist and is willing to prescribe it so i hope in a few days to have it
Do you think the reishi poweder might have helped ratehr than the su mu tea?
I've looked on Amazon here in the UK and there are quite a few reishi options - tablets, powder etc. But I'm not sure what doseage we shoud be looking at ? I haven't heard of this as a treatment or supplement before.
Whic country are you in Whythisishappening? If you don't mind me asking? It may be that some Easter countries such as China have different methods of dealing with peyronies which we in the West and even on this forum may not have such general knowledge of
i do not know Fix maybe both ,try them they do not harm you,just take reishi up to a gram per day not less .Buy reishi in bulk powder form costs less and take a tea spoon twice a day
Thanks, Su Mu in powder form or the red bark is better?
Also any update on the Mofetil?..
Quote from: Whyisthishappening on September 02, 2019, 01:31:27 PM
i do not know man my TWO DENTS ARE smaller but STILL THERE i had an MRI and i have NO FIBROSIS at the moment while a year ago i had ,so reishi or my body helped i stoped su mu after a month of use and i am on reishi powder only
considering mofetil today i called another reummatologist and is willing to prescribe it so i hope in a few days to have it
Hello, I have 3 lumps amd with pain around the area. Are these lump/swelling the same as plaques? Could I be in acute peyronie? What do u recommend at this stage apart from survival guide.
Thank you
fix this i took bark ,i also just got mofetil today but will wait for some days before i take it
hope 77 try reishi mushroom powder apart from that i do not know this is the mofetil thread.. ,take care man and welcome to the forum
Good luck with the Mofetil. I look forward to read about your results!
Thanks Whythis , I'll try the bark :)
Also looking forward to your results with Mofetil
Are you going to try a 5 day course as per the rat tests?
i will try 500mg for 5 days and if does not work 2000mg for 5 days like the rat study
Make sure to take before/after photos! In case it works, it would be good to have some proof :)
@Whyisthishappening: can you send me a private message with the source you bought it from?
Have you completed the 5 days at 500mg yet Whythisishappening? Any improvements?
hi ron i bought mofetil from a pharmacy in my city with a special prescription from a reummatologist
fix i have not started my treatment yet i am planning to start tomorrow or monday
Anything to report?
hi guys i am on mofetil treatment day 2 nothing so far to report i will finish my treatment on saturday
best of luck!!!!!
what country are you in?
mofetil day 5 i have switched yesterday to 2 grams per day so will take it for 4 more days and report about the results ,so far no results.
Just don't overuse it man, there are serious risks of rare uncurable cancers with the use of mofetil. From my perspective its not a risk worth taking however i give you props for being the one with the biggest balls. I just think thrice before using something potent since it can also make you worse in theory... Now i am gonna mix up raloxifene and tadalafil and will let you know about the results. We gonna get through this man
guys it did nothing so far so i quit it
Respect for trying. Who knows, it will take some time to have an effect.
guys i want to thank everybody for your best wishes mofetil at least in theory sounded promising the doctor told me that it takes time to build in your system and work but i followed the rat study protocol with no results and didn't want to try it longer
guys great news
i have no curvature while i had minimal curvature before
and my two dents are better
i should mention that i had NO FIBROSIS established on MRI BEFORE I TOOK MOFETIL
i have soft non palpable plaques so my case is considered very mild
also i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day
i will try again for five days at 2000mg per day in the near future and report back
Great to hear. So after 2 days you saw improvements happening?
How many degrees are we talking about?
Pickatures
i saw improvement 3 days after the last pills i had 5-10 degrees curvature i have no pictures
Hello, can you please be more accurate bro?
Answer these questions please..
1. Curvature degrees BEFORE and AFTER the treatment?
2. How long did the treatment last?
3. How were your erections BEFORE and AFTER the treatment?
4. Which effects did you notice (if you had any) on other deformities, like dents, hourglassing, and so on?
5. What about penile lenght and girth? any improvements?
Thank you!!!
Sorry for me saying to provide pics. Don't mean to be aggressive. You understand we are all just anxious for any positive results.
i have no curvature while i had minimal curvature before (5-10 degrees)
my two dents are better
i had NO FIBROSIS on MRI BEFORE I TOOK MOFETIL
i have soft non palpable plaques so my case is considered very mild
i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day
i never had and i do not have any erection problems
i will try again for five days at 2000mg per day in the near future and report back
I assume by "dents are better" you mean not completely healed yet, but better than before.
Do you want to do it again because you believe you can get further improvements?
Did you experience any side effects during or after this treatment?
And most importantly, would you recommend this treatment to the rest of us?
I believe this sounds pretty amazing.
As you can imagine, 5 days of taking a few pills sounds to good to be true.
But I am open to trying if it works this well, especially because my case sounds very similar to yours.
I assume by "dents are better" you mean not completely healed yet, but better than before
yes
Do you want to do it again because you believe you can get further improvements?
yes i will for 5 days at 2000mg per day
Did you experience any side effects during or after this treatment?
no nothing
And most importantly, would you recommend this treatment to the rest of us?
i CANNOT RECOMMEND A DANGEROUS DRUG I AM NOT A DOCTOR VISIT ONE BEFORE YOU TAKE IT
WHEN ON MOFETIL YOU HAVE TO AVOID UV AND SUN EXPOSURE AND MANY OTHER THINGS LIKE INFECTIONS AND SORE THROAT READ THE MANUAL
Thanks for answering, yeah speaking to a doctor makes sense.
If I understand correctly, if you went from 10 degrees to 0, that means your plaque must have softened or (partially) went back to normal tissue.
Which both sounds pretty impressive.
MMF weakens the immune system, could halt auto immune processes, therefore could stop myofibroblasts.
Also it restores the collagen ratios according to the article. But why does it have an anti-fibrotic effect though?
Restoring the balance of the different elements initiates the process of restoring the damaged tissue?
Quote deleted by moderator. Please read the forum rules.
I'm eager to see what the follow up run will do, any idea how soon you'll do it? And are you planning to take pictures?
Any plans on doing additional dose? Anything to report?
as of today nothing new to report guys do not know when i am going to take it again
Hey whyisthishappening im closely watching on this thread, congratulations on improvement and on balls to do this, did you finished second round and if you can calculate what was your percentage of improvement before and after drug if 100% is perfect healthy erection, thank you and i hope that soon enaugh we will get rid of peyronies..
Whyisthishappening, this is so exciting to hear!!!
do you have:
1) an old ultrasound?
2) before pictures?
3) after pictures?
...
4) suppose you get to the point where you believe you are 100% healed, will you go and do a follow-up ultrasound?
thank you!!! and good luck!
guys i have no pictures
had an MRI with NO FIBROSIS BEFORE i took MOFETIL
I BELIEVE REISHI MUSHROOM OR MY BODY DID THE JOB FOR FIBROSIS I CANNOT TELL
I WILL TRY CHLORELLA BECAUSE OF WOUNDVITE
MOFETIL DID SOMETHING FOR MY MINIMAL CURVATURE AND IMPROVED SLIGHTLY MY TWO DENTS
reply#83
" i have no curvature while i had minimal curvature before (5-10 degrees)
my two dents are better
i had NO FIBROSIS on MRI BEFORE I TOOK MOFETIL
i have soft non palpable plaques so my case is considered very mild
i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day
i never had and i do not have any erection problems
i will try again for five days at 2000mg per day in the near future and report back"
i just finished mofetil treatment 2000mg per day for 5 days will report back if i have any benefits
Look forward to your report whyisthishappening. Did you notice any I'll effects from the dosage with this run vs last run or still relatively easy on the body?
i noticed no side effects
guys no gains so far and i do not believe i will have any
mycophenolate mofetil
Molecular Weight: 433.5 g/mol
Theoretically possible to shuttle in via transdermal application.(ask your doc)
melting you believe its going to have an effect as a topical treatment and why better than oral the rat study was oral
mycophenolate mofetil is also indicated as treatment being injected into a vein(don't do that without a doctor!) so I guess it will work transdermally too.
Most supplements around "Molecular weight 500 g/mol" (I think it gets hard beyond 1000 g/mol) can be transported transdermaly via DMSO directly to the plaque site. (searching google with "Supplement XYZ + molecular weight gives you the weight)
Why Transdermal? Side effects are often high with oral medication.
But the most important reason for transdermal is the PLACE where the Peyronies plaques sit! Penis has not as much blood circulation as let's say your heart, biceps, brain, arms, legs, even your knee.. The plaque also often is right in the Penis tunica which has even less blood circulation than the Penis smooth muscles. The plaque itself has no direct blood supply..
That's why pde5 can help a lot, it increases blood circulation to the penis and allows supplements to go there..
Now imagine you take orally a supplement and it's half life in the blood is 20 minutes.. and your penis is just normal flaccid, no blood in it.. the medication will float through your body getting used up, degraded, secreted into your bladder/urine.. possibly
nothing reaching the plaque/fibrosis.So transdermaly applied at and around your plaque area
it will be right there(yes, some will miss/transported away by blood too)
Doing that 1 to X times daily you can see how this is much more effective than oral. IMO
this is also why oral has such wide range of results between people and studies. Hit or miss! (It still can be good to do both oral and transdermal -WATCH toxicity obviously)
That said..
QuoteThe mean maximum plasma mycophenolic acid concentration (Cmax) after a mycophenolate mofetil 1g dose in healthy individuals was around 25 mg/L, occurred at 0.8 hours postdose, decayed with a mean apparent half-life (t1/2) of around 16 hours, and generated a mean total area under the plasma concentration-time curve
So not that bad of a chance but imo orally you would still need to take is often as possible(and healthy!) to get good concentrations to the plaque site.
I'm no doctor though and maybe this logic only makes sense to me ;)
I'm not sure on mycophenolate mofetil generally, sounds promising, I would have to investigate more(I won't cause I'd need a prescription to use it)
the problem with this transdermally could be that it's biphasic - I posted about it, see https://www.journal-of-hepatology.eu/article/S0168-8278(07)61934-5/pdf, so transdermally we wouldn't have any idea on safe dosage.
also @WhyThis, according to that, 500mg was optimal, 2000mg was slightly too much for an average human.
I would always go with the lower dose transdermally.
So much we intake orally get's lost in the stomach and other transfers through the blood and organs, that a 1-1 comparison might not apply. Though with most substances toxic amounts are known.
Quote from: projectpd on May 12, 2020, 12:02:03 PM
the problem with this transdermally could be that it's biphasic
Could you say what biphasic in relation to transdermal delivery means in a rather simple way? ;)
biphasic means that at sufficiently low doses, it is effective, but as the dose increases, the response changes, it starts to have the opposite effect and gets worse. Like alcohol (maybe) ;) Transdermally, if it works, you would be delivering a vastly higher tissue concentration to the local tissue for a dose meant to be used orally. So it would need to be scaled down, but how much is impossible to quantify.
Thx! Learned something! Makes complete sense.
Just wanted to see if anyone is considering this either orally or transdermally.
For a lot of us it is an autoimmune disease causing it.
Quote from: Hontas on August 30, 2019, 09:01:38 AM
Whyisthishappening,
This isn't an autoimmune disease, it is an autoinflammatory one. The best bet is drugs like Colchicine or biologics that are used to lower certain types of inflammatory cytokines. I have had problems communicating with the doctors in that retrospect and taking immune suppressive drugs will not be the solution from what i know theoretically, as there isn't any antibody being produced if you have a negative autoimmune marker test. Its all about DAMP and PAMP overreaction and response and a bit of underlying genetics that makes you vulnerable to mutation and myofibroblast differentiation. But you can at least try it. Colchicine is a mixed drug for me as i am not sure if it actually helps, as i had severe side effects and had to stop the treatment right now for my own life's sake and i am not even sure if lower doses help by lowering inflammation or make it worse over time by delaying healing. I have realised while taking colchicine that i have a lot of minor scar spots in other places and i am not sure if colchicine is actually returning them back to acute to dissolve them or simply just creates them. First one has a higher chance of happening and i am just betting right now to be honest.
What dose do I ask my doc for? I will try it. What about the IPF drug Ofev? Reversed my friends pulmonary fibrosis
A lot of success treating pulmonary fibrosis with nintedanib and pirfenidone. Also ACE drug Lofarin been shown to stop and reverse fibrosis. Why no one trying it for Peyronie's?
@Michiganguy19, I don't have access to those drugs otherwise I would try them but I bet they have nasty side effects also?
I've tried monk fruit extract which is supposed to reduce pulmonary fibrosis but that didn't do anything for my peyronies.
Here is the study: https://pubmed.ncbi.nlm.nih.gov/28280123/
Anyone else have tried this?
I just messaged my doctor. He said he'd put me on it.
Did you have an easy reason to get it, or did you find a very understanding doctor who was willing to experiment?
but do you have any condition for which mycophenolate mofetil has an on-label use?
also: how do you spell Lofarin? I can't find it...
@Michiganguy19, can you keep this post updated about how the drug goes for your peyronie's?
can i use mycophenolic acid instead?
anybody knows the difference?
Any updates?