Peyronies Society Forums

Peyronies Disease TREATMENT Discussion Boards => Developmental Drugs & Treatments => Topic started by: Senn on June 04, 2023, 11:09:23 PM

Title: New treatment will be mRNA-based.
Post by: Senn on June 04, 2023, 11:09:23 PM
I strongly believe that there will be a treatment in the next 5-7 years based on CAR-T therapy, utilizing mRNA tech. In vitro CAR-T therapy has been a game-changer for certain types of cancers. Now, with mRNA-based delivery it's possible to achieve similar results in vivo and target any type of cell, including fibrotic cells. Benefit of mRNA-based delivery is that the CARs only last for a few days, making it less risky and cheaper. This will likely start with targeting heart disease and lung fibrosis.

This is legit research out of U Penn. In 2019, they targeted heart fibrosis with traditional CAR-T therapy in animal models:
https://www.nature.com/articles/s41586-019-1546-z

Then, in 2022, they did it again but this time in vitro using mRNA injection (which is the potential breakthrough):
https://www.fiercebiotech.com/research/mrna-shot-car-t-therapy-body-repair-heart-disease-damage-university-pennsylvania

Now, these same scientists started a company to bring this to market. Founded by the U Penn team and raised $160m:
https://www.capstantx.com/
Title: Re: New treatment will be mRNA-based.
Post by: Seattleman on June 28, 2023, 10:18:55 PM
I wonder how this would affect scars on your body. Like surgery scars or deep gashes.