Pipe Line | MediWound (http://www.mediwound.com/products/pipe-line/)
Form 6-K MediWound Ltd. For: Jun 04 (http://www.streetinsider.com/SEC+Filings/Form+6-K+MediWound+Ltd.+For%3A+Jun+04/10624847.html)
As of now there is a limited amount of information available about their peyronies product MWPC003. It looks like MWPC003 is at the bottom of their product pipeline unfortunately, nonetheless it seems promising considering the efficacy of there other products.
Looks like this company will likely start Phase 1 of this compound late 2015 or early 2016 based on company prospectus I read. Good to see others are still fighting for us.
I listened to Mediwound's conference call yesterday, seems they will be starting a small trial for their injectable bromelain based drug later this year. It is an exciting development for Peyronie's Disease, dupuytrens and other connective tissue disorders. Ex-vivo tests suggest the drug can dissolve fibrotic tissue without harming regular tissue.
This is an excerpt from the call:
Do you still expect that MWPC003 program will begin clinical studies by the year-end? And if so, what do you need to accomplish between now and then?
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Gal Cohen, Mediwound Ltd. - CEO [46]
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So, first of all, we are very excited about that because we really want to have an injectable form of technology because of the vast opportunities around that. I mean just look at the other companies that use enzymes for connective tissue disorders and you see dupuytrens, Peyronie's, (inaudible) and cellulitis and so many potential indications.
We are shifting a little bit of resources toward that product now that we have BARDA funding the NexoBrid program. We are in the process of finalizing a formulation, an injectable formulation. We will do small clinical studies because, again, we are talking about in these indications of parts of milligrams.
These are some good news right here. Hope it gets through!
In my opinion this is the most important research being done for Peyronies Disease. Every other intra-leasional injectable has serious drawbacks....I'm halfway through the Xiaflex treatment and I have seen zero improvement. Xiaflex seems to do little to break down the plaque.
Anyway I would encourage everyone to contact the Investor relatiotions dept. of Mediwound and let them know how important their work is.
Who knows, maybe a combination of both in the future? But indeed, great news!
i sent an email to mediwound to volunteer for trials . havent heard back
It would probably be better to call....I haven't had any luck emailing them either.
Anne Marie Fields
T: 212.838.3777
It would be great to know who and where the trials will be conducted!
Unfortunately phase 1 means we will not see anything before 2020...
2020, that sounds way too early. I'm sure they'll make us wait longer than that. Maybe I can finally get it when I'm 40. Hopefully I won't be TOO repulsive by that age.
In fact I think all the peyroines suffer should expect more from Atala and its stuff than from this..partial replacement will hit the market first for sure.
From the conference call they indicated that a lot of the pre-clinical work and research from their other products that use the same enzyme will allow them to jump right into Phase 1 trials probably next year. Yes it will be awhile before this is approved (2020-2021) but it is what it is. There just isn't a cure out there in 2016. I've been dealing with this curse for four years now some I realize that patients is needed.
Yes, I also have this condition for four years now. Some guys are on this forum for way longer than that tho.. I agree that the worknof dr.atala seems more promising for a real cure, but I can hardly imagine something so complicated will be widely available soon. I also didny get a reply when I emailed wake forest. Anybody here who had more luck contacting them?
Widely available not, but I do believe that Atala can do it right now. The problem is the FDA approval...
I've been having an unusable penis since the day I started to look for girls. I was 16 and now I am about to turn 26. In the meanwhile..no sex, no relations. We are all on the same boat, teammates in this disgrace.
An update on progress of injectable bromelain solution (IBS, or MWPC003). I think this could very well be the magic bullet you guys. I know it could be awhile but this stuff can completely dissolve the fibrotic plaque WITHOUT damaging healthy tissue. Links:
Data Published in Bone & Joint Research Supports MediWound's Bromelain-Based Enzyme for the Release of Dupuytren's Contracture (NASDAQ:MDWD) (http://ir.mediwound.com/releasedetail.cfm?ReleaseID=973354)
A new bromelain-based enzyme for the release of Dupuytren's contracture | Bone & Joint Research (http://www.bjr.boneandjoint.org.uk/content/5/5/175)
Good news! Hope that it comes available to the public soon.
I just noticed somebody started a thread on Mediwound. I was telling you guys about their bromelain-based injectable back on 7 December 2014 when I was self-injecting bromelain. Their patent application is interesting, if you haven't read it already. The big question is how will Xiaflex' orphan drug status impact them? The market is enormous. My last Xiaflex shots were over ten grand EACH.
I'm going back to bromelain myself but strictly topical. Dr. Carrion recommends against getting the last Xiaflex injection, although it's my call, because of my 2 injection-related surgeries. This time I'll try 5% bromelain in a base of Lipoderm HMW (high molecular weight) after I've fully recovered from the last surgery 9 weeks ago.
From the mixed results of Xiaflex reported here, I am disinclined to even consider it.
The problem is there are so many variables and so many unknowns that it's hard to predict an outcome. The benefits I had from the 2nd cycle – reduction of angle and indent – have remained. Dr. Carrion said mine was one of his most complex cases. The plaque is soft and runs nearly the entire length. As he asked himself aloud after first examining me, So where do I put the needle? Guys with one small hard plaque have a better chance. There are a couple of us here with the same plaque; JobinSpain and YYY, I think. My surgeries were just bad luck.
What makes Xiaflex so dangerous is also what makes it your best shot, aside from surgery: it's powerful. Softening collagen fibers is no easy task. It's like using sulfuric acid to remove a wart. My advice is go to the best doctor you can find and let him or her advise you. I do not hesitate to recommend Rafael Carrion with USF Health in Tampa. And if I had it to do over again, I would. Aside from a Nesbitt or implant, nothing's going to help me.
The ex vivo trials for this and LOS seem quite promising.
However, does anyone know how Xiaflex did in the tests at the same stage?
Was it also as promising in the beginning? (Before it proved to be very moderately effective - at best - in the end)
Not that sure about the early history of Xiaflex but MWPC003 has distinct advantages over Xiaflex because it is proven to not harm normal tissue and blood vessels. They use huge quantities of the stuff for debridment of burned skin. Xiaflex dissoles the plaque but also damages the surrounding tissue so that new scar generally forms and because of this only small amounts of Xiaflex can be used wheras with the bromelain based enzyme you can use much larger amounts which will dissolve more plaque. The bromelain itself inhibits scar formation as an added bonus. They already have the injectable form of MWPC003 ready to go. They were hoping to do some hind of small trial on dupreynes late this year.
Is there any data on whether this product will dissolve calcified plaques?
Is calcification an issue with Dupuytren's? If not, I doubt they are looking at that for the time being. I would be game for a trial of this product for Peyronies Disease though...
What I find less encouraging is that in some ex vivo studies, Xiaflex seems to also dissolve/degrade scar tissue :
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156428 (http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156428)
But as said before, Xiaflex also dissolves healthy tissue, so I hope that Mediwound will succeed where Xiaflex failed.
I certainly do hope they go on with the studies on Dupuytren and Peyronie, and that the product keeps its efficiency throughout human trials.
As depressing, demoralizing and discouraging as Peyronie's is, I think we should be thankful that we're living in a time when products like Xiaflex and hopefully Mediwound are making it to market. It is not beyond the realm of possibility that we will see Peyronies Disease cured in our lifetime, though I know that for the worst-off of us, this is not fast enough. It gives me hope though.
For instance, 15 years ago, when I had my first run-in with Peyronies Disease, there wasn't anything available more "hard-hitting" than Topical Verapamil - and we all know how that proved to be a huge waste of time and money. Things like Xiaflex and Mediwound are taking the fight chemically directly to the Peyronies Disease plaques. Let's hope Mediwound lives up to its promise!
Nemo
I continue to believe that the product being developed by Mediwound could be a major breakthrough for Peyronies Disease. I also think there could be some value in developing a relationship between this board and the company(Mediwound). Mediwound is a small company with limited funding. We may even be able to set up a charity through this site that could provide funding for trials that would help to speed up the release of MWPC-003. We would need someone in an authoritative position associated with this site to act as our representative, make contacts and figure out how we, collectively, can help. Any thoughts?
I like the idea. This forum could easily be a source of trails volunteers and if the trials go well, customers and spokespersons.
I agree .... good idea !
I've been researching MWPC003 and the company a lot myself. I noted in one of their NASDAQ Analyst briefings that they were actually targeting Dupuytren's Contracture and Peyronies Disease with this development but I think they are underestimating the size of the Peyronies Disease market. Personally, I think there are a lot more cases than 8% of men over 50yrs old. I think many don't talk about it and don't seek medical attention out of embarrassment or other issue. There seem to be many men in their 40's with it and also many younger guys from injury or penis enlargement gadgets.
I think a single approach from this Forum would help them see the scale of this market and furnish them with a lot of data (anecdotal or otherwise) and volunteers !!!
We could do a crowd funding site? Or go fund me page? Sure it's expensive to conduct clinical trials..I should know I work for a large Pharma company but as we all know if the product works even moderately it is a multi multi million dollar product.
I have personally tried to contact Mediwounds IR in the past, with no response. I believe we have to have the person that is the head of Peyronie's Disease Society make the first contact. I guess that would be Larry Holcombe (Director, Peyronie's Advocacy Group Peyronies Disease Society)....so if we can get him onboard then we have a starting place.
A very interesting thread right through from Youngdude's initial post. I agree with Gutted, the figure of 8% of men over 50 with Peyronies Disease is probably a low estimate. I guess there are lot in that over 50 age group, as we read about here, who have the disease, but without severe bending or indent or pain, just hidden fibrotic or scar tissue or plaque. I have the dorsal curve and indents, but besides this, the ED and the increasing loss of sensitivity is becoming a real problem for me. Both of these I ascribe to Peyronies. I am considering Xiaflex, but am put off by the damage it can do to normal tissue and cost. It does strike me that Mediwound's MWPC003 could become beyond being a cure for Peyronies and it's symptoms, almost a 'Spring-clean' or re-furb for the penis, restoring a degree of sensation and erectile capability. If it leaves normal tissue unharmed and is capable of clearing fibrotic tissues and calcifications it could be the biggest thing for males since viagra.
I love the idea Crooked Stick and would support the charity/fund, etc.
Cheers,
LeeBee
I don't know that we have a chairperson for our Peyronies Disease Society site. I am the admin and we have a small group of active forum moderators. I know nothing of this site simply as I have not had time to research it yet.
Perhaps we could "organize" at that level? Name a "President" of the group and have them approach Mediwound mfg with that title, and the numbers of men here?
What is all about?
Can't find nothing about this product on they website!
Why we should contact them?
James
Like the red font there James ! ;D
Here is a market briefing from the CEO of Mediwound, albeit November 2014, but slides 4 and 5 make it clear that MWPC003 was in Pre-Clinical trials even back then. Those slides also make it clear that this enzymatic compound (Bromelain) is being specifically developed for connective tissue disorders and they are specifically targetting Peyronies Disease and Dupuytren's Contracture :
http://www.jefferies.com/CMSFiles/Jefferies.com/files/W%201500%205%20MediWound.pdf
Here is the latest info I have found, a very informative press release by Mediwound which will make the position very clear to all Forum members :
Data Published in Bone & Joint Research Supports MediWound's Bromelain-Based Enzyme for the Release of Dupuytren's Contracture (NASDAQ:MDWD) (http://ir.mediwound.com/releasedetail.cfm?releaseid=973354)
lol at the pun to james :D
Gutted, that was a pretty good find. There is a pretty good chance this product comes to the market in the future! Let's hope it's successful.
Ps: what about our pet project dude?
Another article for James ;) :
https://www.ncbi.nlm.nih.gov/pubmed/26761870
This stuff can even soften beef and chicken! Could do wonders for your beef maybe James!
Do you know that what they are injecting are chemicals?
To soften meat (I am a red meat lover) can just massage it, don't need to inject chemicals!!!
Anyhow, I am buying my beef fresh, know what to buy, it is always tender and soft.
QuoteCould do wonders for your beef maybe James!
Luckily "my beef" is still strong with the help of this blue miracle pill (buying white TEVA, much cheaper and white, acting on my beef better)
James
So if the plaque or plaques are completely dissolved with no further damage to surrounding tissue or recurrence of plaque what will to mean to the quality of erections? Will the penis be restored to its original pre peyronie's dimensions?
In theory if you could completely dissolve the plaque without any other damage, then yes your erection should be restored to its pre-Peyronies condition.
Also the length, girth and shape will be back treeza1
James
Anyone know if this mediwound stuff will be capable of dissolving corporal fibrosis? From my understanding corporal fibrosis is still very important from a structural standpoint, and just getting rid of it is not a good idea.
Thanks
Ok..so here's my guess..This product they are looking to get approved in Europe..It will come to market much faster in Europe..obviously they will want to introduce it to the U.S. For big $$ but my guess is they will look to get it approved in Europe for DC and take the money to do a Phase 3 trial in the U.S...However nothing says we cant go to Europe to be treated. Very encouraging indeed. I take Bromelain sups but they prob arent getting to my Peyronies Disease at all..Wonder if you could some how make a cream from teh sups with DMSO and apply it. Although i dont know if the molecule would be small enough to penetrate.
Quote from: FriskyDingo on October 22, 2016, 11:04:28 PM
Anyone know if this mediwound stuff will be capable of dissolving corporal fibrosis? From my understanding corporal fibrosis is still very important from a structural standpoint, and just getting rid of it is not a good idea.
Thanks
Hey.... Huh... Did you smoke anything before writing that or....? I would say you are so wrong....
I've recently tried contacting MediWound through email, as well as dr. Atala and whoever I could reach out who's doing the iMS Cell research at UNSW. No responses from any yet, except automated. I will definately try calling if I don't receive a response this week.
From what I've read on MWPC003, the trials stated that their compound can completely dissolve fibrotic tissue in more than 80% of cases, even with very small amounts used. And as stated earlier, this stuff is claimed safe, and even beneficial for inflammation and proper healing, which means large quantities could be used for better effect.
Just need to be persistent about inquiries into any possible clinical trials
Good work nastyone. Please keep trying, and keep us posted. Never know if/when/where a solution to this disease will be found.
Yea. I think we all know there will be a complete cure for this one day, even if it does mean complete replacement. The issue is how long it will take, and when will there be effective treatment until then, that will atleast restore our quality of life.
Way I see it, contacting doctors and researchers about this can only help. Awareness is important
What if you like 70% of my tissue is scarred. In doubt this would work because if all my plaques disappeared I would basically be castrated right?
I don't think you are using the right term. Castrated is when your testicles are removed. Completely unrelated.
Dared, that's why attacking the scar tissue itself doesn't really fix the issue. You need to improve the health of your tissue, and the cream would do exactly that I imagine. The reason why cialis, pentox, and most treatments work is because they improve the health of your penis itself. VED and traction help expand the penile tissue to "remodel" it and maybe even elongate and grow it. You want to attack penile health, not the scarring really.
But what I'm saying is true. If all my scars disappeared I would have no penis.
Please read.....
MediWound Granted U.S. Patent for MWPC003 for the Treatment of Connective Tissue Diseases (NASDAQ:MDWD) (http://ir.mediwound.com/releasedetail.cfm?ReleaseID=1004964)
Seems cool, since it appears to be a more natural injectable, which we don't have yet. I've been taking bromelain by mouth for a little while now, I really wonder how this will turn out.
That is good news, every time I am feeling helpless against this disease, some new development I've overlooked appears. This and Atala's work will probably have us on the edge of our seats for a breakthrough within the next 5-10 years or so. Until then, I think it's best we just do what we can when it comes to general/sexual/tissue health and stay on the radar of the people who develop such things.
(Glad my first post was provoked by something positive :D)
properyoung
Not to make you bad mood, but 10 years ago Atala was also 5 to 10 years from breakthrough :(
So try whatever you think it may help you in the mean time
By the way, do you have Peyronies?
James
[Full quote removed]
I do ,hence I am lurking this forum for both support and possibility to make it better with the rest of you. Whether it takes 10 or 20, I just hope me and you can live happy, healthy lives until then.
I've been using VED and traction whenever my penis feels soft and pliable, pentox, coq10, l carnitine and l agranine, also low dose cialis. The combination of the said treatments seem to have stabilised my condition, actually improved it at one point when I was still in the early phase (close to half a year of daily heat, traction, ved, meditation and supplements), but then being an excited young idiot I stopped the protocol, went on a three week holiday, drank, smoked and partied.. and by the time I got back, my peyronies got back to it's beginning stage (leans left when flaccid, hour-glassing at base when erect) and I can't seem to repeat my success that easily(rebuilding my previous unshakeable optimism and discipline as I'm typing this).
Started treatments after around 8-10 months after the appearance of indentations and pain from the injury subsiding.
BTW I am 22(about to turn 23, had peyronies since 20, being hopeful is extremely important to me as it's not just about being able to "perform" during my later respectable years, but rather maintaining as much health and function down there until there is an actual viable treatment)
properyoung
Pentox, VED and low dose Cialis helped me to stabilize the Peyronies, eliminate hourglasses, gain of some length and girth I lost.
I started the treatment very late, 3 years after the onset I was still with flareups and worsening, still the treatment helped me.
The key is consistency and patience ans the results are coming slowly.
I tried many things, almost everything, just the treatment above helped me.
And yes, we all hope the solution to Peyronies will come soon :)
James
It goes without saying that this is 4-5 years away.That said, those of us posting on this thread will all have late-stage/chronic peyronies by the time this is availalble to us.
I wonder how effective MWPC003 will be against that... I am pretty hopeful given what is known about it so far. I hope it can clear collagen deposits, calcifications, and restore size and shape. Hopefully someone can expand on this.
I imagine for someone who has had Peyronies Disease for a long time (i.e. 3+ years) that multiple injections over a long course of time would be the way to do it. As opposed to a more recent plaque that may dissolve after 1 or 2 treatments. Just my thoughts.
Any news about this, guys?
,
Mediwound made a strategic decision to hold off on any further research related to their injectable enzyme until their other two products have completed phase 3. That will take about two years and once those products are on the market they will start some kind of phase 1 and that may or may not involve peyronies. It could easily be 10 years......very disappointing.
Where did you read those infos, guys?
Please post the URL.
Has someone got new informations? Did someone try to contact them?
Just an update on Mediwounds' injectable bromelain based drug. I just listened to their lastest conference call:
Q1 MediWound 2019 Conference Call | MediWound (http://ir.mediwound.com/events/event-details/q1-mediwound-2019-conference-call)
near the end of the call the CEO mentions that they will restart their clinical work. They mention peyronies specifically.
Awesome Crooked.. Any notable quotes?
I just emailed a few people at mediwound. If anyone answers, will post here.
Good work Samsung
Yes, please let us know what they say
Fix
I have also emailed Mediwound on their UK email. I recieved a fast reponse within 12 hours saying that he ( the Account Manager for UK and Ireland ) had forwarded my enquiry to their medical team in Israel for a response.
I'll keep you all posted as soon as they reply
I haven't heard anything. Emailed 4 different people there. Will keep trying.
Today i emailed too. One year ago an italian doctor replied to me.. I hope that he will reply again.
Here is my email and Jeremy Feffer's response:
1
Sorry for the delay in response. As the company has mentioned before, this program is still pre-clinical, but there should be updates next year.
On Sep 1, 2019, at 5:18 PM:
Hello,
Are there any updates about MWPC003? Please check out peyroniesforum.net. I would include links to where mediwound products are discussed but you don't know me, so I'm sure would not want to click on links in an email.
At any rate, many, many men are awaiting news of when any clinical trials might be taking place. Thanks in advance for any updates.
Best,
With next year they mean 2020? Let's wait...................
Thanks samsung, well done bro.
Yep. I assume he meant 2020. In the meantime, keep on stretching. Don't play ping pong with your ding dong. Lay off the cheeseburgers, smokes and keep your cock away from sharp objects. All will be well.