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Other Peyronies Disease Discussion Boards => Causes of Peyronies Disease => Topic started by: NeoV on June 30, 2017, 04:40:02 AM

Title: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on June 30, 2017, 04:40:02 AM


--Diabetes of the Penis: Peyronie's and Diet
--
Introduction

Insulin resistance, hyperinsulinemia, and hyperglycemia (high blood sugar) lead to increased levels of tgf-beta, myostatin, reactive oxygen species (ROS), mitochondrial disorder, FOXO3, and decreased nrf2, glutathione, and a weaker endogenous antioxidant system, therefore causing fibrosis and Peyronie's disease. It also increases histone deacetylase (HDAC) which is heavily implied in fibrosis. YOUR BLOOD SUGAR MEANS NOTHING, you can have hyperinsulinemia which takes place before detectable pre-diabetes, and suffer dire consequences. This is not tested for and does NOT show up on a blood sugar test.

Unsurprisingly. Peyronie's and Dupuytren's are more common in those with Diabetes, and statin drugs are known to cause Peyronie's and diabetes while lowering CoQ10 levels. You can be skinny, fit, and muscular and still have insulin resistance. It has only been in recent years that diet has been shown to reverse diabetes type 1 and 2, and with Alzheimer's now being called "Diabetes type 3," and fasting shown to have a great effect against cancer, we have every right to take the role of blood sugar and Peyronie's as serious as ever. Insulin resistance and the overconsumption of carbs, not fat, is now being established as the leading cause of heart disease and other organ damage, and penis disease should be no exception.
*an explanation of how hyperglycemia leads to fibrosis and a raise in tgf-beta can be seen here. (http://www.pnas.org/content/97/14/7667.full)


A personal anecdote: At 24 years old, I started to develop Peyronie's, neuropathy, and tendon pain at the exact same time. My penis, hands, and feet began to go numb, and my father with Peyronie's also has the same symptoms. At age 30, my nerve pain became severe, and after recent brain and body scans and extensive blood work, the only finding was "slightly high blood sugar." I recently got sick and did not eat much of anything for 3 whole weeks, and my nerve pain disappeared and my Peyronie's looked and felt great. Upon starting a carb heavy diet and stopping CoQ10, my nerve pain came back with a vengeance. Doing some digging around online, it appears that even slightly raised blood sugar levels can damage blood vessels and nerves, while the general guidelines on what is low or high may be completely wrong. Upon re-starting CoQ10 and going mostly ketogenic, my Peyronie's is doing the best that it has in years and the feeling in my hands and feet are coming back. UPDATE 2018, I now have NO nerve pain and my Peyronie's is better than ever, following a strict ketogenic diet. I am unable to eat pizza or pasta or anything without nerve pain.

The Diet

Goals - to prevent fibrosis via the below means:
*Inhibit histone deacetylase to deactivate the genes related to Peyronie and fibrosis.
*activate nrf2 pathway (to reduce tgf-beta) -- > decrease tgf-beta and myostatin.
*increase mitochondrial function, improve insulin sensitivity
*decrease reactive oxygen species and inflammation


The Base
Ketogenic or low carb diet / fasting
Deactivates histone deacetylase and the gene behind Peyronie's, and activates nrf2 pathway, reduces tgf-beta, significantly improves mitochondrial function, reduces inflammation, restores insulin sensitivity, increases blood viscosity, while fasting states induce scar reduction through autophagy.

CoQ10 - 300 mg / day (reduce tgf-beta, myostatin, restores insulin sensitivity, reduce ROS and fibrosis)
Alpha Lipoic Acid - (reduce tgf-beta, myostatin, restores insulin sensitivity, reduce ROS and fibrosis)
Creatine Monohydrate - 2 - 5g / day - significantly blocks myostatin and boost mitochondrial health
Broccoli and Cabbage - sulforaphane in these vegetables significantly block histone deacetylase and myostatin.
Caffeine - (a xanthine derivative like pentox that reduces tgf-beta and fibrosis, use within safe limits)
Coffee - Chlorogenic acid reduces fibrosis, ROS,
Green Tea - EGCG blocks myostatin, reduces ROS, fibrosis. Studied at length.

Avoid: Refined carbohydrates and sweets. Never combine refined carbs with saturated fat. Pizza is one of the worst offenders. Save it for special occasions or eliminate. I ate a diet of just cabbage and for six months and continue to eat extremely low carb and moderate fat. Finally now I eat only eggs, meat, and some very low glycemic veggies if any veggies at all.

Do: Exercise, meditate, and drink plenty of water, and keep something on hand to eat if you get low. If you are to eat the "classic" carbs, go for complex or slow digesting carbs.

Tips and Warnings

Budget and Food Choice
Replace rice, bread, or pasta with cabbage at every meal. Shredded cabbage, meat, and eggs, drenched in olive oil, is a calorie and nutrient dense meal you can always rely on. Go crazy on veggies and buy in bulk frozen. Olive oil and coconut oil is your best friend on a ketogenic or low carb diet. Eggplant is another heavy veggie to go for in place of the classic carbs.

Fats
Extra virgin olive oil, extra virgin coconut oil, and butter are the most stable for cooking. Do not consume vegetable oils. MCT oils are very useful for avoiding hypoglycemia and getting into ketosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671041/ (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671041/)

Supplement withdrawal (CoQ10, and others)
Upon stopping this supplement, one's supply will lower below baseline for a short while, possibly even a week. This may be extremely dangerous, and despite no issues ever being documented, I think it's best to slowly wean yourself off it, instead of suddenly stopping 300mg per day. Your body needs to begin to create the nutrient again. That being said, temporary states of low CoQ10 may not be a real issue, but I still find the idea troubling.

**Always consult with a healthcare professional when changing your diet drastically**
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on July 03, 2017, 11:15:39 AM
I just discovered alpha lipoic acid, be sure to read the dosage warning on that one:
https://examine.com/supplements/alpha-lipoic-acid/
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on July 03, 2017, 03:17:47 PM
Guys, for vegetarian lovers ALA can be found in flaxseed, chia seed and hemp.

ALA may increase nerve regeneration rates and be of aid to nervous system injuries, from the symptoms of tingling, burning, and itching.

What makes ALA special is that since it is both water and fat soluble, you are able to absorb it at any time, regardless of what you're eating or drinking with it, it crosses also the blood brain barrier (BBB) also, one of the few antioxidants to do so.

Taking an ALA supplement once every 3 to 6 hours would be preferable over a higher dose that's once or twice daily, for example 100mg pill for systemic administration

Morning: 1 pill upon waking
Mid-morning 1 pill
Lunch: 1 pill
Mid-afternoon 1 pill
Dinner: 1 pill
Late evening 1 pill
Total = 600mg

Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JayGould on July 03, 2017, 06:00:55 PM
Have you heard about YK-11? It's supposed to be the strongest myostatin inhibitor available. Safety profile unknown however as it is a very new substance.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on July 04, 2017, 11:39:43 AM
Quote
YK-11 is a synthetic, steroidal selective androgen receptor modulator (SARM) (...)
The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone (DHT) in this regard.

That just sounds unsafe. I would advise not to try anything like that without the guidance of a clinical andrologist.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on July 04, 2017, 11:41:25 PM
Jay, Myostatin is a major driver of fibrosis and a member of the tgf-beta family. Myostatin is found in the Peyronie's penis and plaques (2008 study). I would love to get my hands on some Follistatin, or what you listed. Until then I'll be eating whole eggs, taking creatine, and coq10. Multiple studies show a reversing of fibrosis when Myostatin is blocked.

I may be dreaming, but my scars are softer and my ridges lesser now that I've been taking that supplement combo for a month or so. I also advise anyone to stick to veggie caps. I would love some input on this. Does anyone know which is better in general, veggie caps or soft gels?

Thanks Paolo! One of the only times my nerve pain went away was when I was eating less and taking ALA and CoQ10. I'll be buying it again!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on July 05, 2017, 03:17:42 AM
NeoV, not for the first time your post was most interesting, particularly about Follistatin, to that end I hope the below link interests you somewhat;

https://examine.com/nutrition/does-dark-chocolates-epicatechin-content-promote-muscle-growth/

Dark chocolate should be raw and unprocessed as much as possible, don't drink chocolate with milk as milk peptides ruin its antioxidant effects greatly, it's not that pleasant but I now prefer it that way, you get used to it.

On a separate note I have just started supplementing Broccomax (Broccoli extract).

Thanks for this  :)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on July 06, 2017, 07:58:30 AM
Quote from: NeoV on July 04, 2017, 11:41:25 PMMyostatin is found in the Peyronie's penis and plaques (2008 study).

Could you link to that study?

It's only quite recently that myostatin was proven to be in smooth muscle at all, and only a few papers on it so I'd really like to see that paper.

Edit. Nvm, I could try being non lazy and find it myself: http://www.jsm.jsexmed.org/article/S1743-6095(15)32106-8/fulltext

Interesting read, bloody myofibroblasts at it again.

This study seems to support our daily pde5 recommendation - https://www.nature.com/ijir/journal/vaop/ncurrent/pdf/ijir201722a.pdf?origin=ppub

Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Stabler on July 06, 2017, 10:12:24 AM
Hi guys,



I would just like to clarify something, there is no diet that will reverse Type 1 diabetes. Type 1 is acquired as a child and when the pancreas no longer  has the ability to produce insulin. There is no diet that will make it produce insulin again.

Also the Ketogenic diet can be very dangerous if not followed by a physician. this diet has your body using its own fats as energy causing your body to produce/spill ketones in the urine which if not monitored can cause coma and death. Now this is not to say that No one should try it however if you are in this forum it is because you have a weakened immune system and compromising it more could be unwise. So please be careful

Stabler67
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on July 07, 2017, 12:13:45 PM
A ketogenic diet or near ketogenic is (in my opinion) one of the most beneficial ways of eating you could follow as a Peyronie's sufferer.

I recall three case studies where type 1 diabetes was reversed in a juvenile with a gluten free diet, eg - https://www.ncbi.nlm.nih.gov/pubmed/22729336. In an adult, I'd agree, is it almost certainly past the point of dietary intervention with regards to no longer requiring treatment. But you can use diet reduce how much medication you need day by day.

Type 2 diabetes is obviously reversible, quite easily in fact.

The 'dangers' of a ketogenic diet have been hugely exagerrated in the media, usually due to incorrectly conflating ketoacidosis with ketosis. They had been used safely for decades to effectively treat epilepsy before the weight loss and health benefits were rediscovered. Before that, we have many hundreds of thousands of years in which humans lived in a ketogenic state almost every hour they were alive.

The ketogenic state is more natural for the human body than being in a non ketogenic state. Before agriculture we would have been in a ketogenic state for 99.99% of the hours in our lives.

For 99.4% of our existence from homo erectus onward, we have been hunter gatherers and existing in a ketogenic state.

The best diet you can eat will be eggs, grass fed beef and wild caught fish, with vegetables as a small side.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on July 09, 2017, 01:39:03 PM
Quote from: skunkworks on July 07, 2017, 12:13:45 PM
The best diet you can eat will be eggs, grass fed beef and wild caught fish, with vegetables as a small side.

The best diet you can get is a diverse mix of unprocessed foods, tackling all the necessary minerals, vitamins, proteins and fats your body needs. We have a bit evolved from our ancestors in terms of energy consumption :) Other than that, totally agree. Ketogenic diet felt great. You don't have to go full scale no-carb. There are several approaches available with low-carb that work to keep you in a mostly ketogenic state.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on July 10, 2017, 10:36:13 AM
Sorry for not providing that study. It is interesting that tgf-beta gets attention and not myostatin, which IS part of the tgf-beta family, and is clearly linked to fibrosis and other issues.

Indeed, as Stabler has said, always be careful when changing your diet and consult a doctor.

When I go low carb I can feel very sick and have panic attacks and nearly pass out. I was never like this until recently, but now heavy carb meals cause this as well. I assume that's because my blood sugar crashes. Now that I eat very low carb and high fat, I don't have panic attacks. If I do go too low, I will eat something a bit sweet and even bough glucose tablets. Experiment and always keep something to eat on hand. If you have Peyronie's, chances are you HAVE some blood glucose issues as well.

I do agree that humans are not meant to eat many carbs, like any other animal. I appreciate the comment Skunkworks!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on July 11, 2017, 12:30:18 AM
It would be VERY interesting to see HbA1c results for a big section of Peyronie's sufferers.

And yeah, you can quibble about the minutae of diet endlessly. As long as processed sugars and grains are gone and carbs are low, you'll be doing way better than most.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on July 11, 2017, 12:52:54 AM
They did HbA1c during my active phase. I even had the whole expensive blood work done, because that was a prequisite for therapy. It was normal. The only values off were VitD, which was on the lower end of the scale and uric acid a bit high, but still not in range of gout.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on July 11, 2017, 04:01:21 AM
Tychy, Your Vitamin D comment is interesting

Transforming growth factor beta-1 (TGF-β1) plays a major role in the pathogenesis of Peyronie's disease (Peyronies Disease). Vitamin D modulates the profibrotic effects of TGF-β1, as shown in recent studies. Therefore, vitamin D deficiency might be a contributing factor in the pathogenesis of Peyronies Disease

I will have to research this more, i.e. toxic dosage etc, thanks  :)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on July 11, 2017, 06:32:21 AM
Tychy, I wonder what "normal" was for the HbA1c. I ask this because from what I read, the standard "normal" is basically already causing damage to your organs. On the extreme side, Dr. Bernstein, says you need a HbA1c of 4.2 to 4.6 or you'll be causing damage.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Crooked_Stick on July 11, 2017, 11:10:13 AM
my HA1C was 5.7 (pre-diabetic) during the active phase...also my vitamin D was at the bottom of the normal range and my T was low, all pre-conditions for Peyronies Disease
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on July 15, 2017, 11:49:26 PM
That's great info Crooked.

My ha1c was only 5.3 earlier this year, with 114 blood sugar, which I believe was fasting, in which case it is very much pre-diabetic. I broke my ketosis yesterday and immediately felt sick with a reactive hypoglycemic episode. I felt dread and panic for hours afterwards and my face and tongue went numb.

I have to say, I am very happy I now know the cause of my nerve pain and numbness, AND my panic attacks. It was never a panic disorder, it was merely an issue or problem with blood sugar. For years I spiked it and let it drop too low.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on July 17, 2017, 03:36:58 AM
Now this is interesting! I was obviously referring to lab reference ranges. Do you have a study or something for me to read? As you've provoked it, have my lab sheet :)

Name:  Value (Reference Range)

HbA1c: 5.1% (4-6)
HbA1c: 32 mmol/mol (20 - 42)

TSH: 0.73 mIE/ml (0.3 - 4.2)
FT3: 4.08 Dmol/l (3.3 - 6)
FT4: 12.7 Dmol/l (7 - 21.1)
TPO-AK: 1.1 IU/ml (0-35) (No Hashimoto)
TRAK: <0.1 IU/ml (0-0.1) (No Morbus Basedow)
Parathormone: 39.7 pg/ml (12-88)
ACTH: 11.5 ng/l (5-60) (Seems I'm not under chronic stress, well...)
Total protein: 6.86 g/dl (6.6-8.3)
GOT: 23 U/l (0-50)
GPT: 24.6 U/l (0-50)
GGT: 17.4 U/l (0-54.9)
Alkaline Phosphatase: 56.9 U/l (30-120)
LDH: 173 U/l (208-378) (Significant for cell turnover (death). It's lower than reference, which means less cells are dying than usual? I suppose that's good)
Bilirubin: 0.57 mg/dl (0-1.19)
Creatinine: 0.93 mg/dl (0.72-1.18)
Uric acid: 7.76 mg/dl (0-7) (I have occasional pain in my hallux and was thinking about gout, but treatment-worthy is 8 or above)
Inorganic Phosphates: 3.09 mg/dl (2.6-4.5)
Iron: 83 µg/dl (70-180)
Calcium: 2.48 mmol/l (2.2-2.65)
Potassium: 4.42 mmol/l (3.5-5.1)
Natrium: 140 mmol/l (135-145)
Magnesium: 0.78 mmol/l (0.73-1.06)
Haemoglobin: 15.4 g/dl (13.5-17.8 )
Erythrocytes: 4.9 M/µl (4.4-5.93)
HKT: 0.45 I/l (0.47-0.53) (I just saw this. Low HKT and iron, though not clinical significant, is sign of Anemia. Ery also in low range )
HBE: 31.5 pg (28-33)
MCV: 92.5 fl (80-96)
MCHC: 34 g/dl (33-36)
Leucocytes: 5.4 k/µl (3.9 - 10.9) (stopping smoking helps! this was usually up to 9)
Thrombocytes: 314 k/µl (140-330)
Vit-D-25-OH: 23.5 ng/ml (30-100) (I did supplement D3 5000 IU once daily for a month after the test)
Folic acid: 6.2 ng/ml (4-20)
Vitamin-B12: 352 pg/ml (180-914)
Ferritin: 43.1 ng/ml (20-200) (well, look. It's also low)
Luthenizing hormone: 2.21 U/l (4-10)
FSH: 5.64 U/l (1.27-19.3)
Estradiol: 23 pg/ml (0-50)
Prolactine: 5.1 ng/ml (5-15)
Testosterone: 3.81 ng/ml (2.7-10.7) (I've asked my uro about this. You'd want to test receptor activity, as low T may be well bound. It's basically different for everyone)
Inhibin_B: 161 ng/l (25-325)
SHBG: 44.7 (13.2-89.5)
Free androgen index: 29.5 (15-95)
Cortisol: 88 ng/mg (50-250)

...and be sure, I'll NEVER type this off this sheet again :P
I suppose my wheat allergy is/was causing malabsorption
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on July 17, 2017, 04:26:31 AM
@Paolo:
This was one of the reasons to think about Ehlers-Danlos-Syndrome...Hypermobility and vascular type has mutations on genes that is relevant for TGF-β1 (COL3A1 to be specific, TNXB). And it would fit with the other symptoms:
https://omim.org/entry/130020
QuoteOverall, those with classic EDS and TNX-deficient EDS reported the most neuromuscular involvement, with muscle weakness, hypotonia, myalgia, easy fatigability, and intermittent paresthesias, although patients in all groups reported these features. Physical examination showed mild to moderate muscle weakness (85%) and reduction of vibration sense (60%) across all groups. Nerve conduction studies demonstrated axonal polyneuropathy in 5 (13%) of 39 patients. Needle electromyography showed myopathic EMG features in 9 (26%) and a mixed neurogenic-myopathic pattern in 21 (60%) of 35 patients. Muscle ultrasound showed increased echo intensity in 19 (48%) and atrophy in 20 (50%) of 40 patients. Mild myopathic features were seen on muscle biopsy of 5 (28%) of 18 patients. Patients with the hypermobility type EDS caused by TNXB haploinsufficiency were least affected. Voermans et al. (2009) postulated that abnormalities in muscle or nerve extracellular matrix may underlie these findings.

I've bolded the things that I'm currently or transiently having.

My mother has expressed some of the same symptoms, especially low blood pressure and she's now in her 60s. As Ehlers-Danlos is always inherited without mutating (Type 3 will always pass down type 3), type IV is unlikely for me. Life expectancy with type IV is 34 for men and 37 for women.
I do have a tendency for bruises and my mother once had a chiropractic treatment where her whole right shoulder was blue from rupturing a blood vessel.....I have to get this on the list to be diagnosed, though I know what my doc is going to say....
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on July 17, 2017, 09:57:16 AM
Tychy, that must have taken some time to type  :P

Did you get your lab tests done privately, or was that through your medical provider?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on July 17, 2017, 01:22:13 PM
You bet, I was late at work xD

This was done through my medical provider as part of the exclusion protocol. I'm basically tired all the time and hypogonadism was one of the possible explanations, so I got looked at by an endocrinologist. Things still in the pipeline are cardiac valvular defect (unlikely) and EDS (yay, got my referral today...waiting time like 2 months or so?).

Did a quick glucose test: 108 after coffee with milk on empty stomach, 98 two hours after lunch. I think that's fairly normal. I'd start to worry around 125 and panic at 140.

What's happening in EDS is actually that the baroreceptor is malfunctioning, so the body does not counter low blood volume and will not properly constrict the blood vessels in your legs when standing. So blood pools in your legs. It will then increase heart rate to supply enough oxygen to the brain, by pushing out stress hormones that can lead to panic attacks. In worst case you have a syncope. Also your kidneys will just drop fluid and salt out of your system, because "everything is fine", leading to dehydration.
I don't have hunger and thirst. Thirst is the baroreceptor. I think there is something similar in the stomach for hunger.

Time will tell. Maybe it's just a genetic dysautonomia. Treatment would be a seven-days-a-week excercise protocol, which I'm actually fine with by now...

Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on July 17, 2017, 02:15:34 PM
Thanks Tychy, I myself have had episodes of PAD (Peripheral Artery Disease) that admittedly I self diagnosed but haven't had symptoms (pain walking that is progressive) for more than 18 months  :-\, think diet and supplements have helped with that  :-\. I used to indoor row a lot, bizarrely exercise seemed to make PAD worse in my case.

If the PAD comes back then I am definitely going to try Pentox as I believe it specifically helps with PAD.

Blood pooling in you legs sounds bad, hope you find a treatment for it, take care  :)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on July 18, 2017, 03:41:01 AM
Huh, be sure to get that checked out at some point. PAD and arteriosclerosis are no fun, if blood vessels in your brain are become involved.

Blood pooling in legs and hands is not that bad. I'm used to it. It feels pressury. No black legs or something like that :D
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on July 20, 2017, 11:06:16 AM
I'll leave this study here, as it's revelant to the topic
https://link.springer.com/article/10.1007%2Fs00394-016-1199-8
(Probiotics and insulin)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on July 20, 2017, 11:52:22 AM
QuoteConclusion

Probiotics modestly improved HbA1c and fasting insulin in people with type 2 diabetes.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on July 20, 2017, 02:33:57 PM
I take probiotics and have done so for some months, so guess that's a good thing in this respect  ;D

Although I am not diabetic its all good  :)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on October 09, 2017, 11:24:39 PM
Quote from: NeoV on July 10, 2017, 10:36:13 AM
Sorry for not providing that study. It is interesting that tgf-beta gets attention and not myostatin, which IS part of the tgf-beta family, and is clearly linked to fibrosis and other issues.

https://www.youtube.com/watch?v=o6A9bbDI6fo

Human Myostatin Knock-Out Targeting CRISPR-Cas9 Plasmid - The ODIN (http://www.the-odin.com/human-myostatin-knock-out-targeting-crispr-cas9-plasmid/)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on February 20, 2018, 08:25:40 AM
Big update here.

The main gene thought to be responsible for Peyronie's, and Dupuytren's has been cited to be HLA-B7. This is activated by histone deacetylase. Activation of the same gene causes an increased risk of cancer, and this was referenced in October 2017 in the report on Peryonie's sufferers at an increased risk of cancer due to genetic etiology.

Guess what is a massive deactivator of hystone deacetylase and this gene is? A ketogenic, or LOW carb, fasking like diet, which has reversed all my nerve pain, penile numbness, and made my Peyronie's the best it's been yet. As I have mentioned, my father has completely numb feet, a numb penis, and calcified Peyronie's disease. The fact that I have reversed my penile numbness and my neuropathy is a huge deal to me.

Histone deacetylase, a new target for Peyronie's
Histone deacetylase inhibition: a new target for Peyronie's disease? - Cellek - 2014 - BJU International - Wiley Online Library (http://onlinelibrary.wiley.com/doi/10.1111/bju.12835/pdf)

Histone deacetylase: a potential therapeutic target for fibrotic disorders.
https://www.ncbi.nlm.nih.gov/pubmed/20719940 (https://www.ncbi.nlm.nih.gov/pubmed/20719940)

Ketogenic diet inhibits histone deacetylase
http://www.cell.com/endocrinology-metabolism/abstract/S1043-2760(13)00156-2 (http://www.cell.com/endocrinology-metabolism/abstract/S1043-2760(13)00156-2)
https://www.ncbi.nlm.nih.gov/pubmed/29024787 (https://www.ncbi.nlm.nih.gov/pubmed/29024787)

"Inhibition of HDACs can repress TGF-bemediated signaling...
They observed a 60% decrease in HDAC2 expression in Peyronies Disease plaque derived
fibroblasts transfected with the HDAC2-targeted siRNA"

From: http://www.smr.jsexmed.org/article/S2050-0521(15)00003-7/pdf (http://www.smr.jsexmed.org/article/S2050-0521(15)00003-7/pdf)

Low carb and ketogenic diets are now being used to treat and reverse alzheimer's symptoms, parkinsons, diabetes type 2 AND 1 even, heart disease, as adjunct cancer therapy, and in many other diseases. A ketogenic or low carb diet does not need to be animal based, it can be done on a plant based diet as well.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on February 20, 2018, 01:16:01 PM
Thanks, wow. That stuff is from 2014
https://www.ncbi.nlm.nih.gov/pubmed/24841412

QuoteRESULTS:
We observed that Ad-HDAC2 shRNA decreased inflammatory cell infiltration, reduced transnuclear expression of phospho-Smad3 and regressed fibrotic plaque of the tunica albuginea in Peyronies Disease rats in vivo. siRNA-mediated silencing of HDAC2 significantly decreased the TGF-β1-induced transdifferentiation of fibroblasts into myofibroblasts and collagen production, and induced apoptosis by downregulating the expression of PARP1, and decreased the expression of cyclin D1 (a positive cell-cycle regulator) in primary cultured fibroblasts derived from human Peyronies Disease plaque in vitro.

Remember that rodent studies have like a 90% failure rate in transferring to humans, still this sounds good! Recently started LCHF diet again to counter weight gain, I think I'll keep at it ;P
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Crooked_Stick on February 20, 2018, 01:24:58 PM
Wow great post NeoV....it looks like niacin is an inhibitor (Class III HDACs (sirtuins) are dependent on NAD+ and are therefore inhibited by nicotinamide as well as derivatives of NAD, dihydrocoumarin, napthopyranone and 2-hydroxynaphaldehydes [5].)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210916/
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on February 20, 2018, 03:27:22 PM
Great work Neo  :)

For those interested or perhaps not below is an article on Butyrate, I found it very interesting;

https://www.selfhacked.com/blog/butyrate-health-benefits-butyrate-derivatives-sodium-butyrate-phenylbutyrate-trybutyrine-butyric-acid-butyrate-prodrugs-butyrate-producing-bacteria/#Butyrate

Paul (paolo)  :)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on February 20, 2018, 04:43:34 PM
Niacin may actually increase diabetes risk, nicotinamide is safe for up to 3g/day: https://link.springer.com/article/10.1007%2Fs001250051536

Note that nicotinamide is used in the methylation cycle and uses up methyl groups. If you have a problem with undermethylation, supply methylcobalamin (methyl-B12).

Edit: interesting! While an overload on these is bad, the following supplements / foods inhibit HDACs: Curcumin, Quercetin, Garlic, Onions, cruciferous vegetables (Broccoli sprouts, cabbage, Brussels sprouts, cauliflower, and kale), Resveratrol, EGCG (green tea).

All of these showed up on my radar in the past. That explains a lot.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on February 20, 2018, 10:42:42 PM
My mistake, I corrected my original and recent post.

The gene is HLA-B7, which is activated via methylization, by histone deacetylase (HDAC). Insulin resistance causes an increase in HDAC, while the ketone body beta hydroxybutyrate (produced by the ketogenic diet or fasting), reduces it. Keep your diet low insulin if anything, and consider a cup of coffee + grass fed butter : )
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on February 21, 2018, 03:49:21 AM
That's good, coffee and butter (grass-fed) = bulletproof coffee  :)
I already use  for months coffee and MCT oil (C8) so I think that's a good thing to do.

BHB (beta-hydroxybutyrate) is chemical the liver produces when going into ketosis. It not only acts as a signalling molecule for the body that fat is to be the primary fuel source, but acts as precursor for ketones. Amongst other things, it is the BHB molecule that signals to lower blood glucose, and the presence of BHB is thought to benefit the body in a number of ways, even if the body is not truly in ketosis. Think of BHB as a signalling molecule first, and an energy source second.
MCTs on the other hand are simply a good energy source. They can pass straight into the mitochondria and get converted into ketones for energy. The presence of MCT and the ketones it is broken down into will undoubtedly do some signalling too, and can stimulate natural production of BHB in the liver. Think of MCT as an energy source first, and a signalling molecule second.

BHB + MCT = Good  :)

MCT Studies:- https://www.ncbi.nlm.nih.gov/pubmed/7072620
https://www.ncbi.nlm.nih.gov/pubmed/18296368
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882694/

Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on February 21, 2018, 04:15:37 AM
I love bulletproof coffee! But I have yet to try it with MCT oil. I have been on a ketogenic diet or close to ketogenic for over six months (probably a lot longer!), and I have loved what it has done for my strange health issues and penis. You're right, even fasting or simply skipping breakfast and having some fat can produce BHB. Checking out that article now.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tychy on February 21, 2018, 06:23:03 AM
I use MCT oil every morning in my protein shake. So far that's keeping me from snacking until lunch ;)

I took 50mg of nicotinamide / niacinamide yesterday (still had a bottle on the shelf) and was greeted by instant dizzyness and stomach upset. Today I have severe anxiolytic effects, like from benzos, and diarrhea. May not be for everyone xD Keeping to broccoli sprouts...

PS: Body does convert tryptophane to niacinamide, if there is not enough in the system. I may have experienced a second hand tryptophane -> serotonine rush.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on April 10, 2018, 09:13:19 AM
Some studies on how insulin directly raises TGF-beta and TGF-beta receptors, plus ROS, all CAUSES of peyronie's.

Insulin directly increases tgf-beta, ROS,
https://www.hindawi.com/journals/ijmg/2014/180270/

Insulin directly increases tgf-beta and fibrosis
https://www.ncbi.nlm.nih.gov/pubmed/26420907

Tgf-beta status of prediabetic americans
http://www.kidney-international.org/article/S0085-2538(15)54527-4/pdf

I made a new YouTube video on this topic. Treat insulin as ENEMY #1 when it comes to ALL diseases of modernity. This is no joke, the research is starting to blow up on how serious hyperinsulinemia (silent pre-diabetes) causes many diseases included all-organ fibrosis.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on May 03, 2018, 02:16:21 AM
NeoV, Linked below is a study on inhibition of HDAC7 (may represent a promising epigenetic therapy for Peyronies Disease).
epigenetic = relating to or arising from non-genetic influences on gene expression.

https://www.ncbi.nlm.nih.gov/pubmed/29706035

Thoughts??
Paul (paolo)  :)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on May 03, 2018, 05:04:48 AM
Oh my god.. so they have been watching my thread and our forums LOL.

Well, keep off the carbs, try fasting, and keto : )
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Crooked_Stick on May 03, 2018, 12:57:25 PM
NeoV.....can you give us the link between keto and HDAC inhibition? Also Sulforaphane (from broccoli) is an HDAC inhibitor.....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777483/

Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on May 04, 2018, 11:16:22 AM
Great finds Paolo and Crooked_Stick!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on May 05, 2018, 03:31:53 AM
which sulphoraphane supplements give the best bang for the buck?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on May 05, 2018, 11:04:57 AM
If you Google Avmacol Nutramax you should find what you are looking for, seems to have good reviews  :)

Advantage is it bundles the enzyme myrosinase alongside its glucoraphanin.

If any benefit after a month then please report back  :)
Paul
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on May 06, 2018, 03:53:08 PM
From the SelfHacked secrets e-book:

«Hi­-maize resistant starch results in butyrate production»

Also, I see there are Sodium Butyrate supplements. Are those related? Would they help?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on May 07, 2018, 08:38:09 AM
No reason to take a supplement. Eat fat and fast, and your liver will pick up lipids in your blood and turn them into beta-hydroxybutarate. This inhibits histone deacetylase.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735349/
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on May 07, 2018, 05:31:12 PM
Quote from: NeoV on May 07, 2018, 08:38:09 AM
Eat fat and fast

I know the theory but it's not easy to follow given my extremely hectic lifestyle. Maize seems like it will stimulate BHB production even if i don't cut carbs from my diet. Can someone confirm?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: TonySa on May 07, 2018, 08:11:38 PM
Doubtful it disbetics would be using it, although I'm not sure
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on May 07, 2018, 09:27:09 PM
«Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice»
Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110446)

is it relevant to this thread?

Reason why I ask is that I just found this new article from the awesome Marcus M Ilg that already presented those posters on high throughput screening of drugs for Peyronie:

«RhoA kinase-inhibition prevents myofibroblast transformation in a cell culture model of Peyronie's disease»
10.1016@S1569-90561831811-6.pdf - DocDroid (http://docdro.id/iRJRm0R)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on May 08, 2018, 02:47:03 AM
Quote from: pey ron on May 07, 2018, 05:31:12 PM
Maize seems like it will stimulate BHB production even if i don't cut carbs from my diet. Can someone confirm?

Yep, I agree, it is somewhat of a cheat if you will rather than going very low carb
Paul  :)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: joao on July 21, 2018, 08:54:03 PM
I had peyronie's for about two years and it is now cured probably 100%
i am quite sure it cured because of intermittent fasting ( after over 8 months of normal intermittent fasting ).
i am 60 years old and i am convinced it is not easy to cure and even less at this age.
i am quite sure that now the skin of the forehead ( foreskin ) is rosier then ever ( in my memory ), so irrigated with blood.
The same for the head of my penis ( glans ) is more irrigated with blood and larger then before the peyronie's started ( when not in erection ).

it was not one of the most severe cases, but is was enough to cause a lot of pain for many months ( even without erection )

i read quite a lot and it makes sense that the intermittent fasting is the reason of the cure.

i finished a water fast of 7 days almost 2 months ago.

But i am quite sure it was solved before that because of the intermittent fasting.
Since i did not wrote it down i am not 100 % sure (but about 99 % sure).
i did a 3 day water fast before but it did not make it cure ( it is really a matter of time at least in my case )
Do not do a many day waterfast without doing first intermittent fasting ( unless you are very young )
remember that fasting while you have diabetes or insulin deficiency can be very dangerous.
in doubt stop the fasting or intermittent fasting until you are sure about not having that.

i tried a few things before and during the intermittent fasting but not long term as i did not feel very secure about it
let us say results took too long and i had not enough discipline and fate to do them long enough ( with the exception of the intermittent fasting ).

i did some jelqing and i believe it can help for some, but i also think it can hurt as well and if your underlying problem is not solved jelcking probably does not solve.
i did do some jelging with coconut oil relatively close to an infrared lamp ( do not burn yourself and increase time and decrease distance gradually ).
it seemed promising ( it irrigates the penis even a while after you finish ) but i did not do it long enough and i think it is not the reason of my cure.

intermittent fasting or fasting or ketogenic diet is not easy but i did it for general health reasons
not really for the peyronie's
i hoped to cure the peyronie's as well

but since it took months i stopped expecting it.

if the intermittent fasting it is hard for you to do
think that it is for your health and mental resistance.

i am very convinced it causes regeneration in general ( literature confirms ).

it also decreased my not so severe essential tremor starting after about one month.

it started to made my white beard and pubic hear turn black again (now about 40-60%) long before the peyronie's cured.
But this only happens very gradual

do not expect fasting or intermittent fasting or ketogenic diet make you see results in a few weeks

( a young person could FEEL a difference in a matter of days, older persons have to count with weeks of months )
But for SEEING a difference better count with months of even better do not expect it.

if you try intermittent fasting or ketogenic diet ( or a combination )
look for and avoid mistakes you can make.
one of the mistakes is (in the case of ketogenic diet)  if you use more than 20 % meat ( proteins ) your body will turn it in glucose
if you measure your glucose do not expect it to fall close to zero ( even if you do not use carbohydrates, sugar, frutose or lactose ).
even after 7 days of water fasting ( no oil, no juices, no nothing ) glucose did not drop below 54 mg/dL ( in my case )
during intermittent fasting it only dropped to 69 mg/dl

i mention this because i expected it to drop more.






Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on July 21, 2018, 09:48:16 PM
Joao, thanks for the detailed post.

Glucose dysregulation is at the root of aging (through glycosis and ROS) and parkinson's and neurological diseases, so it makes sense that your tremor got better. I'm really happy to hear about your success.

Fasting or keto also fixes your body's own endogenous antioxidant system (antioxidants made within the body, such as CoQ10, Glutathione, and SOD).
Instead of taking CoQ10 and rubbing SOD cream on your penis, get rid of insulin resistance and let your body work how it was supposed to. I go into this a bit in my new video: https://youtu.be/7KLlVU0H1Yw?t=1035

Insulin resistance also LOWERS nitric oxide and damages the lymph system and your entire body.
https://www.ncbi.nlm.nih.gov/m/pubmed/30025187/

Also, insulin resistance causes "sticky blood," which is so often cited as being correlated with Peyronie's.
I will update the original post and flesh it out with studies soon.

Keep up the good work man!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: SF99 on July 22, 2018, 12:10:22 AM
I'm confused about the role of diet in stabilizing/eliminating the disease. According to this article, a low cholesterol diet could be effective in preventing plaque build-up. This is used to treat plaque build-up in the arteries. It's pretty frustrating having so much conflicting info.
https://www.superfoodly.com/peyronies-disease-curved-penis-treatment/
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on July 22, 2018, 12:42:44 AM
That is vegan (sugar industry in disguise) PROPOGANDA.
They spend millions to maintain websites like that and nutritionfacts.
Dietary cholesterol does not cause blood cholesterol to raise at all, that is well established.

LOW cholesterol causes Peyronie's, because it is closely related to CoQ10 and vitamin D. Statins lower cholesterol and CAUSE Peyronie's.

Heart disease is caused by carbohydrates and very low density LDL, which is caused by high blood sugar. This is also known as remnant cholesterol. LDL cholesterol is the weakest indicator of atherosclerosis. You need to look at your triglyceride to HDL ratio. High triglycerides are caused by a high carbohydrate diet. If your body cannot use lipids due to carbohydrate dependancy, you have insulin resistance and fats will have nowhere to go. They sit around and become very small density LDL, but this is not a result of eating fat or cholesterol. Saturated fats increase cholesterol but this is not a bad thing. Read in depth about statins and cholesterol. We have all been lied to since the 1950s and Ancel Key's "heart hypothesis" which was based on the Seven Country Study, a deeply biased and laughable study. Keys was a bully and we are all suffering the effects of that study and industry funded research to this day.

All of this said, DO NOT combine carbohydrates with fats. You need to alter your gut biome and mitochondrial DNA by consuming fats and no carbs. Until your body learns how to properly use lipids, you are in a dangerous spot and can surely get heart disease.

Heart disease is caused by insulin resistance and diabetes.

If you are vegan, you can do keto vegan too.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: TonySa on July 22, 2018, 11:17:44 AM
Hey Neo,
I too am on a meat based Keto diet, for almost 6 months now.  That said,  I just don't understand folks on the anti-vegan wagon...calling it propaganda.  I know they can come across strong, but given the treatment of animals in the industrial food complex that's understandable.  Plus, like you said one can eat a healthy vegan keto diet as well.
Tony
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Thomas2 on July 22, 2018, 05:26:45 PM
i have been vegan since 19 to 24 yo roughly when disease first came. Just wanted to put my testament.

I still think vegan diet is feasible and if done right more healthy, i know nothing on other stuff.  My parents stayed on keto-diet for a summer 10 years ago, they nearly destroyed their livers and kidneys, my mother turned into an old lady with low density bones...
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: joao on July 22, 2018, 06:35:42 PM
Hey Neo and others,
I posted here after i got better from Peyronie's ( but from other health problems as well )
because i red forums as well while i had Peyronie's.
I mean i think i had to do this posting at least once.
Reading forums was confusing but it still helps because the articles give you hope and allow you to fight for your health.
It is a struggle when you have Peyronie's or probably more when you have tremor or even essencial tremor ( considered not treathening ).
I do not remember having found a forum as interesting or as good as this one.
So i am glad to end up in this one ( and reading it, i just intended to post and then leave ).

I saw your youtube video and think you are right.
Your voice was not very loud ( that could be because here i hear the waves of the ocean in the background ).
I red a lot about intermittent fasting ( IF ) and ketogenic diet and of course about getting in ketosis.
And it not easy either.

I did not measure ketone bodies (but i did measure glucose).
I think doing it can help but i think it probably will make things even more confusing.
If you do do not draw conclusions too soon you can or should do it off course.

I give a few examples * why it can confuse you even more.

After the 7 day water fasting i started to eat more carbohydrates than i did before ( when i did a combination of keto and IF )
because maybe i had to catch up ( that is what i think ) for the regeneration to take place.
you can do IF and keto forever if you want but you cannot do long term water fasting forever.
My main goal was to cause regeneration and especially neurogenesis ( especially neurogenesis takes 6 months to mature 1/3 of the new neurons ).
And that is what i think happened.

That is also why i gave importance to gray hair turning black again.
stemcells of hair and stemcells for neurons come from the same place ( originally the neural tube )
to some extent they can migrate.
They can migrate in your brain ( it is easy to find info about that ).
Maybe they can migrate between hair and brain ( that is what scientists do and it works. They collect stem cells from your brain and inject them in your brain or in your body with the intention to reach your brain ).
If this is true then these stemcell could migrate to your penis.
I am afraid it is not the highest priority for the stemcells in your facial hair.
Stem cells from your pubic hair make a better chance.
That is why i mentioned the pubic hair turning black ( the ones that turned black are more black then the ones that stayed black )

I sidetracked and did not give one example yet.
Here comes the example.
*
so after starting eating carbohydrates etc after the 7 day water fasting.
glucose shot up to 160
to go down to 100 only the next day
to go back to normal for me ( less then 100 ) while i do mild IF now.
I did not panic when it shot up only because i new in before about this happening in such a case ( I HAD RED ABOUT IT ).

If i had not known about it i would have panicked and think that i had messed it all up ( that i had done something wrong and caused diabetes )
I think the body or delays to make larger amounts or insulin again or it happens on purpose to rack up the deposits all over the bodies.
When i take in more carbohydrates / glucose i feel the blood pressure going up ( i do not really need to measure ).
Just to say it is no mathematic, it is not 1+1.
I have no diabetes and never had ( or knew about it ) ( in fact i think i got it but did not want to measure and just started with fasting and IF ).
When as a side effect the Peyronie's cured, the tremor got better and better and my hear turned more and more black ( still not over 40-60 % as i think it is not the upper priority of the body ).

The other example i wanted to give is that i think that measuring your ketone bodies can confuse even more than measuring glucose.

Because i think that ketone bodies going up shows your that you are burning fat ( that you got in ketosis ).
But also that you are not using all of it.
So just to say that i think them going up is a good sign, but them not going up could be even better because you could be in ketosis and your body able to use all of it. It can do so only when it is metabolically very healthy already ( the mitochondria ).

Thanks Neo and others for all the feedback that you already gave.

I did not use anything other topic than coconut oil.
I did not use cialis, vitamins or anything else.
not internal nor external.
I did not spend money, i just saved money and time ( except for the studying )

I think the IF + keto > ketosis did the job(s)

while i think IF is the main key
for me keto makes IF easier ( but keto is good on its own. keto on its own for me is more dificult than IF )
and IF makes long term fasting easier or even possible ( is necessary to do it in a healthy way )
If you do make mistakes, long term fasting could cause damage ( especially if one is diabetic )

If i did confuse you with too much information
then just remember this.
start intermittent fasting, do not start with more then 12 hours a day.

do that for about 3 weeks and then take your next step ( inform you beter or go slowly ( weeks or months ) in the direction of 18 hours IF a day if possible )

Joao

I did not red other therapies this time.
I am sure they are very interesting and can work, but this way (ketosis) is the most complete and sustainable.
Probably one of the most dificult, at least at first sight.
As always there are some risks if you are not well prepared.
If in doubt return to normal or check a doctor.


Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on July 22, 2018, 10:23:10 PM
Thanks again for all the info Joao.
Intermittent fasting is an amazing tool to beat insulin resistance! Dr. Jason Fung has a lot of books, research, and YouTube videos on this.

To others, yes veganism by itself is a great cause. But the sugar industry pays vegan doctors or supporters as well as funds websites that blatantly lie and harm people. Veganism is fine, and yes keto can be vegan.

Bone density is fine on keto, and only got worse in children with epilepsy due to their medication and low protein intake.

https://www.ncbi.nlm.nih.gov/pubmed/24800673
"Our data suggest that maintaining a KD for more than 5 y does not pose any major negative effects on body composition, bone mineral content, and bone mineral density in adults with GLUT-1 DS, a finding that is at variance with previous reports focusing on children with intractable epilepsy."

Low carb diets have no effect on kidneys
https://www.ncbi.nlm.nih.gov/m/pubmed/29904998/

High protein seems to be fine for kidneys as well.
Nutrients | Free Full-Text | Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study | HTML (http://www.mdpi.com/2072-6643/10/1/54/htm)

Protein does get converted into glucose but at a very slow rate. Protein is definitely important, but going absolutely no protein or low may be necessary for treating severe insulin resistance. For me, too much protein definitely can give me a bit of nerve pain, but not much.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Paolo on July 23, 2018, 02:51:02 AM
I have just started supplementing with Gelatin powder for its 'anti-stress' benefits, particularly the Glycine and Proline content, helps with Cortisol overload, Cortisol = stress. I believe it will also help after cardio exercise and with sleep  :)

Diabetes and Gelatin are mentioned (for those interested) here Gelatin, stress, longevity (http://raypeat.com/articles/articles/gelatin.shtml)

Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on July 27, 2018, 05:09:43 AM
So though I treated my size loss and erectile dysfunction effectively with traction and heat, the dents/hourglassing still remained.

I have been on a carnivore diet for nearly 3 months now, essentially grassfed pieces of steer (beef, fat, gristle, liver if I can stomach it) and canned sardines, drinking only water. I have also been periodically doing 48 hour water fasts. Dents are slowly disappearing. I am very very very very surprised by this, I have had those dents since 2010. 

Fasting previous to carnivore diet, had no discernible effect. Previous to this I was eating a paleo style diet, no wheat, dairy, added sugar, legumes etc.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Jalanlong on August 20, 2018, 09:54:53 PM
I am thinking of starting the Carnivore Diet. Are you still having improvements?  I have moderate Peyronies and was wondering if the diet could help.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on August 21, 2018, 02:53:41 AM
I have had no chance to fast again (too much going on in business world) but previous improvements have remained. I am 100% certain diet can help.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JS1991 on September 05, 2018, 07:59:08 PM
If any of you know Jordan Peterson, his daughter Mikhaila has terrible arthritis throughout her entire body and got a hip and ankle replacement at 17. After experimenting she found that a carnivore diet cures her of all symptoms. Here is a clip of her explaining what she went through: https://www.youtube.com/watch?v=7fncJdVjy5U

Overall, I feel like diet/fasting is the icing on the cake of our Peyronie's treatment regimens; very promising.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on September 05, 2018, 08:05:16 PM
Yeah the idea with that is it is the ultimate elimination diet. Remove everything except beef, salt and water for a month, then slowly add things back in one at a time.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JS1991 on September 06, 2018, 04:23:07 PM
Does anyone know at what point autophagy sets in? Apparently it is after about 16 hours with it peaking shortly after and falling off after 2 days. Apparently it can also coincide with ketosis; one doesn't need to run through their fat stores for it to begin. I am also hearing, separately, that if one water fasts they should expect to see the autophagy occuring after 11 days depending on fat stores? I'm not sure which to believe.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Crooked_Stick on September 06, 2018, 06:02:59 PM
this is a decent article on fasting:

https://besynchro.com/blogs/blog/the-profound-benefits-of-fasting-and-autophagy
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on September 06, 2018, 08:06:29 PM
Quote from: JS1991 on September 06, 2018, 04:23:07 PM
Does anyone know at what point autophagy sets in?

Research it. Get on pubmed, google etc and dig up the most reliable sources you can. It's an important question and putting some time into finding a good answer would be well worth your while.

@crooked_stick, the problem I have with that article is that they are selling something, that specific power/supplement thing. Have you checked the references they link to?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on September 08, 2018, 12:27:00 PM
JS and Skunkworks, I'm really glad you both made me look into carnivore.

I've been keto for a year and 3 months or so, maybe longer, but I notice my issues get MUCH better when I go lower carb. I have 4 eggs a day, cheese, and meat with some veggies such as broccoli (for that mystostatin inhibition and anti-cancer effect). However, I am now foregoing even veggies and really going carnivore. I'm really enjoying it and I feel amazing. Thanks so much for turning me on to this.

I am also doing more rigorous traction starting today and getting on a schedule. Although my symptoms are not problematic anymore, I'm curious just how far I can push this. I have a feeling I can get much more improvement.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Gabriel on September 09, 2018, 06:41:43 AM
Hey guys,

Just stumbled yesterday on an article which stated that food additives significantly increased glucose sensitivity, microbiota negative modifications, inflammatory diseases (metabolic syndrome, irritable bowel syndrome...), diabetes, Crohn's, and obesity.

I can't find the primary sources, but this comes from a very reliable French site (National institute of consuming) which bases its claims on studies published in Nature, etc (https://www.60millions-mag.com/2015/06/12/mefiez-vous-des-additifs-alimentaires-8003).

Sorry if this question had already been treated (I imagine it has), but for me it was quite a discovery... And now I realize how much additives I thought to be innocuous (sucralose, cellulose gum...) are absolutely everywhere, even for me who has a really good diet  :o... Damn
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JS1991 on September 10, 2018, 10:51:11 PM
Neo, I'm glad it's working for you. I know you know this, but please be careful with traction. You seem to be in a pretty good place in terms of your Peyronie's and it would be sad to see you injure yourself.

Gabriel, Always try to consume all natural foods! Especially with Peyronie's disease. It goes hand in hand with the diet and fasting we're discussing.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Christopher1 on September 29, 2018, 07:26:05 PM
I did 4 days of water fasting. That is WATER fasting - no tea or coffee allowed. Drinking tea or coffee messes things up.

It stimulates something called autophagy, which is very good for you.

3 changes - Peyronies Disease scar became somewhat softer, lost water and fat mass (no muscle lost according to my BF% scale), and my beard grew out slower for a month (it returned to normal slowly).
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Christopher1 on September 29, 2018, 07:33:49 PM
Water fasting:
Day 1: No problem. Lots of time and more energy. Also easy on the wallet.
Day 2: More energy.
Day 3: Relaxed. Heart rate around 60. But weak. Definitely not a time you want to be running or lifting heavy objects. No problems.
Day 4: Starting to feel not so good. Bilateral flank pain as well - but nothing severe. I gave up and I started eating some boiled eggs.

I might push it again, but 4 days was tough for me. I think 2 to 3 days is good. With more practice, I will try to push it to a week. Overall, I am far more productive (no time wasted on eating, no sugar crashes, and lots of mental energy) and I have more money in my wallet.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on October 12, 2018, 11:01:56 AM
Great video by Thomas on autophagy and coffee or caffeine.

Conclusion: caffeine CAUSES autophagy even without fasting!

https://www.youtube.com/watch?v=aEuHu5zjQPk

Black coffee in a fasted state boosts autophagy. I am not that into autophagy compared to the mitochondrial effect of keto, but it is something worth getting into! Anyway, thomas' video is very well done.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: TonySa on October 12, 2018, 04:58:42 PM
Great video.  I wonder how long to wait after having coffee before breaking the overnight fast is ideal?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JS1991 on October 12, 2018, 05:07:19 PM
Great video thanks for linking! I do agree that coffee causes a boost to autophagy, but I do believe it also breaks the fast in a way. I follow Dr. Rhonda Patrick for my dieting needs (here is her IG: https://www.instagram.com/foundmyfitness/?hl=en she always gives great advice in her posts), and here is what she has to say on the subject: https://youtu.be/m6KClPkotxM?t=441 I linked to the coffee part but the whole clip is great if anyone is interested in watching, and after they go off topic they come back onto the topic of coffee at 10 minutes exactly, by the way. Does anyone have thoughts? I'm really trying to figure this all out as best I can. I'm thinking maybe drink a lot of coffee during my 8-9 hour feeding window to boost autophagy, then nothing but water during my intermittent fast (which I have yet to start by the way).
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on October 12, 2018, 08:10:47 PM
Interesting, unadulterated coffee would definitely help get through the third day slump.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Gabriel on October 13, 2018, 10:05:58 AM
Hey guys,

I know I'm going to be a stick in the mud here, but after a few months of tests, I'm pretty positive that drinking coffee increases my chance to feel little bursts of pain while flaccid throughout the day. I'm NOT claiming anything scientific nor even 100% sure here; I know caffeine has antioxydants effects, that PTX is derived from caffeine... I'm only saying this shoots of pain seem to happens like 2 times out of 3 when I drink coffee.

Anyone experienced similar symptoms?

Anyway, I now tend to avoid coffee as much as possible, as it instantly and drastically worsens my CPPS symptoms (late drops of urine, etc.).

BTW, I'm going on an apple monodiet for 3 days next week or the week after; I'll keep you up to date if anything cool happens to my small friend down there (not the objective, but who knows ?)!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on October 13, 2018, 11:04:06 AM
Here is the thing about coffee, short term it increases insulin resistance. Like close to immediately. So if you are still eating a normal carb heavy diet then in that regard coffee is a bad thing.

That's obviously not an issue on a fast, nor really an issue if you're eating carnivore or low carb.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Gabriel on October 13, 2018, 11:35:01 AM
Very interesting skunkworks, thank you!!

So, if I drink coffee with ZERO sugar while fasting in the morning, I shouldn't notice any pain... I'm definitly going to try it, because even if it's bad for my CPPS, it does help when it comes to morning fasting workout!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JS1991 on October 14, 2018, 04:50:01 PM
If you're going to drink coffee I would go with black coffee.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Christopher1 on October 14, 2018, 05:44:57 PM
A true fast should be with water only.

No coffee or tea.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on October 14, 2018, 08:30:00 PM
Yes but I'm not doing it for spiritual reasons, so if coffee can boost autophagy then it is potentially a good addition.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Gabriel on November 08, 2018, 04:14:26 PM
Hey guys,

Found this while doing a research on the link between insulin resistance and Peyronie's : https://www.dupuytren-online.info/Forum_English/thread.php?true&board=4&thread=3156

It's old, long (just read the first page so far, lots of science) but absolutely fascinating; it looks a little like the equivalent of this very thread, but about Dupuytren's... And talks about caffeine too!!

Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on November 08, 2018, 10:02:12 PM
Cheers for that Gabriel I will have a read. Yeah the deeper I dig, the more clear it becomes that poor insulin/glucose control is at the heart of the matter.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Bubba dawg on November 25, 2018, 08:28:03 AM
I stated this in another thread. If peyrones disease is diet related then why is it not more common? USA makes have terrible diets on average. Yet most dont get this disease. I am over 55 and have never heard anyone talk about this problem. None of my relatives. Most urologist dont treat it in my area. My Experienced Urologist could not pinpoint a cause. Just seems like it would be more common if it were related to diet. So if diet doesnt cause it, how could it cure it? Fasting may fix one thing and damage something else. So I would want more evidence of this being diet related. Not ruling this out because it seems to work for some. I wouldn't try it myself.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on November 25, 2018, 09:00:48 AM
Dude. Predisposition.

Like how some people can smoke cigarettes their whole life and never get lung cancer, but for others it does not end so well. The predisposition is the thing.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Bubba dawg on November 25, 2018, 09:51:43 AM
There is a lot more health problems from smoke than there is peyrones from diet. Peyrones is rare. Lung cancer from smoking is not rare
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Werther on November 25, 2018, 12:16:11 PM
I may sound negative but there's actually no proof that dietary habits have any impact on this crappy disease in particular.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JS1991 on November 25, 2018, 05:24:48 PM
I'm personally more a believer that keto/fasting can help Peyronie's, than that it is the cause of it. This is mainly due to inflammation reduction in keto and autophagy in fasting. Perhaps it can exacerbate developing Peyronie's, but I personally have never claimed it to be the cause.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on November 25, 2018, 07:10:05 PM
We may be talking about different definitions. I am not saying diet is THE CAUSE of Peyronie's, but that for some people an inflammatory diet can possibly create the conditions for Peyronie's to form when it might not have otherwise. And that's just from the inflammation perspective.

We've been talking about the science of it a lot! And Gabriel also linked to a thread on another forum which contained some very interesting studies. If you want actual studies on diet and Peyronie's specifically you're going to be waiting a long time. It's only recently that serious work has been done on dietary intervention for diabetes, and it's one of the biggest killers in the world, probably the biggest if you included all the conditions diabetes exacerbates if you have a predisposition to them.

And as predispositions to conditions are a factor in almost every single medical condition other than congenital conditions and straight up trauma, I hardly think we need to prove that people have a predisposition to Peyronie's.

Evidence suggests very strongly that Peyronie's an autoimmune component, Nachtsheim DA, Rearden A. Peyronie's disease is associated with an HLA class II antigen, HLA-DQ5, implying an autoimmune etiology. The Journal of urology. 1996;156(4):1330–1334. [PubMed].

There is a small but growing body of research specifically on dietary intervention in autoimmune disease. Case studies and lab work

When in the active stage, Peyronie's is an inflammatory disease. There is a large body of research on diet and inflammation.

Peyronie's has a fibrotic component, autophagy is a scientifically proven method of treating fibrosis.

Autophagy regulates TGF-β expression, and we know TGF-β expression plays a big part in Peyronie's. That's how Pentox works.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on November 25, 2018, 07:18:29 PM
Also, to bubba's original point that it is too rare a condition for diet to be involved (which honestly makes very little sense in the first place) the condition may not be as rare as you think.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150157


There was also a study done on cadavers which showed a far higher incidence of penile lesions than anyone would have thought, around 22%. I will find the study.

Edit. Can't find the actual paper (it was very old) but it is referenced here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442995/

The prevalence of Peyronies Disease is currently estimated at 3–7.1%, with autopsy studies identifying subclinical disease in up to 22% of men [2–13]. Increasing rates have been reported with some comorbidities, including diabetes mellitus (DM, 8.1%), after prostatectomy (15.9%), and combined ED/DM (20.3%) [3,11,12]. Although the incidence of Peyronies Disease is greatest in men aged 40–60 years, cases have been reported in other age groups, including teenagers [14].

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221554/

The prevalence of Peyronies Disease is still under debate. Some studies have shown prevalence rates ranging from 1% to 4%2; autopsy studies have even gone so far as to state that 22% of men have some lesions on the penile tunica albuginea.3
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on November 26, 2018, 12:15:24 AM
Bubba, glucose affects people in different ways depending on your genes. Men with Peyronie's have overactive Wnt genes, which are activated by glucose.

Insulin directly increases TGF-beta and tgf-beta receptors on cells. Insulin also lowers NO in the body, leading to vascular damage and fibrosis.

I have written a long write up with many studies but am not quite ready to post it yet.

Your question is the same as asking why insulin and glucose causes Alzheimer's only in some people, while other's get fat. Alzheimers is clearly diabetes type 3, but it depends again on how their body reacts to glucose toxicity (the epidemic of our times).

I am not suggesting that Peyronie's cannot happen even with the lowest insulin diet ever. I am sure it can, but that doesn't really matter to me. Just because some people don't get cancer but smoke all their lives doesn't mean we should smoke.

I have written up a long post with links to studies on google documents and will post it once it's done. That will allow us to have all the studies available so at least it makes more sense.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Bubba dawg on November 26, 2018, 07:48:28 AM
I dont have diabetes.  I do not eat much sugar , if any, daily. I drink water for lunch. Couple of lite beers for supper. Black no sugar coffee for breakfast. I have been following this regimen for decades.  I have always thought of sugar as poison to the body. Still got peyrones.  But anyway we are all adults free to try what we want too.
You really can't compare smoking to peyrones. A VERY high % of those that smoke get lung cancer. I know several smokers  that have lung cancer. Smoking studies have directly pinpointed it to be the cause of many lung cancers. The evidence is overwhelming.
The general consensus is that peyrones is caused by some type of trauma to the penis. Not by what you eat or drink.
Rare that smokers dont have any health problems directly related to smoking.
I also think that men, who could not have sex , would seek medical attention. I sure did. Leading me to believe that serious peyrones is rare.
The internet can be dangerous. I can put in a question a certain way to prove a point. I can ask a question another way to disprove it. We are all now internet doctors lol Never mind the people who spend 12 years in school and internships.  Fast away!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JS1991 on November 26, 2018, 04:11:30 PM
Peyronie's is more common than you think... estimates range between 5-15% of the male population. In terms of smoking and predisposition, the current oldest man in the world smoked his entire life (still smokes) and is over 120 years old. He is clearly not predisposed to lung cancer. Most people will get it if they smoke chronically, yes, but someone predisposed might get it in their 30s/40s. I agree that Peyronie's is caused by penile trauma; that is how mine began. But that doesn't mean some people aren't naturally more likely to get it, and the route that it seems to take in those individuals manifests itself as a sort of diabetes of the penis. I actually see these as the two main routes to acquiring Peyronie's. Regardless, autophagy is powerful and even if Peyronie's was induced by penile trauma, it should help. I understand your mentality of "lol, what are we all internet doctors now?" so if this is not for you, that's fine. It's not so much being an internet doctor as it is using common sense, your brain, and anecdotal evidence to investigate alternative routes to healing. Many countries have different protocols for different diseases for example; the internet gets the benefit of all.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Bubba dawg on November 27, 2018, 06:29:40 AM
How can you narrow down what foods and drinks contribute to peyronie's? Everybody is effected differently by everything consumed. Everybody has a different genetic makeup. So you cut out everything for a period of time? How long? How often? Just seems so unscientific to me. I would rather go through 5 minutes of injections than starve myself for days. I do think diuretics make peyronie's worse. Spicey foods seem to make it worse. I agree with altering your diet could help.
One fact is smoking narrows arteries in your body. Narrowed arteries constrict blood flow. Constricted blood flow hurts your erection. Many smokers are impotent. Not all but many. Many have weak erections. 
The internet has helped me treat myself for certain illnesses. Sometimes it is good to let the doctor diagnose and heal you. Make them explain everything and why they do what they do. They are not infallible
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on November 27, 2018, 07:25:35 PM
It is not at all the consensus that injury or trauma is the cause of Peyronie's. If anything it's a trigger.

Many of us got the disease without an injury. If you read the research you'll see that the actual consensus doesn't exist, but a mitochondrial (metabolic) and genetic (wnt2) appear to be at the root of it. High tgf-beta is a result of these problems. It is a fact that insulin raises tgf-beta and that the plaques of Peyronie's and Dupuytren's show glucose dysregulation and mitochondrial dysfunction. You don't need diabetes to have damage or fibrosis from hyperinsulinemia. It's not diabetes but before that, that we are worried about.

While it's a bit crazy to say "glucose causes Peyronie's," (maybe it's not) we have a pretty good reason to avoid it. The same is true for something as simple as vascular health.

Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on March 06, 2019, 06:00:38 PM
it is posted also off topic but i believe is relevant
Juvenile Diabetes and Vaccination:New Evidence for a Connection
https://www.nvic.org/vaccines-and-diseases/Diabetes/juvenilediabetes.aspx
BCG (Tuberculosis) Vaccine Induced Inflammation Linked to Type 2 Diabetes Epidemic
BCG (Tuberculosis) Vaccine Induced Inflammation Linked to Type 2 Diabetes Epidemic
Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases
https://www.omicsonline.org/open-access/vaccine-induced-immune-overload-and-the-resulting-epidemics-of-type-diabetes-and-metabolic-syndrome-1747-0862.S1-025.php?aid=24058
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: BAtBAt on March 14, 2019, 06:08:53 PM
Oral propranolol and metoprolol both impair glucose recovery from insulin-induced hypoglycemia in insulin-dependent diabetes mellitus. ... Thus, they are at increased risk for prolonged hypoglycemia if treated with a nonselective beta-adrenergic antagonist such as propranolol.

https://www.ncbi.nlm.nih.gov/pubmed/6376011
Oral propranolol and metoprolol both impair glucose recovery from insulin-induced hypoglycemia in insulin-dependent diabetes mellitus.

Effect of propranolol on delayed glucose recovery after insulin-induced hypoglycemia in normal and diabetic subjects.
https://www.ncbi.nlm.nih.gov/pubmed/6376011


Epinephrine-induced hepatic glucose production. Had to share this but comes a bit from a different post although highly related. Thanks a lot NeoV again-

Glutathione seems very important

Best wishes to all
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 13, 2019, 06:58:56 PM
IMPLANTED MUSCLE DERIVED STEM CELLS AMELIORATE ERECTILE DYSFUNCTION IN A RAT MODEL OF TYPE 2 DIABETES, BUT THEIR REPAIR CAPACITY IS IMPAIRED BY THEIR PRIOR EXPOSURE TO THE DIABETIC MILIEU

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886867/

"MDSC from pre-diabetic rats injected into the corpora cavernosa of long-term diabetic T2D rats improve CVOD and the underlying histopathology. In contrast, MDSC from long-term uncontrolled diabetic T2D rats, are imprinted by the hyperglycemic/dyslipidemic milieu with a noxious phenotype associated with an impaired tissue repair capacity. Diabetes-impacted stem cells may lack tissue repair efficacy as autografts, and should either be reprogrammed in vitro, or substituted by stem cells from allogenic non-diabetic source "
support diabetes of the penis hypothesis
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on April 13, 2019, 10:18:47 PM
Good find Whyisthishappening

"are imprinted by the hyperglycemic/dyslipidemic milieu with a noxious phenotype associated with an impaired tissue repair capacity"

Wow.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Gabriel on April 14, 2019, 03:49:56 AM
Fascinating phenomenon, thanks man.

That's another info supporting fasting... Which, by the way, is considered quite safe even by hard science: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819235/
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: TonySa on April 14, 2019, 05:49:42 AM
Interesting article.
Of note, fasts one greater than one day (less than one day = IF) were medically supervised twice per day.  Any fasts were discontinued if problems arose (noted by patient or MD).
Also, it sounds as if all meds were d/c'd except thyroid meds tittated appropriately.
I believe this is why extended water fasting is recommended to be done under a doctors care and includes bloodwork to screen for appropriateness (as all were in this study)
Good news, intermittent fasting seems pretty straightforward without needing medical clearing or monitoring throughout as does dctrnded water fasting.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Gabriel on April 14, 2019, 08:11:46 AM
Very good point Tony!

It's pretty clear that if you are know as diabetic or fragile in this or that metabolic field, you shouldn't fast without medical precaution; that's common sense. But for anyone said to be healthy (apart from Peyronies Disease of course...), or, better said, without specific syndroms, I do believe fasting alone can be totally safe as long as you investigate it first and get well prepared (with mineral water + electrolytes, an activity planning, good food to break your fast anytime you fell like it, etc.).

That is pure theory from now, as I've just made one 3 days fast so far (everything OK); I'm beginning a 7-10 one from tomorrow, I'll let you know what comes out of it :-)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on April 14, 2019, 09:13:03 AM
Thank you whyisthishappening,

No surprise but very useful find!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: skunkworks on April 14, 2019, 12:31:35 PM
Totally random thought, but it's kinda like the penis is the canary in the coalmine. First thing to show the hurt when things get too toxic.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: TonySa on April 14, 2019, 11:00:29 PM
Personally, even if healthy (could be underlying issues one was Unaware) I'd go no longer than 7 days without medical supervision.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 15, 2019, 12:20:33 PM
L-cysteine supplementation upregulates glutathione (GSH) and vitamin D binding protein (VDBP) in hepatocytes cultured in high glucose and in vivo in liver, and increases blood levels of GSH, VDBP, and 25-hydroxy-vitamin D in Zucker diabetic fatty rats.
https://www.ncbi.nlm.nih.gov/pubmed/26778482
L-Cysteine Supplementation Increases Blood Levels of Hydrogen Sulfide and Nitrite, and Decreases Insulin Resistance and Vascular Inflammation in Zucker Diabetic Rats
https://professional.diabetes.org/abstract/l-cysteine-supplementation-increases-blood-levels-hydrogen-sulfide-and-nitrite-and
Can L-Cysteine and Vitamin D Rescue Vitamin D and Vitamin D Binding Protein Levels in Blood Plasma of African American Type 2 Diabetic Patients?
https://www.ncbi.nlm.nih.gov/pubmed/25816831
guys what do you think about l-cysteine
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on April 17, 2019, 01:43:40 AM
i think both hydrogen sulfide & nitrite are gonna help a lot, so i am gonna get on L-cysteine soon!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 17, 2019, 08:59:19 AM
ron DO NOT try L-CYSTEINE i can elaborate later not now

  this disease is Not us simple as we try to understand it

   i am focusing now on WNT2 PROSTAGLANDINS and prostaglandin receptor abnormalities(thats why some got Peyronies Disease after alprostadil although its antinflammantory(PGE1)  prostaglandin receptors with abnormalities could give signal as it is PGE2 a pro inflammantory and start inflammation cascade ) also HEPARINASE 1 and 2 should have our attention also i am making a link why   thc and cbd are bad for us even if for many is antiinflammantory
       
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 17, 2019, 04:15:45 PM
Structural and dynamic characterization of human Wnt2-Fzd7 complex using computational approaches.
https://www.ncbi.nlm.nih.gov/pubmed/30191337
  "Wnt and Frizzled (Fzd) family members play crucial roles in the self-renewal of tumor-initiating cells. Until now, only a few studies have addressed the distinct mechanism of Wnt-Fzd interactions. In this study, we suggest a possible interaction mode of Wnt2 with the Fzd7 CYSTEINE-rich domain (CRD)-both of which are up-regulated in some types of cancer"
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: TonySa on April 17, 2019, 11:09:16 PM
If same effect, how is it a "cheat"?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on April 18, 2019, 12:11:53 AM
NAC is a very powerful antioxidant.

I believe PGE2 would be anti-fibrotic. And I wonder if PGD2 wouldn't be profibrotic.

WNT is scary as hell, I believe it is proliferative and profibrotic. Well, I believe PGE2 is proliferative as well but oddly antifibrotic.

I also believe that some PPAR's can be strong antifibrotics despite being proliferative.

I would love if someone were able to get to the bottom of these.

Profibrotic = inducing fibrosis
Proliferative = making cancers grow
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 18, 2019, 06:18:21 AM
no man pge2 is pro inflammantory (prolonged inflammation=fibrotic cascade )

"If same effect, how is it a "cheat"?"      tony i do not understand  please explain
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on April 18, 2019, 01:07:47 PM
why are you making statements in the present indicative about PGE2 being pro-fibrotic?

(https://i.ibb.co/NCGpQhd/Screen-Shot-2019-04-18-at-10-04-02.png)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 18, 2019, 03:00:32 PM
it is proinflammantory  and prolonged inflammation in tunica albuginea is bad
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 18, 2019, 03:05:42 PM
Molecular Mechanisms Underlying the Link between Diet and DNA Methylation
https://www.mdpi.com/1422-0067/19/12/4055/htm
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on April 18, 2019, 04:50:01 PM
Prostaglandins are not as easy as that: they also resolve inflammation. PGE2 has an extremely short half-life, in the order of minutes. And not all PG's are born equal. There are several pathways and sometimes a given PG can extert both an anti-fibrotic and a pro-fibrotic effect, depending on the receptor it docks to. For example PGD2 is pro-fibrotic when it docks to the CRTH2 receptor, but anti-fibrotic when it docks to the DP1 receptor. So, blocking the CRTH2 receptor via setipiprant/fevipiprant would be ideal. Dig deeper, keep an open mind.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 18, 2019, 05:29:19 PM
i keep an open eye also
  Penile fibrosis in intracavernosal prostaglandin E1 injection therapy for erectile dysfunction.
https://www.ncbi.nlm.nih.gov/pubmed/9442421
"Penile fibrosis is hence a significant complication of intracavernosal PGE1 therapy"
The long-term safety of alprostadil (prostaglandin-E1) in patients with erectile dysfunction. The European Alprostadil Study Group.
https://www.ncbi.nlm.nih.gov/pubmed/9806184
"Penile fibrosis occurred in 4% of patients"
CAVERJECT IMPULSE®(alprostadil) for injection, for intracavernosaluse Initial U.S. Approval: 1981
http://labeling.pfizer.com/ShowLabeling.aspx?id=667&format=PDF
CONTRAINDICATIONS
"• Treatment of erectile dysfunction in men with fibrotic conditions of the
penis, such as anatomical deformation, angulation, cavernosal fibrosis, or
Peyronie's disease (4)"
Peyronie's-like plaque after penile injection of prostaglandin E1.
https://www.ncbi.nlm.nih.gov/pubmed/8051767
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on April 19, 2019, 02:10:16 AM
1) the needle causes trauma every single time it pierces the tunica
2) PGE1 is not PGE2... PGE1 belongs to the family 1 of prostaglandins, PGE2 to the family 2 of prostaglandins. Most humans have predominantly PG's from the family 2 -- with the sole exception of Eskimos that due to their diets very rich in different kinds of fatty acids have a completely different proportion of ecosanoids.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 19, 2019, 06:16:02 AM
it is not only the needle enthourethral alprostadil is prohibeted also, check the instructions. we can make a thread about prostaglandins or erection injections lots of people here ad them and i think we hijack this thread

  because this is about dibetes of the penis
  in cadavid 2015 igf increases the most after tgf stimulation in plaque ,that is in active Peyronies Disease phase what you want to avoidthe most besides another injury is insulin spikes neos hypothesis is solid

Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 19, 2019, 10:00:42 AM
The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat.
https://www.ncbi.nlm.nih.gov/pubmed/30979969

" FE recovered neurogenic and endothelial dysfunction and decreased glucose levels in diabetic rats."
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: pey ron on April 19, 2019, 09:23:46 PM
yes this thread should have been split off a few posts ago...
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Gabriel on April 22, 2019, 12:18:59 PM
An excellent and pedagogical resumen of the ubiquitous influence of insulin resistance and the benefits of keto/IF about the multiplicity of pathologies involved: https://www.youtube.com/watch?v=tRPqYqa3oLA (title is obviously ironical!)
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 23, 2019, 05:53:48 AM
The negative effect of the adverse systemic milieu on adult stem cells.

https://www.researchgate.net/project/The-negative-effect-of-the-adverse-systemic-milieu-on-adult-stem-cells

Goal: Autologous adult stem cell transplantation is frequently unsuccessful in repairing the targeted problem. Our results suggest that the toxic systemic environment, i.e. hyperglycemia or hyperlipidemia is impairing the repair capacity of adult stem cells via epigenetic modifications. The goal of this study to clarify the underlying mechanisms and determine new biomarkers that can predict stem cell damage before transplantation
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 23, 2019, 08:59:59 AM
Original Article Effects of hypercholesterolemic diet by long-term on elastic system fibers penile tissue: volumetric density analysis of elastic system fibers
https://www.researchgate.net/publication/303475300_Original_Article_Effects_of_hypercholesterolemic_diet_by_long-term_on_elastic_system_fibers_penile_tissue_volumetric_density_analysis_of_elastic_system_fibers
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on April 23, 2019, 05:24:30 PM
check this FQ and DM
Can antibiotics cause, or make Peyronies Disease worse? - Peyronies Society Forums (https://www.peyroniesforum.net/index.php/topic,11619.0.html?PHPSESSID=lrdqrpgm5iukgjebc8vshc2694)

Acute metabolic amplification of insulin secretion in mouse islets is mediated by mitochondrial export of metabolites, but not by mitochondrial energy generation
https://www.sciencedirect.com/science/article/pii/S0026049513001479

Defining and characterizing the critical transition state prior to the type 2 diabetes disease
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180937

Multiple Biomarker Prediction of Type 2 Diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699735/

Identification of Biomarkers for Type 2 Diabetes and Its Complications: A Bioinformatic Approach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614656/

Biomarkers for predicting type 2 diabetes development—Can metabolomics improve on existing biomarkers?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503163/

Predictive biomarkers for type 2 of diabetes mellitus: Bridging the gap between systems research and personalized medicine
https://www.sciencedirect.com/science/article/pii/S187439191830099X



Study of Protein Biomarkers of DIABETES Mellitus Type 2 and THERAPY with VITAMIN B1
https://www.hindawi.com/journals/jdr/2015/150176/
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Christopher1 on April 24, 2019, 08:06:00 PM
My Peyronies Disease was caused by Trimix injections. So...
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: swaggyp12 on June 15, 2020, 11:34:19 AM
Hey guys,

Does this low carb/keto/fasting-like diet only concern the people who are genetically predisposed (i.e. diabetes, parents) or can anyone with Peyronies Disease can benefit from it? I ask because I don't have diabetes, etc. and I also experience no pain since having Peyronies Disease. I know take care to avoid any inflammatory foods and thus my diet is definitely already ketogenetic-like. The problem is that I only have Peyronies Disease for a maximum of 3-4 months and thus still am in the acute phase. So eating meat, especially red meat, and cheese could cause inflammation. Is it best for me to eat low-carb and anti-inflammatory right now? Or would going on a carnivore diet be beneficial to me as well?

I hope someone can shed some light on this, All the best
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: TonySa on June 15, 2020, 07:20:17 PM
There are no hard and fast rules.  Any anti-inflammatory like diet that you can maintain will benefit-but be sure to add other treatments such as pentox, low dose nightly cialis and traction or VED.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Holistic on June 28, 2020, 08:18:31 PM
Quote from: NeoV on July 04, 2017, 11:41:25 PM
Myostatin is a major driver of fibrosis and a member of the tgf-beta family. Myostatin is found in the Peyronie's penis and plaques (2008 study).


Hey NeoV,

Any update on plaque appearance and diet since this post? Does the low carb diet help abolish the plaques? I seem to have a couple little plaques in my penis with no history of DM. I eat fairly healthy organic food. I do eat a good amount of brown rice. I dont divulge in refined carbs much.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on June 28, 2020, 10:03:28 PM
I never ate refined carbs and still got all these issues (as did my dad). Only brown rice basically. The difference between brown rice and white is like comparing a can of coke to to 3/4s a can. Yes my scars softened and the scarred areas became more normal and plump. My penis is better than ever lately, for which I am very thankful!
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Holistic on June 28, 2020, 11:22:09 PM
Quote from: NeoV on June 28, 2020, 10:03:28 PM
Yes my scars softened and the scarred areas became more normal and plump. My penis is better than ever lately, for which I am very thankful!

That is a good analogy for the rice. Awesome to hear about the current news. If I understand your language correctly, when you say "scarred areas are normal and plump" and "better than ever", it sounds like things reversed into a malleable stage...but it sounds like there is a possibility that the plump scars have the ability to harden again? It sounds like the diet and Coq10 have been a constant for the past 3 years since your last post?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on June 30, 2020, 09:51:34 AM
I actually stopped taking supplements for the last three years! Once I went keto I felt it was best to stop and I also feel that I no longer need them.
I have experimented with some supplements such as MSM and pynogenol and others, but I have not taken them like I did before.

Traction changed the structure of my penis so that trauma during sex or masturbation is very unlikely, while the diet seems to simply prevent any inflammation from entering my penis PERIOD. If I ate badly (SAD diet) and had rough sex and drank alcohol, I'm sure these areas could become fibrotic again, but the traction alone, the results of which are permanent, would have me protected from serious worsening most likely.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Holistic on June 30, 2020, 08:51:16 PM
Nice! so you no longer drink alcohol or have a pizza? also do you still sue the VED even with a straight shaft?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on July 15, 2020, 05:17:13 PM
"We report a very high prevalence of Peyronies Disease in a population screened by sophisticated techniques in a young population of heterogeneous ethnic males. The high prevalence of Peyronies Disease in this population prompts concern regarding the true prevalence, etiology, and associated factors of this disease. We searched for but did not find an association of Peyronies Disease with MS but did find that very uncontrolled diabetes (HbA1c >8.5%) was associated with higher rates. This high rate of Peyronies Disease in an expertly evaluated population of males may indicate the need for earlier screening of Peyronies Disease in younger patients presenting to men's health clinics with various complaints."
Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676820/
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JayGould on July 22, 2020, 02:05:07 PM
I've been eating a carnivore diet (only meat and water) for the last 6 months. As soon as I eat anything else (dairy, vegetables etc), my dick gets inflamed and my condition worsen. It's crazy how my condition was stable for about 3 years but then as soon as I got off an antidepressant I had been taken, along with Pentoxifylline, the condition immediately worsened. Anyway, manual stretching and a carnivore diet is what helps at the moment. Meditation and pelvic stretches as well, although I don't do them often enough.

I wish I would've started doing all this immediately.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JayGould on July 22, 2020, 02:09:52 PM
Quote from: NeoV on June 28, 2020, 10:03:28 PM
I never ate refined carbs and still got all these issues (as did my dad). Only brown rice basically. The difference between brown rice and white is like comparing a can of coke to to 3/4s a can. Yes my scars softened and the scarred areas became more normal and plump. My penis is better than ever lately, for which I am very thankful!

Did you ever lose size with Peyronies? And when you say it's now better than ever, does that mean you gained that size back?

Enjoyed watching your youtube videos by the way. Started manual stretching thanks to you, I've added 1-2 cm already (been at it for about 2 months).
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: NeoV on July 22, 2020, 08:46:18 PM
That's great to hear JayGould! Try keeping it on the therapeutic side and you'll likely see more results.
Yes I did lose some length due to the curvature and dents, but I gained it back and then some.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Yardbird on August 20, 2020, 01:30:31 AM
This is an old thread, but it fits me. I'm a T1 diabetic. I agree with Stabler that, other than a very few findings of newly diagnosed children being able to be made to go into remission by a strict diet, adult T1 diabetics will be dead in a fairly short time without injected insulin.As stated by others, the amount of insulin is directly proportional to the amount (and type) of food that gets crammed in the pie hole. All that said, I believe my T1 diabetes, along with an inherited mutation that causes mitochobdrial disease and promotes tumorigenisis, is behind my peyronies. I have Dupuytrens contracture in both hands, I have plantar fibromatosis (Lederhosens)in both feet. ALL of this appeared about the same time as when the peyronies started.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Hontas on November 01, 2020, 05:30:34 AM
Quote from: NeoV on February 20, 2018, 08:25:40 AM
Big update here.

The main gene thought to be responsible for Peyronie's, and Dupuytren's has been cited to be HLA-B7.

i think this might be spot on, i am definitely getting tested for HLA-B7. Do you have any more research regarding HLA-B7? I read an article about it before seeing this and it might be actually very related.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Holistic on November 04, 2020, 09:51:42 AM
Curious if there is more on that gene link to Peyronies Disease.

I find curiousity in catagorizing Peyronies Disease as diabetes of the penis since traditional DM2 is not known to cause fibrosis and can be eliminated through lifestyle and diet (and not only going keto, but eating healthy, exercising and using portion control with times of the day). its like having a good hand of cards and playing them poorly and ending up with DM2. Unlike DM1 which is having a poor hand and playing it strategically to make the best.

Plus, I read in this forum that nutrients from supplement may not reach the tissue of the penis as it all circulates in the body. which brings to question, is diet doing anything to the penis? I read inflammation can be controlled but is there a pathalogical target? What I mean is, is diet addressing the specific "unknown" cause? Because if all dieting does is help with inflammation, than that is cool but doesnt address the underlying cause. I am still skeptical that this pathology is due to a specific gene.

However in my case, in the past year, I have had multiple circular fibroids surface in the tissue in a seemingly interesting pattern. Most are at the base of the shaft near the grundle/taint area and 3 fibroids make a striaght line up the shaft next to the corpus spongiosum.

Highly doubt trauma is a cause, I have been healthy most of my life, lab tests are mainly normal, diet is mainly vegitarian with lean meat and occasional breads and sweets. This could be labled as inflammation in the tissue. But will get some DM tests done out of curiosity like the ab1c test, eyrithrocite sedimentation for inflammation (doubt i need this since it is inflammation) and might do a fasting serum insulin test (doubt i need this because I have no issues with insulin).

So characteristics of this being DM of the penis i think could use more investigation, at least with my presentation
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: JayGould on November 22, 2020, 07:11:25 AM
I have been strict carnivore for almost a year now, so zero carbs. The diet definitely helps, but it hasn't eliminated my symptoms. I can still get flare ups with pain/inflammation and subsequent worsening of scar tissue.

It happens less often for sure, but I don't think that for me, this is all about the diet. I have reactions to environmental toxins too.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: jan.schaller1958 on November 22, 2020, 11:14:42 PM
Holistic,

Since no one knows exact cause of Peyroines, treatment options are designed to only treat the symptoms- plaque reduction through Xiaflex with traction to remodel the shape of the plaque, or surgical options. Everyone is free to experiment if they like with diet or vitamins, Pentox, ED drugs, etc, VED, dry traction, whatever, but there's no evidence that these alternative therapies work,  or the evidence is terrible. How can you expect otherwise in trying to treat a disease the cause of which is unknown? It's likely cause is genetic predisposition plus microtrauma, but that's not that great of an explanation.

I know everyone here knows of Xiaflex and surgery, but that's really about all the specialists have to offer (go ahead and take the Pentox and cialis, they surely won't make the condition worse. Anything like that is worth a try).  All I've ever said is these off label use of these drugs is not guaranteed to do anything. And Peyroines can improve on its own anyway, so it would be impossible for anyone to say these drugs were effective.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Afeb1996 on November 23, 2020, 06:26:06 AM
I just spent the last hour reading your posts and comments. I don't mean this to ridicule you or to insult you in any sense. I am genuinely concerned. You seem like a narcissist. Have you ever been seen by a psychologist regarding this?

Right now, for example: "All I ever said was..." is what you state when it fact it wasn't "all you 'ever' said...."

A common trend in your interactions is that you place yourself on a pedestal of superiority under the guise of "science," when what you really are referring to is "traditional" allopathic medicine and FDA regulations. At the same time, you denounce other evidence that is "off-label" (which has to do with FDA-approval) and have made other claims without specificity that you are making a claim pertaining to your own experience which leads others, and understandably so, to understand you as having made objective claims.

These errors in communication permeate your interactions which result in "clashes" with others and "dysfunction" in your attempts to communicate with others. Yet, you, in your own "reality" or view of the world, are NEVER wrong.

Have you noticed this consistent pattern in your interactions?
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Hontas on November 24, 2020, 08:31:11 PM
https://pubmed.ncbi.nlm.nih.gov/25630575/

Autoimmune disorders and Peyronies.

Just look at psoriatic arthiritis. Oh my F^@$!ng god. Diabetes is two times as prevalent in peyronies patients but psoriatic arthritis is almost 20 times more prevalent with the same confidence interval. I might not even have normal peyronies. Why the F~@< is there no one going to doctor about this? It is a huge quality of life downgrade and i don't want a psoriasis dick, are people actually that scared to take action on this? 20 times? jesus christ.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Tortão Pra Direita on November 25, 2020, 11:29:47 AM
Quote from: jan.schaller1958 on November 24, 2020, 10:21:27 PM
Pfract, how are cialis and viagra different as to different half lives?
Their main mechanism is PDE5 inhibition, but they also affect other PDE's.

Sildenafil (Viagra) inhibits PDE6 much more than Tadalafil. PDE6 is also found in the eye. This is why there are accounts of viagra causing vision problems.
https://www.healthline.com/health-news/viagra-may-cause-visual-problems-in-some-men#An-eye-specialists-discovery

Tadalafil inhibits a PDE (can't remember exactly which) that isn't so inhibited by sildenafil and it causes back pain in some men.

I consider tadalafil safer than sildenafil.
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Holistic on December 01, 2020, 11:04:32 PM
Quote from: Hontas on November 24, 2020, 08:31:11 PM
https://pubmed.ncbi.nlm.nih.gov/25630575/

Autoimmune disorders and Peyronies.

Just look at psoriatic arthiritis.

Peyronies Disease is a difficult subject to pinpoint. There was another article in this thread that mentioned Peyronies Disease was found in those with DM2 but having Peyronies Disease didnt mean you have a metabolic disorder or had any relation. Im sure there is some correlation between diet, the body and Peyronies Disease since Peyronies Disease is in essence, inflammation and then a keloiding response ( at least for me with multiple little bumps. lol I have 3 little pea shaped balls in a straight line on my shaft...not sure how that happens. What makes Peyronies Disease so tough to grasp is its presentation. Some people have bends and hour glass shaped dysfunctions and others have plaques in various shapes and sizes.

In essence, It would be good policy to eat healthy, limit carb intake, exercise, read up on Blue Zones and nutritarian diets or even soft keto. Keto is one option but needs to be taken seriously and not as a 5 month trend then back to before. There are individuals who have had success with diets and fasting in extreme ways but thats not my area.

No one wants any kind of dick other than the kind with healthy tissue and works well. However there are a ton of factors at play in which we have no control over. but what we do have control over are our decisions and actions. So despite the lack of evidence on this matter, we can still treat our bodies the best we can to help it heal. However that may look to you.

lol alrighty ive blabbed on enough. Try not to get overhyped on the medical literature. Science basically means "we dont know and we are learning"
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: Whyisthishappening on February 03, 2022, 10:06:36 PM
Pathway Enrichment Analysis of Microarray Data Fom Human Penis of Diabetic and Peyronie's Patients, in Comparison With Diabetic Rat Erectile Dysfunction Models
Results
Microarray identified 182 differentially expressed protein-coding genes. Pathway analysis revealed similar enrichments with different analytical tools. Down regulated pathways include development, tubular structure, sprouting, cell death, ischemia, angiogenesis, transcription, second messengers, and stem cell differentiation. Erectile Dysfunction patients, who have diabetes, incur significant loss of normal regulatory processes required for repair and replacement of injured corpora cavernosal tissue. Combined with loss of apoptotic regulatory mechanisms, this results in significant architectural remodeling of the corpora cavernosa, and loss of regenerative capacity in the penis.
https://www.sciencedirect.com/science/article/abs/pii/S1743609521007396
Title: Re: Diabetes of the Penis: Peyronie's and Diet
Post by: FrankPD on September 09, 2022, 10:48:43 PM
Quote from: skunkworks on April 14, 2019, 12:31:35 PM
Totally random thought, but it's kinda like the penis is the canary in the coalmine. First thing to show the hurt when things get too toxic.

This is a great statement.  Really makes you think!

Best to all.