First of all, I am not advocating anything illegal here. Just wanting to share an interesting research I came cross.
I've been doing research obsessively and came across this article below.
August 2021.
Anti-Inflammatory Effects of Four Psilocybin-Containing Magic Mushroom Water Extracts in vitro on 15-Lipoxygenase Activity and on Lipopolysaccharide-Induced Cyclooxygenase-2 and Inflammatory Cytokines in Human U937 Macrophage Cells
https://pubmed.ncbi.nlm.nih.gov/34385833/
Results: The four water extracts had poor 15-LOX inhibition activity with IC50 > 250 µg/mL. Extracts were safe at the concentration studied and inhibited the LPS-induced production of pro-inflammatory mediators, TNF-α and IL-1β significantly and lowered IL-6 and COX-2 concentrations in treated human U937 macrophage cells. Water extracts also increased percentage viability of treated cells and levels of anti-inflammatory IL-10 non-significantly.
Conclusion: The study suggested that the hot-water extracts of the four psilocybin-containing magic mushrooms have potential anti-inflammatory effects executed by down-regulating pro-inflammatory mediators.
There are many herbs and plants which have anti-inflammatory properties, but keep in mind that Peyronie's Disease isn't primarily an inflammation, so much as the development of plaque. There are many different kinds of inflammations which can affect all the different parts of the body, so the fact that psilocybin mushrooms may reduce some sorts of inflammations isn't particularly relevant to Peyronie's Disease - in my view at least, but I will admit that I am neither a doctor nor an expert on 'shrooms.
The one thing I can say is that those things are extremely powerful and so at least in their native form they are not appropriate for use in therapy. They're really only for tripping... It would be interesting however if the precise anti-inflammatory substance could be isolated or separated from the hallucinogenic soup they make.
I would recommend we close this thread unless someone has a specific further contribution.