I was researching topical hydrocortisone on the penis but couldn't find much except this paper from 1983.
I also have been wondering about topical aspirin cream on the penis. Both aspirin and hydrocort art anti-inflammatory and anti-fibrotic, especially locally.
Anyone have any experience or knowledge regarding this?
The original paper is attached.
https://pubmed.ncbi.nlm.nih.gov/6868230/ (https://pubmed.ncbi.nlm.nih.gov/6868230/)
QuotePeyronie disease treated with ultrasound and hydrocortisone
H C Miller, J Ardizzone
PMID: 6868230 DOI: 10.1016/0090-4295(83)90197-8
Abstract
Thirty patients with Peyronie disease were treated with ultrasound using hydrocortisone ointment as the conducting vehicle. Twenty-five patients completed at least one course of treatment. Of those 25, 19 had at least some benefit with evidence that multiple courses of treatment were more beneficial than a single course. We conclude that ultrasound with hydrocortisone is beneficial in relieving pain, relieving deviation, and reducing the size of the fibrous plaque. It has the advantages of being noninvasive, repeatable, and without any side effects.
Given that this study is almost 40 years old and I've never heard anyone even trying hydrocortisone for Peyronies Disease, I doubt there's any hope here.
As to aspirin cream, etc., the problem with many topicals is getting them to penetrate all the way into the tunica, where the damage from Peyronies Disease is. Even topical verapamil solutions are of questionable abilities to penetrate effectively. So the notion that an OTC cream could somehow remedy Peyronies Disease is likely just wishful thinking. If it worked, everyone here would be using it and talking about it.
Check out the threads on Hirudoid cream - very similar proposition, very limited results.
Regards,
Nemo
Here's a study reporting success with injected hydrocortisone.
https://sti.bmj.com/content/sextrans/36/3/186.full.pdf (https://sti.bmj.com/content/sextrans/36/3/186.full.pdf)
Pubmed has 13 hits for peyronies and hydrocortisone.
Age doesn't alter the quality of research.
Agreed with nemo, everyone would be talking about it if it helped.
The only real hope at the moment seems to be advancement on stem cell therapy to heal the scar tissue
Age may not alter the quality of the research, but you have to ask yourself why the treatment has not been used if it was truly effective or produced results.
Nemo