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Other Peyronies Disease Discussion Boards => Open Questions or General Comments (that won't fit under any other topics) => Topic started by: Asphyxia on December 27, 2020, 08:23:37 PM

Title: Can healthy tissue replace scar tissue
Post by: Asphyxia on December 27, 2020, 08:23:37 PM
If i manage to get my penis back to being straight with traction, does that mean i no longer have scar tissue or does it mean that my scar tissue is now stretched and functioning like a normal tissue? People are saying traction and erections are "remodeling" i dont understand that term.

if not with traction, can we get healthy tissue to replace scar tissue ever?
Title: Re: Can healthy tissue replace scar tissue
Post by: Bill2020 on January 02, 2021, 09:08:27 PM
Would love to hear some feedback about this from some of the older members.  Any feedback guys?
Title: Re: Can healthy tissue replace scar tissue
Post by: anxioid on January 03, 2021, 08:11:56 AM
I'm pretty new to all this but i think the general consensus is yes.

Mayo clinic says:
"Traction devices place tension on the flaccid penis. The force is translated to the penile plaque and promotes remodeling via a biomechanical process known as mechanotransduction."

And this:
Penile traction therapy for Peyronie’s disease—what’s the evidence? - Usta - Translational Andrology and Urology (http://tau.amegroups.com/article/view/9817/11179)
Says:
"Mechanotransduction, or gradual expansion of tissue by traction, leads to the formation of new collagen tissue by cellular proliferation. As a molecular result, continuous extension of the fibrous plaque causes significant increases in collagenase and metalloproteinases, and, ultimately, to fibrous plaque softening and extension."
Title: Re: Can healthy tissue replace scar tissue
Post by: Asphyxia on January 03, 2021, 01:58:18 PM
"leads to the formation of new collagen tissue"
I cant understand if it means new scar tissue which is laid during a stretched state(and therefore more flexible) or new healthy tissue.

Im still not sure if the scar tissue even replaces healthy tissue, or if it just sits there in addition to the healthy tissue
Title: Re: Can healthy tissue replace scar tissue
Post by: anxioid on January 03, 2021, 09:56:30 PM
Hmm, i see what you mean. I have no idea either.
Title: Re: Can healthy tissue replace scar tissue
Post by: DarthPronius on January 06, 2021, 06:07:46 PM
Here is a study dated 2011. It talks about the potential for PDE5 inhibitors (like sildenafil, aka Viagra, vardenafil, others) and pentoxyfilline to contribute to reducing or even reversing penile fibrosis. This biochemistry is a little over my head but I can get some of the big picture ideas by reading some of the conclusions (like the section titled "Peyronie's Disease").

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149188/
"Reversion of penile fibrosis: Current information and a new horizon"

I am taking pentoxyfilline and sildenafil every day right now (along with a pile of supplements), and I've seen some of my nodules/plaques reduce in size or disappear. Unfortunately I had others appear in the past year, I think due to over-aggressive VED, and so I'm hoping the pentox/sildenafil cocktail I'm taking can help with the new ones. Overall I hope there's a chance of reducing or reversing fibrosis by taking pentox and sildenafil, and focusing on improving blood circulation by exercising and doing stretches that improve things "down south". Doing mild hand traction and massage also, and warm clothing.
Title: Re: Can healthy tissue replace scar tissue
Post by: Asphyxia on January 06, 2021, 07:34:28 PM
Well then this leaves me wondering why this disease is considered to have no cure, and why those who fix the curve are still at a higher risk for reinjury