Peyronies Society Forums

Please login or register.

Login with username, password and session length
Advanced search  

News:

ALL Members PLEASE Add a Signature line with age, history etc
PROFILE -> FORUM PROFILE -> SIGNATURE
More instructions here -> Signature Line - History - Peyronies Society Forums

Pages: 1 2 [3] 4   Go Down

Author Topic: Diabetes of the Penis: Peyronie's and Diet  (Read 28365 times)

0 Members and 1 Guest are viewing this topic.

Gabriel

  • Major Contributor
  • ****
  • Country: fr
  • Offline Offline
  • Gender: Male
  • Posts: 346
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #100 on: April 14, 2019, 03:49:56 AM »

Fascinating phenomenon, thanks man.

That's another info supporting fasting... Which, by the way, is considered quite safe even by hard science: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819235/
Logged
- 31 yo, very healthy lifestyle, Peyronies Disease with Erectile Dysfunction, pain, distal hourglassing & length loss since 09/01/17, still acute.
- Treatments: all oral meds/supps discussed here; traction/VED; ointments (essential oils, diclofenac); PRP/HA injections (5/6 sessions)

TonySa

  • Think Tank
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 5003
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #101 on: April 14, 2019, 05:49:42 AM »

Interesting article.
Of note, fasts one greater than one day (less than one day = IF) were medically supervised twice per day.  Any fasts were discontinued if problems arose (noted by patient or MD).
Also, it sounds as if all meds were d/c’d except thyroid meds tittated appropriately.
I believe this is why extended water fasting is recommended to be done under a doctors care and includes bloodwork to screen for appropriateness (as all were in this study)
Good news, intermittent fasting seems pretty straightforward without needing medical clearing or monitoring throughout as does dctrnded water fasting.
Logged
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Gabriel

  • Major Contributor
  • ****
  • Country: fr
  • Offline Offline
  • Gender: Male
  • Posts: 346
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #102 on: April 14, 2019, 08:11:46 AM »

Very good point Tony!

It's pretty clear that if you are know as diabetic or fragile in this or that metabolic field, you shouldn't fast without medical precaution; that's common sense. But for anyone said to be healthy (apart from Peyronies Disease of course...), or, better said, without specific syndroms, I do believe fasting alone can be totally safe as long as you investigate it first and get well prepared (with mineral water + electrolytes, an activity planning, good food to break your fast anytime you fell like it, etc.).

That is pure theory from now, as I've just made one 3 days fast so far (everything OK); I'm beginning a 7-10 one from tomorrow, I'll let you know what comes out of it :-)
Logged
- 31 yo, very healthy lifestyle, Peyronies Disease with Erectile Dysfunction, pain, distal hourglassing & length loss since 09/01/17, still acute.
- Treatments: all oral meds/supps discussed here; traction/VED; ointments (essential oils, diclofenac); PRP/HA injections (5/6 sessions)

NeoV

  • Global Moderator
  • ****
  • Country: jp
  • Offline Offline
  • Gender: Male
  • Posts: 2052
    • Neoman
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #103 on: April 14, 2019, 09:13:03 AM »

Thank you whyisthishappening,

No surprise but very useful find!

skunkworks

  • Global Moderator
  • ****
  • Country: au
  • Offline Offline
  • Gender: Male
  • Posts: 1606
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #104 on: April 14, 2019, 12:31:35 PM »

Totally random thought, but it's kinda like the penis is the canary in the coalmine. First thing to show the hurt when things get too toxic.
Logged
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

TonySa

  • Think Tank
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 5003
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #105 on: April 14, 2019, 11:00:29 PM »

Personally, even if healthy (could be underlying issues one was Unaware) I’d go no longer than 7 days without medical supervision.
Logged
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #106 on: April 15, 2019, 12:20:33 PM »

L-cysteine supplementation upregulates glutathione (GSH) and vitamin D binding protein (VDBP) in hepatocytes cultured in high glucose and in vivo in liver, and increases blood levels of GSH, VDBP, and 25-hydroxy-vitamin D in Zucker diabetic fatty rats.
https://www.ncbi.nlm.nih.gov/pubmed/26778482
L-Cysteine Supplementation Increases Blood Levels of Hydrogen Sulfide and Nitrite, and Decreases Insulin Resistance and Vascular Inflammation in Zucker Diabetic Rats
https://professional.diabetes.org/abstract/l-cysteine-supplementation-increases-blood-levels-hydrogen-sulfide-and-nitrite-and
Can L-Cysteine and Vitamin D Rescue Vitamin D and Vitamin D Binding Protein Levels in Blood Plasma of African American Type 2 Diabetic Patients?
https://www.ncbi.nlm.nih.gov/pubmed/25816831
 guys what do you think about l-cysteine
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

pey ron

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 547
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #107 on: April 17, 2019, 01:43:40 AM »

i think both hydrogen sulfide & nitrite are gonna help a lot, so i am gonna get on L-cysteine soon!
Logged
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
age, date of onset, symptoms, treatments tried,
relationship status, etc
** You will waste less time and get better answers **

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #108 on: April 17, 2019, 08:59:19 AM »

ron DO NOT try L-CYSTEINE i can elaborate later not now

  this disease is Not us simple as we try to understand it
 
   i am focusing now on WNT2 PROSTAGLANDINS and prostaglandin receptor abnormalities(thats why some got Peyronies Disease after alprostadil although its antinflammantory(PGE1)  prostaglandin receptors with abnormalities could give signal as it is PGE2 a pro inflammantory and start inflammation cascade ) also HEPARINASE 1 and 2 should have our attention also i am making a link why   thc and cbd are bad for us even if for many is antiinflammantory
       
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #109 on: April 17, 2019, 04:15:45 PM »

Structural and dynamic characterization of human Wnt2-Fzd7 complex using computational approaches.
https://www.ncbi.nlm.nih.gov/pubmed/30191337
  "Wnt and Frizzled (Fzd) family members play crucial roles in the self-renewal of tumor-initiating cells. Until now, only a few studies have addressed the distinct mechanism of Wnt-Fzd interactions. In this study, we suggest a possible interaction mode of Wnt2 with the Fzd7 CYSTEINE-rich domain (CRD)-both of which are up-regulated in some types of cancer"
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

TonySa

  • Think Tank
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 5003
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #110 on: April 17, 2019, 11:09:16 PM »

If same effect, how is it a “cheat”?
Logged
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

pey ron

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 547
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #111 on: April 18, 2019, 12:11:53 AM »

NAC is a very powerful antioxidant.

I believe PGE2 would be anti-fibrotic. And I wonder if PGD2 wouldn't be profibrotic.

WNT is scary as hell, I believe it is proliferative and profibrotic. Well, I believe PGE2 is proliferative as well but oddly antifibrotic.

I also believe that some PPAR's can be strong antifibrotics despite being proliferative.

I would love if someone were able to get to the bottom of these.

Profibrotic = inducing fibrosis
Proliferative = making cancers grow
Logged
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
age, date of onset, symptoms, treatments tried,
relationship status, etc
** You will waste less time and get better answers **

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #112 on: April 18, 2019, 06:18:21 AM »

no man pge2 is pro inflammantory (prolonged inflammation=fibrotic cascade )

"If same effect, how is it a “cheat”?"      tony i do not understand  please explain
 
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

pey ron

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 547
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #113 on: April 18, 2019, 01:07:47 PM »

why are you making statements in the present indicative about PGE2 being pro-fibrotic?

Logged
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
age, date of onset, symptoms, treatments tried,
relationship status, etc
** You will waste less time and get better answers **

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #114 on: April 18, 2019, 03:00:32 PM »

it is proinflammantory  and prolonged inflammation in tunica albuginea is bad
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #115 on: April 18, 2019, 03:05:42 PM »

Molecular Mechanisms Underlying the Link between Diet and DNA Methylation
https://www.mdpi.com/1422-0067/19/12/4055/htm
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

pey ron

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 547
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #116 on: April 18, 2019, 04:50:01 PM »

Prostaglandins are not as easy as that: they also resolve inflammation. PGE2 has an extremely short half-life, in the order of minutes. And not all PG's are born equal. There are several pathways and sometimes a given PG can extert both an anti-fibrotic and a pro-fibrotic effect, depending on the receptor it docks to. For example PGD2 is pro-fibrotic when it docks to the CRTH2 receptor, but anti-fibrotic when it docks to the DP1 receptor. So, blocking the CRTH2 receptor via setipiprant/fevipiprant would be ideal. Dig deeper, keep an open mind.
Logged
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
age, date of onset, symptoms, treatments tried,
relationship status, etc
** You will waste less time and get better answers **

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #117 on: April 18, 2019, 05:29:19 PM »

i keep an open eye also
  Penile fibrosis in intracavernosal prostaglandin E1 injection therapy for erectile dysfunction.
https://www.ncbi.nlm.nih.gov/pubmed/9442421
"Penile fibrosis is hence a significant complication of intracavernosal PGE1 therapy"
The long-term safety of alprostadil (prostaglandin-E1) in patients with erectile dysfunction. The European Alprostadil Study Group.
https://www.ncbi.nlm.nih.gov/pubmed/9806184
"Penile fibrosis occurred in 4% of patients"
CAVERJECT IMPULSE®(alprostadil) for injection, for intracavernosaluse Initial U.S. Approval: 1981
http://labeling.pfizer.com/ShowLabeling.aspx?id=667&format=PDF
CONTRAINDICATIONS
"• Treatment of erectile dysfunction in men with fibrotic conditions of the
penis, such as anatomical deformation, angulation, cavernosal fibrosis, or
Peyronie’s disease (4)"
Peyronie's-like plaque after penile injection of prostaglandin E1.
https://www.ncbi.nlm.nih.gov/pubmed/8051767
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

pey ron

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 547
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #118 on: April 19, 2019, 02:10:16 AM »

1) the needle causes trauma every single time it pierces the tunica
2) PGE1 is not PGE2... PGE1 belongs to the family 1 of prostaglandins, PGE2 to the family 2 of prostaglandins. Most humans have predominantly PG's from the family 2 -- with the sole exception of Eskimos that due to their diets very rich in different kinds of fatty acids have a completely different proportion of ecosanoids.
Logged
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
age, date of onset, symptoms, treatments tried,
relationship status, etc
** You will waste less time and get better answers **

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #119 on: April 19, 2019, 06:16:02 AM »

it is not only the needle enthourethral alprostadil is prohibeted also, check the instructions. we can make a thread about prostaglandins or erection injections lots of people here ad them and i think we hijack this thread

  because this is about dibetes of the penis
  in cadavid 2015 igf increases the most after tgf stimulation in plaque ,that is in active Peyronies Disease phase what you want to avoidthe most besides another injury is insulin spikes neos hypothesis is solid
 
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #120 on: April 19, 2019, 10:00:42 AM »

The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat.
https://www.ncbi.nlm.nih.gov/pubmed/30979969

" FE recovered neurogenic and endothelial dysfunction and decreased glucose levels in diabetic rats."
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

pey ron

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 547
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #121 on: April 19, 2019, 09:23:46 PM »

yes this thread should have been split off a few posts ago...
Logged
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
age, date of onset, symptoms, treatments tried,
relationship status, etc
** You will waste less time and get better answers **

Gabriel

  • Major Contributor
  • ****
  • Country: fr
  • Offline Offline
  • Gender: Male
  • Posts: 346
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #122 on: April 22, 2019, 12:18:59 PM »

An excellent and pedagogical resumen of the ubiquitous influence of insulin resistance and the benefits of keto/IF about the multiplicity of pathologies involved: https://www.youtube.com/watch?v=tRPqYqa3oLA (title is obviously ironical!)
Logged
- 31 yo, very healthy lifestyle, Peyronies Disease with Erectile Dysfunction, pain, distal hourglassing & length loss since 09/01/17, still acute.
- Treatments: all oral meds/supps discussed here; traction/VED; ointments (essential oils, diclofenac); PRP/HA injections (5/6 sessions)

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #123 on: April 23, 2019, 05:53:48 AM »

The negative effect of the adverse systemic milieu on adult stem cells.

https://www.researchgate.net/project/The-negative-effect-of-the-adverse-systemic-milieu-on-adult-stem-cells

Goal: Autologous adult stem cell transplantation is frequently unsuccessful in repairing the targeted problem. Our results suggest that the toxic systemic environment, i.e. hyperglycemia or hyperlipidemia is impairing the repair capacity of adult stem cells via epigenetic modifications. The goal of this study to clarify the underlying mechanisms and determine new biomarkers that can predict stem cell damage before transplantation
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #124 on: April 23, 2019, 08:59:59 AM »

Original Article Effects of hypercholesterolemic diet by long-term on elastic system fibers penile tissue: volumetric density analysis of elastic system fibers
https://www.researchgate.net/publication/303475300_Original_Article_Effects_of_hypercholesterolemic_diet_by_long-term_on_elastic_system_fibers_penile_tissue_volumetric_density_analysis_of_elastic_system_fibers
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #125 on: April 23, 2019, 05:24:30 PM »

check this FQ and DM
Can antibiotics cause, or make Peyronies Disease worse? - Peyronies Society Forums

Acute metabolic amplification of insulin secretion in mouse islets is mediated by mitochondrial export of metabolites, but not by mitochondrial energy generation
https://www.sciencedirect.com/science/article/pii/S0026049513001479

Defining and characterizing the critical transition state prior to the type 2 diabetes disease
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180937

Multiple Biomarker Prediction of Type 2 Diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699735/

Identification of Biomarkers for Type 2 Diabetes and Its Complications: A Bioinformatic Approach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614656/

Biomarkers for predicting type 2 diabetes development—Can metabolomics improve on existing biomarkers?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503163/

Predictive biomarkers for type 2 of diabetes mellitus: Bridging the gap between systems research and personalized medicine
https://www.sciencedirect.com/science/article/pii/S187439191830099X



Study of Protein Biomarkers of DIABETES Mellitus Type 2 and THERAPY with VITAMIN B1
https://www.hindawi.com/journals/jdr/2015/150176/
 
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

Christopher1

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 526
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #126 on: April 24, 2019, 08:06:00 PM »

My Peyronies Disease was caused by Trimix injections. So...
Logged
Snake Diet + 5-day fasts + NeoV's stretching routine. Curvature 99% gone. Still have bothersome scar pain. Please message me for a good Peyronies Disease pain cure.

I also recommend an auto CPAP device --> increases REM sleep --> increased nocturnal erection.

swaggyp12

  • Voting Member
  • **
  • Country: de
  • Offline Offline
  • Gender: Male
  • Posts: 39
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #127 on: June 15, 2020, 11:34:19 AM »

Hey guys,

Does this low carb/keto/fasting-like diet only concern the people who are genetically predisposed (i.e. diabetes, parents) or can anyone with Peyronies Disease can benefit from it? I ask because I don't have diabetes, etc. and I also experience no pain since having Peyronies Disease. I know take care to avoid any inflammatory foods and thus my diet is definitely already ketogenetic-like. The problem is that I only have Peyronies Disease for a maximum of 3-4 months and thus still am in the acute phase. So eating meat, especially red meat, and cheese could cause inflammation. Is it best for me to eat low-carb and anti-inflammatory right now? Or would going on a carnivore diet be beneficial to me as well?

I hope someone can shed some light on this, All the best
Logged

TonySa

  • Think Tank
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 5003
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #128 on: June 15, 2020, 07:20:17 PM »

There are no hard and fast rules.  Any anti-inflammatory like diet that you can maintain will benefit-but be sure to add other treatments such as pentox, low dose nightly cialis and traction or VED.
Logged
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Holistic

  • Voting Member
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 89
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #129 on: June 28, 2020, 08:18:31 PM »

Myostatin is a major driver of fibrosis and a member of the tgf-beta family. Myostatin is found in the Peyronie's penis and plaques (2008 study).


Hey NeoV,

Any update on plaque appearance and diet since this post? Does the low carb diet help abolish the plaques? I seem to have a couple little plaques in my penis with no history of DM. I eat fairly healthy organic food. I do eat a good amount of brown rice. I dont divulge in refined carbs much.
Logged
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

NeoV

  • Global Moderator
  • ****
  • Country: jp
  • Offline Offline
  • Gender: Male
  • Posts: 2052
    • Neoman
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #130 on: June 28, 2020, 10:03:28 PM »

I never ate refined carbs and still got all these issues (as did my dad). Only brown rice basically. The difference between brown rice and white is like comparing a can of coke to to 3/4s a can. Yes my scars softened and the scarred areas became more normal and plump. My penis is better than ever lately, for which I am very thankful!

Holistic

  • Voting Member
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 89
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #131 on: June 28, 2020, 11:22:09 PM »

Yes my scars softened and the scarred areas became more normal and plump. My penis is better than ever lately, for which I am very thankful!

That is a good analogy for the rice. Awesome to hear about the current news. If I understand your language correctly, when you say "scarred areas are normal and plump" and "better than ever", it sounds like things reversed into a malleable stage...but it sounds like there is a possibility that the plump scars have the ability to harden again? It sounds like the diet and Coq10 have been a constant for the past 3 years since your last post?
Logged
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

NeoV

  • Global Moderator
  • ****
  • Country: jp
  • Offline Offline
  • Gender: Male
  • Posts: 2052
    • Neoman
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #132 on: June 30, 2020, 09:51:34 AM »

I actually stopped taking supplements for the last three years! Once I went keto I felt it was best to stop and I also feel that I no longer need them.
I have experimented with some supplements such as MSM and pynogenol and others, but I have not taken them like I did before.

Traction changed the structure of my penis so that trauma during sex or masturbation is very unlikely, while the diet seems to simply prevent any inflammation from entering my penis PERIOD. If I ate badly (SAD diet) and had rough sex and drank alcohol, I'm sure these areas could become fibrotic again, but the traction alone, the results of which are permanent, would have me protected from serious worsening most likely.

Holistic

  • Voting Member
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 89
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #133 on: June 30, 2020, 08:51:16 PM »

Nice! so you no longer drink alcohol or have a pizza? also do you still sue the VED even with a straight shaft?
Logged
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

Whyisthishappening

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 312
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #134 on: July 15, 2020, 05:17:13 PM »

"We report a very high prevalence of Peyronies Disease in a population screened by sophisticated techniques in a young population of heterogeneous ethnic males. The high prevalence of Peyronies Disease in this population prompts concern regarding the true prevalence, etiology, and associated factors of this disease. We searched for but did not find an association of Peyronies Disease with MS but did find that very uncontrolled diabetes (HbA1c >8.5%) was associated with higher rates. This high rate of Peyronies Disease in an expertly evaluated population of males may indicate the need for earlier screening of Peyronies Disease in younger patients presenting to men's health clinics with various complaints."
Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676820/
Logged
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

JayGould

  • Solid Contributor
  • ***
  • Country: gb
  • Offline Offline
  • Gender: Male
  • Posts: 166
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #135 on: July 22, 2020, 02:05:07 PM »

I've been eating a carnivore diet (only meat and water) for the last 6 months. As soon as I eat anything else (dairy, vegetables etc), my dick gets inflamed and my condition worsen. It's crazy how my condition was stable for about 3 years but then as soon as I got off an antidepressant I had been taken, along with Pentoxifylline, the condition immediately worsened. Anyway, manual stretching and a carnivore diet is what helps at the moment. Meditation and pelvic stretches as well, although I don't do them often enough.

I wish I would've started doing all this immediately.
Logged

JayGould

  • Solid Contributor
  • ***
  • Country: gb
  • Offline Offline
  • Gender: Male
  • Posts: 166
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #136 on: July 22, 2020, 02:09:52 PM »

I never ate refined carbs and still got all these issues (as did my dad). Only brown rice basically. The difference between brown rice and white is like comparing a can of coke to to 3/4s a can. Yes my scars softened and the scarred areas became more normal and plump. My penis is better than ever lately, for which I am very thankful!

Did you ever lose size with Peyronies? And when you say it's now better than ever, does that mean you gained that size back?

Enjoyed watching your youtube videos by the way. Started manual stretching thanks to you, I've added 1-2 cm already (been at it for about 2 months).
Logged

NeoV

  • Global Moderator
  • ****
  • Country: jp
  • Offline Offline
  • Gender: Male
  • Posts: 2052
    • Neoman
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #137 on: July 22, 2020, 08:46:18 PM »

That's great to hear JayGould! Try keeping it on the therapeutic side and you'll likely see more results.
Yes I did lose some length due to the curvature and dents, but I gained it back and then some.

Yardbird

  • Voting Member
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 23
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #138 on: August 20, 2020, 01:30:31 AM »

This is an old thread, but it fits me. I'm a T1 diabetic. I agree with Stabler that, other than a very few findings of newly diagnosed children being able to be made to go into remission by a strict diet, adult T1 diabetics will be dead in a fairly short time without injected insulin.As stated by others, the amount of insulin is directly proportional to the amount (and type) of food that gets crammed in the pie hole. All that said, I believe my T1 diabetes, along with an inherited mutation that causes mitochobdrial disease and promotes tumorigenisis, is behind my peyronies. I have Dupuytrens contracture in both hands, I have plantar fibromatosis (Lederhosens)in both feet. ALL of this appeared about the same time as when the peyronies started.
Logged
Age 61
T1 diabetic. Scarring is circumferential, causing narrowed bendable erection & 1.5" length loss, and 50° bend to left.
Also have bilateral Dupuytren's contracture, bilateral Lederhosen's disease, and right side adhesive capsulitis.

Hontas

  • Major Contributor
  • ****
  • Country: 00
  • Offline Offline
  • Gender: Male
  • Posts: 411
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #139 on: November 01, 2020, 05:30:34 AM »

Big update here.

The main gene thought to be responsible for Peyronie's, and Dupuytren's has been cited to be HLA-B7.

i think this might be spot on, i am definitely getting tested for HLA-B7. Do you have any more research regarding HLA-B7? I read an article about it before seeing this and it might be actually very related.
Logged

Madorno

  • Voting Member
  • **
  • Country: br
  • Offline Offline
  • Gender: Male
  • Posts: 14
Re: Silymarin
« Reply #140 on: November 01, 2020, 03:23:03 PM »

Logged

TonySa

  • Think Tank
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 5003
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #141 on: November 01, 2020, 09:36:47 PM »

Is that the correct link?
Logged
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Holistic

  • Voting Member
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 89
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #142 on: November 04, 2020, 09:51:42 AM »

Curious if there is more on that gene link to Peyronies Disease.

I find curiousity in catagorizing Peyronies Disease as diabetes of the penis since traditional DM2 is not known to cause fibrosis and can be eliminated through lifestyle and diet (and not only going keto, but eating healthy, exercising and using portion control with times of the day). its like having a good hand of cards and playing them poorly and ending up with DM2. Unlike DM1 which is having a poor hand and playing it strategically to make the best.

Plus, I read in this forum that nutrients from supplement may not reach the tissue of the penis as it all circulates in the body. which brings to question, is diet doing anything to the penis? I read inflammation can be controlled but is there a pathalogical target? What I mean is, is diet addressing the specific "unknown" cause? Because if all dieting does is help with inflammation, than that is cool but doesnt address the underlying cause. I am still skeptical that this pathology is due to a specific gene.

However in my case, in the past year, I have had multiple circular fibroids surface in the tissue in a seemingly interesting pattern. Most are at the base of the shaft near the grundle/taint area and 3 fibroids make a striaght line up the shaft next to the corpus spongiosum.

Highly doubt trauma is a cause, I have been healthy most of my life, lab tests are mainly normal, diet is mainly vegitarian with lean meat and occasional breads and sweets. This could be labled as inflammation in the tissue. But will get some DM tests done out of curiosity like the ab1c test, eyrithrocite sedimentation for inflammation (doubt i need this since it is inflammation) and might do a fasting serum insulin test (doubt i need this because I have no issues with insulin).

So characteristics of this being DM of the penis i think could use more investigation, at least with my presentation
Logged
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

JayGould

  • Solid Contributor
  • ***
  • Country: gb
  • Offline Offline
  • Gender: Male
  • Posts: 166
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #143 on: November 22, 2020, 07:11:25 AM »

I have been strict carnivore for almost a year now, so zero carbs. The diet definitely helps, but it hasn't eliminated my symptoms. I can still get flare ups with pain/inflammation and subsequent worsening of scar tissue.

It happens less often for sure, but I don't think that for me, this is all about the diet. I have reactions to environmental toxins too.
Logged

jan.schaller1958

  • Major Contributor
  • ****
  • Country: de
  • Offline Offline
  • Gender: Male
  • Posts: 499
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #144 on: November 22, 2020, 12:27:29 PM »

There’s no evidence that this is about diet for anybody. That’s complete pseudoscience.
Logged

jan.schaller1958

  • Major Contributor
  • ****
  • Country: de
  • Offline Offline
  • Gender: Male
  • Posts: 499
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #145 on: November 22, 2020, 11:14:42 PM »

Holistic,

Since no one knows exact cause of Peyroines, treatment options are designed to only treat the symptoms- plaque reduction through Xiaflex with traction to remodel the shape of the plaque, or surgical options. Everyone is free to experiment if they like with diet or vitamins, Pentox, Erectile Dysfunction drugs, etc, VED, dry traction, whatever, but there’s no evidence that these alternative therapies work,  or the evidence is terrible. How can you expect otherwise in trying to treat a disease the cause of which is unknown? It’s likely cause is genetic predisposition plus microtrauma, but that’s not that great of an explanation.

I know everyone here knows of Xiaflex and surgery, but that’s really about all the specialists have to offer (go ahead and take the Pentox and cialis, they surely won’t make the condition worse. Anything like that is worth a try).  All I’ve ever said is these off label use of these drugs is not guaranteed to do anything. And Peyroines can improve on its own anyway, so it would be impossible for anyone to say these drugs were effective.
Logged

Afeb1996

  • Voting Member
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 16
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #146 on: November 23, 2020, 06:26:06 AM »

I just spent the last hour reading your posts and comments. I don't mean this to ridicule you or to insult you in any sense. I am genuinely concerned. You seem like a narcissist. Have you ever been seen by a psychologist regarding this?

Right now, for example: "All I ever said was..." is what you state when it fact it wasn't "all you 'ever' said...."

A common trend in your interactions is that you place yourself on a pedestal of superiority under the guise of "science," when what you really are referring to is "traditional" allopathic medicine and FDA regulations. At the same time, you denounce other evidence that is "off-label" (which has to do with FDA-approval) and have made other claims without specificity that you are making a claim pertaining to your own experience which leads others, and understandably so, to understand you as having made objective claims.

These errors in communication permeate your interactions which result in "clashes" with others and "dysfunction" in your attempts to communicate with others. Yet, you, in your own "reality" or view of the world, are NEVER wrong.

Have you noticed this consistent pattern in your interactions?
Logged
03/06/2018: Forceful-downwards [from the penile base] injury) > Affected PSL (Penile Suspensory Ligament) > Pelvic Floor Dysfunction > Erectile Dysfunction (tentatively assumed venogenic) > Peyronies (07/01/2018)

jan.schaller1958

  • Major Contributor
  • ****
  • Country: de
  • Offline Offline
  • Gender: Male
  • Posts: 499
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #147 on: November 23, 2020, 11:58:35 AM »

I’m not really sure what you are talking about. Studied and approved therapies are the best we’ve got to go on. Obviously people are free to try whatever the like (garlic and ginger cures, diets, etc) but those just produce anecdotes, often through the placebo effect (about 30%), and anecdotes are not science. It’s just about the strength of the evidence is all.
Logged

TonySa

  • Think Tank
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 5003
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #148 on: November 23, 2020, 01:15:21 PM »

Jan, try hitting the pause button and listen to what feedback you’re getting.  As he says, you often just don’t seem to be able to take it in. 
Logged
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

jan.schaller1958

  • Major Contributor
  • ****
  • Country: de
  • Offline Offline
  • Gender: Male
  • Posts: 499
Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #149 on: November 23, 2020, 01:33:07 PM »

Take what in? Invented treatments by non-medical people?
Logged
Pages: 1 2 [3] 4   Go Up
 

Related Topics

  Subject / Started by Replies Last post
1 Replies
2089 Views
Last post October 29, 2015, 01:56:22 PM
by Sta
8 Replies
1840 Views
Last post September 19, 2017, 07:53:27 AM
by Miro_11
39 Replies
5458 Views
Last post July 02, 2019, 03:35:10 PM
by TonySa