Caffeine thread

[NeoV]

It turns out there are many studies on coffee or caffeine and fibrosis. It is a xanthine derivitive just like pentox, and appears to work the same way by inhibiting TGF-beta and Smad2.

TGf-beta and fibrosis
2016- Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices -- Tatler et al. -- Thorax
2014 - Caffeine prevents experimental liver fibrosis by blocking the expression of TGF-β. - PubMed - NCBI
2008 - Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via
2009 - Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver
2009 - Less Smad2 is good for you! A scientific update on coffee's liver benefits - Gressner - 2009 - Hepatology - Wiley Online Library
2009 - About coffee, cappuccino and connective tissue growth factor-Or how to protect your liver!? - PubMed - NCBI
2008 - Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. - PubMed - NCBI

Penis and erection
2012 - Caffeine relaxes smooth muscle through actin depolymerization. - PubMed - NCBI
2008 - Effect of caffeine on erectile function via up-regulating cavernous cyclic guanosine monophosphate in diabetic rats. - PubMed - NCBI
2004 - Effect of caffeine on response of rabbit isolated corpus cavernosum to high K+ solution, noradrenaline and transmural electrical

Inflammation in general
2013 - Effects of caffeine on the inflammatory response induced by a 15-km run competition. - PubMed - NCBI
2004 - http://ajcn.nutrition.org/content/80/4/862.full

[NeoV]

New one on TGF-beta! Good one,

Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices -- Tatler et al. -- Thorax

[james1947]

Thanks NeoV, my blood pressure is low, so I can continue sipping the many daily coffees 
Seriously I didn't see any negative side effects from coffee, just positive.

James