Rho-Kinase inhibitors

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NeoV

What exactly is Rho-kinase (ROCK)?

The below study is on RATS, but hey, given the scarcity of any studies on humans I'll take whatever scraps I can get.

"ROCK mediates vascular smooth muscle contraction, actin cytoskeleton organization, cell adhesion, and motility.55 Thus, abnormal ROCK activity may contribute to abnormal smooth muscle contraction". (from a different study)

Restoration of Erectile Function by Suppression of Corporeal Apopto... - PubMed - NCBI
RESULTS:
The cavernous nerve crush injury group showed significantly lower intracavernous pressure/mean arterial pressure, and higher maintenance and drop rates than the sham surgery group. Rho-kinase inhibition in the injury plus fasudil group restored erectile responses and dynamic infusion cavernosometry parameters. Increased apoptosis, decreased immunohistochemical staining of α-SMA and increased caspase-3 activity were noted in the injury group. In that group densitometry revealed increased ROCK1 expression, increased MYPT1 phosphorylation, decreased Akt phosphorylation, decreased Bad phosphorylation and a decreased Bcl2-to-Bax ratio. A significantly decreased smooth muscle-to-collagen ratio and increased fibroblast pCofilin were also observed in the injury group, as was increased phosphorylation of cofilin, a downstream effector of LIMK2. Rho-kinase inhibition in the injury plus fasudil group alleviated the histological and molecular dysregulation."

james1947

I would like very much to fully restore my erectile function, but I don't understand nothing from the study in the link :(

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

lonelyboy

I also wish I could understand it properly, I did note though that the article says "Our data suggest that early inhibition of Rho-kinase ..." and made me wonder that any of us would benefit as we tend (generally) to hope it goes away before seeking help.

BTW I've been taking statins for a while and yes they got my cholesterol down but they haven't helped my peronies  :-\