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Welcome to Dr. Landon Trost - Directly answering member questions in the "Medical Professionals" section below the Treatment boards. https://www.peyroniesforum.net/index.php/topic,16512.0.html

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Author Topic: Minoxidil  (Read 3791 times)

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gerMike

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Minoxidil
« on: December 13, 2014, 04:01:22 PM »

Anybody tried applying Minoxidil? Just found a study that sounds interesting to me as Minoxidil seems to stimulate elastin production in smooth muscle cells.

Quote
Minoxidil was found to inhibit the proliferation of smooth muscle cells in the proliferating phase, but not in the quiescent phase. Treatment of proliferating or quiescent cells with minoxidil resulted in a dose- and time-dependent stimulation of elastin synthesis specifically. Maximum stimulation (fourfold) occurred in cells treated with 1 mM minoxidil for 48 h. The stimulation of elastin synthesis was accompanied by a proportional increase in elastin mRNA level, and it was partially prevented by a K+ channel blocker (tetraethylammonium) and completely prevented by high K+ salt (0.1 M). Minoxidil had no significant effect on the extent of prolyl hydroxylation in newly synthesized elastin. These results indicate that minoxidil stimulates elastin synthesis at a pretranslational level by a mechanism unrelated to cell proliferation but one that may involve K+ efflux. As a pharmacological agent capable of stimulating elastin expression, minoxidil would be a useful drug for the treatment of abnormal elastin metabolism.

Minoxidil stimulates elastin expression in aortic smooth muscle cells. - PubMed - NCBI

There are some hair products which contain Minoxidil. So it would be easy to get and propably easy to apply.


On a side note, I've read today that Vitamin C downregulates elastin production and increases collagen production, so I think it could do harm to take excessive amounts of Vitamin C. ( Ascorbate differentially regulates elastin and collagen biosynthesi... - PubMed - NCBI )
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Old Man

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Re: Minoxidil
« Reply #1 on: December 13, 2014, 08:24:22 PM »

germike:

If my memory serves me right, Monoxidil is/was used for treating hair loss in the USA. It was used by many men who later reported Erectile Dysfunction as well as Peyronies Disease symptoms. They suffered for many years before it was deemed detrimental to their sexual health and was discontinued. It may be a ''partner'' to Finestaride too.

Hopefully, other members may have more knowledge about this and correct me if I am wrong about the above notes about Monoxidil.

Old Man
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Age 92. Peyronies Disease at age 24, Peyronies Disease after radical prostatectomy in 1995, Heart surgery 2004 with three bypasses/three stents.
Three more stents in 2016. Hiatal hernia surgery 2017 with 1/3 stomach reduction.
Many other surgeries in the last 10 years.

nowhereman

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Re: Minoxidil
« Reply #2 on: December 26, 2014, 06:39:24 PM »

Finasteride is what causes all of those issues......Minoxidil, known by its tradename rogaine, is pretty benign.
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pey ron

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Re: Minoxidil
« Reply #3 on: October 04, 2017, 01:35:32 AM »

Minoxidil works because it eats away collagen and hair-loss is due to perifollicular fibrosis.

For the same reason, I would expect that applied on the glans Minoxidil would be beneficial.

But...

1) it should be dissolved in a better solvent without alcohol
2) you should be extremely careful with its dosage since I suspect that minoxidil may give priapism
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lessor

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Re: Minoxidil
« Reply #4 on: October 04, 2017, 05:11:59 AM »

So minoxidil is not bad? Only is dangerous finasteride? I was taking minoxidil a few times in some years ago.. do you think it could have something to do with my Erectile Dysfunction or is it innofensive?
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Jack1909

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Re: Minoxidil
« Reply #5 on: October 06, 2017, 05:57:49 AM »

Don't know if reliable or not but I read about people reporting Erectile Dysfunction issue related to minoxidil.
As bizzarre as it might sound, I thought it would be harmless if not beneficial
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

Christopher1

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Re: Minoxidil
« Reply #6 on: October 09, 2017, 07:02:23 PM »

I have never read it is dangerous.
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Snake Diet + 5-day fasts + pentox + NeoV's stretching routine. Curvature 99% gone.

I also recommend an auto CPAP device --> increases REM sleep --> increased nocturnal erection.

james1947

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Re: Minoxidil
« Reply #7 on: October 15, 2017, 08:42:41 AM »

From Wikipedia:
Quote
...is widely used for the treatment of hair loss.
and then side effects:
Quote
...minoxidil-induced hair loss is a common side effect and describe the process as "shedding"
Contradicting, no?

From WebMed:
Quote
...solution and foam are used to help hair growth in the treatment
Quote
Minoxidil belongs to a class of drugs known as vasodilators. It is not known how minoxidil causes hair growth

I read other sources, Erectile Dysfunction was not mentioned anywhere. But I didn't read everything on the web.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

pey ron

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Re: Minoxidil
« Reply #8 on: October 16, 2017, 06:17:36 PM »

@James1947: minoxidil and other hair loss treatments may cause hair cycle synchronization amongst all follicles where applied. Hence when all the follicles finally get into telogen, you'll shed a lot of hair. It's normal. It grows back.
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james1947

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Re: Minoxidil
« Reply #9 on: October 17, 2017, 09:16:54 PM »

Thanks for the explanation Pey Ron
Now is clear :)

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum
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