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Author Topic: Peyronie's Disease Treated with Oral Weekly Dexamethasone and Cyclophosphamide  (Read 4042 times)

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skunkworks

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Peyronie's Disease Treated with Oral Weekly Dexamethasone and Continuous Low-dose Cyclophosphamide

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Dexamethasone (5 mg) for two consecutive days weekly orally was started. The condition improved in the first 6 months with reduction in basal bending to 10% and coronal bending to 15%, but the condition became static thereafter during the next 2 months. At this juncture, cyclophosphamide (50 mg) daily was added, which lead to complete clearance of the angulations back to normal in 8 months along with complete resolution of the plaque. Radiograph of the penis showed no calcification. During the next 4 years of follow-up, there was no recurrence of any plaque or angulations of the penis.
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This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

skunkworks

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The obvious issue of course is the timeframe, short enough that it could have been spontaneous resolution.

However, a potent anti-inflammatory in the early stage could be beneficial. cyclophosphamide is used to treat some auto-immune disorders.
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This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

NeoV

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There was a thread on this, or at least someone brought it up before. Looking into those drugs most of us got scared away by cyclo's side effects. The study was on one man unfortunately. Dexa on the other hand looks pretty viable, and deserves more research perhaps. It would be amazing if it worked!

An interesting thing about that link is that they describe Peyronie's as resulting from vascular trauma, not trauma to the penis itself. I've heard this elsewhere and it falls in line with what I believe the disease often times actually is, but that's a separate topic.

Anyone else know about these drugs?

I guess I might be able to get Dexamethasone here in Japan since a doctor thinks I have an immune disorder giving me arthritis. If they have it that is.. And do I really want to take that?

skunkworks

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Ahh my bad, thanks NeoV. James if you want to merge Dcp treatment. New opportunity? - Peyronies Society Forums

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This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

james1947

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  • Age 71. Peyronies from January 2009

skunkworks

Not to understand wrong, do you mean to merge this topic with:
Dcp treatment. New opportunity? - Peyronies Society Forums
?

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Michiganguy19

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About to try this
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Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1
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