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Author Topic: Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfun  (Read 4837 times)

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muffslayer

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Chronic daily tadalafil prevents the corporal fibros... [BJU Int. 2008] - PubMed - NCBI

2008 Jan

Abstract

OBJECTIVES:


To determine whether a long-term single daily oral dose of a longer half-life phosphodiesterase-5 (PDE5) inhibitor, tadalafil, has a similar effect to that of the shorter half-life PDE5 inhibitors sildenafil and vardenafil, and can prevent the fibrosis and resultant corporal veno-occlusive dysfunction (CVOD) occurring after cavernosal nerve (CN) injury.

MATERIALS AND METHODS:

Male rats (10 per group) had either a sham operation, unilateral CN resection (CNR) or bilateral CNR, and were left untreated or given retrolingually 5 mg/kg per day of tadalafil. After 45 days, CVOD was assessed via cavernosometry, and the underlying corporal tissue changes were examined by immunohistochemistry and histochemistry (followed by quantitative image analysis), Western blots, and ad hoc methods.

RESULTS:

Tadalafil treatment normalized the low response to papaverine and high drop rate in the intracavernosal pressure measured by cavernosometry after CNR compared with sham-operated rats. Tadalafil also normalized the increase in penile shaft collagen content, and the reduction in corporal smooth muscle cell (SMC) content, SMC/collagen, and replication index, and improved the lower collagen III/I ratio and the increase in apoptotic index, caused by CNR, compared with sham operation. There were no effects of tadalafil on increased transforming growth factor beta1, inducible nitric oxide synthase and xanthine oxidoreductase levels.

CONCLUSIONS:

A long-term single daily dose of tadalafil prevented CVOD and the underlying corporal fibrosis in the rat caused by CN damage, as effectively as the previously reported continuous treatment with vardenafil or sildenafil, through a cGMP-related mechanism that appears to be independent of inducible nitric oxide synthase induction.
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Skjaldborg

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Here is an English to English translation of the conclusion:

Original:
A long-term single daily dose of tadalafil prevented CVOD and the underlying corporal fibrosis in the rat caused by CN damage, as effectively as the previously reported continuous treatment with vardenafil or sildenafil, through a cGMP-related mechanism that appears to be independent of inducible nitric oxide synthase induction.

Translation:
A long-term single daily dose of the erection drug Cialis prevented the problem where veins in the penis become blocked and stopped the scar tissue that forms in the penis of the rat due to damage to the main penis nerve just as effectively as treatment with the other erection drugs Levitra and Viagra. This works through a process related to a messenger chemical that relaxes blood vessels and increases blood flow instead of the process where nitric oxide is released into the blood to relax blood vessels and increase blood flow.

Long story short: Cialis is just as good at preventing penis vein blockages as other erection drugs but does so in a different way.


-Skjald
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