Developmental drugs & treatments - Still in trial or not approved for Peyronies

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newguy

J - Yes, I read a few stories about how surgery doesn't always go to plan, and can occasionally result in nerve damage etc. I suppose it's something worth catching early to maximise (the limited) treatment options. Radiation therapy appears to be all the rage on the dupuytrens forum for early stage intervention.

cowboyfood

Quote from: newguy on September 05, 2009, 05:40:37 PM
The early clinical trial results for peyronie's revealed  . . .

newguy,

thanks for the response.  do you have a link or a document with these "early clinical trial results?"  Or, maybe it's already posted somewhere on the forum.

CF
Currently:  L-Arginine (2g), Vit D3)

newguy

CF - I think numbers here is all we have so far: http://www.auxilium.com/ProductPipeline/PeyroniesDisease.aspx It's very limited but at least it suggests that they are fine tuning their technique.


Tim468

I missed that one (I follow for any publication that uses "Peyronie's Disease" as a key term having the medical library scan for it weekly).

It is very exciting news. The issue I wonder about is this: are there multiple forms of Peyronies that have different inciting events and pathways to fibrosis. This blocks it (and more excitingly - it causes regression!) in a rat model of disease. I wonder how it might work for you or me.

Tim
52, Peyronies Disease for 30 years, upward curve and some new lesions.

slowandsteady

Nice find -- thanks.
QuoteAntagonizing TGF-beta signaling through the use of ALK5 inhibitors may represent an exciting new therapeutic strategy for the future treatment of Peyronies Disease.

Leads me to wonder what other ALK5 inhibitors are out there. The study cited used IN-1130.

newguy

It was posted a while back: https://www.peyroniesforum.net/index.php/topic,36.msg20393/topicseen.html#msg20393  Certainly looks like something of interest.  

newguy


QuoteAdvanced glycation end products (AGEs) contribute significantly to diabetic complications, both macro- and microvascular. TRC4186 is an AGE-breaker that has been evaluated in vitro and in vivo and shown to reduce AGE burden. The aim of this study was to determine the effect of TRC4186 on diabetic cardiomyopathy and nephropathy in obese Zucker spontaneously hypertensive fatty rats (Ob-ZSF1), an animal model of diabetes with progressive cardiac and renal dysfunction. Ob-ZSF1 rats loaded with 0.5% salt were treated with TRC4186, 9 or 27 mg/kg twice daily intraperitoneally or vehicle control and monitored telemetrically throughout the study. Cardiac function was assessed terminally by Millar catheter. Markers of cardiac and renal dysfunction were measured and changes evaluated histopathologically. TRC4186 at 27 mg/kg prevented rise in blood pressure (BP) and also improved cardiac output (CO) secondary to better diastolic relaxation as well as systolic emptying in association with the reduction in afterload. At 9 mg/kg, CO was improved by compensatory increase in pre-load however afterload reduction was not adequate to allow efficient systolic emptying. Brain natriuretic peptide (BNP) and interleukin-6 (IL-6) expression was reduced with treatment. Deterioration in renal function was retarded as evident from albumin to creatinine ratio and renal histopathology. TRC4186, an AGE-breaker, clearly preserved cardiac function and reduced the severity of renal dysfunction in Ob-ZSF1, an animal model with persistent severe hyperglycemia leading to diabetic heart failure and renal failure.
- http://www.ncbi.nlm.nih.gov/pubmed/19546815?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Another AGE-breaker working its way through the system..

bodoo2u

Regarding your remark, in your most recent statement below, on how well the treatment might work for humans, do we need to consider that a mouse's life is much shorter than a human's and therefore calculate the time accordingly. Do you, or anyone else on the forum, know what 45 mouse days is in human days, or years?

George999

I really think that what we learn through the IN-1130 study is that if one can block or stop TGF-beta1 effectively enough, one can REVERSE Peyronie's effectively returning penile tissue to NORMAL.  That would be a HUGE achievement which everyone here would cheer.  It indicates that the reason Pentox is so ineffective is because it simply does not block TGF-beta1 sufficiently to effect an outright reversal.  It does block it enough to thwart its progress and initiate a feeble reversal.  ALL of this is more evidence for autoimmune processes being the driving force behind Peyronie's.  Remove that factor and everything goes back to normal.  So what are the flies in the ointment for IN-1130?  I see some big ones.  First of all, TGF-beta1 is an essential cytokine which has a lot of legitimate immune functions.  If we block it completely, we could run into unexpected consequences like cancer or vulnerability to infectious disease.  In order to avoid those pitfalls, one has to specifically block ONLY the autoimmune pathways while allowing normal immune pathways to remain functional.  I really don't know whether IN-1130 is a SELECTIVE TGF-beta1 blocker or a brute force broad spectrum blocker.  A broad spectrum blockade would be scary to me.  - George

ComeBacKid

Why was this study being done in korea?  Aren't there more studies going on in the united states or a bigger country with more doctors? ???

Could one obtain this drug for usage? Is it as safe as pentox, what do we know about it , or should I say what do the medical experts know about it, how safe is it?

The real question I have is what if one used this drug and it was effective, for a complete reversal of peyronies, then quit using it, would the peyronies come back?  Perhaps a few months on it could outweigh the risk of getting diseases if it works and we know it works.  

newguy

A IN-1130 study here includes an email address from a college of pharmacy should anybody wish to attempt to follow this one up:

http://www.informahealthcare.com/doi/abs/10.1080/00498250701871121

College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Korea, 82-2-3277-3028, 82-2-3277-3051 yysheen@ewha.ac.kr

UK

this is interesting and could provide an option for getting medication into the tunica one day for you younger sufferers


"A cream allowing erectile dysfunction drugs to be applied directly to the skin could one day make them safer to use, say New York scientists. Studies in rats suggest that Viagra, Levitra and Cialis could pass through the skin in tiny capsules, they say."

Full article here

http://news.bbc.co.uk/1/hi/health/8263307.stm





newguy

Quote from: UK on September 19, 2009, 02:39:04 AM
Full article here

http://news.bbc.co.uk/1/hi/health/8263307.stm

Very interesting. It reminds me of topical ibuprofen where the topical version provides a similiar level of relief, but very little of it circulates beyond that area.  In studies where viagra has helped to inhibit fibrosis in rats, much higher doses than we are able to take were used. If in future it can be intensely targetted in such a way, maybe it will be much more effective.  



mischelstraus

thanks to all people for sharing and advice me very informative info.
keep sharing in future also.

sunny sky

Thanks for the heads-up on this research.  I am going to Email some of these links to urologists in my region so they can get us involved in these studies.
66 years of age.  Began to develop fibrosis in mid 2009.  Diagnosed with fibrosis january 2010.

percival

Back to the subject of heat treatment, I have always thought that there may be a temperature trigger which may cause or promote Peyronies Disease. Testicles are situated outside the body because a lower temperature favours sperm production. The penis is in a similar - even more 'exposed' environment, so could it be that the lower temperature it experiences causes plaque to form there when certain other factors are present.
I would certainly try heat treatment, but I don't know of any (safe) gadgets available for localised application.
Regards
Percival

percival

Further to my earlier post I have tried applying a thermal heat patch to the affected area. It seems to stay in place in my underpants and gives out a gentle heat all day - it is rather pleasant. Don't know if it will do any good though! I am also trying Pentox, Arginine and daily Cialis. Also trying traction: first results after a month are encouraging. I think that the plaque had bunched up and the traction has pulled it straight and given back a little length.
One word of warning concerning thermal patches - there are many on the market so check that they don't get too hot. You may need to wrap them in a sock to moderate the output.
Warm regards
Percival

ocelot556

Saw this link in my random clinical trial searching... maybe it's been reported, maybe not - but it looks interesting! Arresting Suspect #1 in the inflammation cascade - TGF-Beta.

http://www.medpedia.com/clinical-trials/NCT00043706

"Excess Transforming Growth Factor Beta-1 (TGF-beta1) activity may result in the abnormal fibrosis characteristic of Systemic Sclerosis. An antibody against TGF-beta1 may modify pathologic processes characterized by inappropriate fibrosis. Genzyme Corporation is currently investigating a human monoclonal antibody (CAT-192) that neutralizes active TGF-beta1. This study is being conducted in the U.S. and Europe to evaluate the safety, tolerability, and pharmacokinetics of repeated treatments with CAT-192 in patients with early stage diffuse Systemic Sclerosis."

George999

The problem I see with this approach is that it simply has to have significant negative side effects.  The immune system produces TGF-beta1 for a reason.  When you snuff out that metabolic function, there are bound to be negative consequences.  - George

mike67

George999
Neprinol
I am really digging back to your old post from 2008. There doesn't appear to be anything directly related recently from anyone.
I have just completed my first round of 26 wks of VED 3 cyliner protocol. I recently switched to Ubiquinol , am taking PENTAX and L'Arginine. I am sorry to report that I have not yet had any noticable improvement in curvature.
Rifling thru my files from my initial diagnosis , I turned up an article on the product Neprinol as well as an article by Dr. Herazy.
Just wondering , now that I am beginning a new 26 wk protocol , if there is anything anyone can report on lately as to whether Neprinol can be taken in combination with the above , with some hope of success.
Thanks
Mikey

George999

Hello Mike,

Sorry you are not seeing results at this point, but I would advise you to be patient.  It really takes a long time, but both Pentoxifylline and Ubiquinol DO work and so does the VED.  But they don't work overnight.  In my experience, Neprinol is useless for Peyronie's.  It can really clear your lungs out and be beneficial in other ways, but for Peyronie's, its useless. Its very expensive and I've still got an old half full bottle around.  I just gave up on it because it just doesn't work.  Also, I am sending shadesofblue your way.  He just posted under the Causes of Peyronie's topic.  He's in Toronto and planning to make an appointment with Levine.  I told him you were on to a good Peyronie's doc in Toronto.  So if you could advise him on that I would appreciate it.  Thanks!  - George