Alpha 1 blockers causing ED?

[james1947]

Have anyone experience using Alpha 1 blockers, in my case Flomax causing ED?
How long time can be used?
Other names for this drug:
Harnal D
Tamsulosin
Tamsulosin hydrochloride
Flomaxtra
Contiflo XL
Urimax
Pradif

James

[pizzaman]

I'm on doxazosin, which is a less selective alpha blocker. All alpha blockers list ED as a possible side effect, but my understanding is that this can only happen due to the alpha blocker lowering blood pressure too far. Also, you're on a very selective alpha blocker that minimizes systemic (i.e. blood pressure lowering) effects.

Add to that, a couple of recent studies have shown doxazosin to potentiate PDE5i drugs. Anecdotal reports suggest flomax should do the same. Here is one such study:
Combined oral therapy with sildenafil and doxazosin for the treament of non-organic erectile dysfunction refractory to sildenafil monotherapy

[james1947]

Pizzaman

Thanks for the link. It is calming me down as I don't want any "addition" to my bad ED.
I am taking 0.2mg or 0.4mg daily until I will find solution with a doctor to my slow urinary problems.

James

[MattFoley]

Guys, I might be reading this study wrong but it says that doxazosin will help with "non-organic" ED. This is the type of ED that is a result of something other than something physically wrong with the penis, i.e. Peyronie's. If I didn't have the dorsal vein messed up by the plaque, I wouldn't have any ED.

Please correct me if I'm wrong. Thank you.

[funnyfarm]

Matt just curious, is it possible the leaking vein causes the scaring and not vice versa ?

[MattFoley]

funnyfarm, I wish I knew the answer to that. I have plaque running almost the full length of the top of the penis and it interferes with the dorsal vein. I have no idea what the heck is going on. I hope that Dr. Lue can answer some questions for me. I see him on 3/22.

[funnyfarm]

Got it.  Just trying to think outside the box, I read low grade bleeding can cause scar tissue in some cases when it is chronic.

[Hawk]

My answer to FunnyFarn is NO!  As you know the vein is not leaking blood into the tissue where it could cause scaring.  Blood just flows out the vein as it is made to do.  The only exception is that in the penis, the erection places pressure against the vein to squeeze it semi-closed.  If in the wrong place scar tissue just acts like laying a brick on each side of a garden hose (not on top of or under).  Then imagine trying to compress the hose.  The bricks would protect the hose running through the channel.  The brick would keep the compression off of the hose. In a similar way plaque prevents veins from compressing IF the plaque is precisely located.

[funnyfarm]

thanks Hawk !

[MattFoley]

I'll just post this here:

I was trying to figure a way to overwhelm my venous leakage and I think I found a technique that might work to getting me at 80-85% of a full erection.

I took 90 mg. of Sildenafil, 25 mg. of Tadalafil, 250 mcg. of Muse, and then put an erection band at the base of my penis.

Worked great. I got up around 80-85% of a normal full erection. In fact, it worked so great that I successfully masturbated 4 times within an hour or so.

I certainly don't recommend this to guys who have heart issues. In fact, I don't recommend this to anyone since you're not supposed to combine all these PDE5's.

I'm awaiting my shipment of Caverject. Hopefully that will help me as well.

[Hawk]

If you have venous leakage as the major part of your problem then it should take little more than a good erection ring/band to prevent that.  In theory at least a constriction band has got to seriously constrict the veins that drain the penis since they are all much closer to the surface than the arteries than supply the blood.

I have similar issues where I need various combinations of Levitra, L-Arginine, trazodone, VED, and a band.  That is not to say I use all 5 of those at once, but I need more than one of them and usually 3 of the 5. I did have a radical prostatectomy however but my erections were coming back good fairly soon after surgery until Peyronies Disease hit.

[pizzaman]

Here's a thread from another forum I frequent: Ultimate Adrenergic Control of Erections

It's long but there's a lot of valuable information, particularly in regards to using alpha blockers with pde5i. There's a lot of experimentation and anecdotes on different ways to combat ED and/or potentiate the effects of PDE5i drugs.

[MattFoley]

Hawk, you're description below pretty much states the situation of my leakage. Because the plaque is essentially surrounding the dorsal vein, it can't properly close so I hit it with everything I have to make it work. An erection band will work if the plaque isn't completely surrounding the vein. In my case, the plaque is doing just that.