Hybrid H-100

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skunkworks

This was mentioned in the paper Dros found:

Topical treatment for acute phase Peyronie's disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study. - PubMed - NCBI

QuoteAbstract

Safety and efficacy of topically applied gel H-100 composed of Nicardipine, superoxide dismutase and emu oil for treatment of acute phase Peyronie's disease (Peyronies Disease) was evaluated. Twenty-two patients (Peyronies Disease <12 months duration) were studied in a prospective, randomized, double-blind, placebo-controlled study. Eleven patients received H-100 and 11 patients received placebo for 3 months. All 22 patients then received H-100 for the final 3 months. Flaccid-stretched penile length, degree of penile curvature, pain level and side effects were assessed monthly. H-100 showed significant improvement in all Peyronies Disease parameters at 6 months: mean stretched penile length increase (22.6%, P=0.0002), mean curvature reduction (40.8%, P=0.0014), and mean pain level reduction (85.7%, P=0.004). Placebo group showed no significant improvement except for mean stretched penile length increase (6.8%, P=0.009). Crossover patients from placebo to H-100 showed significant improvement in all parameters: mean stretched penile length increase (17.5%, P=0.000007), mean curvature reduction (37.1%, P=0.006), and mean pain level reduction (40%, P=0.17). Treatment was well tolerated. A self-limited rash was the only side effect in three patients. Statistically significant improvements in flaccid-stretched penile length, curvature and pain suggest that H-100 is a safe and possibly effective non-invasive, topically applied treatment for acute phase Peyronie's Disease.International Journal of Impotence Research advance online publication, 24 December 2015; doi:10.1038/ijir.2015.22.
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

NeoV

That study was very recent (posted in pubmed in December 2015).

In the review Dros posted,

"Recently, a small placebo controlled trial of topical nicardipine and superoxide dismutase
compounded with emu oil in 22 men with untreated acute phase Peyronies Disease demonstrated
significant improvement in multiple Peyronies Disease parameters (length gain, curvature reduction,
pain scores) compared to placebo"

Freemason

Neo...yea I've done lots of reading on their compounds..I think all 3 have potentially a synergistic affect...but SoD has been studied alone with Peyronies Disease patients a while ago with moderate success in all parameters.  SOD is highly powerful anti oxidant and anti inflammatory.  As for the Emu Oil it's commonly used in expensive skin/face creams for wrinkles/scars etc..has transdermal effects.  I just haven't taken time to have a pharmacy compound me some. I'm sure u could get a Uro to prescribe the calcium channel blocker...pretty harmless on our penis.  Any way...you'll have to have a compounding pharmacy with the rx for calcium compound u a gel with these ingredients. If u look enough on their product you can find the patent and they list out the ingredients and percentage of each used.

Dros

Here's the patent: http://www.google.com/patents/EP2804606A1?cl=en

H-100 is:
20% Nicardipine
0.2% SOD
1% gelling agent (e.g. fatty acids)
78.8% Emu Oil

I will ask my Uro to prescribe me this :-)

skunkworks

Was there ever a definitive answer on how important (or not important) DHT is in an adult penis? The  linolenic acid in emu oil is a reasonably potent 5 alpha reductase inhibitor, so it could decrease the levels of DHT in the penis.

DHT is essential to development of the penis, but I am not sure how important (if at all) it is for an adult penis.  
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

Jack1909

I think DHT is important to preserve the tissues integrity. I don't have any scientific proof of it but I know for sure that some people who take finasteride/propecia for hairloss develop tissue changes, scarring and sometimes a real Peyronie.  
31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe ED after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

NeoV

That's interesting to note, however the results of the trial seemed to suggest the formula can overcome this. Still could be a reason to be wary.

It looks like it has quite a lot of the nicardipine, and not much SOD, unless 0.2% is a lot.

I have been reading online about emu oil, and I cannot find any information regarding it's mechanism of action for being a trans-dermal carrier, though it is repeatedly touted as one on emu oil websites. One writer thought olive oil or any fatty acid would and should do the same thing.

It would be important to see a good study on how the stuff works. Because I might as well just use grape seed oil and SOD and see how that goes.

Anyway, I guess this stuff really is mostly nicardipine. I hope we can use it and see how we feel in not too long.

Freemason

It's a lot of SOD..doesn't take much. Just read up on SOD a little and you begin to realize that this compound is prob the most powerful antioxidant scavanger there is to date. One interesting thing I read recently is h2o2 a lot of doctors don't want people using it for cuts etc because it prohibits scaring over to take place, it's really just a debriding agent..intersting. Peroxide inhibits fibrosis from forming...at all. So in theory using peroxide in the acute and very early phase might do something?  If only u could discover a way to get it into the skin..idk.

skunkworks

That is really interesting Freemason re peroxide. I will be reading up on that.
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

Freemason

Yea I was just reading online an old text book on oxidizing compounds and stuff...it seems older texts, when all these compounds were discovered, have a lot of interesting info and I came across Peroxide.  There's a cult group of folks who firmly believe in drinking very small amounts of it to cleanse and do various things. I'm not advocating that. I had a friend who was into it decades ago and I tried it for a week or so. Nasty nasty tasting. We are talking a couple drops in a full glass of water and it completely alters the water.  Some theorize that by raising oxygen levels you eliminate bad stuff etc..

One other thing I thought about...Liposuction..there are all kinds of diff types and techniques but I wonder if one could have it done on the plaque? Lol. Seems crazy prob. There is Air lipo dome by the top guys in Beverly Hills but it just under skin in fat layers. I guess no plastic surgeon is skilled enough to get thru the nerve bundle into the plaque without destroying your dick.  Any way..dumb idea never mind.

skunkworks

Google any lipo video and you'll forget that idea very quickly. It's basically a person getting stabbed with a metal straw hundreds of times.
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

Freemason

Lol. Yea I've seen it. Idk I just thought there's got to be a way of just sucking out the plaque without damaging stuff..I guess u have to replace it with something though. Hence the graft.

Pey-penis

Quote from: Freemason on May 08, 2016, 10:54:28 AM
There's a cult group of folks who firmly believe in drinking very small amounts of it to cleanse and do various things. I'm not advocating that. I had a friend who was into it decades ago and I tried it for a week or so. Nasty nasty tasting. We are talking a couple drops in a full glass of water and it completely alters the water.  Some theorize that by raising oxygen levels you eliminate bad stuff etc..
For a long time I am drinking hydrogen peroxide 3% every day in the form of "lemonade" consisting of 1/2 cup of water, a tablespoon apple cider vinegar, a teaspoon of honey or syrup of pine shoots, and 50 drops of pure hydrogen peroxide 3%. To this amount of H2O2 I was slowly went up for several months. The only visible effect of this is a regrowth of black hair instead of gray and not actually fall back on any type of  catching cold disease for several years. I support this way the bacteria e-coli, where the byproduct of the activities in the large intestine is the production of H2O2. It is indispensable for macrophages, which uses it to perform "oxygen explosions" thus destroying pathogens.

jim morrison

At least orally, they do not think SOD can be absorbed in the body unless coated and carried through liposomes. Here are a couple links to products that I found with topical liposomic SOD and how it is beneficial for anti inflammatory diseases. The last link is a report stating that SOD may be beneficial for peyronies. In this instance they use iontophoresis to drive it home.  Also, this narcidipine is a calcium channel blocker just like Verapamil so I wander if it would be beneficial to use SOD while using a topical Verapamil if you can get it to penetrate? Maybe it will give a similar or even better outcome of the H-100. Just a thought.

[I removed the commercial links as we don't want to promote sales for these products. I left the book link for information purposes]

https://books.google.com/books?id=07ucAgAAQBAJ&pg=PA194&lpg=PA194&dq=can+i+mix+verapamil+and+superoxide+dismutase&source=bl&ots=NLyvl9sCbp&sig=cdP1CokcuLF9RyMbDII4FsA-F5I&hl=en&sa=X&ved=0ahUKEwijotjUpJTOAhUi7YMKHaFhCe4Q6AEIYDAJ#v=onepage&q=can%20i%20mix%20verapamil%20and%20superoxide%20dismutase&f=false


peyter

Dear all,

I have found:

Innovation | Hybrid Medical
http://www.nature.com/nrurol/journal/v13/n2/full/nrurol.2016.6.html Study about H-100 trials.

Any info about a comercial launch?

Is that the same H-100 product?

Thanks!!!

james1947

The link posted by Peyter yesterday November 21, 2016
&
The link posted by Funnyfarm on April 26, 2013
Is the same link.
So what happened during 3 & 1/2 years?
If it is such a miracle cure, they were billionaire already from the sales of this cream

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

spyrosg

May i point out that the two recent posted liks refer to some hopefull indications out of the performed study, that were published almost 11 months ago...

Let us all hope that some more positive info will soon flow in ...

Member ''Freemason'' was supposed to try mixing his own version of H-100, but I don't recal seeing any updates  

Lucketts



Outstanding research, gentleman.  Please keep up apprised of anything further you learn.

Freemason

Quote from: spyrosg on November 22, 2016, 05:37:04 AM
May i point out that the two recent posted liks refer to some hopefull indications out of the performed study, that were published almost 11 months ago...

Let us all hope that some more positive info will soon flow in ...

Member ''Freemason'' was supposed to try mixing his own version of H-100, but I don't recal seeing any updates


Correct..but I never got around to it:(. But boy I would love to.  I do live somewhat near Minneapolis i could just make an appt with the Urologist who is heading this and tell him to just write me a RX compounded..the Pharmacy they used for the formulation is in Minneapolis..My question would be how come none of these 22 men have come on this forum?  I mean I'm very happy if this product works for Acute phase patients but how about the millions that aren't in the Acute phase anymore?

Lucketts



Freemason, you are a prophet ahead of your time!

Perhaps when they do trials, they have to be very selective and well defined, and just focussed on the acute phase as a starter.

Just learning about compounding pharmacies.  By making a lot of drugs themselves, they seem to be a lot more flexible, and can sell drugs (i.e. cialis) at a fraction of the price of a drug store.

pizzaman

A quick google search shows a bunch of oil-based SOD creams. I may try one as an experiment.
I am no longer in the acute phase, but still get some pain/irritation and palpable inflammation.

Paul52

Hi all,

Has anybody tried making and applying the H-100 gel? Any results?

I'm in the acute phase and willing to make/try it.

Best,
Paul

Paolo

Paul52, I think this has all gone quite, if you are willing to try it please update when you can

Emu Oil, SOD and narcidine where the main ingredients, think this gel is dead in the water (scam)  :(
Whenever you find yourself on the side of the majority, it is time to pause and reflect.

Freemason

It's not dead in the water yet..I haven't gotten around to having a pharmacy mix it myslef..But they are in phase 3 trials I believe..Have a feeling it will be more beneficial for those in acute phase rather than chronic phase..based on the ingredients it a lot of anti inflammatory stuff etc..

But hey if it works some that's great for anyone..

Oh...and I hate this f ing disease..

pey ron

I can easily compound stuff. Where to source the SOD though?
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TonySa

PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

NeoV

Oh man... Here we go. How to get our hands on this... The science looks incredibly simple, but I like simple. Very exciting.

TonySa

Looks like the compounding pharmacy is promoting it, just fax a prescription.  Please let us know the cost.
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Paolo

A very exciting development, any member trying this please post back with testimonials in 3-6 Months.

Why hasn't Hybridmedical made contact with this forum of 1'000s of members????  ???

Hope it rolls out internationally  :)
Whenever you find yourself on the side of the majority, it is time to pause and reflect.

swiss

If anyone gets prescribed this in Illinois please let me know what doctor did it for you.

Thanks!  

Crooked_Stick

I guess it bothers me that they haven't released the results of the 'trial' that included a whopping 22 people. This treatment has not been approved by the FDA to treat anything. My uro won't prescribe unapproved treatments and no ones insurance will cover it. Just seems sketchy to me. They also mention on their site that H 100 is more effective for those in the acute phase so that eliminates 98% of the members here as far as max benefit. Sorry, can't get too excited about this  
Born 1960, Diagnosed 2013
Initial 40 degree bend, 1" loss, Xiaflex 3 rds of 2 injections
Current 25 degree bend, no palpable plaque, 1/4" loss
VED 5-6 days/week, traction daily,
TRT 20 ml twice weekly, Cialas 3 mg - No ED - Doing Well!

diehardpatriot

It's not available in California, damn. Anyone know why it's omly available for certain states even tho it all comes from the same pharmacy ?? Also, wasn't there a guy who ended up making his own H-100 using the exact formula a while back with no results ?? Anyway, still kind of exciting  
Penis injury in late 2017. A lump formed at injury site that caused no deformity, just pain and a palpable lump. Pain is improving through proper rest and use, diet, and mindfulness. I am always learning and looking to share things that have helped.

MJohn

Ya I hear you on the 22 people in the study.  they do say it works best in the acute phase but anyone can benefit from it.  The ingredients are fairly innocuous, the Nicardipine being the only ingredient needing a prescription.  Like most of us on here, I will try it if the cost isn't too crazy and I can get my doc to prescribe it.  I will be printing out the documentation and prescription form and going to give it a whirl and see if I can convince my Doc to give me a script.    

TonySa

If we have the formulation, any compounding pharmacy can do it.  I suspect that particular pharmacy marketing it does not have a license in CA
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

pey ron

Quote from: diehardpatriot on March 05, 2018, 12:28:01 PMa guy who ended up making his own H-100 using the exact formula a while back

who's that? I'd love to send them a message and ask them where they procured the ingredients, to try it myself
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diehardpatriot

Yo, we do have the formulation. I have a screenshot of it from a post in the forum a while back . The problem is getting a doc to prescribe it. Since it sounds crazy giving him a list of crap to compound you. Now that it actually Has a name and brochure, and someone who actually perfected the compound, it's much easier to pbtain IMO. But us Californians aren't so lucky this time. The compound I saw was. Anyway , isn't Hybrid medial the only pharmacy that can make this now? Did they put a patent on it?

20 percent Nicardipine
.2 percent SOD
1 percent geling agent
78.8 percent emu oil
Penis injury in late 2017. A lump formed at injury site that caused no deformity, just pain and a palpable lump. Pain is improving through proper rest and use, diet, and mindfulness. I am always learning and looking to share things that have helped.

pey ron

I can easily make it if I manage to get the ingredients. I have precision scales, a magnetic stirrer and the stir bars and the borosilicate bekers. Just like in a lab :P
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swiss


MJohn

Ya know if you read the studies they cite as evidence for their formula, only the SOD and the EMU oil have studies to show topically they help fibrosis and inflammation.  The Nicardipine study they tout is for injectable version not topical.  And if you think about it, there are many things that have been shown to be effective when injected.  Even saline injected has been shown to help and they surmise the physical injection in the scar tissue actually helps to break down and remodel the scar.  MY point of all this is it really seems that the EMU and SOD are the only things that possibly could make a difference topically.  PLUS, they mention manually tugging on your member multiple times per day.  I am thinking about getting EMU oil and SOD cream and tugging on it for 30 seconds multiple times per day.  

Paolo

MJohn, I love your eagerness here but I think you would also need a calcium channel blocker, that would be the Nicardipine, by all means give emu and SOD a go meantime but I presume H-100 should become available soon  :-\
If a calcium channel blocker increases oxygen by widening arteries I presume the SOD is required to mitigate or limit damage resulting from this  :-\ I wish I understood this better.
Presume the manual stretching along with H-100 breaks up the plaque over 3-6 Months??????
Whenever you find yourself on the side of the majority, it is time to pause and reflect.

TonySa

 The beauty of a compounding prescription is any compounding pharmacy can make it themselves. The study is published by Dr. Levine out of Chicago  
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

JS1991

Awesome news!! Can't wait to add this to my current regimen. I actually had my first urologist appointment today and got referred to a Peyronie's/ED specialist, so I plan on printing out the brochure and bringing it with me when I go to see him. Will update as things happen!
Do your homework before attempting a prolonged fast. JS1991 Timeline - Peyronies Society Forums (updated)

pey ron

Tsanchez12369: how to find a compounding pharmacy in the US???
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
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TonySa

PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Freemason

you could try your own Emu Oil mix and SOD but they have looked at the pharmacology of all the ingredients combined to give maximum penetration and effectiveness...hence the studies.  SOD is arguably the strongest anti inflammatory compound known..

I'm def going to use it..cant hurt..I don't care about cost..I'd spend $20,000 for a straight penis. Heck more...

I'm guessing it is more effective for acute phase bc in that phase lowering inflammation is critical, however those wiht pain (fortunately im not one) might benefit from this compound i'd Guess..

Hope so.


Guess we will know in 6 months right.

TonySa

The patent has multiple formulations, any idea which formulation they landed on?
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

TonySa

Is Dr Levine using it as he was one of the original authors?
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

skunkworks

Are there not many different kinds of SOD available? Which one are they using?
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]