Topic: Hybrid H-100 (Read 41359 times)

LMP · « **on:** January 31, 2013, 07:33:11 AM »

Has this ever been mentioned or discussed on here - can't see that it has. Treat with a large dose of salt I assume???

The Hybrid Medical invention for the treatment of Peyronie’s disease is a new viscous, oil based tissue delivery system called H-100 which combines an effective carrier agent with proven plaque reducing compounds.

(link deleted by administrator)

Hawk · « **Reply #1 on:** January 31, 2013, 10:09:45 AM »

It is more of the transdermal Verapamil treatment or scam. You decide which.

What is clear they put up a slick website and yet will not tell you the drug they use even though they say it is proven effective. They also do not disclose their the transdermal delivery agent. Buyer Beware!

james1947 · « **Reply #2 on:** January 31, 2013, 04:08:30 PM »

I can just second Hawk and add:
In my opinion is a scam like many other miracle cures!!!
They will became rich

, you will became poor

and you Peyronies? in best case no change to worse

James

Angus · « **Reply #3 on:** January 31, 2013, 06:33:47 PM »

Members young and old, male and female, be advised:
The internet is full of fishermen. Their web sites are the hooks and the "wonderful" treatment they offer is the bait. These fishermen have no problem preying on men afflicted with Peyronies Disease and offer "hope" to the desperate men who they KNOW are surfing the web for HOURS looking for the magic cure for Peyronies. I know that surfing the web for a cure lets you feel better because you're doing SOMETHING to try and help your affliction. There is not one of us here, including moderators and the forum owner, that has not been through this.
These people wanting to sell you a tub of hand lotion with some herbs and things in it have NO problem taking money from the ill and desperate. They go to sleep at night with no problem and feel NO remorse over their scam.
I won't ask you to stop surfing the web for information on a cure because I know it is something you are compelled to do. But I can tell you, from experience, to do your best to try and have some objectivety when you land on one of these sites and ask yourself what are they offering. Read with reason and constraint, and you will discover that they offer.... nothing. Members here have explored every type of treatment, both logical ones and the rediculous ones, many times over. The scams and ineffective treatments have been posted about many, many hundreds of times here.
Please ask yourself do I really want to pad some web sites PayPal account with my hard earned money for a product that may not even have a list of ingredients? Men will always be willing to try ANYTHING to rid themselves of Peyronies. The scammers know this. It is up to you to read with caution and make smart decisions.

TomP · « **Reply #4 on:** February 02, 2013, 05:37:00 PM »

I agree.

But I read that levine is their chief medical advisor. Is someone can ask him what do we have to think about h-100 ?

Tom

Hawk · « **Reply #5 on:** February 02, 2013, 10:00:16 PM »

I have never known Dr. Levine to prescribe TV. The verdict against TV is so well established that I would question his motives if he ever attached his name to such a treatment. At this point I am not convinced that he has.

funnyfarm · « **Reply #6 on:** February 02, 2013, 10:10:49 PM »

I won't paste the link but he is listed on their website as Chief Medical Advisor, as Tom pointed out. The site itself does not give any specifics about what the product contains or when it will be available. My personal impression is that they are trying to get seed money to fund the venture rather than find customers right now. Perhaps one of his patients can ask him about this during the next visit. If it is indeed TV, I agree with Hawk, it would very likely be a huge waste of time for everyone involved including investors, clinicians, and patients.

Hawk · « **Reply #7 on:** February 02, 2013, 10:12:52 PM »

Paste the quote in full context if you will.

Thanks

Hawk · « **Reply #8 on:** February 02, 2013, 10:29:12 PM »

FF,
I just want the quote in context not the link so I removed your post. Here is the Quote _________________________________________________
Laurence A. Levine, MD, FACS

Chief Medical Advisor

Professor of Urology, Rush University, Chicago, Illinois. Dr. Levine has made a substantial contribution to the medical press in the form of peer- reviewed articles, abstracts, book chapters, and Internet publications regarding Peyronie’s disease, male sexual dysfunction, fertility, chronic orchialgia and reconstructive urology. He is an ad hoc reviewer for The Journal of Urology, Urology, Journal of Sexual Medicine, Journal of Andrology, Asian Journal of Andrology, British Journal of Urology, European Journal of Urology and International Brazilian Journal of Urology.

Dr. Levine is the editor and contributor to the first textbook on Peyronie’s disease published by Humana Press in December 2006 and a patient guide entitled “Understanding Peyronie’s disease” published by Addicus Books in 2007. He also has an active involvement in basic science research on Peyronie’s disease at Rush University Medical Center where he and his colleagues are looking for the causes and new treatments for this distressing medical problem._____________________________________________________________________

They get his bio right but seem a little vague on his actual association. I too wish a patient would get a straight answer from Dr. Levine. If they are misusing his name he will no doubt want to know and he will stop it in its tracks.

funnyfarm · « **Reply #9 on:** February 02, 2013, 10:34:00 PM »

Thanks Hawk, also I emailed Hybrid Medical requesting more info on the product. I will share it with the forum if they reply.

dvdmaven · « **Reply #10 on:** February 05, 2013, 07:54:31 PM »

Just because a person is listed on a site as being connected with a company does not mean they know about it.

Since there isn't any treatment out there that has FDA approval* (my standard of effective) I'll call this a scam.

*Soon there will be one, but it ain't H100.

funnyfarm · « **Reply #11 on:** February 06, 2013, 01:27:56 AM »

I think it is just in the conceptual stage. The website is short on info, and offers nothing for sale.

They did not reply to my inquiry either so I will write it off as a lost cause.

fxt · « **Reply #12 on:** April 25, 2013, 08:38:26 AM »

I was recently diagnosed with Peyronies Disease but the condition likely began 9-12 months ago. My urologist is recruiting for a double blind study on a new topical compound that he thinks is likely to produce positive results. I can choose to participate in the study but can't use any other form of treatment while waiting for it to start and until it ends and there is also a 50% chance I will be in the placebo group. The study doesn't start for another month and a half and runs 3 months. There is a possibility that by participating in the trial, I may miss the opportunity to treat the symptoms while still in the inflammatory stage. (I will have had Peyronies Disease for 13-18 months by the end of the study.)

My urologist won't tell me exactly what the compound is, only that it is likely to absorb better than verapmil gel and has shown to be effective on other types of scar tissue. He also mentioned that Dr. Levine is the independent advisor but I have been unable to get a response from Dr. Levine to get his opinion first hand.

Would I be better off starting pentox/arginine/coQ10/cialis right away and skipping the study or holding off on other treatments so that I can participate in the study? Is it more important to treat it early or are current treatments fairly ineffective to the point where I should take the 50/50 risk of either having no treatment for 4.5 mo (placebo) or trying something new (which may or may not work)?

GS · « **Reply #13 on:** April 25, 2013, 11:50:20 AM »

Obviously, this is only one man's opinion. But, I would start treatment right away with stuff that's proven to help. Let other guys that have had the condition for a longer time be in the trials.

GS

funnyfarm · « **Reply #14 on:** April 25, 2013, 01:21:21 PM »

This sounds like the mysterious H-100

Innovation | Hybrid Medical

I have emailed them several times for info and never heard back. There are a few other threads about this you can find here on the forum. I was hoping someone would ask Dr Levine about it at their appt., but this never happened.

If it were me I would take pentox first since to date there are no topicals with a good track record and this company has provided very little useful information about H-100 safety and efficacy. I guess that is why they need test subjects..

james1947 · « **Reply #15 on:** April 25, 2013, 06:23:59 PM »

Fxt

Welcome to the forum.
It is very difficult to give you an advice in the subject as we are talking about your body and not mine or someone else.
I am proposing you to get much as possible information (on the forum and on the web) before you are deciding what to do.

James

skunkworks · « **Reply #16 on:** April 25, 2013, 10:02:47 PM »

Yeah more info on the substance would be useful. If it is this h-100 stuff I'd say skip it and go with what you know works, that product does not look very promising.

Youngdude22 · « **Reply #17 on:** August 23, 2015, 12:30:44 AM »

Hybrid Medical | Treatment for Peyronie's Disease

Anyone know about this products active ingredients? I was initially skeptical of it until I found out that Dr. Levine is a medical advisor for the company. Thoughts?

skunkworks · « **Reply #18 on:** August 23, 2015, 12:58:33 AM »

https://www.google.com/patents/EP2804606A1

https://clinicaltrials.gov/ct2/show/NCT02072018

goodluck · « **Reply #19 on:** August 23, 2015, 09:12:01 AM »

Interesting! Emu oil and a calcium channel blocker(likely Veraprimil) are its main listed ingredients. They also mention other items may be used in a generic sense. Carriers, fragrances etc.

I have no personal experience with Emu oil. But, I know Emu oil is used as a skin moisturizer, anti inflammatory and anti bacterial/fungal.

Has anyone heard of using Emu oil for Peyronies or even tied it? For any reason.

skunkworks · « **Reply #20 on:** August 23, 2015, 09:37:11 AM »

Not with Peyronie's but it has been used as a successful transdermal vehicle for other treatments, progesterone for one and some other lipid soluble steroids. From memory I think verapamil is lipid soluble.

That said, this has been around for a while it seems - Hybrid H-100 - Peyronies Society Forums

According to the clinicaltrial info, if it was ever completed it was completed a year ago, so either results were bad therefore not published or the study was never completed.

I'm a bit sceptical of a company seeking FDA approval who don't even have a product pipeline on their website and don't mention the active ingredients. That is quite shady.

goodluck · « **Reply #21 on:** August 23, 2015, 01:37:38 PM »

Their website has very little information. It looks like the company was formed just for this product and pending its approval.

They do mention one doctor's name who is affiliated with the company.

Youngdude22 · « **Reply #22 on:** August 23, 2015, 07:50:07 PM »

I have not been able to get in contact with them. I will continue to try to get ahold of them to find out the latest on this product.

Freemason · « **Reply #23 on:** August 27, 2015, 05:56:47 PM »

Just wanted everyone to know I did reach out to them and got this reply...FWIW

Thank you for your inquiry regarding H-100 and for volunteering to participate in a clinical study.

Hybrid Medical (hybridmedicalmn.com) is testing H-100 and we have seen positive results. However, it is not available for commercial use at this time. Please continue to monitor the website for updates and suggest the same to your urologist.

Dros · « **Reply #24 on:** December 30, 2015, 05:49:05 PM »

"Safety and efficacy of topically applied gel H-100 composed of Nicardipine, superoxide dismutase and emu oil for treatment of acute phase Peyronie’s disease (Peyronies Disease) was evaluated. Twenty-two patients (Peyronies Disease <12 months duration) were studied in a prospective, randomized, double-blind, placebo-controlled study. Eleven patients received H-100 and 11 patients received placebo for 3 months. All 22 patients then received H-100 for the final 3 months. Flaccid-stretched penile length, degree of penile curvature, pain level and side effects were assessed monthly. H-100 showed significant improvement in all Peyronies Disease parameters at 6 months: mean stretched penile length increase (22.6%, P=0.0002), mean curvature reduction (40.8%, P=0.0014), and mean pain level reduction (85.7%, P=0.004). Placebo group showed no significant improvement except for mean stretched penile length increase (6.8%, P=0.009). Crossover patients from placebo to H-100 showed significant improvement in all parameters: mean stretched penile length increase (17.5%, P=0.000007), mean curvature reduction (37.1%, P=0.006), and mean pain level reduction (40%, P=0.17). Treatment was well tolerated. A self-limited rash was the only side effect in three patients. Statistically significant improvements in flaccid-stretched penile length, curvature and pain suggest that H-100 is a safe and possibly effective non-invasive, topically applied treatment for acute phase Peyronie’s Disease."

http://www.nature.com/ijir/journal/vaop/ncurrent/full/ijir201522a.html

Freemason · « **Reply #25 on:** December 30, 2015, 06:26:59 PM »

[Full quote removed by admin]

FreeMason.... please use the 'Reply' button instead of 'Quote'.

Great news early at least. I'm wondering if they are developing this for actor phase and not chronic phase? Seems as though a gel or product would be easier to get results during acute phase rather than an established chronic phase like 5 years down road.

krazylord · « **Reply #26 on:** December 30, 2015, 11:27:26 PM »

This is great news. I wonder if this also helos with general fibrosis, not only tunica, even if it is small, and both in the tunica and the corpora. That being said, it is a pity that they don't say the amount of each component. If we had that data, we could order it and try ourselves.

Thanks for the link!

Nemo · « **Reply #27 on:** December 31, 2015, 10:50:12 AM »

Everything about the website causes me to be very suspicious (including the fact that the address listed for the company is a residential house in Minnesota), but the fact that Dr. Levine is associated with the product definitely gives it credibility. Here's hoping the results from the test bear out in real world application, whenever that comes.

Will be interesting to see how the treatment is priced. The closest comparison is the infamous Topical Verapamil from PDLabs in San Antonio, Texas, which was thoroughly abandoned by forum members years ago as being a ridiculously expensive waste of time (if not total scam). I would also note, though, that PDLabs had their own "study" showing TV's efficacy, conducted in San Antonio, so just because there's a study doesn't mean it's rock solid - you have to look at the details, who conducted it, etc.

But as I say, Dr. Levine's participation brings credibility, as besides being at the front of the field, he's also the one who showed through testing how little TV actually penetrates the tunica (virtually none). So one assumes he's confident this new medication actually penetrates.

For now I'll be guarded but hopeful.

Nemo

LWillisjr · « **Reply #28 on:** December 31, 2015, 11:19:21 AM »

I saw Doctor Levine in November and he shared this new treatment approach with me. I haven't posted much on it because I haven't had much time to research it. But the Doc was very positive towards it.

Freemason · « **Reply #29 on:** December 31, 2015, 11:38:41 AM »

Sorry about hitting Quote button before. Thought it was reply..lol.

Hope this is ok but I did some research on H-100 product. Seems like the key ingredient is SOD or super oxide dismutase. Emu oil and a blood pressure med are the other active ingredients in their cream or gel it seems. If you do some research on SOD you can see that it's a pretty powerful enzyme that counter acts...well...super oxide, a free radical most common in our bodies.

A definition of SOD:
Superoxide Dismutase (SOD) is an enzyme that repairs cells and reduces the damage done to them by superoxide, the most common free radical in the body. SOD is found in both the dermis and the epidermis, and is key to the production of healthy fibroblasts (skin-building cells).

So I looked further and found that years or decades ago SOD was used to look at treating all kinds of arthritic and skin scarring issues. A Bovine version of SOD was first used in many trials outside the US. There are two types..Bovine and Human. Apparently there really isn't really any efficacy differences in the two...but I found this information interesting on a SOD patent for peyronnies and using Bovine SOD:
Outcome of bovine SOD (orgoteine) therapy for Peyronie's Disease
Bartsch,   23 pts   Excellent (≈100%) resolution of pain
Europ. J. Rheumatol.      7/15 patients penile deviation
Inflamm., 1981      disappeared
Danner   39 pts.   75% pain improved
Prog. Reprod. Biol.      78% decrease of plaque size
Med., 1983      53% deviation improved
Gustafson,   22 pts.   18/22 patients significantly improved
Europ. J. Urol.,
1981 Berlin   31 pts.   50% pain improved
J. Urol., 1986      50% improved
De Vries,   35 pts.   21/25 patients significantly improved
Akt. Urol.,1988      10 patients treatment discontinued
Schilling     78 pts.     72% pain improved
Symposium 1985      33% decrease ofplaque size
33% deviation improved
Pisani, 1985   70 pts.   90% pain improved
50% decrease of plaque size
50% deviation improved

This is some remarkable results at least in these studies with SOD. Again this was Bovine version which is no longer used due to serious side effects I guess. But human version seems same.

reading up on SOD it appears that you need a carrier to get it into skin obviously. I wonder ve ever looked at DSMO and SOD together.

Any way...this product from H-100 is prob a few years away if all goes well but based on what they are using and past success that I can see with SOD it is at the least encouraging.

Hope it's ok that I provided this info.

Freemason · « **Reply #30 on:** December 31, 2015, 11:54:06 PM »

Out of curiosity I looked up the patent for this future drug. I've got it book marked but the describe in detail exactly what is used as ingredients and the formulations used, how much, and compounding pharmaceutical instructions! Lol. I'm thinking Of taking it to my local compounding pharmacy and having them make me some cream? One hiccup is it requires Veraprimil cream or another calcium channel blocker. Other than that it's basically Super Oxide Dismutase(very powerful anti inflammatory and scar destroyer), Emu Oil. Those are it basically. As some on here have probably found out..Veraprimil cream was worthless...by itself..but added with SOD and Emu oil and a strong carrier like DSMO and there might be something here. It's been proven that SOD can reduce plaque and improve this curvature in Peyronies Disease it's just no one has come out with a product. Well this could be it.

Freemason · « **Reply #31 on:** January 01, 2016, 12:13:10 AM »

I have a ? About Veraprimil cream for those that have used? Maybe this is wrong area if so sorry. But I've read the large studies done with it and it's quite impressive results? What's the deal? So many on here have claimed it does nothing. I've not tired it. Any thoughts?

Douglas Hall · « **Reply #32 on:** January 01, 2016, 12:26:00 AM »

Quote from: LWillisjr on December 31, 2015, 11:19:21 AM

I saw Doctor Levine in November and he shared this new treatment approach with me. I haven't posted much on it because I haven't had much time to research it. But the Doc was very positive towards it.

Did he say when it might be released?

Freemason · « **Reply #33 on:** January 01, 2016, 10:28:18 AM »

Looks like they just might have completed phase 1/2 study. This drug is prob at least 2 years away. Just depends on how long it takes to do phase 3. What I'd actually like to see them do is a triple arm study. H-100, control arm, Veraprimil cream. I don't know why Veraprimil cream has studies that show literally thousands of men wh had significant improvements yet on this board less than 1% have.

Nemo · « **Reply #34 on:** January 01, 2016, 10:31:39 AM »

Can you link to these studies you're referring to on Verapamil cream? The only study I remember from back when TV from PDLabs was even part of a relevant discussion was a study in San Antonio, literally conducted by the company, so obviously pretty questionable. You keep referring to multiple studies showing tremendous results. Can you provide links?

Thanks,
Nemo

Freemason · « **Reply #35 on:** January 01, 2016, 11:08:57 AM »

Heres the one on 15% Veraprimil. I wonder how many on here tired the original 8% and didn't see much and didn't try the 15%? This is a smaller study but if a new cream came out today with these results people on here would be ecstatic.

Topical verapamil HCl, topical trifluoperazine, and topical magnesium sulfate for the treatment of Peyronie's disease--a placebo-controlled pilot s... - PubMed - NCBI

Freemason · « **Reply #36 on:** January 01, 2016, 11:16:00 AM »

But yea I see what you are saying. The data appears to be conflicting results. Could mean the company just falsified the data...could be possible that many who tried Veraprimil didn't try it long enough? It appears that the longer you use it the more effective..takes 9 months or more. I don't know. Clearly Verprimil works to reduce scaring and plaque it's a matter of actually reaching the tunica...maybe this new drug being studied, that uses Veraprimil in its compound, uses other carriers to finally get the drug where we need it to go? If you read up on Superoxide Dismutase and peyronnies..you can see that it's been studied for Peyronies Disease with success but it was with Bovine SOD. Although human SOD seems to be same. I think one could create his own compound with a compounding pharmacy. They give instructions on how to compound their new drug on the patent.

Freemason · « **Reply #37 on:** January 01, 2016, 11:17:53 AM »

Off topic...but it would be nice if the moderators were able to conduct polls on here. It's so difficult to sift thru what has worked for folks etc..

Freemason · « **Reply #38 on:** January 01, 2016, 01:45:06 PM »

What's encouraging about this early study is two things...1- Levine was part of the investigators...and 2- the crossover group(meaning they took placebo group who showed no improvement and then gave them the compound) showed almost as good of improvements.

Also...where are the guys who used this stuff!!!?? Get on this board..lol. Probably signed a NDA:(

Nemo · « **Reply #39 on:** January 01, 2016, 03:50:25 PM »

That Verapamil study you point to is several years old and I can guarantee you, if real world results echoed what they claim in the study (which I believe is the study conducted by PDLabs) you'd hear about it on this forum. I realize you're frustrated by the belief that topically applied verapamil should work, but overwhelming anecdotal experience of this forum is that it does not. And Levine's research on tissue excised surgically showed that verapamil applied topically simply did not penetrate the tunica. The ridiculous prices charged by PDLabs only made this treatment looks more and more like a lose/lose proposition.

Nemo

user of no names · « **Reply #40 on:** January 01, 2016, 09:27:46 PM »

This is very interesting. The business address is 8 miles from my house. Dr Jeffry Twidwell seems to be a decent urologist from a google search. I am going to call on Monday and see if there is any trials I can get into.

itsme · « **Reply #41 on:** January 01, 2016, 10:05:03 PM »

Simplespress is the best forum platform with more than 100000 thousands wordpress plugins to be integrated with. This platform is really bad. Its easy to migrate though.

Freemason · « **Reply #42 on:** January 02, 2016, 01:22:29 PM »

User of no names...lol..good name btw...I too live wishing 4 hours of them and what I thought about doing is going into Moudry RX compounding pharmacy..they are the pharmacy that's made the drug for the trial and see if I can talk them into making some for me. Only ingredient of ? Would be Veraprimil but I actually think they used narcidine? Another calcium channel blocker. Would require a rx but Emu Oil and SOD no problem. I think I mentioned in a previous post but the patent is online if u look and they go into detail different formulations and rational along with actual compounding instructions...which seems odd they would do that. No need to wait a couple years.

james1947 · « **Reply #43 on:** January 03, 2016, 07:45:20 AM »

Nemo, I agree with you 100% that if Dr. Levine is involved it may be more in it than snake oil.
Freemason, I hope you are really excited by the subject and not a part of the marketing of the product.

James

Freemason · « **Reply #44 on:** January 03, 2016, 02:03:38 PM »

lol. I wish I were part of it. If I were part of it I wouldn't be looking to have some local pharmacy compound me some, I'd just ask them.

So I read the abstract of H-100 presented by Dr Tidwell in Nov 2014. Their Phase 1 study was done on acute phase Peyronies Disease. I'm sure Phase 2-3 will include chronic but maybe they are just looking to launch a product that has bigger impact on Acute Peyronies Disease patients. Makes me wonder if Peyronies Disease in its chronic stage has simply reached point of no return for topical applications?

Nemo · « **Reply #45 on:** January 03, 2016, 03:21:34 PM »

We have yet to see that even the acute stage is treatable with a topical application. Fingers crossed, but it remains to be seen. Topical Verapamil certainly failed to impress.

Nemo

Dros · « **Reply #46 on:** February 18, 2016, 06:23:11 AM »

Freemason, did you end up getting a cream? And have you tried it yet?

Freemason · « **Reply #47 on:** February 18, 2016, 12:13:53 PM »

Ha. No I haven't yet. But I am planning on trying.

Dros · « **Reply #48 on:** February 18, 2016, 12:40:01 PM »

Where did you find the ingredients? Might be interedted in trying it for myself.

NeoV · « **Reply #49 on:** February 18, 2016, 04:36:32 PM »

It's quite easy to make, at least the emu oil and SOD could be bought anywhere and combined. The Nicardipine would be hard to get which is the calcium blocker. Maybe I'll try the SOD and emu oil for fun.

Keep in mind that emu oil is very likely to do nothing, or be entirely a scam. There is little research on it, and even if it does work, something like olive oil or grapeseed oil should work as well. I do not think anyone knows the mechanism behind its transdermal effects, and again, it's just an expensive olive oil most likely.

As for SOD, this is interesting, Antifibrotic action of Cu/Zn SOD is mediated by TGF-β1 repression and phenotypic reversion of myofibroblasts

I guess the question is still up in the air, as to whether or not topical SOD can effect Peyronie's, but there are a few studies now showing that it might.

News:

Author Topic: Hybrid H-100 (Read 41359 times)