Peyronies articles: review

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Hi there,

I would like to create a list of all (or at least of the most relevant ones) academic articles/expected clinical studies/news articles etc. published in the recent years on Peyronies.

I do not know about you but for me it is super useful to have a list of all articles that have been published recently and then update it every month - just to keep track of all developments in the area.

Important Clinical trials:

Stem Cell Treatment of Peyronie´s Disease (Denmark):
� posted: 25 February 2021; 22 participants
� expected completion: May 30, 2024

PRP for treatment of Peyronies (US):
� posted: August 23, 2020; 80 participants; randomised
� expected completion: April 1, 2024

Academic articles – 2023

January 2023:

Yang CH, Lin DY, Lin YS, Hsu CY, Tung MC, Tan KT, Ou YC. The Immunological Microenvironment and the Emerging Role of Stem Cells Therapy in Peyronie's Disease: A Systematic Narrative Review. Int J Mol Sci. 2023 Jan 1;24(1):777. doi: 10.3390/ijms24010777. PMID: 36614220; PMCID: PMC9821411.

February 2023:

Reddy AG, Dai MC, Song JJ, Pierce HM, Patel SR, Lipshultz LI. Peyronie's Disease: An Outcomes-Based Guide to Non-Surgical and Novel Treatment Modalities. Res Rep Urol. 2023 Feb 2;15:55-67. doi: 10.2147/RRU.S278796. PMID: 36756281; PMCID: PMC9901485.

Kulkarni Y, Green B, Pattillo C, Stirland I, Flores A, Ziegelmann M, Kohler T, Helo S, Trost L. Efficacy of collagenase Clostridium histolyticum in men with congenital penile curvature. J Sex Med. 2023 Feb 14;20(2):194-199. doi: 10.1093/jsxmed/qdac006. PMID: 36763911.

Li MK, Sigalos JT, Yoffe DA, Modiri N, Hu MY, Gaither TW, Santamaria A, Walker DT, Regets KV, Mills JN, Eleswarapu SV. Multiple courses of intralesional collagenase injections for Peyronie disease: a retrospective analysis. J Sex Med. 2023 Feb 14;20(2):200-204. doi: 10.1093/jsxmed/qdac030. PMID: 36763912.

Falcone M, Preto M, Peretti F, Gontero P, Pyrgidis N, Sokolakis I, Hatzichristodoulou G. The use of collagen fleece to correct residual curvature during inflatable penile prosthesis implantation (PICS technique) in patients with complex Peyronie disease: a multicenter study. J Sex Med. 2023 Feb 14;20(2):229-235. doi: 10.1093/jsxmed/qdac003. PMID: 36763916.

Searl T, Ohlander S, McVary KT, Podlasek CA. Pathway analysis of microarray data from corpora cavernosal tissue of patients with a prostatectomy or Peyronie disease in comparison with a cavernous nerve-injured rat model of erectile dysfunction. J Sex Med. 2023 Feb 14;20(2):139-151. doi: 10.1093/jsxmed/qdac019. PMID: 36763930.

Gundogdu G, Nguyen T, Namasivayam A, Starek S, Gelman J, Mauney JR. Characterization of a novel rabbit model of Peyronie's disease. Int J Impot Res. 2023 Feb 13. doi: 10.1038/s41443-023-00671-y. Epub ahead of print. PMID: 36782023.

Spirito L, Manfredi C, La Rocca R, Napolitano L, Preto M, Di Girolamo A, Arcaniolo D, De Sio M, Creta M, Longo N. Long-term outcomes of extracorporeal shock wave therapy for acute Peyronie's disease: a 10-year retrospective analysis. Int J Impot Res. 2023 Feb 14. doi: 10.1038/s41443-023-00673-w. Epub ahead of print. PMID: 36788352.

Sicignano E, Imperatore V, Sciorio C, Di Girolamo A. The clinical potential of flavonoids in Peyronie's disease. J Basic Clin Physiol Pharmacol. 2023 Feb 15;34(2):121-123. doi: 10.1515/jbcpp-2023-0006. PMID: 36790332.

Vieiralves RR, Schuh MF, Favorito LA. Low-intensity extracorporeal shockwave therapy in the treatment of erectile dysfunction - a narrative review. Int Braz J Urol. 2023 Feb 15;49. doi: 10.1590/S1677-5538.IBJU.2023.9904. Epub ahead of print. PMID: 36794846.

Bole R, Alom M, Habashy E, Ahmed M, Ziegelmann M, Kohler T, Helo S. The clinical significance of imperfection: is idiopathic corporal asymmetry related to curvature during penile prosthesis placement? Int J Impot Res. 2023 Feb 16. doi: 10.1038/s41443-023-00669-6. Epub ahead of print. PMID: 36797455.

Kothiya AB, Adlakha N. Cellular nitric oxide synthesis is affected by disorders in the interdependent [Formula: see text] and [Formula: see text] dynamics during cystic fibrosis disease. J Biol Phys. 2023 Feb 22. doi: 10.1007/s10867-022-09624-w. Epub ahead of print. PMID: 36811722.

Brant A, Basourakos SP, Lewicki P, Kang C, Marinaro J, Punjani N, Kashanian JA. Real-world practice in Peyronie's disease management: Results from a national survey of urologists. Andrology. 2023 Feb 23. doi: 10.1111/andr.13414. Epub ahead of print. PMID: 36815582.

Schifano N, Capogrosso P, Antonini G, Baldini S, Scroppo F, Salonia A, Zerbinati N, Dehò F. The Application of Hyaluronic Acid Injections in Functional and Aesthetic Andrology: A Narrative Review. Gels. 2023 Feb 1;9(2):118. doi: 10.3390/gels9020118. PMID: 36826290; PMCID: PMC9957416.

Ziegelmann M. Is there a new role for oral therapy to treat peyronie's disease? Commentary on Daily low-dose tadalafil may reduce the penile curvature progression rate in patients with acute Peyronie's Disease: a retrospective comparative analysis. Int J Impot Res. 2023 Feb 24. doi: 10.1038/s41443-023-00684-7. Epub ahead of print. PMID: 36828955.

March 2023:

Levine LA. What's the new thing for surgical treatment of Peyronie's disease? Extratunical grafting. J Sex Med. 2023 Mar 31;20(4):416-417. doi: 10.1093/jsxmed/qdac039. PMID: 36763947.

Ziegelmann M, Hu Y, Xiang Q, Liu G, McLane MP, Trost L. Incremental Treatment Response by Cycle With Collagenase Clostridium Histolyticum for Peyronie's Disease: A Pooled Analysis of Two Phase 3 Trials. Urology. 2023 Mar 1:S0090-4295(23)00182-6. doi: 10.1016/j.urology.2023.02.019. Epub ahead of print. PMID: 36863600.

Paulis G, Paulis A, Perletti G. Congenital penile curvature as a possible risk factor for the onset of Peyronie's disease, and psychological consequences of penile curvature. Arch Ital Urol Androl. 2023 Mar 15;95(1). doi: 10.4081/aiua.2023.11238. PMID: 36924365.

Pakpahan C, Ilhamsyah I, Supardi S, Narulita P, Agustinus A, Darmadi D. The interplay between neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, erectile dysfunction, and Peyronie's disease: A meta-analysis of observational studies. Arch Ital Urol Androl. 2023 Mar 15;95(1). doi: 10.4081/aiua.2023.11162. PMID: 36924369.

April 2023:

Conlon WJ, Herzog BJ, Hellstrom WJG. Residual penile curvature correction by modeling during penile prosthesis implantation in Peyronie's disease patients. Int J Impot Res. 2023 Apr 13. doi: 10.1038/s41443-023-00694-5. Epub ahead of print. PMID: 37055523.

Chung E, Moon DG, Hui J, Chang HC, Hakim L, Nagao K, Tan R, Mak SK, Tantiwongse K, Lin H, Mai DBT, Nguyen Q, Tan HM, Sato Y, Jiann BP, Park K, Xin ZC, Park HJ. Clinical recommendations on penile reconstructive and prosthetic surgery: a consensus statement from the Asia-Pacific Society of Sexual Medicine. Sex Med. 2023 Apr 11;11(2):qfad003. doi: 10.1093/sexmed/qfad003. PMID: 37056790; PMCID: PMC10086569.

Thomas J, Sencaj M, Ghomeshi A, Zucker IJ, Best JC, Ramasamy R. Stem-Cell, Shockwave, and Platelet Rich Plasma Therapy for the Treatment of Erectile Dysfunction and Peyronie's Disease: A Survey of Clinics Across the US. Urology. 2023 Apr 17:S0090-4295(23)00323-0. doi: 10.1016/j.urology.2023.01.061. Epub ahead of print. PMID: 37076023.

Feng CL, Langbo WA, Anderson LK, Cao D, Bajic P, Amarasekera C, Wang V, Levine LA. Subcoronal inflatable penile prosthesis implantation: indications and outcomes. J Sex Med. 2023 Apr 19:qdad049. doi: 10.1093/jsxmed/qdad049. Epub ahead of print. PMID: 37076135.

Ilg MM, Ralph DJ, Cellek S. Statins synergize with phosphodiesterase type 5 inhibitors but not with selective estrogen receptor modulators to prevent myofibroblast transformation in an in vitro model of Peyronie's disease. J Sex Med. 2023 Apr 20:qdad051. doi: 10.1093/jsxmed/qdad051. Epub ahead of print. PMID: 37082866.

News articles:

January 2023:

• Scientists Reverse Erectile Dysfunction in Pigs Using Synthetic Tissue Link

February 2023:

• Endo Launches "Man With a Plan" Campaign to Support Men With Symptoms of Peyronie's Disease Link

April  2023:

• Early-onset diabetes appears to affect Peyronie disease severity  Link

26 y. o. Peyronie since 2020: upward congenital curvature from the bottom - 20*; twist and curve to the left - 25*; two visible dents on the left side; multiple nodules everywhere; no pain;

VED and traction; can have sex


It's nice to know there's that many studies.  If felt nearly nonexistent to me even after being 16 months since diagnosis.  Most don't even know this exists. 

Age 47, No injury
Diagnosis January 2022  
Six plaques
Hourglassing when flaccid and semi-erect
Still have my congenital curve, no severe curving
Massaging with vitamin E cream twice a day 
5mg Tadalafil, Healthy diet
Discomfort/aching sometimes