It seems peptides will be the cure

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YoungPrince

Age:27
Self induced peyron 2022.04.?
Fibrous ring on the base.
Gluten free diet helped to sit down and enjoy sex again.
Still working on to get my original dick back.
Lost 0.5 inch in girth.
Narrowing, Right side does not fill properly.

thegreycat

From Google:

CONCLUSION: E4 peptide shows oral bioavailability and exerts anti-fibrotic activity in a bleomycin-induced pulmonary fibrosis model. We suggest that E4 peptide is a novel oral drug for fibroproliferative disorders. 

Can you imagine if we end up being able to just take an oral peptide?! 8)
35. No injury. Lump Feb 22.
Pain, dent, left & upward bend ~50deg. Bad EQ.
Cialis Dac 22 - ear issues.
Diagnosed Feb 23.
VED Oct 22. PMP Feb 23.
Lump reduced May 23, dent remains, angle a little better. EQ improved.

Supportive partner, depression.

Mikel7

If this is a cure you can just imagine how much this is going to cost us $$$$$$$$$. Just like if they really found a cure for cancer how much money would the drug companies charge for it? They are already making billions of dollars from the treatments and drugs to treat cancer.
Lump 4/2020, age 63 , Dr Levine 6-26-20, Dors Curve 11/2020, Peyronies
Vit E400mg, COQ10, Heat Therapy, Penimaster, Pentox, Cialis, Restorex
SNHL 7/2020 - Stopped all Meds because ototoxicity  Heat/traction/VED are working. CPPS Diagnosis - Stable :)

YoungPrince

I think it will be costly but not impossible to buy it. A smaller fee with more customer with longer treating period will give them more than a short but very expensive. These conditions are not that common.
Age:27
Self induced peyron 2022.04.?
Fibrous ring on the base.
Gluten free diet helped to sit down and enjoy sex again.
Still working on to get my original dick back.
Lost 0.5 inch in girth.
Narrowing, Right side does not fill properly.

beaulieu1008

But when would these be available then.
60 years old. Peyronie disease since 2020. Upward curve 30 degrees. Thick calcified plaque, dorsal, just beneath glans. 2cm wide, 1cm long. No ED. Except soft glans.

nironus

Quote from: Mikel7 on April 11, 2023, 06:32:31 AMIf this is a cure you can just imagine how much this is going to cost us $$$$$$$$$. Just like if they really found a cure for cancer how much money would the drug companies charge for it? They are already making billions of dollars from the treatments and drugs to treat cancer.

I'd be willing to heist it and distribute it to the people, no worries.
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hope4thebest

Guys, things can be done. It's likely possible to do a custom synthesis in China and get it delivered to your door. We would just need to find out the dose, which is not difficult, and inquire about the price and we could do a group buy.
Trauma 2022 August, first deformation seen 2022 November. Very mild curve to the right. Indentation on the right side below the glans. Now hourglass just below the glans. Looking for treatment options.

happyman


Omg are you me? literally same boat and have been preaching this. getting the e4 is not the problem folks! I already know a lab that can synthesize it and they quoted me at 1600$/gram. its the dosing that is the question!
20s
been 5 years
hourglass, ed, soft glans
diagnosed corporal fibrosis

happyman

@everyone

i know a lab that can synthesize e4 (the peptide in the news article linked on fibrosis). hmu if you want to talk about this more
20s
been 5 years
hourglass, ed, soft glans
diagnosed corporal fibrosis

pauli

how long do we have to wait until there will be a test with a peyronie patient? what do you think? maybe it is possible to get in touch we the research team?
31 yrs old; in a supportiv relationship
first symptoms and diagnosed in february 2018
severe progression since spring 2020
several plaque/indentations and currently 40° up curve

Sonic

Quote from: pauli on April 19, 2024, 05:33:39 PMhow long do we have to wait until there will be a test with a peyronie patient? what do you think? maybe it is possible to get in touch we the research team?

There is limited info. We do not know if it will be an oral medication or injectable. Regardless it would likely be very expensive. I've searched around and can practically find nothing. They've been studying since at least 2012.
30 years. Sudden rightwards curve detected in June 2020
Narrowing on right side and about a 20° curve to the right.
ED + instability due to narrowing.

pauli

But is there a study for peyronies or just in general fibrosis?

I really do not care what it costs, if it stops this nightmare...
31 yrs old; in a supportiv relationship
first symptoms and diagnosed in february 2018
severe progression since spring 2020
several plaque/indentations and currently 40° up curve

Sonic


I have looked around and no there is none that I can find.
30 years. Sudden rightwards curve detected in June 2020
Narrowing on right side and about a 20° curve to the right.
ED + instability due to narrowing.

Bluepy

The only forums talking about this E4 peptide are penis related  :D  only other one i saw was a reddit for Long Covid sufferers. you'd think there would be more talk about it on forums for people with deadly fibrotic conditions like pulmonary fibrosis
late 20's
severe ED
semi erect curve

Trying to cope with the situation (with ups and downs)

happyman

message me to join a discord where we discuss the e4 peptide
20s
been 5 years
hourglass, ed, soft glans
diagnosed corporal fibrosis

Restorexuser110033

Quote from: pauli on April 19, 2024, 05:33:39 PMhow long do we have to wait until there will be a test with a peyronie patient? what do you think? maybe it is possible to get in touch we the research team?

I'm all for this. I was wondering the same thing..
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pauli

I wrote an email to the scientist named in the article. She actually responded directly. she wrote the following

Thank you for reaching out. We are moving forward with our peptide development as funds become available. You will be happy to know that Peyronie's disease is in our top list of diseases to consider testing, so we definitely have interest in the disease.


I would say it is really a promising and encouraging, but also vague answer. it would be great to find out more. Are we talking about one two years or ten years?
31 yrs old; in a supportiv relationship
first symptoms and diagnosed in february 2018
severe progression since spring 2020
several plaque/indentations and currently 40° up curve

Bluepy

Last year in June another user on this site ''Vett''also sent an email to the researcher Feghali-Bostwick.
He got the response that they hoped it would be avaiable in the next 2 years.

https://www.peyroniesforum.net/index.php/topic,19415.0.html

There's also a screenshot of her message.

 
late 20's
severe ED
semi erect curve

Trying to cope with the situation (with ups and downs)

Dune

It is still in the pre-clinical stages. It seems that it has at least ten years to go, if it succeeds in passing advanced clinical trials. This is very disappointing.
https://synapse.patsnap.com/drug/e773261c0cdb45d5a3e8092e77271bad

Is it possible to send someone to the doctor to inquire why the medication was not continued in the pre-clinical stages?
Age29

happyman

I know how to get it now but no one wants to join on a group buy for it and i dont have thousands myself
20s
been 5 years
hourglass, ed, soft glans
diagnosed corporal fibrosis

Blitzangel

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happyman

Full previous quote removed by Admin

I sent the chemical formula and all the info to a lab that I've used before for other peptides. I used the patent ibio released so it's exactly how they were using it. Anyways, like I've said multiple times, I know how to get a hold of it. If anyone's interested in talking about this more they can message.

Also can someone let me know they saw this message so I know I'm not shadow banned? Just say "banana" if u see it
20s
been 5 years
hourglass, ed, soft glans
diagnosed corporal fibrosis

happyman

20s
been 5 years
hourglass, ed, soft glans
diagnosed corporal fibrosis

MunichPatient1989

Hi,

I wrote with some experts (doctors, researchers).
Peyronie's is on their mind for Peptide treatment.
Clinical studies are super expensive so, especially getting everything approved with the FDA.

In case Peptides are tested for other diseases and save for use in humans then testing the same drug in a "compatibility study" for Peyronie's is much more realistic/cheap and we could even try to crowd fund it e.g. via peyronies.org.
One expert told me to keep hopes realistic as laboratory tests are often more successful compared to in human application of a new drug.

The whole process will take time (expert said 10-20 years for a new drug to be fully approved and available).
Therefore let us hope for the best, keep our eyes open to help experts and to spread awareness for Peyronie's and our hope in treatments like Peptides so that it is in the collective mind of the society and experts :).

In case someone knows a Philanthropist who could pay a study I guess we could expedite research for Peptides for Peyronie's so... :).

KR
T
35 yo, first symptoms 2021 (32 yo)
ED, bottleneck dent, right behind glans, shortening
Plaque calcification
5 mg Tadalafil 1-2/week
-.- new plaque appeared on right side of shaft