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Has anything changed in 10 years?

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Seems like the only change is Pentox is less recommended than before (maybe?) and Xiaflex turned out to have lots of sides making it higher risk/lower reward than hoped.

I started having other health issues that made exercise more difficult and have started to have Erectile Dysfunction again, but it seems there's not a lot of advancements in the official treatments and we're just stuck with the pumps/stretchers and diet/supplementation still.


You might be too harsh on xiaflex. Skilled doctors are getting pretty good results. It sounds like Trost is perfecting the protocols and getting better and better results. You might not get your pre-peyronies dick back, but some doctors are getting restored dicks that most women would not recognize as being anything out of the ordinary.
57 yrs old.
55 degree upward curve.


Having been away for several years myself, and sadly now back, I would concur with your assessment.

Pentox is still probably the closest thing to a legitimate pharmaceutical being used against Peyronies Disease, but the enthusiasm has waned as no studies have ever verified its effectiveness, and the original Italian study that touted it was pulled down as half-baked. It's probably more of a psychological comfort (at least I'm doing something!) than anything. I no longer take it, as I just never saw results, and in fact, developed new nodules after more than a year on Pentox.

And yes, Xiaflex is breakthrough, but not the "godsend" we'd all hoped.

To my mind, I don't put any credence in the oral supps/vitamin route either. I just don't think there's any solid support that any of that works.

Finally, doctors even disagree on VED usage, though most seem to be ok with traction.

In a nutshell, you're right - not a lot has changed, unfortunately. We're all still taking it day by day and hoping for the best.

51 yrs. old, multiple auto-immune conditions. First episode of Peyronies Disease in 2002. Recurred a couple times since. Over the years I have tried Topical Verapamil, Iontophoresis, all the supps and Cialis + Pentoxifylline. Still functional, always worried.