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QuoteAbstractBACKGROUND Peyronie's disease is a chronic inflammatory disease involving the tunica albuginea of the penile corpora cavernosa. Conservative medical treatment includes oral therapy, intralesional injections, and physical treatment. No cases of Peyronie's disease with complete plaque regression after conservative medical treatment are described in the literature. CASE REPORT Case 1: A 50-year-old man presented with penile pain, combined penile curvature (left dorso-lateral), a palpable nodule, and normal penile rigidity. The patient underwent multimodal therapy with oral antioxidants, topical diclofenac gel, and periodic perilesional penile injections with pentoxifylline. At follow-up after over 3 years of multimodal treatment, the patient no longer had penile deformity or pain. Ultrasound imaging did not show any area affected by disease and plaque could no longer be observed. Case 2: A 55-year-old man presented with penile lichen sclerosus, dorsal penile curvature with onset about 6 months before, penile plaque, no penile pain, and normal penile rigidity. He underwent multimodal therapy with oral antioxidants, topical diclofenac gel, and periodic perilesional penile injections with pentoxifylline. At follow-up after over 3 years of multimodal treatment, he presented a dorsal curvature of the penis of about 5°, similar to his condition prior to the onset of congenital penile curvature. Ultrasound no longer showed plaque. CONCLUSIONS This study showed that multimodal combined antioxidant treatment had satisfactory results. However, to accomplish this, we deem it essential to have a correct ultrasound assessment that is performed with a sufficiently advanced machine by an operator with extensive experience in the field.
Quote from: bentoboy on August 10, 2022, 06:17:40 PM"antioxidants oral propolis 600 mg, bilberry 160 mg, silymarin 400 mg, ginkgo biloba 250 mg, L-carnitine 1000 mg, coenzyme Q10 100 mg, and vitamin E 30 mg daily; topical diclofenac gel 4% twice daily; and peri-plaque penile injection of pentoxifylline 100 mg with a 30 G needle every 2 weeks for 6 months."This is fascinating. Now I'm wondering whether I should try this treatment out and see what happens. Has anyone started using some of these things?
Quote from: thegreycat on August 11, 2022, 04:48:36 AMAnyone know where to get Propolis, Bilberry, Silymarin, Biloba? Got the rest (minus the Pentox injections obviously)
Quote from: nemo on August 11, 2022, 01:14:53 PMYeah, guys, I wouldn't go spend a bunch of money on these specific antioxidants. Supplements have never proven to achieve any real good with Peyronies Disease - and Dr. Trost has said as much. The notion that something you're taking orally is going to selectively reverse scarring in your penis and not everywhere else in your body doesn't really make sense. He doesn't even believe Pentox offers any benefit. Also, the Italians seem to pop out these Peyronie's focussed studies every couple years and the results never seem to get verified anywhere else. I'd just take it all with a grain of salt.
Quote from: fartoolong on September 01, 2022, 06:19:48 PMI could cry when I think how much money I have spent on supplements over the last 10 years and not one of them has made an iota of difference that I can tell over the longterm. Some like evening primrose oil in large dosage could make the plaque seem much softer, but only for half a day.I do think there is a lot to be said for antioxidants, but it comes through eating a variety of the right food types every day for months, while blocking any and all foods that can cause problems.
Quote from: hope794 on September 18, 2022, 10:13:54 AM100% NOT recommended. I tried this "cure" and had no results at all. The ultrasound said i was improving but my penis got worse and worse, my curve worsened and my penis shortened. My Erectile Dysfunction worsened as well. BE AWARE.
Quote from: hope4thebest on December 05, 2022, 09:59:47 AMPersonally I'm thinking about trying all the antioxidants + diclofenac + try to convince my urologist to do pentoxi injections, although I know it won't be easy. I have really bad stomach issues and I'm pretty sure I won't be able to tolerate most, if not all of those antioxidants, so I see PTX injections as my only option right now. Optimizing vitamins and minerals is another thing that I'm doing. @FlatteningTheCurve posted a very good study (thanks!!) showing lower levels of Cu, Mn, Fe, Zn in Peyronie's patients. I think that's definitely something to think about.