Peyronies Society Forums

Please login or register.

Login with username, password and session length
Advanced search  

News:

Welcome to J Francois Eid, MD - Directly answering member questions in the "Medical Professionals" section below the Treatment boards.
https://www.peyroniesforum.net/index.php/topic,17819.0.html

Pages: [1]   Go Down

Author Topic: Study - Complete Plaque Regression After Treatment with Antioxidants  (Read 1186 times)

0 Members and 1 Guest are viewing this topic.

Pfract

  • Global Moderator
  • ****
  • Country: ca
  • Offline Offline
  • Gender: Male
  • Posts: 2335
  • #whateverittakes

https://pubmed.ncbi.nlm.nih.gov/35430575/



Quote
Abstract

BACKGROUND Peyronie's disease is a chronic inflammatory disease involving the tunica albuginea of the penile corpora cavernosa. Conservative medical treatment includes oral therapy, intralesional injections, and physical treatment. No cases of Peyronie's disease with complete plaque regression after conservative medical treatment are described in the literature. CASE REPORT Case 1: A 50-year-old man presented with penile pain, combined penile curvature (left dorso-lateral), a palpable nodule, and normal penile rigidity. The patient underwent multimodal therapy with oral antioxidants, topical diclofenac gel, and periodic perilesional penile injections with pentoxifylline. At follow-up after over 3 years of multimodal treatment, the patient no longer had penile deformity or pain. Ultrasound imaging did not show any area affected by disease and plaque could no longer be observed. Case 2: A 55-year-old man presented with penile lichen sclerosus, dorsal penile curvature with onset about 6 months before, penile plaque, no penile pain, and normal penile rigidity. He underwent multimodal therapy with oral antioxidants, topical diclofenac gel, and periodic perilesional penile injections with pentoxifylline. At follow-up after over 3 years of multimodal treatment, he presented a dorsal curvature of the penis of about 5°, similar to his condition prior to the onset of congenital penile curvature. Ultrasound no longer showed plaque. CONCLUSIONS This study showed that multimodal combined antioxidant treatment had satisfactory results. However, to accomplish this, we deem it essential to have a correct ultrasound assessment that is performed with a sufficiently advanced machine by an operator with extensive experience in the field.

I found this interesting even tho this was just two patients. Surprised to read about injecting Pentox into the penis! This is a new finding for me.

Anybody new about this?

nemo

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 893
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #1 on: August 09, 2022, 01:47:38 AM »

I wish they would clearly state what oral antioxidants they were employing, and in what amounts.

nemo
Logged
51 yrs. old, multiple auto-immune conditions. First episode of Peyronies Disease in 2002. Recurred a couple times since. Over the years I have tried Topical Verapamil, Iontophoresis, all the supps and Cialis + Pentoxifylline. Still functional, always worried.

Tobyg

  • Solid Contributor
  • ***
  • Country: cl
  • Offline Offline
  • Gender: Male
  • Posts: 160
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #2 on: August 09, 2022, 01:56:30 AM »

The ultrasound does not work for peyronie, my 2 plaques also disappeared and my penis continued to get worse.
Logged
30 years,injured at 25.
Slight curve, narrowing and retraction in flaccid and semi-erect.
Loss of sensitivity due to peyronie and circumcision  moderate erectile dysfunction, pain.
I improved the pelvic floor with kinesiology.

bentoboy

  • Solid Contributor
  • ***
  • Country: be
  • Offline Offline
  • Gender: Male
  • Posts: 103
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #3 on: August 10, 2022, 06:17:40 PM »

“antioxidants oral propolis 600 mg, bilberry 160 mg, silymarin 400 mg, ginkgo biloba 250 mg, L-carnitine 1000 mg, coenzyme Q10 100 mg, and vitamin E 30 mg daily; topical diclofenac gel 4% twice daily; and peri-plaque penile injection of pentoxifylline 100 mg with a 30 G needle every 2 weeks for 6 months.”

This is fascinating. Now I’m wondering whether I should try this treatment out and see what happens. Has anyone started using some of these things?
Logged
26 y. o. Peyronie since 2020: upward congenital curvature from the bottom - 20*; twist and curve to the left - 25*; two visible dents on the left side; multiple plaques everywhere; no pain

Vitamins; Tadafil; traction/bending; VED - nothing worked

thegreycat

  • Voting Member
  • **
  • Country: gb
  • Offline Offline
  • Gender: Male
  • Posts: 49
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #4 on: August 11, 2022, 04:48:36 AM »

“antioxidants oral propolis 600 mg, bilberry 160 mg, silymarin 400 mg, ginkgo biloba 250 mg, L-carnitine 1000 mg, coenzyme Q10 100 mg, and vitamin E 30 mg daily; topical diclofenac gel 4% twice daily; and peri-plaque penile injection of pentoxifylline 100 mg with a 30 G needle every 2 weeks for 6 months.”

This is fascinating. Now I’m wondering whether I should try this treatment out and see what happens. Has anyone started using some of these things?

Anyone know where to get Propolis, Bilberry, Silymarin, Biloba? Got the rest (minus the Pentox injections obviously)
Logged
35. No injury. Lump found Feb/early Mar 22.
Misdiagnosed, now waiting on Urologist referral.
Possible cause Vit D/Propranolol.
Large dent, left hand hinge, pain on erection.
Supportive partner, depression/anxiety.
Started VED Oct 22.

HenH

  • Voting Member
  • **
  • Country: nl
  • Offline Offline
  • Gender: Male
  • Posts: 15
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #5 on: August 11, 2022, 05:11:27 AM »

In the Netherlands you can get them at homeopathic / naturepathic pharmacies or supplement stores. I guess this is the same in the UK?

@Pfract: thnx for sharing! Did not know about pentoxifylline injections...
Logged
34 y/o, peyronie since 22 y/o, lump visable mid peniel, slight 20 degree bend upwards, recently pain came back, l, using Pentoxifylline and VED

blex

  • Voting Member
  • **
  • Country: de
  • Offline Offline
  • Gender: Male
  • Posts: 72
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #6 on: August 11, 2022, 09:56:06 AM »

Anyone know where to get Propolis, Bilberry, Silymarin, Biloba? Got the rest (minus the Pentox injections obviously)

Got all of these from amazon. Did nothing though.
Logged
36 years old, married
---
Symptoms since trauma in July 21:
Calcified nodule in septum near glans
Calcified plaque almost circumferential
Pain (flaccid/erect), 45° upwards curvature, hourglassing
---
Nothing helped, looking for surgery now

nemo

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 893
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #7 on: August 11, 2022, 01:14:53 PM »

Yeah, guys, I wouldn't go spend a bunch of money on these specific antioxidants. Supplements have never proven to achieve any real good with Peyronies Disease - and Dr. Trost has said as much. The notion that something you're taking orally is going to selectively reverse scarring in your penis and not everywhere else in your body doesn't really make sense. He doesn't even believe Pentox offers any benefit.

I think you'd be smarter to just eat foods abundant in anti-oxidants like blueberries, strawberries, etc., etc. - get the benefits from food, not supplements. At least it's tastier than swallowing a handful of expensive capsules and tablets everyday.

Also, the Italians seem to pop out these Peyronie's focussed studies every couple years and the results never seem to get verified anywhere else. I'd just take it all with a grain of salt.

nemo
Logged
51 yrs. old, multiple auto-immune conditions. First episode of Peyronies Disease in 2002. Recurred a couple times since. Over the years I have tried Topical Verapamil, Iontophoresis, all the supps and Cialis + Pentoxifylline. Still functional, always worried.

Fierarul

  • Voting Member
  • **
  • Country: ro
  • Offline Offline
  • Gender: Male
  • Posts: 7
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #8 on: August 30, 2022, 11:50:19 AM »


after 6 years of illness can something be done, I have a 5 mm nodule on the left side of the penis, and the curve is 15 degrees to the left, I wonder if it can get worse over time and if the erection will be affected
Logged
30 years old, January 2022, circumcision surgery as a result of repeated candida infection, 5 months after that I noticed a painful lump after sex, I consulted two urologists who diagnosed Peyronie's disease, pentox twice a day , citrulline, vitaminE

fartoolong

  • Voting Member
  • **
  • Country: gb
  • Offline Offline
  • Gender: Male
  • Posts: 23
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #9 on: September 01, 2022, 06:19:48 PM »

I could cry when I think how much money I have spent on supplements over the last 10 years and not one of them has made an iota of difference that I can tell over the longterm. Some like evening primrose oil in large dosage could make the plaque seem much softer, but only for half a day.

I do think there is a lot to be said for antioxidants, but it comes through eating a variety of the right food types every day for months, while blocking any and all foods that can cause problems.
Logged
54 years old. First developed Peyronie's in 2012. Tried all the usual treatments without success and generally only got worse. Seeing improvement following a move to a raw whole food plant based diet, plus flax seeds & lots of water in summer of 2022

hope794

  • Major Contributor
  • ****
  • Country: it
  • Offline Offline
  • Gender: Male
  • Posts: 437
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #10 on: September 18, 2022, 10:13:54 AM »

100% NOT recommended. I tried this "cure" and had no results at all. The ultrasound said i was improving but my penis got worse and worse, my curve worsened and my penis shortened. My Erectile Dysfunction worsened as well. BE AWARE.
Logged
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
Erectile Dysfunction for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

FlatteningTheCurve

  • Global Moderator
  • ****
  • Country: se
  • Offline Offline
  • Gender: Male
  • Posts: 194
Re: Study - Complete Plaque Regression After Treatment with Antioxidants
« Reply #11 on: September 19, 2022, 09:40:13 AM »

I think the main thing to keep in mind here is that antioxidants alone cannot cure Peyronies Disease. Antioxidants may contribute to reducing the likelihood of continued inflammation or flare ups but there is no limited proof of this. That is, it might contribute to not making the condition worse, not necessarily improving it.

There have been a few studies that have looked into the impact of antioxidants in combination with various injections. They have found some evidence of a greater positive effect (e.g. reduced curvature and pain) for the people who have been taking antioxidants and receiving injections compared to those who only received injections. See for example:

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2605.2011.01219.x

https://www.tandfonline.com/doi/10.1080/13685538.2018.1474195

https://www.nature.com/articles/3900880

This is only an indication of a correlation but further studies are needed.

I have been taking a few antioxidant supplements but mainly changed my diet somewhat to include more natural antioxidants. I have done this together with traction and VED in 2020. I then had Verapamil injections for almost a year and now I am back on traction and VED.

I have seen good improvements over the course of all of this, but I am not saying that this is due to antioxidants. Ultimately, there is no evidence that I had not seen these improvements had I not included antioxidants as a part of my regime.

All in all, I doubt that taking a few supplements or changing your diet will hurt you, but do not expect it to 'cure' Peyronies Disease on its own.
Logged
Early 30s, diagnosed with Peyronies in 2017 after trauma during sex. ca 15 degrees upward curvature. Restorex, VED, 5mg Cialis, Pentox, L-arginine, Coq10, Propolis, Vitamin E. Underwent 12 rounds of Verapamil injections 2021-22
Pages: [1]   Go Up
 

Related Topics

  Subject / Started by Replies Last post
2 Replies
2395 Views
Last post December 22, 2014, 10:40:08 AM
by skunkworks
12 Replies
808 Views
Last post September 17, 2021, 08:25:10 AM
by Hawk
6 Replies
793 Views
Last post September 11, 2022, 07:52:26 PM
by Fix This