RE: Xiaflex and working out

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Hi Everyone,

Wish me luck. I had my first injection in the first cycle of Xiaflex today. I'm hoping it will make a difference, as my curvature is quite extreme. Been ok psychologically by focusing on other things and staying busy, but not it's back to focusing on trying to see if improvement is possible.

Quick question for those who have been through this and exercise regularly. Doctor told mt to take it easy with no specific directions. If you exercise, how soon have you started working out again. Right after 2nd injection ok? Wait a a few days? Week?

Any personal experience y'all can share would be appreciated.

Age 52
first symptoms occurred March 2021
Diagnosed with acute stage Peyronie's Disease
Currently taking 2x400mg Pentoxifylline, 1x Cialis, doing stretches
Waiting for follow-up appointment
Intercourse is currently painful
In a stable relationship


I went through 3 rounds, 6 injections, each was worse than the last with pain and swelling. I just used how I felt as a guide. I run 5 miles x 5 days per week and lift weights 2 x per week. After 1st round (2nd injection) I was running (slowly) in 3 days. After 2nd round more like 7 days and after 3rd round, about 2 weeks because I really swelled up on that 3rd round and it was very painful. I would wait a few days and see how you feel. If you feel ok (which to me means without a lot of pain), try an easy exercise and see how you feel and go from there. I wouldn't do contact sports, basketball or maybe even tennis until you really had no pain. Just my opinion.
62YO, hourglass indent/hinging at base 30deg bend up 3cmx2cm hard plaque at dorsal base. No Erectile Dysfunction. 3 rounds Xiaflex decreased plaque/indent/hinge/bend. 1 year later, penis went from 7.5 to 5.5 in, but only 15 degree bend and no hinging.